scholarly journals AN OPEN CLINICAL STUDY TO ASSESS THE COMBINED EFFECT OF JANUBASTHI AND MATRA BASTHI WITH SAIREYAKA TAILA IN JANUSANDHIGATAVATA W.S.R TO OSTEOARTHRITIS OF KNEE JOINT

2021 ◽  
Vol 9 (11) ◽  
pp. 2684-2691
Author(s):  
Diksha Masimade ◽  
Rajesh Sugur ◽  
Doddabasayya Doddabasayya
Keyword(s):  
Clinical Study ◽  
Medical Science ◽  
Combined Effect ◽  
Specific Method ◽  
Open Label ◽  
Radiographic Evidence ◽  
Osteoarthritis Of Knee ◽  
Treat Ment ◽  
Almost All ◽  
Flexion And Extension

Basti is considered the best modality of treatment in managing the disorders of Vata Dosha. As Sandhigatavata is also one among Vatavyadhi, Basti is the effective line of treatment, which is characterized by swelling, pain during flexion and extension of joints. Osteoarthritis is a common degenerative joint condition with a prevalence of about 22% to 39% in India. There is a steady rise in prevalence from age 30 such that by age 65, 80% of people will have radiographic evidence of osteoarthritis. It is caused by the degradation of the joints, the articular cartilages and subchondral bone. It is characterized by pain, stiffness and loss of flexibility of joints.1 By foregoing, Sandhi- gatavata can be readily correlated to Osteoarthritis. In contemporary medical science, they use NSAIDs for control of the symptoms. Acharya Sushrutha and Acharya Charaka have mentioned Snehana (Oleation) as a line of treat- ment in Sandhigatavata. So here an attempt is made through Janubasthi and Matrabasthi using Saireyaka Taila2 mentioned in Gada Nigraha under Vata Vyadhi for treating Janusandhigatavata in specific. Method: This study is an open-label, observational and clinical study containing 30 patients, who were posted for Janu Basti and Matra Basti with Saireyaka Taila for 9 days. The assessment was carried out before treatment, during treatment (5th day), after treatment (on 10th day) and after following up (28th day) and the gradings were noted. Results: Out of 30 patients in this study, 5 patients (17%) were getting Moderate Improvement and 25 patients (83%) were gettingGood Improvement. The overall effect of the treatment is 69.44%. Conclusion: It is concluded that the combined effect of Janubasti and Matrabasti with Saireyaka Taila is clinically and statistically significant in almost all the parameters. Keywords: Janu Basti, Matra Basti, Sandhivata, Osteoarthritis, Saireyaka Taila.

An exploratory prospective clinical study to assess the combined effect of Virechana and Raktamokshana in Vicharchika - A Case Study.

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Paresh Katariya ◽  
Mayur Pawaskar ◽  
Nikhil Joglekar ◽  
Yogesh Katariya ◽  
Arati Datye
Keyword(s):  
Clinical Study ◽  
Skin Disease ◽  
Marked Improvement ◽  
Lower Extremities ◽  
Combined Effect ◽  
Prospective Clinical Study ◽  
Choice Of Treatment ◽  
Almost All

Vicharchika is one of the Kshudra Kushta (skin disease). Kashyapa mentioned it as Sadhya Vyadhi. Almost all symptoms are Vata-Pitta or Kapha-Pitta predominant and even Tridosha involvement and it is specifically located at lower extremities. The choice of treatment is Virechana (purgation) and Raktamokshan (bloodletting). We can use this modality as per requirement. Kandu (itching), Pidika (pimples), Bahusrava (discharge) get relieved completely (100%) after Virechana. Mild effect was noticed in Shyava (blackish discoloration) and Rukshata (dryness) i.e. (33.33%). Highly significant result found after both the therapies (Virechana and Raktamokshana) and marked improvement was seen in Shyava and Rukshata after Raktamokshana. It shows over all Ayurvedic modality gives very good result in Vicharchika..

scholarly journals An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee

2013 ◽  
Vol 4 (1) ◽  
pp. 33
Author(s):  
SanjayU Nipanikar ◽  
Manjit Saluja ◽  
Arvind Chopra ◽  
KalyanP Kadbhane ◽  
NamdevR Khade ◽  
...  
Keyword(s):  
Clinical Study ◽  
Prospective Clinical Study ◽  
Open Label ◽  
Polyherbal Formulation ◽  
Osteoarthritis Of Knee

scholarly journals A COMPARATIVE CLINICAL STUDY OF MATRAVASTI AND PICHU WITH RASNA TAILA IN SANDHIGATAVATA W.S.R TO OSTEOARTHRITIS

2021 ◽  
Vol 9 (12) ◽  
pp. 2975-2984
Author(s):  
Nupur Biswas ◽  
Kultar Singh
Keyword(s):  
Clinical Study ◽  
Weight Bearing ◽  
Medical Science ◽  
Joint Damage ◽  
Disease Process ◽  
Point Of View ◽  
Clinical Appearance ◽  
Comparative Clinical Study ◽  
Almost All ◽  
Selection Of

