Clinical Treating Effect of Nourishing-Yin and Clearing-Stasis Decoction on Allergic Purpura

In oriental medicine, mixtures of medical plants are always used as prescriptions for diseases. Natural products extracted from herbs have great potential antiaging effects. Previous studies and clinical trials have shown several critical functions of Erjingwan (EJW), such as nourishing Yin, kidney tonifying and aging-resistance. We assumed that EJW extracts exerted the antiaging effects through nourishing Yin. We examined the antiaging effects of EJW extracts on healthy human skin by noninvasive measurements. Then we estimated the cell proliferation and DPPH radical scavenging rate. Western blotting analysis was used to determine the expressions of matrix metalloproteinase-1 (MMP-1), type I collagen (COL1A2), p-NF-κB, NF-κB, p-IκBα, IκBα, p-Nrf2, and HO-1. EJW extracts did not affect moisture content, TEWL and skin chroma, while it significantly improved skin glossiness and skin elasticity. Moreover, EJW extracts could downregulate the MMP1 expression and upregulate the COL1A2 expression. In addition, it promoted the Nrf2 pathway while it inhibited the NF-κB pathway. With the application of cream containing EJW extracts, the skin aging state was significantly improved. Furthermore, in vitro studies showed that EJW extracts contributed to the repair of skin after injury. Taken together, the antiaging effects of EJW extracts were related to its antioxidant and anti-inflammatory abilities.

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Reconfiguring East Asian Modernity

Asian Medicine ◽

10.1163/15734218-12341379 ◽

2016 ◽

Vol 11 (1-2) ◽

pp. 61-99

Author(s):

James Flowers

Keyword(s):

Twentieth Century ◽

East Asian ◽

Nourishing Yin ◽

Toxic Drug ◽

The World ◽

Unique Approach

Around the turn of the twentieth century, Korean thinkers debated on the dilemma of how their country should deal with the challenge of modernity. Aiming to resist the westernisation of Korea, the physician Sŏk-kok took the unique approach of using the medical theories of Chinese antiquity to explain Korea’s propitious place in the world. In the context of Japan’s increasing influence leading to annexation in 1910, Sŏk-kok used the model of regionalqiin China to explain variation ofqiin the world. With China’s collapse, Korea had become the new centre of civilised learning, characterized by its increasing yangqi. Thus, identifying strengthening yang of the East as his solution, Sŏk-kok also challenged the traditional medical orthodoxy of nourishing yinqiby arguing for focusing more on strengthening people’s yangqi. To put theory into practice, the powerful toxic drug aconite became his metaphor to strengthen the yang of Korea as a civilisation through aconite-based drug therapies supporting the heart-minds of individuals.

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Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome

Chinese Journal of Integrative Medicine ◽

10.1007/s11655-011-0850-8 ◽

2011 ◽

Vol 17 (9) ◽

pp. 710-714 ◽

Cited By ~ 10

Author(s):

Guo-lin Wu ◽

Tian-yi Li ◽

Yong-sheng Fan ◽

Guo-you Yu

Keyword(s):

Quality Of Life ◽

Herbal Medicine ◽

Therapeutic Effect ◽

Chinese Herbal Medicine ◽

Primary Sjögren’S Syndrome ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

Chinese Herbal ◽

Nourishing Yin

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Effect of Nourishing “Yin” Removing “Fire” Chinese Herbal Mixture on Hypothalamic Mammalian Target of Rapamycin Expression during Onset of Puberty in Female Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/157846 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Gulan Zeng ◽

Xinghui Han ◽

Jian Yu ◽

Yonghong Wang ◽

Zhanzhuang Tian

Keyword(s):

Normal Saline ◽

Mammalian Target Of Rapamycin ◽

Female Rats ◽

Sprague Dawley ◽

Expression Levels ◽

Herbal Mixture ◽

Chinese Herbal ◽

Nourishing Yin ◽

Mtor Protein ◽

Puberty Onset

Aim. The present study aims to investigate the effects of nourishing “Yin” removing “Fire” (NYRF) Chinese herbal mixture on puberty onset and hypothalamic mTOR expression in female rats.Materials and Methods. Forty female 20-day-old Sprague-Dawley rats were randomly divided into Chinese herbal mixture (CHM) and normal saline (NS) groups. Rats in CHM and NS were treated with NYRF mixture and normal saline, respectively, from d22. Rats in each group were sacrificed on d28, d31, and d34. Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and estradiol (E2) levels were analyzed by ELISA. Hypothalamic mTOR mRNA expression levels were determined by RT-PCR and hypothalamic p-mTOR protein levels were assayed by western blot.Results. The vaginal opening time in CHM group was significantly delayedP<0.05. On d31, in comparison with NS group, the coefficients of uteri and ovaries, levels of serum LH and E2, and the expression levels of hypothalamic mTOR mRNA and p-mTOR protein were significantly lower in CHM groupP<0.05.Conclusion. The mechanism by which the nourishing “Yin” removing “Fire” Chinese herbal mixture delays puberty onset may be associated with the inhibition of the hypothalamic mTOR signaling.

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