Tooth Derived Bone Graft Material

2016 ◽  
Vol 7 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Kalyana Chakravarthy Pentapati ◽  
Komal Smriti ◽  
Chayanika Bhattacharjya ◽  
Srikanth Gadicherla ◽  
Abhay Taranath Kamath
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Grafting ◽  
Alveolar Bone ◽  
Autogenous Bone ◽  
Graft Material ◽  
Bone Graft Material ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

ABSTRACT Alveolar bone deficiency is a major postoperative complication in the treatment of traumatic injuries, periodontal diseases and likewise. Hence, alveolar bone repair remains a major hurdle in tissue engineering. Autogenous bone can be wellthought- of as benchmark for bone grafting sans its limitations and complications. In order to overcome these limitations, there is an increased demand of bone graft materials that led to numerous studies on different techniques and materials for bone regeneration over the years. Dentin and bone having same biochemical similarities led to the idea of using it as a bone regenerative material. Demineralized dentin matrix (DDM), an organic material obtained from dentin has been shown to possess osteogenic capacity. Demineralized dentin matrix may prosper in future endodontic world as an apexification material and as a permanent root canal filling material as well. Quick in bone forming as compared to conventional bone graft, this material is a boon to the dental world in this era. This manuscript reviews various studies on different types of DDM as a bone grafting material, and also summarizes the suggested pathway of bone regeneration. How to cite this article Bhattacharjya C, Gadicherla S, Kamath AT, Smriti K, Pentapati KC. Tooth Derived Bone Graft Material. World J Dent 2016;7(1):32-35.

Osteogenic Potential of Demineralized Dentin Matrix as Bone Graft Material

2017 ◽  
Vol 26 (2) ◽  
pp. 223-230 ◽  
Author(s):  
Hyo-Jung Lee ◽  
Ji-Soo Hong ◽  
Young-Kyun Kim ◽  
In-Woong Um ◽  
Jae-Il Lee
Keyword(s):  
Bone Graft ◽  
Osteogenic Potential ◽  
Graft Material ◽  
Bone Graft Material ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Full Regeneration of Maxillary Alveolar Bone Using Autogenous Partially Demineralized Dentin Matrix and Particulate Cancellous Bone and Marrow for Implant-Supported Full Arch Rehabilitation

2020 ◽  
Vol 46 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Mayumi Umebayashi ◽  
Seigo Ohba ◽  
Tadafumi Kurogi ◽  
Sawako Noda ◽  
Izumi Asahina
Keyword(s):  
Cancellous Bone ◽  
Alveolar Bone ◽  
Graft Material ◽  
Oral Rehabilitation ◽  
Wide Range ◽  
Old Japanese ◽  
Sinus Floor Augmentation ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Autogenous partially demineralized dentin matrix (APDDM) has been reportedly used as a superior bone graft material. A 52-year-old Japanese man who exhibited severe periodontitis was referred for oral rehabilitation. He underwent wide-range anterior maxillary alveolar bone and bilateral sinus floor augmentation by grafting of a mixture of APDDM and particulate cancellous bone and marrow (PCBM); subsequently, he underwent implant-supported full arch rehabilitation. He has been followed up for 4 years after placement of the final restoration without any complications, and his physiological bone volume has been maintained. APDDM constitutes an alternative treatment that may increase the volume of graft material and might prevent rapid resorption of PCBM, because APDDM served as a scaffold for osteoblasts from PCBM. When possible, it may be useful to apply APDDM as a graft material with PCBM for large-volume alveolar bone regeneration.

scholarly journals Long-Term Evaluation of Autogenous Demineralized Dentin Matrix: A Retrospective 7-Year Clinical Study

2020 ◽  
Author(s):  
Yonsoo Shin ◽  
Young-Kyun Kim ◽  
In-Woong Um
Keyword(s):  
Bone Loss ◽  
Bone Graft ◽  
Bone Grafting ◽  
Marginal Bone Loss ◽  
Ridge Augmentation ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Autogenous demineralized dentin matrix (ADDM), derived from human extracted tooth, is commonly used as a bone-graft substitute to reconstruct alveolar defects when placing dental implants. The purpose of this retrospective study is to examine efficacy of ADDM in terms of surgical complications and marginal bone resorption by analyzing the medical records and radiographs of patients who received ADDM graft from 2008 to 2011 in our institute. Occurrence of complications, marginal bone loss around implants were investigated with regard to the type of defect, location of bone grafting, and types of bone graft techniques. ADDM-based bone grafting was performed on 221 sites in 82 patients and 208 implants were placed afterwards: The percentage of complications after bone grafting was 15.84%, and the implant survival rate was 95.19%. All complications were resolved with conventional treatment except for the 10 cases of osseointegration failure. The average marginal bone loss was 0.31 mm at the last examination after the average follow-up period of 7.2 years. Within the limitation of this study, the results of long-term follow-up are consistent with the short-term results of relevant studies. ADDM can produce promising clinical outcomes when used for alveolar ridge augmentation around implants.

