scholarly journals Clinical and laboratory characteristics of chronic spontaneous urticaria with connective tissue diseases: A cross-sectional study

2021 ◽  
Author(s):  
Songül Çildağ ◽  
Gökhan Sargın ◽  
Taşkın Şentürk
Keyword(s):  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Cross Sectional Study ◽  
Sjögren Syndrome ◽  
Chronic Spontaneous Urticaria ◽  
Sjogren Syndrome ◽  
Cross Sectional ◽  
Female Patients ◽  
Study Results

Objectives: The aim of this study was to investigate the frequency of connective tissue diseases (CTDs) in patients with chronic spontaneous urticaria (CSU) and to evaluate clinical and laboratory characteristics of CSU accompanied by CTDs. Patients and methods: Between January 2017 and December 2020, a total of 390 CSU patients (120 males, 270 females; mean age: 38.9±13.7 years; range, 18 to 78 years) were included in the study. Clinical and laboratory characteristics of CSU in patients with and without CTD were analyzed. Results: A total of 6.4% patients (n=25) with CSU had CTD, and the rate was found to be 8.9% in female patients (n=24). In these patients, Sjögren syndrome (SS) was seen in 15 (5.5%), rheumatoid arthritis in five (1.85%), undifferentiated connective tissue disease in three (1.11%), and systemic lupus erythematosus in one (0.37%). Anti-thyroglobulin antibody, rheumatoid factor, anti-cyclic citrullinated peptide antibody, antinuclear antibody positivity, low complement 4 level, and erythrocyte sedimentation rate were significantly different between CSU patients with and without CTD (p=0.013, p<0.001, p<0.001, p<0.001, p=0.0182, p<0.001, respectively). Conclusion: Our study results suggest that CSU is associated with CTDs, particularly with Sjögren syndrome. Every patient diagnosed with CSU should be questioned about rheumatic symptoms, particularly female patients and those having later-onset CSU.

scholarly journals Evaluation of Dot Immunoblot for identification of antibodies to Extractable nuclear antigen

2011 ◽  
Vol 5 (1) ◽  
pp. 12-15
Author(s):  
Sadia Sharmin ◽  
Sharmee Ahmed ◽  
Humayun Sattar ◽  
Ahmed Abu Saleh ◽  
Shirin Tarafdar
Keyword(s):  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Simultaneous Detection ◽  
Connective Tissue Diseases ◽  
Cross Sectional Study ◽  
Connective Tissue Disorder ◽  
Nuclear Antigen ◽  
Dot Blot ◽  
Cross Sectional ◽  
Number Of Patients

This cross sectional study was done from January 2009 to June 2010 in Microbiology department of Dhaka Medical Collage. The study was designed to evaluate the advantages and reliability of dot immunoblot (DB) for identification of antibodies to extractable nuclear antigens (anti-ENA) in autoimmune connective tissue disorder (CTD). Sera from systemic lupus erythematosus patients (n = 37), systemic sclerosis patients (n = 13), rheumatoid arthritis patients(n=11), mixed connective tissue disease patients (n=6), polymyositis patients (n=7), and sjogren’s syndrome (n=2)were tested for antinuclear antibody (ANA) by Indirect Immunofluorescence (IIF) on HEp-2 cell and analyzed for the presence of antibodies to RNP, Sm, SSA, SSB, Scl-70, and Jo-1 (anti-ENAs) by dot immunoblot and ELISA. Out of 76sera of autoimmune connective tissue diseases 35 (46.05%) samples were found to be positive by DB and 33 (43.4%)were positive by ELISA. The dot blot assay exhibited 100% sensitivity for SSA, SSB, Scl-70 antibodies and for RNP the sensitivity was 90%; specificity was over 98% for these 4 ENA antibodies. Multiple reactivities were also found in a substantial number of patients sera. No serum was positive for anti-Sm and anti-Jo-1.Healthy controls also revealed no positive reactivity for anti-ENA by DB and ELISA. In conclusion, the dot immunoblot is a valid method for the detection of specific autoantibodies in autoimmune connective tissue disorder. Its most notable advantages are simultaneous detection of several autoantibodies in the same serum and its lower cost.DOI: http://dx.doi.org/10.3329/bjmm.v5i1.15815 Bangladesh J Med Microbiol 2011; 05 (01): 12-15

scholarly journals Clinical profile of cutaneous manifestations of connective tissue diseases in North-East India

