C-reactive protein as an inflammatory marker of acute infections outside intensive care settings: case report and evidence-based literature review

Abstract. Background: This prospective study was designed to evaluate the effect of inflammatory markers on the presence and progression of subclinical markers of carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 diabetes mellitus (T2DM). Patients and methods: A total of 595 subjects with T2DM were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima media thickness (CIMT), plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment and again after 3.8 years. Subjects with T2DM were divided into 2 groups according to the plasma high sensitive C-reactive protein (hs-CRP) levels (subjects with hs-CRP ≥ 2 mg/L and subjects with hs-CRP below 2 mg/L). Results: Subjects with T2DM and hs-CRP levels ≥ 2 mg/L had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L, and higher incidence of plaques/unstable plaques in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic regression analysis found the association between the HDL cholesterol level and presence of plaques, whereas the inflammatory marker hs-CRP was not associated with subclinical markers of progression of carotid atherosclerosis. Multiple linear regression analysis found the association between the hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up. Conclusions: We demonstrated an association between the inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found the association between hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up in subjects with T2DM.

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Non-surgical periodontal treatment impact on C-Reactive Protein levels in patients with Rheumatoid Arthritis – literature review

10.26226/morressier.5ac383202afeeb00097a3f80 ◽

2018 ◽

Author(s):

Daniela Santos Silva

Keyword(s):

Rheumatoid Arthritis ◽

Literature Review ◽

Periodontal Treatment ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

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C-reactive protein to predict intensive care unit readmission?

Journal of Critical Care ◽

10.1016/j.jcrc.2006.03.007 ◽

2006 ◽

Vol 21 (3) ◽

pp. 265-266 ◽

Cited By ~ 2

Author(s):

Suzana M.A. Lobo

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

C Reactive Protein ◽

Reactive Protein ◽

Intensive Care Unit Readmission

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Comparison of the Neutrophil/Lymphocyte Ratio and C-Reactive Protein Levels in Patients With Amputation for Diabetic Foot Ulcers

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734617696729 ◽

2017 ◽

Vol 16 (1) ◽

pp. 23-28 ◽

Cited By ~ 4

Author(s):

Hasan Metineren ◽

Turan Cihan Dülgeroğlu

Keyword(s):

Diabetic Foot ◽

Inflammatory Marker ◽

Foot Ulcer ◽

Diabetic Foot Ulcer ◽

C Reactive Protein ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Protein Levels ◽

Reactive Protein ◽

Before And After

This study compared the effectiveness of the neutrophil/lymphocyte ratio (NLR) versus C-reactive protein (CRP) for evaluating the prognosis and degree of inflammation in patients with amputation for a diabetic foot ulcer (DFU). This study enrolled 56 patients with amputations for DFU with gangrene and compared the CRP levels and NLR measured before and after surgery. Overall, 24 patients (42%) died within 2 weeks postoperatively. Mortality increased with a preoperative/postoperative CRP difference ≤1.5 ( P < .001) and age 73 years or older ( P < .001). The postoperative NLR was lower than the preoperative value but was not significant as a prognostic or inflammatory marker ( P = .945). An increasing serum CRP level is a significant predictor of mortality. CRP and old age are reliable prognostic factors in patients with DFU.

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Case Report: High-Sensitivity C-Reactive Protein is a Potentially Useful Marker of the Need for Psychotic Treatment for Cognitive Dysfunction Related to Low-Grade Inflammation

Journal of Alzheimer’s Disease & Parkinsonism ◽

10.4172/2161-0460.1000402 ◽

2017 ◽

Vol 07 (06) ◽

Author(s):

Koji Hori ◽

Kimiko Konishi ◽

Misa Hosoi ◽

Michiho Sodenaga ◽

Hiroyuki Kamatani ◽

...

Keyword(s):

Case Report ◽

Cognitive Dysfunction ◽

High Sensitivity ◽

Low Grade ◽

C Reactive Protein ◽

Reactive Protein ◽

Low Grade Inflammation

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THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD

Journal of Experimental Medicine ◽

10.1084/jem.85.5.491 ◽

1947 ◽

Vol 85 (5) ◽

pp. 491-498 ◽

Cited By ~ 72

Author(s):

Maclyn McCarty

Keyword(s):

Infectious Diseases ◽

Early Phase ◽

Serum Proteins ◽

Protein A ◽

Normal Serum ◽

C Reactive Protein ◽

Reactive Protein ◽

Acute Infections

A procedure is described for the isolation and crystallization from human serous fluids of the C-reactive protein, a substance which appears in the blood especially in the early phase of certain acute infectious diseases. Immunological studies confirm earlier work in showing that the protein is highly antigenic and serologically specific, and demonstrate that crystallization of the protein effectively separates it from normal serum proteins.

