scholarly journals Role of Polidocanol as Sclerosant in Treatment of Hemangiomas of Head and Neck Region

2017 ◽  
Vol 25 (3) ◽  
pp. 148-153 ◽  
Author(s):  
Rupanjita Sangma ◽  
Mukul Patar
Keyword(s):  
Side Effects ◽  
Head And Neck ◽  
Surgical Intervention ◽  
Neck Region ◽  
Complete Regression ◽  
Head And Neck Region ◽  
Common Presentation ◽  
Intralesional Injections

Introduction Haemangiomas are common presentation in head and neck, prevalence being 60% followed by 25% and 15% respectively in trunk and limbs. This report studies the efficacy of Polidocanol as sclerosant in the treatment of heamangiomas in head and neck. Materials and Methods The two year prospective study conducted from January 2015 to December 2016 with Polidocanol as sclerosant on 55 patients attending the department of ENT. Intralesional injections of 3 % polidocanol were given at 2 week intervals. Results Out of 55 patients 15 cases did not follow up after the first dose, so results were calculated out of 40 patients. 12 patients showed complete regression & 15 showed regression to half the size. Thus 67.5 % patients showed acceptable results. There were no side effects except hyperpigmentation in 2 patients. There were no cases of recurrence during our study period. Conclusion Sclerotherapy is a promising method of treatment for haemangiomas of head and neck that may obviate the need for surgical intervention.

scholarly journals Role of sclerotherapy in management of low flow vascular malformations

2021 ◽  
Vol 8 (4) ◽  
pp. 1234
Author(s):  
Manpreet Kaur ◽  
Parul Sachdeva ◽  
Rajan Syal ◽  
Savijot Singh
Keyword(s):  
Head And Neck ◽  
Vascular Malformations ◽  
Neck Region ◽  
Low Flow ◽  
Vascular Lesions ◽  
Surgical Removal ◽  
Complete Regression ◽  
Head And Neck Region ◽  
Life Threatening

Background: Low flow vascular malformations are most common in the head and neck region. Only symptomatic malformations require treatment. Sclerotherapy followed by surgery was considered the gold standard treatment but in the head and neck region, it may produce cosmetic and physiological defects. In the present study, multiple injections of sclerotherapy with 3% sodium tetradecyl sulphate was used for the treatment of low flow vascular malformations.Methods: Twenty cases of low flow vascular malformations of the oral cavity who presented in the outpatient department of ESIC Model Hospital, Ludhiana from 2014-2016 were selected for the study. Only significantly sized (>4 cm) and easily accessible lesions were included. Staged sequential sclerotherapy with 3% STS under strict fluoroscopy control was used as the sole treatment.Results: A total of 20 patients were taken of which, 25% required three sessions, 65% five to six sessions each and 10% required eight sessions each. All patients showed good results with complete regression and no mucosal ulceration.Conclusions: Staged sequential sclerotherapy with 3% STS should be the treatment of choice in low flow vascular lesions involving mucosal and cutaneous structures of head and neck region especially anterior two-thirds of tongue, palate, gingiva, buccal mucosa and lips. Surgical removal may affect critical neurovascular structures and cause cosmetic deformity. So the removal is advisable in life-threatening conditions, lesions requiring general anaesthesia and single sitting removal.

scholarly journals Efficacy of topical tacrolimus 0.1% in the treatment of vitiligo

2014 ◽  
Vol 3 (1) ◽  
pp. 4-7
Author(s):  
Afsana Nahid ◽  
Lubna Khondker ◽  
Md Shirajul Islam Khan ◽  
Samaresh Chandra Hazra
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Head And Neck ◽  
Therapeutic Option ◽  
Topical Steroid ◽  
Neck Region ◽  
Head And Neck Region ◽  
Tacrolimus Ointment ◽  
Topical Tacrolimus

