Patients with Implanted Permanent Pacemakers: Baseline Characteristics and Coronary Angiographic Profile

Mapping Intimacies ◽

10.5083/ejcm20424884.176 ◽

2020 ◽

Author(s):

Ismail Alsuz ◽

Mahdi Al-Zaidi

Keyword(s):

Coronary Artery Disease ◽

Blood Flow ◽

Matched Control ◽

Control Group ◽

Study Group ◽

Conduction Disturbances ◽

Type Iv ◽

Lv Dysfunction ◽

Artery Disease

ABSTRACT Background: Etiology of severe cardiac conduction disturbances is frequently uncertain. The risk factors of both coronary artery disease and conduction defects often overlap. Considering this, the present study aimed to find the relationship between complete heart block and specific pathological coronary anatomy. Material and Methods: Seventy-eight patients, (39 patients with a permanent pacemaker and 39 matched control patients who underwent coronary angiography procedure) were studied. The lesions were classified into four types, according to the anatomy of blood supply to the different segments of the conduction system. Results: Type IV lesion was common in study group compared to matched control group where type III lesion was common. Lesions that compromise blood flow to septal branches (types II and IV) were common in study group and the lesion types that do not compromise blood flow (types I and III) were common in control group (p<0.001). Type 1 lesion were common in females (p<0.001). Type IV lesions were common in hypertensive, whereas, non- hypertensive and non-diabetic patients had type 1 lesions (p<0.001). Similarly, patients with LV dysfunction had type 4 lesion compared to the patients without LV dysfunction who had type 1 lesions (p<0.001) Conclusions: Patients with permanent pacemakers having coronary artery disease are more likely to have specific coronary angiographic findings. Therefore, the site of lesions and not the severity or extent of atherosclerosis is responsible for the conduction disturbances.

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TRUST Study: Participation in Randomized Controlled Trials and Subsequent Adherence to Visiting Medical Institutions and Taking Medications in Patients with Cardiovascular Diseases. Part II. Assessment of the Quality of Therapy

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2020-12-06 ◽

2020 ◽

Vol 16 (6) ◽

pp. 977-983

Author(s):

N. O. Vasyukova ◽

N. P. Kutishenko ◽

Yu. V. Lukina ◽

O. I. Zvonareva ◽

S. Yu. Martsevich

Keyword(s):

Blood Pressure ◽

Coronary Artery Disease ◽

Clinical Trials ◽

Control Group ◽

Controlled Trials ◽

Study Group ◽

Randomized Controlled ◽

Quality Of Therapy ◽

Artery Disease

Aim. Based on the data of the TRUST study (Influence of Participation in Randomized Controlled Trials on adheRence to Medicines' Intake and regUlar viSits to the docTor) to assess the quality of drug therapy and patients' awareness of achieving target blood counts and blood pressure (BP) among patients with coronary artery disease (CAD), diabetes mellitus (DM), hypertension.Material and methods. 102 patients are enrolled in the study group of the TRUST study who participated in one or more randomized clinical trials (RCT) in the period from 2011 to 2018. A control group (n=109) included patients who had never participated in an RCT was selected. From January to April 2020, face-to-face or telephone contact was established with patients from both groups. In the study group, the response was 86.3%, in the control group - 81.7%. The adherence to drug therapy accordingly to current clinical guidelines was analyzed in patients with coronary artery disease in both groups.Results. Patients with CAD who previously participated in RCTs take drugs with proven efficacy significantly more often than patients who did not participate in clinical trials. All groups of drugs intake was significantly more frequent in the study group than in the control group: angiotensin-converting-enzyme inhibitors/angiotensin receptor blockers (odds ratio [OR] 7.66, 95% confidence interval [CI] 2.5-22.6; p=0.006), statins (OR 5.12, 95%CI 1.8-14.5; p=0.002), beta-blockers (OR 2.96, 95%CI 1.03-8.5; p=0.038), antiplatelet agents (OR 2.94, 95%CI 1.1-7.7; p=0.026). In the main group, 54.3% of patients with CAD knew about their level of low-density lipoprotein cholesterol (LDL-c), and 68% of them had an LDL level of ≤ 1.8 mmol/l. Patients with DM in 92.9% of cases were aware of their glucose level, and in 76.9% of them had the fasting glucose level <7 mmol/L. Hypertensive patients in 92.8% of cases controlled their blood pressure twice a day and 89.2% of them had a target blood pressure level (<140/90 mm Hg).Conclusion. Patients who participated in RCTs showed better adherence to treatment and health awareness compared to the control group. Partly, the approach to patient management, as it takes place in the RCTs model, can be implemented in real clinical practice to improve the quality of therapy in patients with cardiovascular disease.