2021 ◽  
Vol 7 (5) ◽  
pp. 702
Author(s):  
Deepa Mala Subba ◽  
Nandakishore Thokchom ◽  
Linda Kongbam ◽  
Erika Salam ◽  
Deepa Yumnam
Keyword(s):  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Skin Lesions ◽  
Discoid Lupus Erythematosus ◽  
Serological Tests ◽  
Cross Sectional ◽  
Cutaneous Manifestations ◽  
North East

<p class="abstract"><strong>Background:</strong> Connective tissue diseases (CTDs) are a heterogeneous group of autoimmune disorders having overlapping clinical features. Skin is often involved and it may be the earliest sign of the disease. This study highlighted the various cutaneous manifestations of common CTDs.</p><p class="abstract"><strong>Methods:</strong> A hospital-based cross-sectional study was carried out for a period of two years in 83 patients with CTDs in dermatology OPD, RIMS, Imphal. Detailed history taking, examination and relevant serological tests were performed.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean age was 39.78±17.29 years with female to male ratio of 4.5:1. Majority of the patients had lupus erythematosus (LE) (N=45) followed by systemic sclerosis (SSc) (N=25), rheumatoid arthritis (RA) (N=6), mixed connective tissue disease (MCTD) (N=4) and morphea (N=3). The most common presentation was raised skin lesions (45.8%) followed by Raynaud’s phenomenon (36.1%), photosensitivity (27.7%), skin tightness (26.5%) and joint pain (19.3%). Among LE patients, chronic cutaneous lupus erythematosus (CCLE) was the commonest variant and localised discoid lupus erythematosus (DLE) (22.9%) was the commonest presentation followed by malar rash and annular subacute lupus erythematosus (SCLE). Skin induration, microstomia and sclerodactyly were seen in most patients of SSc. Antinuclear antibodies were positive in 89.1% of patients. Anti-dsDNA and anti-Sm antibodies were positive in 62.2% and 33.3% of LE patients, anti-Scl 70 antibody was positive in 68% of SSc patients.</p><p class="abstract"><strong>Conclusions:</strong> CTDs are rare but potentially life-threatening. Proper understanding of the spectrum of cutaneous manifestations of CTDs is therefore necessary for early diagnosis and efficient management.</p>

scholarly journals Psoriasis and connective tissue diseases: What about Sjogren syndrome?

2015 ◽  
Vol 19 (2) ◽  
pp. 114-116
Author(s):  
Zohra Aydi ◽  
Sana Toujani ◽  
Fatma Daoud ◽  
Besma Ben Dhaou ◽  
Lilia Baili ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome

scholarly journals Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Kevin John John ◽  
Mohammad Sadiq ◽  
Tina George ◽  
Karthik Gunasekaran ◽  
Nirmal Francis ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Diagnostic Criteria ◽  
Connective Tissue Disease ◽  
Lupus Erythematosus ◽  
Mixed Connective Tissue Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Immunological Profile ◽  
Immune Mediated ◽  
Organ Systems

Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study. A clinical diagnosis of MCTD was made in 111 patients, of whom 103 (92.8%) were women. The mean age at presentation was 39.3 years (SD±11.6). The most common organ systems that were involved were musculoskeletal system (95.5%), skin and mucosa (78.4%), and the gastrointestinal and hepatobiliary systems (56%). The maximum sensitivity was for the Kasukawa criteria with a sensitivity of 77.5% (95% CI 68.4-84.6) and specificity of 92.2% (95% CI 87-95.5). The Kahn criteria and Alarcón-Segovia criteria had the maximum specificity; the Alarcón-Segovia criteria had a sensitivity of 69.4% (95% CI 59.8-77.6) and a specificity of 99.4% (95% CI 96.5-99.9), while the Kahn criteria had a sensitivity of 52.3% (95% CI 42.6-61.7) and a specificity of 99.4% (95% CI 96.5-99.9). The sensitivity and specificity of Sharp criteria were 57.7% (95% CI 47.9-66.87) and 90% (95% CI 84.4-93.8), respectively.

scholarly journals Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India

2018 ◽  
pp. 283-291 ◽  
Author(s):  
Yasmeen Jabeen Bhat ◽  
Muzafar Ahmad Mir ◽  
Abid Keen ◽  
Iffat Hassan
Keyword(s):  
Connective Tissue ◽  
Lichen Planus ◽  
Connective Tissue Diseases ◽  
Diagnostic Procedures ◽  
Cross Sectional Study ◽  
North India ◽  
Cross Sectional ◽  
Pigmented Lesions ◽  
Important Diagnostic Tool ◽  
Longitudinal Melanonychia

