scholarly journals An Unusual Case of Carcinoma Ex-pleomorphic Adenoma of the Parotid Gland: A Comprehensive Clinicopathological Review

2015 ◽  
Vol 1 (2) ◽  
pp. 44-46
Author(s):  
K Harish ◽  
PS Sharmila ◽  
K Shashikala ◽  
Padmini Jeychandran
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Unusual Case ◽  
Minor Salivary Gland ◽  
Sudden Onset ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Malignant Neoplasms ◽  
Diagnostic Challenge ◽  
Histologic Subtype

ABSTRACT Carcinoma ex-pleomorphic adenoma (CaxPA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma (PA). It presents approximately 11.6% of all malignant neoplasms of salivary gland and mostly originates from major salivary glands. It is a common histologic subtype of primary parotid malignancy. Location in the minor salivary gland is uncommon and occurs in less than 7% of all cases. The majority of CaxPA develops from epithelial component of PA. Salivary gland tumors are known to have a benign clinical behavior with unrecognized metastatic potential. It often poses a diagnostic challenge to clinicians and pathologists. The entity is difficult to diagnose preoperatively. Pathologic assessment is the gold standard for making the diagnosis. We present a case of a 55-year-old female patient who had a right preauricular mass of 10 years duration, with sudden onset of pain of duration of 1 month. How to cite this article Sharmila PS, Shashikala K, Harish K, Jeychandran P. An Unusual Case of Carcinoma Expleomorphic Adenoma of the Parotid Gland: A Comprehensive Clinicopathological Review. J Med Sci 2015;1(2):44-46.

PP - AN UNUSUAL CASE OF POLYMORPHOUS LOW-GRADE ADENOCARCINOMA EX-PLEOMORPHIC ADENOMA INVOLVING A MINOR SALIVARY GLAND: A DIAGNOSTIC CHALLENGE

2017 ◽  
Vol 123 (2) ◽  
pp. e66
Author(s):  
MONICA GHISLAINE OLIVEIRA ALVES ◽  
YONARA MARIA FREIRE SOARES MARQUES ◽  
ADRIANA ROCHA DE CARIS ◽  
CELSO MULLER BANDEIRA ◽  
SUZANA CANTANHEDE ORSINI MACHADO DE SOUZA ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Unusual Case ◽  
Minor Salivary Gland ◽  
Low Grade ◽  
Diagnostic Challenge ◽  
A Minor

scholarly journals Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma

2021 ◽  
Author(s):  
Costantino Ricci ◽  
Federico Chiarucci ◽  
Francesca Ambrosi ◽  
Tiziana Balbi ◽  
Barbara Corti ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumors ◽  
Melanin Pigment ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Pertinent Literature

AbstractThe presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.

scholarly journals Salivary gland tumours - a three years experience at King Edward Medical College, Lahore

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Asmaa Qureshi ◽  
Khalilur Rehman ◽  
Sohail Husain ◽  
Nasirul Hasan Khawaja ◽  
Ghulam Rasood Qureshi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Single Case ◽  
Malignant Neoplasms ◽  
Salivary Gland Tumours ◽  
Medical College ◽  
Common Location ◽  
Female Predominance

Salivary gland tumours make an important part of oral & maxillofacial pathology. Only few studies have been done in Pakistani population. The aim of this study was to describe morphological types of salivary gland tumours diagnosed at King Edward Medical College/ Mayo Hospital, Lahore during the years 1999-2001 and to compare their demographic data with those previously published. Material & Methods: This descriptive cross-sectional study was carried out at King Edward Medical College/ Mayo Hospital, Lahore. It reports 117 cases of salivary gland tumours diagnosed at Pathology Department during 1999-2001. Results: Of the 128 specimens of salivary glands, 117(91.4%) were confirmed as salivary neoplasms. Out of them, 62.7% were benign and 37.6% malignant and a slight female predominance (58.1%) was found. The most common location was the parotid gland (65.8%) followed by minor salivary glands (19.6%). Majority oft he t tumours was diagnosed during 3rd to 5 decades of life. Median age for benign tumours was 33 years (range 1-78) and a female predominance (58.9%) was seen again. Median age for malignant neoplasms was 45 years (range 9-70) with a female predilection ( 56.8%). However, 4 out o f 5 patients with Warthin`s tumour were men. Pleomorphic adenoma was the most frequent tumour (51.3%), followed by mucoepidermoid carcinoma (25.6%), adenoid cystic carcinoma (7.7)), Warthin`s tumour (4.3%) and monomorphic adenoma (2.6%). Two cases each of oncytoma & adenocarcinoma were recorded. Rare categories (single case each) of salivary tumours included lipoma, acinic cell carcinoma, basal cell adenoma, capillary haemangioma, metastatic carcinoma and non Hodgkin`s lymphoma. Conclusion: The principal site of salivary tumours was the parotid gland and females were most affected. Pleomorphic adenoma was the most frequent finding. The results of this study are comparable with other studies.

scholarly journals Carcinoma ex Pleomorphic Adenoma in the Parapharyngeal Space

2013 ◽  
Vol 28 (1) ◽  
pp. 24-27
Author(s):  
Sudipta Pal ◽  
Sampurna Pati ◽  
Somnath Saha ◽  
Vedula Padmini Saha
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Parapharyngeal Space ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Gland Tumor ◽  
Mandibular Swing ◽  
Operative Recovery

