scholarly journals An assembling procedure for DNA bipyramids with minimum component strands

2021 ◽  
Vol 87 (01) ◽  
pp. 179-192
Author(s):  
Tao Deng ◽  
Mengge Huang ◽  
Jingyi Zhang
Keyword(s):  
Drug Delivery ◽  
Dna Molecules ◽  
Design And Synthesis ◽  
Multiple Component ◽  
Half Twist

DNA cages are ideally suited to make nanostructures which serve as containers for drug delivery. Using fewer strands to assemble DNA cages is of importance to the design of DNA molecules with multiple component strands. In this study, we propose a rational assembling procedure to design and analyze DNA bipyramids with minimum strands. The results show that the odd-half twist has a major impact on assembling strands required to construct DNA cages and this method could offer a search of DNA bipyramids with minimum component strands faster. This research provides new insights into design and synthesis for DNA bipyramid-like cages from mathematical perspective.

Viscoelastic Properties of Genetically Engineered Silk-Elastin-Like Protein Polymers

2008 ◽  
Author(s):  
Weibing Teng ◽  
Joseph Cappello ◽  
Xiaoyi Wu
Keyword(s):  
Drug Delivery ◽  
Viscoelastic Properties ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Genetically Engineered ◽  
Structural Proteins ◽  
Design And Synthesis ◽  
Cross Links ◽  
New Protein ◽  
Polypeptide Sequences

Genetic engineering of protein-based materials provides material scientists with high levels of control in material microstructures, properties, and functions [1]. For example, multi-block protein copolymers in which individual block may possess distinct mechanical or biological properties have been biosynthesized [2, 3]. Polypeptide sequences derived from well-studied structural proteins (e.g., collagen, silk, elastin) are often used as motifs in the design and synthesis of new protein-based material, in which new functional groups may be incorporated. In this fashion, we have produced a series of silk-elastin-like proteins (SELPs) consisting of polypeptide sequences derived from silk of superior mechanical strength and elastin that is extremely durable and resilient [2, 4]. Notably, the silk-like blocks are capable of crystallizing to form virtual cross-links between elastin-mimetic sequences, which, in turn, lower the crystallinity of the silk-like blocks and thus enhance the solubility of SELPs. Consequently, SELPs may be fabricated into useful structures for biomedical applications, including drug delivery. In this study, we will characterize viscoelastic properties of SELPs, which are particularly relevant to tissue engineering applications.

Design and Synthesis of Zn II ‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery

2020 ◽  
Vol 15 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Sourabh Bera ◽  
Abhinanda Chowdhury ◽  
Koushik Sarkar ◽  
Parthasarathi Dastidar
Keyword(s):  
Drug Delivery ◽  
Coordination Polymers ◽  
Design And Synthesis

scholarly journals Stimuli-Responsive Aliphatic Polycarbonate Nanocarriers for Tumor-Targeted Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2890
Author(s):  
Adrian Domiński ◽  
Tomasz Konieczny ◽  
Khadar Duale ◽  
Monika Krawczyk ◽  
Gabriela Pastuch-Gawołek ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Immune Surveillance ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Endogenous Factors ◽  
Design And Synthesis ◽  
Oxidation Reduction ◽  
Pharmacokinetic Properties ◽  
Reactive Groups ◽  
Targeting Ability

Nanoparticles based on amphiphilic copolymers with tunable physicochemical properties can be used to encapsulate delicate pharmaceutics while at the same time improving their solubility, stability, pharmacokinetic properties, reducing immune surveillance, or achieving tumor-targeting ability. Those nanocarriers based on biodegradable aliphatic polycarbonates are a particularly promising platform for drug delivery due to flexibility in the design and synthesis of appropriate monomers and copolymers. Current studies in this field focus on the design and the synthesis of new effective carriers of hydrophobic drugs and their release in a controlled manner by exogenous or endogenous factors in tumor-specific regions. Reactive groups present in aliphatic carbonate copolymers, undergo a reaction under the action of a stimulus: e.g., acidic hydrolysis, oxidation, reduction, etc. leading to changes in the morphology of nanoparticles. This allows the release of the drug in a highly controlled manner and induces a desired therapeutic outcome without damaging healthy tissues. The presented review summarizes the current advances in chemistry and methods for designing stimuli-responsive nanocarriers based on aliphatic polycarbonates for controlled drug delivery.

Design and synthesis of novel amphiphilic Janus dendrimers for bone-targeted drug delivery

Tetrahedron ◽  
2012 ◽  
Vol 68 (14) ◽  
pp. 2943-2949 ◽  
Author(s):  
Junzhu Pan ◽  
Min Wen ◽  
Dongqin Yin ◽  
Bo Jiang ◽  
Dongsheng He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Design And Synthesis ◽  
Targeted Drug

Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery

Tetrahedron ◽  
2009 ◽  
Vol 65 (45) ◽  
pp. 9436-9442 ◽  
Author(s):  
Adel S. Abdelrahim ◽  
Zyta M. Ziora ◽  
Julie A. Bergeon ◽  
Anne R. Moss ◽  
Istvan Toth
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Penetration Enhancers ◽  
Oral Drug ◽  
Design And Synthesis

Design and synthesis of aptamer AS1411-conjugated EG@TiO2@Fe2O3 nanoparticles as a drug delivery platform for tumor-targeted therapy

2020 ◽  
Vol 44 (37) ◽  
pp. 15871-15886 ◽  
Author(s):  
Nahid Mansouri ◽  
Razieh Jalal ◽  
Batool Akhlaghinia ◽  
Khalil Abnous ◽  
Roya Jahanshahi
Keyword(s):  
Drug Delivery ◽  
Targeted Therapy ◽  
Sustained Release ◽  
Targeted Drug Delivery ◽  
Fe2o3 Nanoparticles ◽  
Ph Responsive ◽  
Release System ◽  
Design And Synthesis ◽  
Delivery Platform ◽  
Targeted Drug

AS1411@GMBS@EG@TiO2@Fe2O3 nanoparticle is an effective and safe pH-responsive sustained release system for targeted drug delivery into nucleolin-positive cells.

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