A clinical trial was carried out with thirty patients affected with vitiligo. Repigmentation was observed in 26.7% cases on the first follow up visit. At the end of 4th week with tacrolimus ointment in the next visit, it was perceptible in 15 cases 50.1% and after 12 weeks of therapy 83.3% yielded repigmentation. Among those who had repigmentation, 20% had > 75% repigmentation, 23.3% had 50-75% repigmentation. The percentage of repigmentation on head and neck (83.3%) was greater than that on extremities (55.6%). Complete (>75%) repigmentation was 33.3% cases on head and neck and 26.7% along with extremities. A total of 83.3% cases had some repigmentation and among them, 10 cases had focal presentation and 15 cases had generalised or segmental presentation. There was statistically significant (p<0.005) difference observed between presentation and pigmentation. By using topical steroid minimum side effects like pruritus in 6.7% cases and burning in 10% cases were evidenced. This study reflects that tacrolimus ointment 0.1% is an effective topical therapeutic option for vitiligo especially on the head and neck region with minimum side effects. CBMJ 2014 January: Vol. 03 No. 01 P: 4-7

Iodoterapia e seus Efeitos Colaterais no Tratamento de Neoplasia de Tireoide

REVISTA FIMCA ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 15-27
Author(s):  
Abraão Carmo Sussuarana ◽  
Josimar Albuquerque Roque ◽  
Grace Kelly Almeida
Keyword(s):  
Side Effects ◽  
Neck Region ◽  
Laryngeal Edema ◽  
Head And Neck Region ◽  
Oral Infections ◽  
Thyroid Neoplasia ◽  
Increased Sensitivity ◽  
Therapeutic Doses

Introdução: A neoplasia de tireoide é o câncer mais comum na região de cabeça e pescoço. Inicialmente o tratamento é cirúrgico com a retirada do tumor, e após esta intervenção inicia-se a Iodoterapia, tratamento em que o paciente recebe doses terapêuticas de Iodo131 que são absorvidas pela glândula tireoide para extinguir qualquer tecido remanescente de células tumorais. Pouco se sabe sobre os efeitos colaterais do tratamento iodoterápico em paciente com neoplasia de tireoide. Objetivos: Esta pesquisa teve por objetivo realizar um levantamento bibliográfico sobre esses efeitos colaterais, através do método de revisão bibliográfica integrativa. Materiais e Métodos: Foi realizado um levantamento bibliográfico em bancos de dados, de artigos científicos nacionais e internacionais publicados sobre o tema, tendo preferência pelas publicações mais recentes, nos idiomas Espanhol, Português e Inglês. Resultados: Os principais efeitos colaterais abordados pelos trabalhos revisados foram: xerostomia, sialoadenite, hipossalivação, perda de paladar, maior susceptibilidade a infecções bucais, dificuldade de mastigação, deglutição e fonação, maior susceptbilidade ao aparecimento de lesões de cáries, variações na fala, edema da laringe, alterações nas funções dos músculos da face, riscos teratogênicos, obstrução do canal nasolacrimal, náuseas, mialgia, vômitos, epigastralgia, taquicardia, insônia, tremores, calor intenso, fadiga, labilidade emocional, perda de peso, irregularidade menstrual, adinamia, disfagia, exoftalmia, queda de cabelo, cefaleia, câimbras, ganho de peso, sensibilidade ao frio e diminuição de libido. Conclusão: Os efeitos colaterais devem ser relatados ao profissional de saúde responsável pelo acompanhamento do tratamento, para que medidas possam ser tomadas. Além disso, abordou-se a importância do papel do farmacêutico no tratamento da Iodoterapia. Ressalta-se a necessidade do fomento de pesquisas sobre esse assunto no meio científico. Introduction: Thyroid neoplasm is the most common cancer in the head and neck region. Initially, the treatment is surgical with the removal of the tumor, and after this interven+on Iodotherapy begins, a procedure in which the patient receives therapeutic doses of Iodine131 that are absorbed by the thyroid gland to extinguish any remaining tissue of tumor cells. Little is known about the side effects of iodotherapy treatment in patients with thyroid neoplasia. Objectives: This research aimed to perform a bibliographic survey on these side effects, through the method of integrative bibliographic review. Materials and Methods: A bibliographic study was carried out on databases of national and international scientific articles published on the subject, with preference being given to the most recent publications, in Spanish, Portuguese and English. Results: The main side effects were: xerostomia, sialoadenitis, hyposalivation, loss of taste, increased susceptibility to oral infections, difficulty in chewing, swallowing and phonation, increased sensitivity to cavities, speech changes, laryngeal edema, changes in the functions of facial muscles, teratogenic risks, nasolacrimal canal obstruction, nausea, myalgia, vomiting, epigastralgia, tachycardia, insomnia, tremors, intense heat, fatigue, emotional lability, weight loss, menstrual irregularity, adynamia, dysphagia, exophthalmia, hair loss, headache, cramps, weight gain, sensi+vity to cold and decreased libido. Conclusion: Side effects should be reported to the healthcare provider responsible for the follow-up of treatment so that measures can be taken. Also, the role of the pharmacist in the treatment of iodine therapy was discussed. Promo+ng research on this subject in the scientific field is necessary.

