Immunohistochemical Expression of MCM-2 for Evaluation of Proliferative Activity in the Epithelial Lining of Radicular Cyst, Dentigerous Cyst, and Odontogenic Keratocyst: A Retrospective Study

2018 ◽  
Vol 8 (1) ◽  
pp. 20-26
Author(s):  
Niharika Swain ◽  
Shilpa Patel ◽  
Jigna Pathak ◽  
Smita Vishwanath Rathod
Keyword(s):  
Retrospective Study ◽  
Proliferative Activity ◽  
Dentigerous Cyst ◽  
Odontogenic Keratocyst ◽  
Epithelial Lining ◽  
Radicular Cyst ◽  
Immunohistochemical Expression

scholarly journals Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst

2018 ◽  
Vol 61 (1) ◽  
pp. 17-21
Author(s):  
Zohreh Jaafari-Ashkavandi ◽  
Ahmad Alipour Tuyeh ◽  
Sepideh Assar
Keyword(s):  
Dentigerous Cyst ◽  
Odontogenic Cysts ◽  
Radicular Cyst ◽  
Immunohistochemical Expression ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Dentigerous Cysts ◽  
Pathologic Lesions ◽  
The Mean ◽  
Post Hoc

CDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous cysts, 18 odontogenic keratocysts (OKC) and 13 radicular cysts immunohistochemically. The mean expression of CDC7 was analyzed using ANOVA and Post-HOC methods. All specimens revealed CDC7 expression. Higher expression of CDC7 in OKC and radicular cyst was shown in comparison to dentigerous cyst (P < 0.001), while radicular cyst and OKC groups showed no difference in CDC7 expression (P = 0.738). The high expression of CDC7 in OKC suggests that this protein could be related to the higher proliferation rate and invasiveness of OKC. On the other hand, the higher CDC7 expression in radicular cyst may simply be related to inflammation as this cyst is neither aggressive nor invasive.

scholarly journals A Comparative Study of Proliferative Activity within Odontogenic Cyst Epithelium : Radicular Cyst and Odontogenic Keratocyst

1995 ◽  
Vol 49 (1) ◽  
pp. 157-165
Author(s):  
Qi Zhao ◽  
Tung Huai Hsu ◽  
Eiko Nakanishi ◽  
Chihiro Iuchi ◽  
Michihiro Takubo ◽  
...  
Keyword(s):  
Comparative Study ◽  
Proliferative Activity ◽  
Odontogenic Cyst ◽  
Odontogenic Keratocyst ◽  
Radicular Cyst

scholarly journals Evaluation of Microvessel Density in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

2021 ◽  
pp. 96-100
Author(s):  
Premkumar ◽  
Maya Ramesh ◽  
Mathew Jacob ◽  
B Sekar ◽  
K. Indrapridharshini ◽  
...  
Keyword(s):  
Microvessel Density ◽  
Dentigerous Cyst ◽  
Odontogenic Keratocyst ◽  
Radicular Cyst

scholarly journals Clinical and Histopathological Concordance of oral Bone Lesions. Retrospective Study

2019 ◽  
pp. 307-317
Author(s):  
Yadira V. Boza Oreamuno DDS, MSc ◽  
Andrea López Soto DDS, MSc
Keyword(s):  
Retrospective Study ◽  
Clinical Diagnosis ◽  
Dentigerous Cyst ◽  
Bone Lesions ◽  
Odontogenic Cysts ◽  
Histopathological Diagnosis ◽  
Radicular Cyst ◽  
Anterior Maxilla ◽  
Kappa Test ◽  
Periapical Granuloma

Bone lesions of the jaws have their origin from odontogenic and non-odontogenic structures. They can be benign or malignant, asymptomatic, they can be located around the root of the tooth, around the crown and in the interradicular area or they may not be related to the teeth. OBJECTIVE: to determine the frequency of the different bone lesions and the concordance between the clinical and histopathological diagnosis, in the clinical internship of the Faculty of Dentistry of the University of Costa Rica (UCR). METHODOLOGY: retrospective study of bone lesions recovered from the biopsy archive of the Faculty of Dentistry of the UCR from 2008 to 2015. Information on sex, age, location of the lesion, clinical diagnosis and diagnosis were evaluated and described. The agreement between the clinical and histopathological diagnosis was verified by the Kappa test. RESULTS: The 77 cases of oral bone lesions preferentially affected men 53.8% (n=41), the average age was 34.7 years (s.d.±19.6) and with lesions predominantly located in the posterior jaw 36.4% (n=28) and anterior maxilla 35.1% (n=27). Odontogenic cysts (OC) 42.9% (n=33), non-specific or unclassified diagnosis 28.6% (n=22) and inflammatory lesions of pulp and periapical origin 14.2% (n=11). TOs accounted for 7.8% (n=6) of the lesions. The four most predominant lesions were the radicular cyst, nonspecific diagnosis, dentigerous cyst and periapical granuloma. Concordance with the first diagnostic hypothesis was presented in 24 (31.2%) cases, the value of Kappa was 0.274 (discrete concordance) and 20.8% without clinical diagnosis only a description of the lesion. CONCLUSIONS: The OC were the predominant; being individually the radicular cyst the most frequent lesion. The clinical and histopathological concordance was discrete.