Sandhigata Vata (Osteoarthritis) is a type of Vatavyadhi (degenerative disease) that mainly occurs in Vrid- dhavastha (Old age) due to Dhatukshaya (cellular degeneration). Vagabhatta has also considered Vata Vyadhi as a Maharoga. It appears from the point of view of modern medical sciences that Sandhigata vata can be simulated with Osteoarthritis in its clinical appearance. Osteoarthritis is the most common articular disorder that begins asymptomatically in the 2nd and 3rddecades and is extremely common by age 70. Almost all persons by age 40 have some pathologic change in the weight-bearing joint. 25% of females and 16% males have symptomatic OA. This disease has been described in Ayurveda from ancient times. The disease Arthritis causes work disability. It limits everyday activities such as walking, dressing, bathing etc, thus making individuals handicapped. No treat- ment is available which can prevent the disease process. In western medical science, mainly analgesics, anti- inflammatory drugs or surgery are the options for the treatment of Osteoarthritis; don’t provide remarkable recov- ery but causes great adverse effect. Researchers are trying their level best for making drugs that can prevent or slow down or reverse joint damage. Panchakarma therapy is one of the important branches of Ayurveda, which deals mainly with the purification of the aggravated Doshas from the human system. This is the reason behind the selection of the topic entitled “A COMPARATIVE CLINICAL STUDY OF MATRA VASTI AND PICHU WITH RASNA TAILA IN SANDHIGATA VATA W.S.R TO OSTEOARTHRITIS”. We have used Panchakarma treatment procedure. Panchakarma treatment is believed to help in the radical elimi- nation of the disease-causing factors and maintain the equilibrium of doshas. The selection of Matravasti and pichu both are based on repeated recommendations of different Acharyas on Sandhigatavata. We used Rasna taila. Keywords: Sandhigata vata, Osteoarthritis, MatraVasti, Pichu, Rasna taila

A clinical study on management of Gridhrasi

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Ankur Singhal ◽  
Komal Gupta
Keyword(s):  
Clinical Study ◽  
Medical Science ◽  
Signs And Symptoms ◽  
Normal Activity ◽  
Painful Condition ◽  
Almost All

Gridhrasi is a painful condition in which the person can’t sit and walk properly that hampers his normal activity. Almost all signs and symptoms of Gridhrasi resemble with the condition of sciatica described by the modern texts. Its detail symptomatology has been described in Ayurvedic classics since 5000 years, while this condition was known to modern medical science just two centuries ago. According to Ayurveda principles treatment for Vatavyadhi should be Shodhana followed by Shamana therapy. According to present era it should be less time consuming and more effective. Keeping this in mind, A clinical study in the management of Gridhrasi with Shodhana and Shamana therapy was undertaken in VYDSAMC and Hospital, Khurja,Bulandshahr, with the aim to give promising results to the patient of Gridhrasi. Shodhana therapy as Mridu Virechana followed by Shamana with Yograja Guggulu and Maharasnadi Kwatha was given to 29 patients with classical symptoms of Gridhrasi, it showed significant results. The following study can be taken for further research in this field.

scholarly journals Combined effectiveness of Maharasnadi Kashaya with Shunti Churna and Matra Basti with Ksheerabala Taila in Janu Sandhigata Vata (Osteoarthritis Knee) : An open label, single arm clinical study

2020 ◽  
Vol 5 (04) ◽  
pp. 62-67
Author(s):  
Kiran K ◽  
Vasantha B ◽  
Muttappa Totad
Keyword(s):  
Risk Factors ◽  
Clinical Study ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Signs And Symptoms ◽  
Osteoarthritis Of The Knee ◽  
Open Label ◽  
Factors Associated ◽  
Osteoarthritis Of Knee ◽  
Osteoarthritis Knee

Sandhi Gata Vata is a clinical condition that comes under the heading of Vata Vyadhi where Prakupita Vata affects Sandhi and causes specific signs and symptoms. Lakshanas of Sandhi Gata Vata of Janu Sandhi resembles the signs and symptoms of osteoarthritis of knee. Osteoarthritis of the knee is more commonly found in women than men, and the prevalence increases dramatically with age. The major risk factors associated with osteoarthritis knee joint are old age, obesity, excessive usage of knee joint (occupational), which makes it an important cause of disability. A clinical study was conducted on 31 subjects by administering combination of Maharsnadi Kashaya with Shunti Churna and Matra Basti with Ksheerabala Taila and the results obtained were statistically analysed. Statistically significant reduction in Lakshanas of Janu Sandhi Gata Vata and WOMAC scores were noted.

A Multicenter Study of Recombinant Factor VIII (RecombinateTM) in Previously Treated Patients with Hemophilia A

1997 ◽  
Vol 77 (04) ◽  
pp. 660-667 ◽  
Author(s):  
G C White ◽  
S Courter ◽  
G L Bray ◽  
M Lee ◽  
E D Gomperts ◽  
...  
Keyword(s):  
Hemophilia A ◽  
Recombinant Dna ◽  
Home Treatment ◽  
Pharmacokinetic Parameters ◽  
Pharmacokinetic Studies ◽  
Open Label ◽  
Treat Ment ◽  
Previously Treated Patients ◽  
Bleeding Episodes

SummaryA prospective, open-label multicenter investigation has been conducted to compare pharmacokinetic parameters of recombinant DNA-derived FVIII (rFVIII) and plasma-derived FVIII concentrate (pdFVIII) and to assess safety and efficacy of long-term home-treat- ment with rFVIII for subjects with hemophilia A. Following comparative in vivo pharmacokinetic studies, 69 patients with severe (n = 67) or moderate (n = 2) hemophilia A commenced a program of home treatment using rFVIII exclusively for prophylaxis and treatment of all bleeding episodes for a period of 1.0 to 5.7 years (median 3.7 years). The mean in vivo half-lives of rFVIII and pdFVIII were both 14.7 h. In vivo incremental recoveries at baseline were 2.40%/IU/kg and 2.47%/IU/kg, respectively (p = 0.59). The response to home treatment with rFVIII was categorized as good or excellent in 3,195 (91.2%) of 3,481 evaluated bleeding episodes. Thirteen patients received rFVIII for prophylaxis for twenty-four surgical procedures. In all cases, hemostasis was excellent. Adverse reactions were observed in only 13 of 13,591 (0.096%) infusions of rFVIII; none was serious. No patient developed an inhibitor to r FVIII.

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