Objective: To present a case of carcinoma ex pleomorphic adenoma in the parapharyngeal space and discuss its management.   Methods: Design:            Case Report Setting:           Tertiary Government Teaching Hospital Subjects:         One   Results:  A 40-year-old male patient with dysphagia for three months and a left-sided mucosa-covered oropharyngeal mass was found to have a prestyloid parapharyngeal lesion on CT Scans. Fine Needle Aspiration Cytology (FNAC) revealed a pleomorphic adenoma. With a past history of parapharyngeal pleomorphic adenoma excised transorally three years before, the present mass was excised by mandibular swing approach. Post-operative recovery was uneventful, but the final histopathological report was carcinoma ex pleomorphic adenoma.   Conclusion: Malignant transformation should be suspected in recurrent salivary tumors in the parapharyngeal space. Provided there was truly no pre-existing malignant focus in the originally-excised tumor, and that early recurrence was not due to inadequate initial excision, this patient had a rare condition where the same tumor underwent malignant transformation within 3 years only. To the best of our knowledge, such an early transformation to malignancy of a minor salivary gland tumor of the parapharyngeal space has not been reported in the English literature.   Keywords: carcinoma ex pleomorphic adenoma, pleomorphic adenoma, carcinoma,  parapharyngeal space, malignant, transformation, minor salivary gland tumor,  mandibular swing

scholarly journals A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis

2015 ◽  
Vol 16 (7) ◽  
pp. 603-606
Author(s):  
Felipe Perozzo Daltoe ◽  
Liliane Janete Grando ◽  
Maria Inês Meurer ◽  
Elena Riet Correa Rivero ◽  
Filipe Modolo
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Periodic Acid ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Immunohistochemical Analysis ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Periodic Acid Schiff

ABSTRACT Mucoepidermoid carcinoma ex pleomorphic adenoma (MCxPA) is a rare salivary gland tumor predominantly found in major salivary glands. A case of MCxPA involving the soft tissue and bone of the retromolar region of a 26-year-old man is presented. The histopathological features revealed a neoplasm with predominance of pleomorphic adenoma (PA) elements, and presence of mucoepidermoid carcinoma malignant epithelial cells in several areas. Histochemical and immunohistochemical studies were positive for periodic acid Schiff, alcian blue, cytokeratins 7, 13, 14, and 19, Bcl-2, c-erbB-2, FGF-2 and maspin in the malignant areas. The patient underwent a partial resection of the left side of the mandible with neck dissection and MCxPA diagnosis was confirmed. How to cite this article Daltoe FP, Grando LJ, Meurer MI, Rivero ERC, Modolo F. A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis. J Contemp Dent Pract 2015;16(7):603-606.

Carcinoma Ex Pleomorphic Adenoma of Upper Lip: An Unusual Presentation

2010 ◽  
Vol 1 (2) ◽  
pp. 121-124
Author(s):  
Devarshi Nandi ◽  
S Shivaprasad ◽  
L Ashok ◽  
BR Ahmed Mujib
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Benign Tumor ◽  
Minor Salivary Gland ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Rare Tumor ◽  
Upper Lip ◽  
Salivary Gland Carcinomas ◽  
Salivary Gland Malignancy

ABSTRACT Carcinoma ex-pleomorphic adenoma is a rare salivary gland malignancy, usually derived from a long-standing or recurrent benign tumor, the pleomorphic adenoma.1 This rare tumor comprises less than 4% of salivary gland neoplasms and 11.6% of salivary gland carcinomas. They mostly involve the “major” salivary glands1 and their occurrence in the minor salivary gland is considered rare, especially in the upper lip. So far there is only one report of CXPA occurring in the upper lip in the literature.13 Hereby, we present a case of carcinoma ex-pleomorphic adenoma in a 52-year-old woman who reported to our department with a painful swelling on the upper lip which was diagnosed and treated successfully.

scholarly journals Histopathological spectrum of salivary gland lesions - in a tertiary care centre

2020 ◽  
Vol 9 (1) ◽  
pp. 97
Author(s):  
Gomathi Srinivasan ◽  
Francis Asir Joseph J. ◽  
Shanmugam Kaliyaperumal ◽  
Arunalatha Ponnaiah
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Benign Tumors ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Malignant Neoplasms ◽  
Morphological Aspect ◽  
Chronic Sialadenitis

ABSTRACT Background: Histopathology is the most important means in diagnosis of salivary gland lesions. The objective of this study is, to study occurrence of salivary lesions during a period of one year from January 2019 to December 2019, to study age, sex and site distribution of various salivary gland lesions, to study histo-morphological aspect of these lesions.Methods: Surgically resected salivary gland specimens received at Department of Pathology, Government Stanley Medical College, Chennai were subjected to histopathological examination. Specimens were fixed in 10% neutral buffered formalin, processed, embedded, sections cut and stained with hematoxylin and eosin stain.Results: There were a total of 30 salivary gland specimens. Out of thirty, 25 were neoplastic and 5 were non-neoplastic. Pleomorphic adenoma was the commonest of all benign tumors. Mucoepidermoid carcinoma was the most common malignant tumor. Among the 21 benign tumors, 16 cases of pleomorphic adenoma and a case each of myoepithelioma, benign metastasising pleomorphic adenoma, basal cell adenoma, warthins tumor and schwannoma were found. Among the 4 malignant tumors, 2 cases of mucoepidermoid carcinoma, a case of carcinoma ex pleomorphic adenoma and a case of myoepithelial carcinoma were found. Among the 5 non neoplastic lesions a case each of chronic sialadenitis, Sjogren’s syndrome, inflammatory myofibroblastioc tumor, parotid abscess and lymphoepithelial cyst were found.Conclusions: The diagnosis of salivary gland lesions by histopathological examination is the most important method in diagnosis and differentiating benign and malignant lesions and to predict prognosis by typing, staging and grading of malignant neoplasms.

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