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ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease

Disease Markers ◽

10.1155/2019/6129748 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Zhen Wang ◽

Di Ye ◽

Jing Ye ◽

Menglong Wang ◽

Jianfang Liu ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diagnostic Value ◽

Control Group ◽

Artery Disease ◽

A Disintegrin And Metalloproteinase ◽

The Relationship ◽

Spearman’S Correlation

The current study demonstrates that a disintegrin and metalloproteinase with thrombospondin type 1 motif- (ADAMTS-) 5 is a key extracellular matrix protease and associated with cardiovascular diseases. However, the plasma ADAMTS-5 levels and relevance of coronary artery disease (CAD) remain largely unknown. This study is aimed at examining the relationship between the plasma ADAMTS-5 levels and the severity of coronary stenosis in patients with CAD. In the present study, the expression of ADAMTS-5 was analyzed in coronary artery samples and blood. The results showed that the plasma ADAMTS-5 levels were lower in the CAD group than in the control group. In addition, significantly higher matrix metalloproteinase- (MMP-) 2 and MMP-9 levels were also observed in the patients with CAD, and the ADAMTS-5 levels were negatively correlated with the MMP-2 and MMP-9 levels. Spearman’s correlation analysis showed that the Gensini score was negatively correlated with the ADAMTS-5 levels but was positively correlated with the MMP-2 and MMP-9 levels. Receiver-operating characteristic (ROC) analysis revealed that ADAMTS-5, MMP-2, and MMP-9 may have a certain diagnostic value in CAD and that the combination of all three metalloproteinases had a higher diagnostic value. The findings provided a better understanding of the role of ADAMTS-5 in the diagnosis of CAD.

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CARDIOVASCULAR HEALTH KNOWLEDGE OF PATIENT ATTENDANTS IN SOUTHERN OF IRAN, SHIRAZ

The Professional Medical Journal ◽

10.29309/tpmj/2012.19.05.2399 ◽

2012 ◽

Vol 19 (05) ◽

pp. 604-610

Author(s):

ABDUL HAMEED CHOHEDRI ◽

MANSOUR MASJEDI ◽

MOHAMMAD HOSSEIN EGHBAL

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Risk Factor ◽

Coronary Artery ◽

Cardiovascular Health ◽

Health Knowledge ◽

Control Group ◽

Study Group ◽

Cross Sectional ◽

Artery Disease

Background : Knowledge about coronary artery disease and it’s risk factors is a very important factor in prevention of ischemicheart disease. The aim of this study was to investigate knowledge of patient attendants about coronary artery disease and its risk factors insouthern of Iran; Shiraz. Design: Cross sectional study. Setting: Shiraz University of Medical Sciences. Materials and Methods: 800 patientattendants (persons accompanying patients) selected randomly and divided into two groups (study and control) each including 400 patientattendants. Face to face interview was done and knowledge was measured by correct answers to our standard questionnaire. Results: Themedian knowledge score was 6.89 for study group and was 2.82 for control group out of a possible maximum of 15. Majority of respondents instudy group could identify up to three risk factors for coronary artery disease, but in control group could identify only one risk factor. About 5.8%in study group and 37.5% in control group were not able to identify even a single risk factor for coronary artery disease. Conclusions:According to our results there is a big gap in knowledge about coronary artery disease and it’s risk factors in our population. It means that moreeducational programs are needed to prevent the increasing rate of coronary artery disease.

