Design and synthesis of aptamer AS1411-conjugated EG@TiO2@Fe2O3 nanoparticles as a drug delivery platform for tumor-targeted therapy

AS1411@GMBS@EG@TiO2@Fe2O3 nanoparticle is an effective and safe pH-responsive sustained release system for targeted drug delivery into nucleolin-positive cells.

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Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽

10.3390/polym13010059 ◽

2020 ◽

Vol 13 (1) ◽

pp. 59

Author(s):

Abeer M. Beagan ◽

Ahlam A. Alghamdi ◽

Shatha S. Lahmadi ◽

Majed A. Halwani ◽

Mohammed S. Almeataq ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Folic Acid ◽

Drug Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Ethyl Methacrylate ◽

Mesoporous Nanoparticles ◽

Targeted Drug ◽

Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

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SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment - An in vitro evaluation

Molecular Oncology ◽

10.1016/j.molonc.2016.05.003 ◽

2016 ◽

Vol 10 (7) ◽

pp. 1133-1145 ◽

Cited By ~ 2

Author(s):

Johannes M. Ludwig ◽

Yongkang Gai ◽

Lingyi Sun ◽

Guangya Xiang ◽

Dexing Zeng ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Targeted Drug Delivery ◽

In Vitro Evaluation ◽

Drug Eluting ◽

Delivery Platform ◽

Targeted Drug

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A pillar[5]arene-based [2]rotaxane lights up mitochondria

Chemical Science ◽

10.1039/c6sc00036c ◽

2016 ◽

Vol 7 (5) ◽

pp. 3017-3024 ◽

Cited By ~ 98

Author(s):

Guocan Yu ◽

Dan Wu ◽

Yang Li ◽

Zhihua Zhang ◽

Li Shao ◽

...

Keyword(s):

Drug Delivery ◽

Anticancer Drugs ◽

Targeted Drug Delivery ◽

Therapeutic Agents ◽

Delivery Platform ◽

Targeted Drug ◽

Mitochondria Targeting

Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.

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Programmable shape-morphing microrobots for localized cancer cells treatment

10.21203/rs.3.rs-198740/v1 ◽

2021 ◽

Author(s):

Chen Xin ◽

Dongdong Jin ◽

Yanlei Hu ◽

Liang Yang ◽

Rui Li ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Targeted Drug Delivery ◽

Biological Applications ◽

Proof Of Concept ◽

Ph Responsive ◽

Solution Ph ◽

Shape Morphing ◽

On Demand ◽

Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

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Aptamer-based self-assembled supramolecular vesicles for pH-responsive targeted drug delivery

Science China Chemistry ◽

10.1007/s11426-016-0351-5 ◽

2016 ◽

Vol 60 (5) ◽

pp. 628-634 ◽

Cited By ~ 20

Author(s):

Shuxian Wu ◽

Juan Li ◽

Hong Liang ◽

Liping Wang ◽

Xian Chen ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Targeted Drug ◽

Self Assembled

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Facilely synthesized pH-responsive fluorescent polymer dots entrapping doped and coupled doxorubicin for nucleus-targeted chemotherapy

Journal of Materials Chemistry B ◽

10.1039/c7tb00394c ◽

2017 ◽

Vol 5 (16) ◽

pp. 2921-2930 ◽

Cited By ~ 7

Author(s):

Yixiao Guo ◽

Fengwen Cao ◽

Yao Li ◽

Liqin Xiong

Keyword(s):

Targeted Drug Delivery ◽

Drug Loading ◽

Tumor Therapy ◽

Targeted Chemotherapy ◽

Ph Responsive ◽

Polymer Dots ◽

Chemical Coupling ◽

Delivery Platform ◽

Targeted Drug ◽

Fluorescent Polymer

The combination of physical doping and chemical coupling can significantly enhance the drug loading/release efficiency and improve the effect of cancer treatment. Based on this strategy, PEG-Dox doped and coupled PFBT polymer dots were optimized as a nucleus-targeted drug delivery platform for tumor therapy.

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