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A Worthwhile Measurement of Early Vigilance and Therapeutic Monitor in Axial Spondyloarthritis: A Literature Review of Quantitative Sacroiliac Scintigraphy

EMJ Rheumatology ◽

10.33590/emjrheumatol/21-00014 ◽

2021 ◽

pp. 129-139

Author(s):

Zhu Wei Lim ◽

Shih-Chuan Tsai ◽

Yi-Ching Lin ◽

Yuan-Yang Cheng ◽

Shin-Tsu Chang

Keyword(s):

Early Detection ◽

Literature Review ◽

Reactive Arthritis ◽

Sacroiliac Joint ◽

Bone Scan ◽

Human Model ◽

C Reactive Protein ◽

Sacroiliac Joints ◽

Reactive Protein ◽

Quantitative Sacroiliac Scintigraphy

Background: Back pain a common cause for hospital visits. Nuclear skeletal scintigraphy, at a high sensitivity, provides a functional imaging for detecting bone diseases. Sacroiliitis is an inflammation of the sacroiliac joint. Bone scan with quantitative sacroiliac scintigraphy (QSS) has been a useful inflammation indicator for sacroiliac joints. However, QSS has been ignored in the rehabilitation practice. Objective: To present the background, mechanisms, and current clinical applications of bone scan with QSS in spondyloarthropathy (SpA). Methods: The authors performed a literature review of QSS through database searching of MEDLINE, Embase, CINAHL, HaPI, Cochrane Review, and citation mining. Studies were included if they had QSS in the methodology performed in adult patients with various diseases. Any articles, including the authors’, that can be performed in a clinical setting were enrolled. Articles explicitly referencing QSS were retained for screening. Results: QSS appearance of SpA, including ankylosing spondylitis, may give rise to early detection. The specificity of sacroiliitis based on QSS increases from 73% to 97%. After investigating the relationship between serum C-reactive protein and sacroiliac joint inflammation in patients with SpA, there appeared to be a significant difference between serum C-reactive protein in serum and in sacroiliac ratio (particularly the middle part of the both joints), indicating a systemic inflammatory response to flair-up of SpA, for example, serum C-reactive protein as an indicator of inflammation. Sacroiliitis also occurs in post-streptococcal reactive arthritis. The involvement of sacroiliac joints in the development of post-streptococcal reactive arthritis had been demonstrated a significant correlation between anti-streptolysin O titres and QSS in patients with post-streptococcal reactive arthritis. Lower extremity periostitis acts as a human model in the study of bottom-up processing for periostitis-induced sacroiliac pain. The use of QSS can also monitor sacroiliac joint dysfunction before and after laser therapy. Improvements of the sacroiliac joint after convalescing of foot periostitis have been reported. Conclusions: Bone scan using QSS is a good screening measurement in scintigraphy rehabilitation for early detection of SpA and raises awareness of physicians toward the next step of diagnosis.

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Gambaran kadar C-reactive protein (CRP) serum pada perokok aktif usia >40 tahun

Jurnal e-Biomedik ◽

10.35790/ebm.4.2.2016.12657 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Hendrika N. C. Dewi ◽

Michaela E. Paruntu ◽

Murniati Tiho

Keyword(s):

Inflammatory Marker ◽

Systemic Disease ◽

Toxic Chemical ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Positive Serum ◽

Cross Sectional Design ◽

Serum Crp ◽

Descriptive Method

Abstract: Cigarette are the most cause of death around the world. Smoking cigarrete is harmful to the organs because it contains many toxic chemical that can stimulate inflammatory process. Smoking cigarrete is a risk factors for heart disease and chronic pulmonary disease (COPD). C-reactive protein (CRP) are a non spesific inflammatory marker that can elevated in both local and systemic disease. Beside biomarker, CRP also use as prognostic marker for inflammation. The purpose of this study was to identify the level of serum CRP of smokers aged >40 years old. Twenty eight smokers were eligible to this criteria and participated in this study. Cross-sectional design with a descriptive method was employed in this study. Sampels were analysed in laboratory for serum CRP levels. The results showed that 23 subjects (82%) had normal (negatif) serum CRP level and five subjects (18%) had positive serum CRP level. It can be concluded that serum CRP level of >40 years old smokers in Kolombo village, west Bitung two were mostly in normal level.Keywords: c-reactive protein (crp), active smoker, at age >40 years oldAbstrak: Rokok menjadi salah satu penyebab kematian terbesar di dunia. Merokok membahayakan hampir semua organ tubuh karena mengandung berbagai bahan kimia berbahaya yang dapat merangsang proses peradangan dan merupakan faktor utama penyakit jantung dan penyakit paru obstruktif kronik (PPOK). C-Reactive Protein (CRP) merupakan petanda inflamasi non-spesifik yang meningkat pada penyakit lokal maupun sistemik. Selain biomarker CRP juga dijadikan sebagai penanda prognostik untuk inflamasi. Tujuan dari penelitian ini untuk mengetahui kadar CRP serum pada perokok berusia >40 tahun. Dua puluh delapan perokok memenuhi syarat untuk kriteria ini dan berpartisipasi dalam penelitian ini. Penelitian ini menggunakan desain cross-sectional dengan metode deskriptif. Kadar CRP serum sampel dianalisis di laboratorium. Hasil penelitian menunjukkan bahwa 23 subyek (82%) memiliki kadar CRP serum normal (negatif) dan lima subjek (18%) memiliki kadar CRP serum positif. Dapat disimpulkan bahwa kadar CRP serum perokok berusia >40 tahun di desa Kolombo, Bitung barat dua kebanyakan dalam kadar normal.Kata kunci: c-reactive protein (crp), perokok aktif, usia >40 tahun.

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