scholarly journals Evaluating Blood Glucose-6-Phosphate Dehydrogenase Activity with Oxidative Stress: A Study in Uncomplicated Type 2 Diabetes Mellitus Patients

2020 ◽  
Vol 24 (1) ◽  
pp. 4-8
Author(s):  
Ruchika Priyadarsini ◽  
Pramila K Mishra ◽  
Nirupama Devi ◽  
Rasmita K Padhy
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Dehydrogenase Activity ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Oxidative stress in patients with type 2 diabetes mellitus treated with metformin

2017 ◽  
Vol 27 (2) ◽  
pp. 25857
Author(s):  
Samuel Selbach Dries ◽  
Bárbara Da Silveira Soares ◽  
Ana Luiza Ziulkoski ◽  
Simone Gasparin Verza ◽  
Rafael Linden ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Superoxide Dismutase ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Side Effects ◽  
Diabetic Complications

*** Oxidative stress in patients with type 2 diabetes mellitus treated with metformin ***AIMS: To evaluate oxidative stress parameters in patients with type 2 diabetes mellitus treated with metformin, relating these values to its side effects, plasma levels, glycemic control, diabetic complications, lipid profile, and the influence of pharmacotherapeutic follow-up.METHODS: Patients with type 2 diabetes mellitus, on metformin and in pharmacotherapeutic follow-up for four months, were evaluated. The pharmacotherapeutic follow-up consisted in providing information and answering patients’ questions about medication and disease. In addition, administration times, dosages, and presence or absence of side effects related to the use of metformin were verified. Glycemic and lipid profile, oxidative stress (superoxide dismutase and malondialdehyde) and plasma metformin were evaluated. Pearson’s correlation and Spearman’s correlation were performed to evaluate the relationship between the variables at the beginning of the study. The independent t-test and Mann-Whitney U test were used to assess the difference between the groups with and without diabetic complications. The range of values between the beginning and  end of the study was evaluated using Student’s t-test or Wilcoxon U test. The significance level was set at 5%.RESULTS: The initial sample consisted of 49 patients aged 59±9 years with a body mass index of 29.8±5.1 kg/m2, who have had diabetes for a median time of 36 months (interquartile range of 1-240) and have been on metformin for a median time of 36 months (interquartile range of 1-180). Twenty-five patients left the study between the second and fourth meetings. Malondialdehyde levels differed between before and after pharmacotherapeutic follow-up, being positively correlated with blood glucose, glycohemoglobin, and triglyceride level, and negatively correlated with metformin and superoxide dismutase. Blood glucose, glycohemoglobin, and malondialdehyde levels increased, whereas metformin levels decreased in the group with diabetic complications, and there was a correlation between malondialdehyde and the number of diabetic complications per patient.CONCLUSIONS: In this sample of patients with type 2 diabetes mellitus treated with metformin, oxidative stress was more pronounced in those with poor glycemic control and diabetic complications.

Comment on: acute and chronic fluctuations in blood glucose levels can increase oxidative stress in type 2 diabetes mellitus

2012 ◽  
Vol 50 (5) ◽  
pp. 825-826
Author(s):  
Turgay Ulas ◽  
Mehmet Sinan Dal ◽  
Irfan Tursun ◽  
Mehmet Emin Demir ◽  
Hakan Buyukhatipoglu
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Short-Term Consumption of Probiotic Yogurt Improved HDL-C of Type 2 Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial

2019 ◽  
Vol 26 (4) ◽  
pp. 381-392
Author(s):  
Lily Arsanti Lestari ◽  
Dian Ratnasari ◽  
Elsa Fairuz Azizah ◽  
Ivana Noor Farida ◽  
Farah Nuriannisa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Fasting Blood Glucose ◽  
Probiotic Yogurt

Abstract Background and aims: Cardiovascular disease is the main complication and cause of morbidity and mortality in type 2 diabetes mellitus (T2DM) patients. The main cause of complication in T2DM is oxidative stress caused by insulin resistance, hence it can increase lipid profiles (cholesterol, LDL, and triglycerides) which exacerbates endothelial dysfunction. Among various functional foods with antioxidant effects, probiotic foods have been reported to suppress oxidative stress, and also improve the fasting blood glucose (FBG) and lipid profile in patients with T2DM. The aim of this clinical trial is to study the effects of probiotics and conventional yogurt on FBG and lipid profile in patients with T2DM. Material and method: Thirty-eight patients with T2DM, aged 30 to 60 years old, were assigned to two groups in this randomized, doubleblind, controlled clinical trial. The subjects in the intervention group consumed 100 ml/day probiotic yogurt containing Lactobacillus acidophilus La-5 and Bifidobacterium lactis BB-12, whereas subjects in the control group consumed 100 ml/day conventional yogurt for four weeks. Anthropometric indices, dietary intake, physical activity, serum FBG, and lipid profile were evaluated at the beginning and end of the intervention. Results: Consumption of 100 mL/day conventional yogurt could significantly reduce the fasting blood glucose (FBG) level, whereas probiotic yogurt could not reduce FBG significantly. Although the total cholesterol and triglyceride were not improved after yogurt consumption, both type of yogurt could improve HDL-C level. Conclusion: Both conventional yogurt or probiotic yogurt could be used as functional food since it improved the HDL-C in type 2 DM patients.