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Effect of intramyocardial injection of erytropetin stimulated autologus bone marrow cells on myocardial perfusion using 99mТC-MIBI spect in long-term

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2018-4-171-179 ◽

2018 ◽

Vol 17 (4) ◽

pp. 171-179

Author(s):

A. M. Chernyavskiy ◽

A. V. Fomichev ◽

N. A. Nikitin ◽

O. V. Poveshchenko ◽

J. E. Kareva ◽

...

Keyword(s):

Coronary Artery Disease ◽

Bone Marrow ◽

Coronary Artery ◽

Myocardial Perfusion ◽

Bone Marrow Cells ◽

Control Group ◽

Study Group ◽

Artery Disease ◽

Mibi Spect

Purpose.To evaluate the changes of myocardial perfusion using 99mТс-MIBI single-photon emission computed tomography (SPECT) after the intramyocardial implantation of erythropoietin preconditioned autologous bone marrow cells (ABMC) in laser channels during coronary artery disease (CAD) surgery.Materials and methods.Randomized study of 40 patients (mean age 58.0 ± 6.9, 9 females) with diffuse and (or) distal right coronary artery disease (RCA). Patients of the study group (n= 23) underwent coronary artery bypass grafting (CABG) of the left coronary artery (LCA) system and intramyocardial implantation of erythropoietin preconditioned ABMC in the left ventricular (LV) inferior wall. Patients of the control group (n= 17) underwent CABG of the LCA system only. 99mТс-MIBI SPECT performed 1–2 days before and 12 months after surgery.Results.In study group after 12-month follow-up the summed stress score in a typical RCA supply area (SSSRCA) improved from 7.0 [5.5; 10.5] to 4.0 [1.0; 5.5] (p<0.01), summed rest score (SRSRCA) improved from 3.0 [0.0; 7.0] to 1.0 [0.0; 3.5] (p<0.01), and summed different score (SDSRCA) improved from 3.0 [1.0; 4.0] to 1.0 [0.0; 2.0] (p= 0.03). Control group patients after 12-month follow-up showed significant improvement of SSS RCA only – from 8.0 [6.0; 12.0] to 5.0 [4.0; 7.0] (p<0.01).Conclusion.After 12-month follow-up in patients with diffuse and (or) distal RCA disease, the procedure of intramyocardial implantation of the erythropoietin preconditioned ABMC in laser channels is demonstrated to be safe and induces the improvement of myocardial perfusion.

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Association between angiotensin II type-1 receptor A1166C polymorphism and the presence of angiographically-defined coronary artery disease in an Iranian population

Asian Biomedicine ◽

10.2478/abm-2010-0038 ◽

2010 ◽

Vol 4 (2) ◽

pp. 307-314 ◽

Cited By ~ 4

Author(s):

Akram Assali ◽

Javad Behravan ◽

Roghayeh Paydar ◽

Mohsen Mouhebati ◽

Mitra Hassania ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Angiotensin Ii ◽

Coronary Angiography ◽

Iranian Population ◽

Control Group ◽

A1166c Polymorphism ◽

Significant Difference ◽

Artery Disease

Abstract Background: There are reported associations between a polymorphism of the angiotensin II type 1 receptor (AT1R/A1166C) gene and coronary artery disease (CAD), hypertension, and myocardial infarction in some populations. Objective: Investigate the association between A1166C polymorphism and CAD in an Iranian population. Methods: Four hundred and thirteen patients with suspected CAD were recruited. Based on coronary angiography, the patients were classified into CAD+ (n=315) and CAD- (n=98) groups defined as >50% and <50% stenosis of any major coronary artery, respectively. One hundred and thirty-five healthy subjects were also recruited as the control group. The AT1R polymorphism was assessed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) based method. Results: A higher frequency of the AC and CC genotypes and lower frequency of the AA genotype was observed in both CAD+ and CAD- groups, compared with the control group (p <0.05). CAD+ and CAD- groups also had a higher frequency of the C allele than controls (p <0.01). There was no significant difference in genotype and allele frequencies between hypertensive and non-hypertensive patients (p > 0.05). In addition, the AT1R genotype frequencies did not differ significantly among different subgroups of CAD+ patients, based on the number of affected coronary vessels (p >0.05). Conclusion: The frequency AT1R/A1166C polymorphism was higher among patients with some degrees of coronary stenosis who are candidates of coronary angiography.

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