Vibroacoustic Stimulation and Brain Oscillation: From Basic Research to Clinical Application

2017 ◽  
Vol 9 (3) ◽  
pp. 153 ◽  
Author(s):  
Lee R. Bartel ◽  
Robert Chen ◽  
Claude Alain ◽  
Bernhard Ross
Keyword(s):  
Steady State ◽  
Brain Stimulation ◽  
Electric Stimulation ◽  
Brain Connectivity ◽  
Basic Research ◽  
Health Conditions ◽  
Oscillatory Activity ◽  
The Brain ◽  
Selection Of ◽  
Stimulation Of

Abstract: This paper addresses the importance of steady state brain oscillation for brain connectivity and cognition. Given that a healthy brain maintains particular levels of oscillatory activity, it argues that disturbances or dysrhythmias of this oscillatory activity can be implicated in common health conditions including Alzheimer’s disease, Parkinson’s Disease, pain, and depression. Literature is reviewed that shows that electric stimulation of the brain can contribute to regulation of neural oscillatory activity and the alleviation of related health conditions. It is then argued that specific frequencies of sound in their vibratory nature can serve as a means to brain stimulation through auditory and vibrotactile means and as such can contribute to regulation of oscillatory activity. The frequencies employed and found effective in electric stimulation are reviewed with the intent of guiding the selection of sound frequencies for vibroacoustic stimulation in the treatment of AD, PD, Pain, and depression.

scholarly journals A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
A. Paffi ◽  
F. Apollonio ◽  
M. G. Puxeddu ◽  
M. Parazzini ◽  
G. d’Inzeo ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Brain Stimulation ◽  
Electric Stimulation ◽  
Numerical Study ◽  
Optimal Parameters ◽  
The Brain ◽  
Correct Target ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation is a clinical technique for the treatment of parkinson’s disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.

Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus

Epilepsia ◽  
2021 ◽  
Author(s):  
Barbora Deutschová ◽  
Petr Klimeš ◽  
Zsofia Jordan ◽  
Pavel Jurák ◽  
Lorand Erőss ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Oscillatory Activity ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Deep stimulation in neurosurgery

2019 ◽  
Vol 10 (1) ◽  
pp. 63-71
Author(s):  
Aleksandr A. Kalinkin ◽  
Alexey G. Vinokurov ◽  
Olga N. Kalinkina ◽  
Alexander S. Ilinykh ◽  
Andrey A. Bocharov ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Deep Brain Stimulation ◽  
High Risk ◽  
Brain Stimulation ◽  
Conservative Therapy ◽  
The Central Nervous System ◽  
The Brain ◽  
Deep Brain ◽  
Stimulation Of

The technique of deep brain stimulation is used to treat patients with various diseases of the central nervous system who are not amenable to conservative therapy, while open interventions in them are associated with a high risk of complications. In the review, we evaluate the efficiency of the deep stimulation of different regions of the brain in some pharmacoresistant forms of diseases.

scholarly journals Effects of high-frequency stimulation of the internal pallidal segment on neuronal activity in the thalamus in parkinsonian monkeys

2016 ◽  
Vol 116 (6) ◽  
pp. 2869-2881 ◽  
Author(s):  
Stefan Kammermeier ◽  
Damien Pittard ◽  
Ikuma Hamada ◽  
Thomas Wichmann
Keyword(s):  
Electrical Stimulation ◽  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Brain Stimulation ◽  
Oscillatory Activity ◽  
Internal Globus Pallidus ◽  
Ventral Thalamus ◽  
Deep Brain ◽  
Stimulation Of ◽  
Spiking Activity

Deep brain stimulation of the internal globus pallidus (GPi) is a major treatment for advanced Parkinson's disease. The effects of this intervention on electrical activity patterns in targets of GPi output, specifically in the thalamus, are poorly understood. The experiments described here examined these effects using electrophysiological recordings in two Rhesus monkeys rendered moderately parkinsonian through treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), after sampling control data in the same animals. Analysis of spontaneous spiking activity of neurons in the basal ganglia-receiving areas of the ventral thalamus showed that MPTP-induced parkinsonism is associated with a reduction of firing rates of segments of the data that contained neither bursts nor decelerations, and with increased burst firing. Spectral analyses revealed an increase of power in the 3- to 13-Hz band and a reduction in the γ-range in the spiking activity of these neurons. Electrical stimulation of the ventrolateral motor territory of GPi with macroelectrodes, mimicking deep brain stimulation in parkinsonian patients (bipolar electrodes, 0.5 mm intercontact distance, biphasic stimuli, 120 Hz, 100 μs/phase, 200 μA), had antiparkinsonian effects. The stimulation markedly reduced oscillations in thalamic firing in the 13- to 30-Hz range and uncoupled the spiking activity of recorded neurons from simultaneously recorded local field potential (LFP) activity. These results confirm that oscillatory and nonoscillatory characteristics of spontaneous activity in the basal ganglia receiving ventral thalamus are altered in MPTP-induced parkinsonism. Electrical stimulation of GPi did not entrain thalamic activity but changed oscillatory activity in the ventral thalamus and altered the relationship between spikes and simultaneously recorded LFPs.