Background: Nail disorders comprise approximately10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Objective: To study the dermoscopic features of various nail disorders to determine the correlation between KOH examination and onychoscopic patterns in patients with the clinical suspicion of onychomycosis, and to differentiate benign pigmented lesions from malignant ones. Methods: An open, observational and cross-sectional study of 237 patients was conducted. All patients underwent clinical examination and the affected nails were examined with a dermatoscope. The onychoscopic patterns were identified and recorded. Results: The study included 237 patients with the following diagnoses: 81 onychomycosis, 63 psoriasis, 27 lichen planus, 30 longitudinal melanonychia, 24 connective tissue disorders, 5 onychophagia and nail tics, 3 subungual verrucae, 2 glomus tumor, 1 Darier disease, and 1 enchondroma. The most common onychoscopic findings were spiked pattern in cases of onychomycosis, dilated and tortuous capillaries in cases of psoriasis, longitudinal streaks and nail fragmentation in cases of lichen planus, and enlarged capillaries in cases of connective tissue diseases. Limitations: The study was only observational and did not compare the results to biopsy and culture. Conclusions: Onychoscopy may be used as an important diagnostic tool when evaluating nail disorders. It should be used to aid in the diagnosis of various nail disorders and to avoid unnecessary and time-consuming investigations.

scholarly journals Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study

2017 ◽  
Vol 46 (3) ◽  
pp. 1162-1171 ◽  
Author(s):  
Visnja Kokic ◽  
Dusanka Martinovic Kaliterna ◽  
Mislav Radic ◽  
Leida Tandara ◽  
Dijana Perkovic
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Female Patients ◽  
Hydroxyvitamin D

Objectives To investigate possible associations between 25-hydroxyvitamin D3 (25(OH)D3), oestradiol (E2) and IFN-gamma (IFNγ) in female patients with inactive systemic lupus erythematosus (SLE). Methods Female patients with inactive SLE and age-matched healthy controls were recruited into this cross-sectional study. Serum concentrations of 25(OH)D3, E2 and IFNγ were measured by radioimmunoassay with gamma-counters and enzyme-linked immunosorbent assay. Results 36 patients and 37 controls were enrolled. In patients with SLE, the concentration of 25(OH)D3 was lower and E2 was higher compared with controls. In vitamin D deficient (i.e., 25(OH)D3≤20 ng/ml) patients, IFNγ was 150% higher compared with patients with 25(OH)D3>20 ng/ml and controls. The concentration of E2 was higher in all patients compared with controls independently of the vitamin D level. A difference was found between patients and controls in the correlation of 25(OH)D3 with E2 and a positive correlation was found between E2 and IFNγ in all participants. Conclusions Our results suggest that E2 may have a strong modulating effect on vitamin D function which is significant only at low concentration of E2.

scholarly journals Prevalence of Pruritus in Cutaneous Lupus Erythematosus: Brief Report of a Multicenter, Multinational Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Dominik Samotij ◽  
Justyna Szczęch ◽  
Carolyn J. Kushner ◽  
Mohammad Rafiqul Mowla ◽  
Aleksandra Dańczak-Pazdrowska ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Cutaneous Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Well Being ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Pruritus is an important symptom frequently accompanying various inflammatory skin conditions. Some recent data have indicated that it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis; however, studies on the prevalence and clinical characteristics of pruritus in CLE are limited. We have performed a multinational, prospective, cross-sectional study in order to assess the prevalence and intensity of pruritus in adult patients suffering from various subtypes of CLE. After developing a questionnaire assessing various aspects of pruritus, we have surveyed 567 patients with cutaneous involvement during the course of LE regarding the presence and intensity of pruritus. Pruritus was present in 425 of all patients (75.0%) and was most frequently reported by subjects with acute CLE (82.1%), followed by chronic CLE (78.8%), subacute CLE (65.9%), and intermittent CLE (55.6%) (p<0.001). Based on the Numerical Rating Scale, the severity of itch was mild, moderate, and severe in 264 (62.1%), 98 (23.1%), and 63 (14.8%) patients, respectively. The highest mean pruritus intensity was reported by subjects with hypertrophic LE (5.1±3.0 points) followed by generalized discoid LE (3.6±3.0 points), subacute CLE (3.0±3.0 points), chilblain LE (3.0±1.0 points), localized discoid LE (2.6±2.0 points), intermittent CLE (2.6±3.0 points), acute CLE (2.5±1.2 points), and lupus erythematosus profundus (1.9±2.7 points). In conclusion, pruritus is a frequent phenomenon in CLE; however, in most patients it is of mild severity. Further studies are needed to better characterize its clinical characteristics and influence on patients’ well-being.

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