scholarly journals COMPARATIVE CLINICAL STUDY OF SHUNTHYAADI SNEHA YOGA NASYA OVER KSHAVATHU ROGA W.S.R. TO ALLERGIC RHINITIS BASED ON SNEHA MEDIA

2021 ◽  
Vol 9 (10) ◽  
pp. 2310-2317
Author(s):  
Shreeganesh Aithal ◽  
Laxmi. B. Kurle
Keyword(s):  
Allergic Rhinitis ◽  
Indian Population ◽  
Nasal Congestion ◽  
Atopic Disease ◽  
Allergen Exposure ◽  
Inflammatory Disorder ◽  
Disease Entity ◽  
Postnasal Drip ◽  
Comparative Clinical Study ◽  
Ige Mediated

Shunthyaadi Sneha Yoga which is a Sneha Kalpana developed with Ghrita and Taila Paka method containing ingredients which are Kshavathu hara and indicated specifically in Kshavathu Roga. In Ayurveda, Kshavathu is a symptom of many diseases and at the same time a separate disease entity. The literal meaning of Kshavathu is sneezing and is the main symptom of Allergic Rhinitis and both share similar etiological factors. Allergic rhinitis is an atopic disease characterised by symptoms of nasal congestion, clear rhinorrhea, sneezing, postnasal drip, and nasal pruritis. It is an inflammatory disorder of the nasal mucosa induced by allergen exposure triggering IgE- mediated inflammation. Around 20–30 % of the Indian population suffers from allergic rhinitis and that 15 % develop asthma. In the present study, an attempt has been made to compare the efficacy of Shunthyaadi Taila Nasya and Shunthyaadi Ghrita Nasya designed in two groups comprising fifteen patients each and analysed with parametric and non-parametric tests. Both the groups showed remarkable results in the management of Kshavathu. Keywords: Kshavathu, Shunthyaadi Sneha Yoga, Shunthyaadi Taila, Shunthyaadi Ghrita, Nasya,

Mast cell stabilizers

1992 ◽  
Vol 107 (6_part_2) ◽  
pp. 841-844 ◽  
Author(s):  
Hueston C. King
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cell ◽  
Cell Membrane ◽  
Nasal Mucosa ◽  
Nasal Polyps ◽  
Nasal Congestion ◽  
Correct Diagnosis ◽  
Vasomotor Rhinitis ◽  
Ige Mediated ◽  
Exercise Induced

The precise mode of action of the well-studied cromolyn sodium and the newer nedocromil sodium has not been completely elucidated. Because the drugs do not pass the cell membrane and enter the cell, they are virtually not metabolized, do not exert a systemic action, and therefore are associated with only minimal systemic toxicity. To be effective either drug must be applied topically and directly to the nasal mucosa. Proper contact with the nasal mucosa is essential for efficacy; in patients with nasal congestion and secretions, vasoconstrictors or saline lavages are indicated before cromolyn or nedocromil use. Both products are highly effective in patients who have IgE-mediated allergic rhinitis but must be administered prophylactically before exposure to an allergen to prevent development of the allergic event. Neither drug is effective in vasomotor rhinitis, exercise-induced rhinitis, or in the management of nasal polyps. Correct diagnosis is essential before therapy.

scholarly journals Experience Of Ocular Symptoms Among Allergic Rhinitis Patients Depending On The Type Of Aeroallergens

2015 ◽  
Vol 16 (4) ◽  
pp. 313-318
Author(s):  
Vesna Velickovic ◽  
Sladjana Simovic ◽  
Tatjana Sarenac ◽  
Natasa Mihailovic ◽  
Svetlana Ristic ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Congestion ◽  
Statistical Significance ◽  
Runny Nose ◽  
Ocular Symptoms ◽  
Nasal Symptoms ◽  
Study Population ◽  
Ige Mediated ◽  
Indoor Aeroallergens ◽  
Indoor And Outdoor

Abstract The aim of this study was to determine the frequency of ocular symptoms and compare the demographic and clinical characteristics in AR patients depending on sensitisation to various types of aeroallergens. Allergic rhinitis is defined as an IgE-mediated inflammation of the lining of the nose that is characterized by nasal symptoms, including nasal congestion, sneezing, itching of nose and runny nose. Patients suffering from allergic rhinitis frequently experience ocular symptoms such as ocular redness, eye itching and tears. The frequency of ocular symptoms in our study population was 27,6%. No statistical significance was found in the mean ages of the patients who did or did not experience ocular symptoms p>0,05 (p=0,243). Our results indicated that there were no statistical differences (p>0,05) among the groups of allergic rhinitis patients based on experiencing nasal symptoms according to the types of aeroallergens. Our results indicated that there were significant experiences of ocular symptoms in patients who were sensitised to outdoor aeroallergens (p<0,001) and significant sensitisation to both outdoor and indoor aeroallergens (p<0,05). Experiencing the examined ocular symptoms, including ocular redness, eye itching and tears, demonstrated highly statistical significance (p<0,001) among the groups of allergic rhinitis patients who were sensitised to indoor aeroallergens and outdoor aeroallergens, and there was statistical significance (p<0,05) among the groups of allergic rhinitis patients who were sensitised to indoor aeroallergens and both types of aeroallergens (indoor and outdoor). Ocular symptoms are more common in patients who are sensitised to outdoor aeroallergens.