Lever-Pressing Performance for Brain Stimulation on F-I and V-I Schedules in a Single-Lever Situation

1970 ◽  
Vol 26 (3) ◽  
pp. 699-706 ◽  
Author(s):  
Stephen Brown ◽  
Jay A. Trowill
Keyword(s):  
Electrical Stimulation ◽  
Brain Stimulation ◽  
Lever Press ◽  
Variable Interval ◽  
Fixed Interval ◽  
Schedule Of Reinforcement ◽  
Single Lever ◽  
Lever Pressing ◽  
The Brain ◽  
Stimulation Of

Rats were trained to lever press for electrical stimulation of the brain (ESB) and ultimately were assigned to either a fixed interval 1 min. (FI-1 min.) or a variable interval 1 min. (VI-1 min.) schedule of reinforcement. All Ss easily attained and maintained responding on the schedule to which they had been assigned. Patterns of responding during training and extinction were similar to those observed when conventional rewards, such as food or water, are used. Fixed-interval Ss demonstrated scalloped responding; variable-interval Ss demonstrated steady rates of responding. The implications of these results for understanding ESB as a reward are discussed.

scholarly journals Current Stimulation of the Midbrain Nucleus in Pigeons for Avian Flight Control

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 788
Author(s):  
Jung-Woo Jang ◽  
Changhoon Baek ◽  
Sunhyo Kim ◽  
Tae-Kyeong Lee ◽  
Gwang-Jin Choi ◽  
...  
Keyword(s):  
Flight Control ◽  
Motion Tracking ◽  
Electrode Array ◽  
Movement Control ◽  
Basic Research ◽  
Flight Behavior ◽  
Electrode Arrays ◽  
Channel Electrode ◽  
The Brain ◽  
Stimulation Of

A number of research attempts to understand and modulate sensory and motor skills that are beyond the capability of humans have been underway. They have mainly been expounded in rodent models, where numerous reports of controlling movement to reach target locations by brain stimulation have been achieved. However, in the case of birds, although basic research on movement control has been conducted, the brain nuclei that are triggering these movements have yet to be established. In order to fully control flight navigation in birds, the basic central nervous system involved in flight behavior should be understood comprehensively, and functional maps of the birds’ brains to study the possibility of flight control need to be clarified. Here, we established a stable stereotactic surgery to implant multi-wire electrode arrays and electrically stimulated several nuclei of the pigeon’s brain. A multi-channel electrode array and a wireless stimulation system were implanted in thirteen pigeons. The pigeons' flight trajectories on electrical stimulation of the cerebral nuclei were monitored and analyzed by a 3D motion tracking program to evaluate the behavioral change, and the exact stimulation site in the brain was confirmed by the postmortem histological examination. Among them, five pigeons were able to induce right and left body turns by stimulating the nuclei of the tractus occipito-mesencephalicus (OM), nucleus taeniae (TN), or nucleus rotundus (RT); the nuclei of tractus septo-mesencephalicus (TSM) or archistriatum ventrale (AV) were stimulated to induce flight aviation for flapping and take-off with five pigeons.

Effects of Sodium Phenobarbital on Brain Stimulation Behavior, Behavioral Seizures, and EEG Seizure Activity

1978 ◽  
Vol 42 (3) ◽  
pp. 1007-1016 ◽  
Author(s):  
Sharon N. Schnare ◽  
Irmingard I. Lenzer
Keyword(s):  
Electrical Stimulation ◽  
Brain Stimulation ◽  
Seizure Activity ◽  
Sprague Dawley ◽  
Continuous Reinforcement ◽  
Sprague Dawley Rats ◽  
Sodium Phenobarbital ◽  
The Brain ◽  
Rate Of Response ◽  
Stimulation Of

The effects of sodium phenobarbital on (a) behavior reinforced by electrical stimulation of the brain, (b) behavioral seizures, and (c) EEG seizure activity were observed in seven male Sprague-Dawley rats. Rate of response on placebo day, over a 30-min. continuous reinforcement session, was compared to rate of response on drug day; an increase in response on the drug day over the placebo day was called a positive phenobarbital effect and a decrease a negative phenobarbital effect. For some animals the positive phenobarbital effect disappeared when the animal's rate of response was calculated for seizure-free time, i.e., when the time spent in seizure was subtracted from the 30-min. period. For other animals, however, the phenobarbital effect, whether positive or negative, was not directly related to time gained on the drug day compared to the placebo day. A new concept was advanced, that of seizure-proneness, measured by the number and duration of seizures and spike after-discharges. Significant correlations were found for seizure-proneness and phenobarbital effect.

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