The role of surgery and radiotherapy in treatment of soft tissue sarcomas of the head and neck region: Review of 30 cases

2009 ◽  
Vol 37 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Merdan Fayda ◽  
Gorkem Aksu ◽  
Fulya Yaman Agaoglu ◽  
Ahmet Karadeniz ◽  
Emin Darendeliler ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas ◽  
Neck Region ◽  
Head And Neck Region

scholarly journals The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region

2019 ◽  
Vol 10 (1) ◽  
pp. 48-53
Author(s):  
Mohammad Sowkat Hossain ◽  
S M Mahbubul Alam ◽  
Sk Md Jaynul Islam ◽  
Wasim Selimul Haque ◽  
Shamoli Yasmin
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Histopathological Examination ◽  
Malignant Neoplasm ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Head And Neck Region

Background: Undifferentiated tumours in the head and neck region are not uncommon. They can arise from different sites like in mucosa as well as in salivary glands, soft tissues or lymph nodes. Histopathological examination plays a central role in the diagnosis but difficulties arise with some tumours which are poorlydifferentiated due to their high inter- and intra-observer variability. In those cases, immunohistochemistry has greatly assisted to diagnose the tumours that cannot be accurately identified using routine histopathological procedures. The correct histopathological diagnosis is essential especially in case of malignant tumourwhere subsequent specific therapy is required. The aim of this study was to determine the role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region. Methods: This cross-sectional study was conducted during July 2014 to June 2015. A total of 35 Bangladeshi patient’s specimens of head and neck swelling were collected from two renowned laboratories in Dhaka city.These cases were diagnosed as undifferentiated tumour in histopathological examination.Standard protocol was followed for immunohistochemistry.Then primary immunohistochemical panel which included the markers for Epithelial CK (AE1/AE3),mesenchymal marker (Vimentin) and lymphoid marker (LCA) were used.The cases which were not resolved by primary immunohistochemistry panel, the second panel was applied for further sub classification (Desmin, Chromogranin, CK20, CEA, CD20, CD30, HMB45, NSE). Based on interpretation of immunohistochemical findings final diagnoses were made.Data analysis was performed using the Statistical Package for the Social Sciences for Windows version 22.0 (SPSS, Chicago, Illinois, USA). Results: A total of 35 undifferentiated tumorsof head-neck region were studied.The mean age was 46.3±17.6 years and male to female ratio was 4.8:1. The majority 13 (37.1%) patient had cervical lymphadenopathy, 11 (31.4%) had neck mass and 4(11.4%) had in nasal/sinonasal mass.Regarding histopathologicalcell types, round cell was 21 (60.0%), spindle cell 6 (17.1%), pleomorphic cells 6(17.1%) and epithelioid cells 2(5.7%). In initial histopathological examination, majority 25(71.4%) were undifferentiated malignant neoplasm, 8(22.8%) were metastatic undifferentiated carcinoma, 1(2.9%) was pleomorphic sarcoma and the remaining 1(2.9%) had malignant adnexal tumour. By application of immunohistochemistry, most (33, 94.3%) of the cases were resolved and the two cases remained unresolved. Among the resolved cases majority (15, 45.5%) were lymphoma, 4(12.1%) were metastatic carcinoma, 3(9.1%) were Ewing’s sarcoma and malignant melanoma were found in 3(9.1%) cases. Conclusion: This study supports that the immunohistochemical technique has a fundamental role in the investigation of undifferentiated tumour origin, to determine the correct guidance for treatment and improving the prognosis for head and neck tumour patients. Birdem Med J 2020; 10(1): 48-53

scholarly journals Congenital Infantile Fibrosarcoma of the Tongue: Case Report and Review of the Literature