scholarly journals Dentin-Derived-Barrier Membrane in Guided Bone Regeneration: A Case Report

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2166
Author(s):  
Jeong-Kui Ku ◽  
In-Woong Um ◽  
Mi-Kyoung Jun ◽  
Il-hyung Kim
Keyword(s):  
Case Report ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Successful Outcome ◽  
Collagen Membrane ◽  
Type I ◽  
Barrier Membrane ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

An autogenous, demineralized, dentin matrix is a well-known osteo-inductive bone substitute that is mostly composed of type I collagen and is widely used in implant dentistry. This single case report describes a successful outcome in guided bone regeneration and dental implantation with a novel human-derived collagen membrane. The authors fabricated a dentin-derived-barrier membrane from a block-type autogenous demineralized dentin matrix to overcome the mechanical instability of the collagen membrane. The dentin-derived-barrier acted as an osteo-inductive collagen membrane with mechanical and clot stabilities, and it replaced the osteo-genetic function of the periosteum. Further research involving large numbers of patients should be conducted to evaluate bone forming capacity in comparison with other collagen membranes.

scholarly journals Histomorphometric Evaluation of Socket Preservation Using Autogenous Tooth Biomaterial and BM-MSC in Dogs

Scanning ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jin-Hyun Kim ◽  
Puneet Wadhwa ◽  
HongXin Cai ◽  
Dong-Hyung Kim ◽  
Bing Cheng Zhao ◽  
...  
Keyword(s):  
Bone Graft ◽  
Alveolar Bone ◽  
Control Group ◽  
Ridge Preservation ◽  
Graft Material ◽  
Socket Preservation ◽  
Bone Graft Material ◽  
Premolar Extraction ◽  
Bone Width ◽  
Significant Difference

This study is aimed at assessing the dimensional alterations occurring in the alveolar bone after premolar extraction in dogs with histomorphometric and histological analysis. After atraumatic premolar extraction, tooth-derived bone graft material was grafted in the extraction socket of the premolar region in the lower jaws of six dogs in two experimental groups. In the second experimental group, BM-MSCs were added together with the graft. The control was left untreated on the opposite side. After twelve weeks, all six animals were sacrificed. Differences in alveolar bone height crests lingually and buccally, and alveolar bone width at 1, 3, and 5 mm infracrestally, were examined. Histologic study revealed osteoconductive properties of tooth biomaterial. A statistically significant difference was detected between the test and control groups. In the test groups, a reduced loss of vertical and horizontal alveolar bone dimensions compared with the control group was observed. Tooth bone graft material may be considered useful for alveolar ridge preservation after tooth extraction, as it could limit the natural bone resorption process.

scholarly journals Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4391
Author(s):  
Yoona Jung ◽  
Won-Hyeon Kim ◽  
Sung-Ho Lee ◽  
Kyung Won Ju ◽  
Eun-Hee Jang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Octacalcium Phosphate ◽  
Autogenous Bone ◽  
Graft Material ◽  
Calvarial Defect ◽  
Bone Area ◽  
Defect Model ◽  
Bone Graft Material ◽  
Experimental Group

Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

scholarly journals Allogenic Demineralized Dentin Matrix, An Ideal Bone Graft

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Neema Bakhshalian ◽  
Shirin Hooshmand ◽  
Sara Chelland Campbell ◽  
Sheau Ching Chai ◽  
Bahram H Arjmandi
Keyword(s):  
Bone Graft ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

scholarly journals Microcomputed Tomography and Histological Study of Bone Regeneration Using Tooth Biomaterial with BMP-2 in Rabbit Calvarial Defects

Scanning ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Puneet Wadhwa ◽  
Jeong Hun Lee ◽  
Bing Cheng Zhao ◽  
HongXin Cai ◽  
Jae-Suk Rim ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Histological Study ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Control Group ◽  
Block Type ◽  
Graft Material ◽  
Synthetic Bone ◽  
Ct Analysis

Our study was aimed to analyze the osteoinductive effect of powdered and block type autogenous bone graft along with bone morphogenetic protein (BMP-2) as compared to synthetic bone graft. Three circular bicortical defects were made in the calvaria of each rabbit and randomly divided into three groups as follows: powdered tooth biomaterial+BMP-2, block tooth biomaterial+BMP-2, and control group: synthetic bone+BMP-2. The samples taken from these defects after 4 and 8 weeks were analyzed histologically along with micro CT analysis. In our study, both powered and block type tooth autogenous bone graft successfully stimulated mesenchymal cells leading to endochondral ossification and bone regeneration. We observed that the powered bone graft material which is acid insoluble especially is preferable as a carrier for BMP-2.

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