Recent Trends in Management of Allergic Rhinitis

2016 ◽  
Vol 9 (3) ◽  
pp. 130-136 ◽  
Author(s):  
Rajalaxmi Panigrahi ◽  
Sudhir K Acharya
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Adverse Effects ◽  
Immunoglobulin E ◽  
Nasal Congestion ◽  
Symptomatic Relief ◽  
Dust Mite ◽  
Recent Trends ◽  
Ige Mediated

ABSTRACT Allergic rhinitis is an inflammatory, immunoglobulin E (IgE)- mediated disease, characterized by nasal congestion, rhinorrhea, and sneezing with or without nasal itching. It can significantly interfere with patient's quality of life. The goals of treatment are to provide the patient with symptomatic relief and improve the quality of life with minimal adverse effects. Prevention has been a large focus in the treatment of allergic rhinitis, but few interventions have proven effective. Although dust mite allergies are more common. How to cite this article Panigrahi R, Acharya SK. Recent Trends in Management of Allergic Rhinitis. Clin Rhinol An Int J 2016;9(3):130-136.

scholarly journals Management of Symptoms of Allergic Rhinitis by Panchakarma Therapy: Concept and Application

2020 ◽  
Author(s):  
Alka Mishra ◽  
Lalima Batham ◽  
Saurabh Mishra
Keyword(s):  
Allergic Rhinitis ◽  
Short Duration ◽  
Curcuma Longa ◽  
Nasal Congestion ◽  
Herbal Medicines ◽  
Complete Relief ◽  
Inflammatory Disorder ◽  
Head Region ◽  
Patient Reported ◽  
Therapeutic Procedures

Background: Allergic Rhinitis is an inflammatory disorder of the nasal mucosa; common symptoms include nasal congestion, sneezing, rhinorrhea, nose itching, etc. Effective management of this disease, in short duration of time, is still a challenge. As per the classical texts of Ayurveda, the disease that resembles the symptoms associated with allergic rhinitis is Vataja Pratishyaya; Nasya procedure of Panchakarma therapy has shown encouraging results in managing its symptoms.Methodology: Panchakarma therapy was administered for 13 days to a male patient suffering from allergic rhinitis and associated ailments. According to Ayurveda, this disease is associated with the imbalance of Kapha and Vata doshas. Hence, Kapha and Vata pacifying therapeutic procedures and herbal medicines, that also provide nourishing effect to the respiratory system, were used. Later, patient took raw Haridra (Curcuma longa) for self-management of disease at home.Results: The patient experienced significant reduction in sneezing episodes, from about 150 per day to about 20 per day; relief in heaviness in the head region; and, complete relief in itching in nose and throat. Overall, the patient reported a good experience. In a followup taken after about one and a half years, the patient reported complete relief in sneezing episodes and heaviness in the throat, as well as non-recurrence of the earlier condition.Conclusion: Panchakarma Therapy showed encouraging results with regards to the management of the symptoms associated with allergic rhinitis and associated ailments, in a short duration of time.

scholarly journals Cholinergic Synapse Pathway Gene Polymorphisms Associated With Late-Phase Responses in Allergic Rhinitis

2021 ◽  
Vol 2 ◽  
Author(s):  
Simranjit K. Samra ◽  
Ashwini Rajasekaran ◽  
Andrew J. Sandford ◽  
Anne K. Ellis ◽  
Scott J. Tebbutt
Keyword(s):  
Gene Expression ◽  
Allergic Rhinitis ◽  
Nasal Congestion ◽  
Late Phase ◽  
Allergen Exposure ◽  
Phase Response ◽  
Cholinergic Synapse ◽  
Predominant Symptom ◽  
Pathway Gene ◽  
Novel Method

Allergic rhinitis (AR) is characterized by an early-phase response (EPR), and in a subgroup of individuals, a late-phase response (LPR). We sought to investigate polymorphisms in cholinergic synapse pathway genes, previously associated with late-asthmatic responses, in the LPR. Twenty healthy participants and 74 participants with AR underwent allergen exposure using the Environmental Exposure Unit. Allergic participants were sub-phenotyped using self-reported nasal congestion scores; congestion is the predominant symptom experienced during the LPR. Acute congestion (AC, n = 36) participants developed only an EPR, while persistent congestion (PC, n = 38) participants developed both allergic responses. We interrogated blood samples collected before allergen exposure with genotyping and gene expression assays. Twenty-five SNPs located in ADCY3, AKT3, CACNA1S, CHRM3, CHRNB2, GNG4, and KCNQ4 had significantly different allele frequencies (P &lt; 0.10) between PC and AC participants. PC participants had increased minor allele content (P = 0.009) in the 25 SNPs compared to AC participants. Two SNPs in AKT3 were associated with gene expression differences (FDR &lt; 0.01) in PC participants. This study identified an association between the LPR and polymorphisms in the cholinergic synapse pathway genes, and developed a novel method to sub-phenotype AR using self-reported nasal congestion scores.