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Francis Lee ◽  
Jennifer Ha ◽  
Shyan Vijayasekaran
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Unusual Case ◽  
Neck Region ◽  
Complete Resection ◽  
Review Of The Literature ◽  
Head And Neck Region ◽  
Infantile Fibrosarcoma ◽  
Neo Adjuvant Chemotherapy

Introduction: Congenital infantile fibrosarcoma is often misdiagnosed. It may be more common than noted in the literature. We present an unusual case of paediatric head and neck fibrosarcoma. Methods: Restrospective case report and literature review. Results: We report the surgical management of a fibrosarcoma of the tongue in an 8-month-old child where neo-adjuvant chemotherapy was unsuccessful. Conclusion: Surgical resection is the mainstay of treatment, in the head and neck region where critical structures are close to the tumour, complete resection with wide margins can be difficult. The role of chemotherapy is yet to be defined.

Low-grade fibromyxoid sarcoma of the parapharyngeal space: an unusual location

2021 ◽  
Vol 14 (5) ◽  
pp. e237083
Author(s):  
Muhammad Hammad Deewani ◽  
Muhammad Hassan Danish ◽  
Muhammad Sohail Awan ◽  
Nasir Ud Din
Keyword(s):  
Head And Neck ◽  
Parapharyngeal Space ◽  
Neck Region ◽  
Low Grade ◽  
Head And Neck Region ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Fibromyxoid Sarcoma ◽  
Established Treatment

Low-grade fibromyxoid sarcoma (LGFMS) is an uncommon soft-tissue malignancy. LGFMS preferentially affects trunks and extremities of young adults; however, occasional cases have been reported in different sites of head and neck region including oral cavity, larynx and oropharynx. LGFMS usually exhibit areas of collagenised and myxoid stroma with appearance of spindle cells in whorling pattern. It is a challenge to diagnose it accurately as most of the time it is misdiagnosed as benign neoplastic entity of spindle cells. There have been only few isolated cases of LGFMS reported in head and neck region and LGFMS originating from the parapharyngeal space has never been reported before. We recently experienced a case of low grade fibomyxoid sarcoma in parapharyngeal space of neck. LGFMS have the propensity to locally recur and to metastasise. Due to its rarity in head and neck region, there are no well-established treatment and follow-up guidelines.

scholarly journals Multicenter Study of Buruli Ulcer Disabilities in the Head and Neck Region

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Pius Agbenorku
Keyword(s):  
Head And Neck ◽  
Functional Disability ◽  
Buruli Ulcer ◽  
Neck Region ◽  
Clinical Findings ◽  
Head And Neck Region ◽  
Surgical Interventions ◽  
Ulcer Disease ◽  
Total Hospital Stay

Objective. To identify disabilities caused by Buruli Ulcer Disease (BUD) when it affects the Head and Neck Region (HNR) of patients in endemic areas and suggest possible ways to overcome the complications involved. Methods. Data for the study was collected from six different hospitals in the central part of Ghana from 2004–2009. Diagnosis of BUD was based on clinical findings and confirmed by positive result of Ziehl-Neelson Test for Acid Fast Bacilli, Polymerase Chain Reaction, or Histopathology. Treatment of BUD involved a combination of surgical interventions and antimycobacterial chemotherapy for 8 weeks. Results. The age of the 38 patients ranged from 0–56 years (mean age of 14.3 years), with males outnumbering females. Most (55.3%, ) of the patients reported to the facilities with developed BUD deformities. Patients who lost their eyeball () recorded the highest in terms of functional disability. A mean total hospital stay of 52 days and follow-up period of 2.3 years were recorded for the study. Conclusion. Visual impairment was the commonest form of disability recorded in the HNR. Management difficulties and BUD disabilities could be avoided by early detection of the disease and training of health professionals at district levels.

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