scholarly journals Triphala improves glucose homeostasis by alleviating atherogenic lipids and oxidative stress in human Type 2 diabetes mellitus

2015 ◽  
Vol 6 (3) ◽  
Author(s):  
Nita Singh ◽  
Sunil Mahajan ◽  
Senthil K Subramani ◽  
Dhananjay Yadav ◽  
Lokendra Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Protective Effect ◽  
Tail Length ◽  
Protective Effects ◽  
Lipid Levels

Aims: ‘Triphala’ constituting equal parts of three medicinal dried plant fruits Emblica Officinalis Gaertn., Terminalia chebula Retz. and Terminalia bellerica Gaertn. is an antioxidant rich Ayurvedic formulation. The present study assessed therapeutic as well as protective effects of Triphala on human subjects with Type 2 diabetes mellitus (T2DM) and Impaired glucose tolerance (IGT). Materials and methods: Triphala at a dose of 5 gms BD was administered to two cohorts viz., IGT, N= 20 and T2DM, N=30 consecutively for a period of 12 months. The therapeutic efficacy was assessed quarterly by monitoring blood glucose and lipid levels; the protective effect by monitoring antioxidants level quarterly and DNA damage annually. Toxicity if any, to liver and kidney due to long term administration was assessed quarterly in both cohorts.Results: Continuous ‘Triphala’ therapy for 12 months significantly reduced blood glucose (p≤0.001) and lipid levels (p≤0.05) in both the cohorts. Triphala resisted oxidative stress generated during the course of hyperglycemia by significantly increasing the activity of super oxide dismutase and Catalase (p≤0.001) and the level of reduced glutathione (p≤0.001). Protective effect on DNA was accessed through significant reduction in the comet tail length (p≤0.001).Conclusions: ‘Triphala’ ameliorated not only the oxidative stress but also normalized glucose and lipid homeostasis in subjects with impaired glucose and T2DM. 

scholarly journals THE EFFECT OF GAMBIER EXTRACT ON THE LEVELS OF MALONDIALDEHYDE, SUPEROXIDE DISMUTASE, AND BLOOD GLUCOSE IN TYPE 2 DIABETES MELLITUS PATIENTS

2018 ◽  
Vol 11 (10) ◽  
pp. 121 ◽  
Author(s):  
Yunita Sari Pane ◽  
Ratna Akbari Ganie ◽  
Dharma Lindarto ◽  
Aznan Lelo
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Superoxide Dismutase ◽  
Type 2 Diabetes Mellitus ◽  
Placebo Group ◽  
Blood Glucose ◽  
Randomized Clinical Study ◽  
The Impact

Objective: Diabetes mellitus is a disease associated with dysfunction of pancreatic β-cells and oxidative stress. A treatment which can reduce the impact of oxidative stress may be beneficial in the treatment of diabetes. Therefore, this study aimed to investigate the effect of gambier extract on the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and blood glucose level (BGL) in type 2 diabetes mellitus (T2DM).Methods: This research was a randomized clinical study consisted of two groups, namely placebo group (n=10) and gambier group (n=6). The blood samples were collected from the vein after fasting overnight and before consuming 100 g white bread to measure the levels of MDA, SOD, and BGL. The same procedure was conducted after fasting and 2-h postprandial on day 1 and day 14. The data obtained were analyzed with Student’s t-test with a statistical significance level of p<0.05.Results: The results showed that there was no change in MDA levels in the placebo group during the observation, but there was a significant decrease in MDA levels in the gambier group on day 14. In contrast, SOD levels increased in all measurements although there was no change on day 1 in the placebo group. The present study also found a significant increase of BGLs after consuming 100 g bread in both groups, but less BGL elevation in the gambier group.Conclusion: It is concluded that gambier extract has special mechanisms in the treatment of T2DM as an antioxidant and BGLs reduction.

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