scholarly journals Immunohistochemical expression of Cyclooxygenase 2 reflects the proliferative activity in the epithelium of odontogenic lesions

2022 ◽  
Vol 10 (1) ◽  
Author(s):  
Vani Verma ◽  
Chetana Chandrashekar ◽  
Raghu Radhakrishnan ◽  
Monica Charlotte Solomon
Keyword(s):  
Epithelial Cells ◽  
Dentigerous Cyst ◽  
Cyclooxygenase 2 ◽  
Odontogenic Keratocyst ◽  
Odontogenic Cysts ◽  
Radicular Cyst ◽  
Chi Square ◽  
Ki 67 ◽  
Odontogenic Epithelium ◽  
Cox 2

Purpose:  Odontogenic cysts and tumors comprise a major component of lesions of the oral and maxillofacial region. The pathogenesis of these lesions involves the interaction between the odontogenic epithelium and the ectomesenchyme. However, the clinical behavior of these biological entities is unpredictable. The aim of this study was to evaluate the role of Cyclooxygenase 2 (COX-2) in the pathogenesis and prognostication of odontogenic lesions.Material and method:  : In this study formalin-fixed paraffin-embedded tissue section of Odontogenic Keratocyst (n=10) Dentigerous cyst (n=10), Radicular cyst (n=10) and unicystic ameloblastoma (n=10) were immunohistochemically stained with COX-2 (NCL2-COX-2- 4H12) and with Ki 67 (Ki-67 GM001) using standard staining protocols. The cytoplasmic expression of COX-2 in all the lesions was semi-quantitatively assessed. The pattern of expression of COX-2 among the different odontogenic lesions was statistical analyzed using the ANOVA test and the chi-square test.Results: All the 40 odontogenic lesions that were evaluated expressed COX-2 immunohistochemically. A high number of odontogenic epithelial cells expressed COX-2 in most of the odontogenic keratocyst, radicular cyst and unicystic ameloblastomas. The expression of COX-2 was significantly (p=0.036) higher in Unicystic Ameloblastomas and Radicular cyst compared to that of Odontogenic Keratocyst and the dentigerous cyst.Conclusion: The recognition that expression of COX-2 by odontogenic epithelial cells may indeed shed a new light on the biological mechanisms involved in the development of these benign yet aggressive lesions of the jaws. An insight into the molecular interactions occurring in the odontogenic epithelium will aid in better management of these lesions. 

scholarly journals Cistos e tumores odontogênicos: estudo retrospectivo dos casos diagnosticados no período de 10 anos em um hospital no sul do Brasil

2021 ◽  
Vol 62 (1) ◽  
pp. 56-62
Author(s):  
Bruna Luísa Neumann ◽  
Stéfanie Thieme ◽  
Amanda De Farias Gabriel ◽  
Virgilio Gonzales Zanella ◽  
Felipe Martins Silveira ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Medical Records ◽  
Dentigerous Cyst ◽  
Odontogenic Tumors ◽  
Odontogenic Cysts ◽  
Histopathological Diagnosis ◽  
Radicular Cyst ◽  
Pathological Characteristics ◽  
The Mean ◽  
Odontogenic Neoplasm

Introduction: odontogenic lesions (OLs) represent a heterogeneous group of oral and maxillofacial pathologies presenting distinct characteristics. The present study aimed to identify the clinical and pathological characteristics of OLs diagnosed in a southern Brazilian hospital. Materials and methods: a retrospective study was performed to evaluate cases with histopathological diagnosis of OLs identified in the period between 2007 and 2017. The patient's medical records were evaluated in order to obtain the clinical and pathological characteristics and the histopathological diagnosis from each case. Results: a total of 255 cases of OLs were identified. From these, 197 (77%) odontogenic cysts and 58 (23%) odontogenic tumors were surveyed, with only one case (0,39%) of a malignant odontogenic neoplasm. The most prevalent diagnosis were radicular cyst (32.5%) and dentigerous cyst (31.76%), followed by odontogenic keratocyst (10.98%), odontoma (10%) and ameloblastoma (10%). The majority of the cases affected the mandible (53.7%) with a slight preference by female individuals (51%). The mean age was 34±20.53 years old. Discussion: the presented data are in accordance with the literature regarding the rarity of the diagnosis of odontogenic tumors. Conclusion: the present study demonstrated the main clinical and pathological characteristics of OLs diagnosed in a southern Brazilian hospital, contributing to a better understanding of these injuries profiles.

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