Efficacy of Shunthyadi Taila Nasya in the Management of Vataja Pratishyaya W.S.R. to Allergic Rhinitis: A Case Study

2021 ◽  
Vol 11 (10) ◽  
pp. 158-161
Author(s):  
Pinki Meena ◽  
Aparna Sharma
Keyword(s):  
Allergic Rhinitis ◽  
Key Words ◽  
Nasal Mucosa ◽  
Treatment Approach ◽  
Nasal Congestion ◽  
Clinical Status ◽  
Age Group ◽  
The People ◽  
Ige Mediated

Background- Vataja Pratishyaya is a Nasagataroga and one among five types of Pratishyaya. It is most common and annoying nasal problem which affect the people of all age group. Vataja Pratishaya is a disease which possesses symptoms like Nasagata Tanusrava, Kshavathu and Nasaavarodha. These symptoms are also found in allergic rhinitis which is induced by an IgE mediated inflammation of the nasal mucosa. While treating the Pratishyaya, special attention should be given to the stages of the disease because the treatment approach of Amavastha, Pakwavastha and Dushta stages are entirely different. Nasya is the most important Shodhana method in Urdhwgatrugata Vyadhies and can execute Uttamanga Shuddhi, Snehana, and Swedana. The continuous sneezing is a main disturbing symptom of allergic rhinitis. Shunthyadi Taila was selected for this purpose which is given in Kshavathu Adhikara for managing the allergic conditions of the nose. Method – The patient with Vataja Pratishyaya was given two courses of Shunthyadi Taila Nasya, each course consisting of one sitting per day for 7 days. Six drops of Shunthyadi Taila were poured into each nostril during each session. Result- Patients clinical status was assessed on 7th, 15th, 21st and 28th day. Remission of symptoms like sneezing, rhinorrhoea, itching, nasal congestion etc. was observed after 2 courses of treatment. Patient was followed up for 1 month and no recurrences of symptoms were observed. Key words: Vataja Pratishyaya, allergic rhinitis, Shunthyadi Taila.

Cytokine expression in the lower airways of nonasthmatic subjects with allergic rhinitis: Influence of natural allergen exposure

2000 ◽  
Vol 106 (5) ◽  
pp. 904-910 ◽  
Author(s):  
Jamila Chakir ◽  
Michel Laviolette ◽  
Hélène Turcotte ◽  
Michel Boutet ◽  
Louis-Philippe Boulet
Keyword(s):  
Allergic Rhinitis ◽  
Allergen Exposure ◽  
Cytokine Expression ◽  
Lower Airways

Comparison of efficacy and tolerability of oral desloratadine, rupatadine and ketotifen in seasonal allergic rhinitis

2021 ◽  
Vol 4 (3) ◽  
pp. 106-114
Author(s):  
Syed Khadeer ◽  
B Jagannath
Keyword(s):  
Allergic Rhinitis ◽  
Adverse Events ◽  
Nasal Congestion ◽  
Primary Outcome Measure ◽  
Nasal Symptom ◽  
Secondary Outcome ◽  
Open Label ◽  
Non Allergic Rhinitis ◽  
The Individual ◽  
Change In Mean

Rhinitis is inflammation of nasal mucosa which characteristically presents as running nose, blocked nose, itching on nose or sneezing. Allergic rhinitis is more common than non-allergic rhinitis. Anti-histamines are the mainstay of SAR treatment. Desloratadine, rupatadine and ketotifen are the commonly prescribed anti histamines in our region. In this study, we have compared efficacy and tolerability of desloratadine, rupatadine and ketotifen in SAR. This was a prospective, randomized, three arm, open label comparative study of desloratadine, rupatadine and ketotifen in SAR, conducted at Department of ENT, Kempegowda Institute of Medical Sciences, Bangalore; between January 2014 and December 2014. Patients’ severity of SAR symptoms were assessed by TNSS, QoL was measured using Medical Outcomes Study questionnaire (SF-12). SF-12 was administered at the start of study and then at the end of study. Adverse effects were monitored during clinical examination at each visit. Study subjects were systemically randomized into three groups – desloratadine (DES), rupatadine (RUP) and ketotifen (KET). Based on the assigned group; desloratadine was given orally in dose of 10mg OD, rupatadine orally 10 mg OD and ketotifen orally 1mg BD. All medications were given for 4 weeks. Follow up was done for all patients every week during treatment period of 4 weeks. The primary outcome measure was change in mean TNSS from baseline; secondary outcome measures were changes in the individual nasal symptom scores, change in the quality of life and tolerability to the study medications. Total 150 patients were recruited for this study, divided into 3 groups. DES and RUP were equally effective but significantly better than KET in improving rhinorrhea, nasal congestion, TNSS and AEC. (p=0.05). All the drugs were equally effective with no statistically significant intergroup difference in improving sneezing, nasal itching and QoL. RUP appeared to have better tolerability as the total number of adverse events were marginally less. DES and RUP are comparatively more effective and faster acting than KET. All the study medications were well tolerated with few mild, self-limiting, transient adverse events requiring no intervention.

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