Risk factors and prediction model construction of post-operative atrial fibrillation after thoracic surgery in Chinese patients

IntroductionThe purpose of this study was to analyze the risk factors of post-operative atrial fibrillation (POAF) after thoracic surgery, and to build a predictive model for accurate preoperative identification of high-risk patients.Material and methodsIn this study, data of 2072 patients with pulmonary masses and esophageal cancer who attended our hospital in the period from January 1, 2017 to December 31, 2018 were analyzed retrospectively. According to whether AF occurred after the operation, the patients were divided into atrial fibrillation (AF) and non-AF (NAF) groups. The general information (age, sex, height, etc.), previous medical history (chronic lung disease, hypertension, etc.), medication history, preoperative ultrasound and cardiogram results, and preoperative and postoperative electrocardiogram (ECG) were collected. The operation mode, resection scope, histopathology and hospitalization were recorded. Univariate and multivariate logistic regression were used to screen out the risk factors of AF and establish a prediction model.ResultsThe incidence of POAF was 5.98%. Univariate analysis showed that sex, age, body mass index, left atrial diameter and operation organ were the risk factors of POAF. The above factors were included in the multivariate logistic regression analysis, and the results showed that male sex, age, anteroposterior diameter of left atrium and surgical organs were related to POAF. On this basis, a POAF prediction model was constructed, which had good discrimination and calibration. The area under the curve (AUC) is 0.784 with 95% CI: 0.746–0.822.ConclusionsThe prediction model of POAF based on the risk factors selected in this study can accurately predict the occurrence of AF after thoracic surgery.

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Risk Factors for and Outcomes Associated with Clinical Isolates ofEscherichia coliandKlebsiellaSpecies Resistant to Extended-Spectrum Cephalosporins among Patients Admitted to Canadian Hospitals

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2009/725872 ◽

2009 ◽

Vol 20 (3) ◽

pp. e43-e48 ◽

Cited By ~ 11

Author(s):

Marianna Ofner-Agostini ◽

Andrew Simor ◽

Michael Mulvey ◽

Alison McGeer ◽

Zahir Hirji ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Univariate Analysis ◽

Multivariate Logistic Regression Analysis ◽

Care Facility ◽

P Value ◽

Third Generation ◽

Multivariate Logistic Regression ◽

Extended Spectrum ◽

Third Generation Cephalosporins

BACKGROUND: Clinical features associated with Gram-negative bacterial isolates with extended-spectrum beta-lactamase (ESBL)- and AmpC-mediated resistance identified in Canadian hospitals is largely unknown. The objective of the present study was to determine the demographics, risk factors and outcomes of patients with ESBL- or AmpC-mediated resistant organisms in Canadian hospitals.METHODS: Patients with clinical cultures ofEscherichia coliorKlebsiellaspecies were matched with patients with a similar organism but susceptible to third-generation cephalosporins. Molecular identification of the AmpC or ESBL was determined using a combination of polymerase chain reaction and sequence analysis. Univariate and multivariate logistic regression analysis was performed to identify variables associated with becoming a case.RESULTS: Eight Canadian hospitals identified 106 cases (ESBL/AmpC) and 106 controls. All risk factors identified in the univariate analysis as a predictor of being an ESBL/AmpC cases at the 0.20 P-value were included in the multivariate analysis. No significant differences in outcomes were observed (unfavourable responses 17% versus 15% and mortality rates 13% versus 7%, P not significant). Multivariate logistic regression found an association of becoming an ESBL/AmpC case with: previous admission to a nursing home (OR 8.28, P=0.01) or acute care facility (OR 1.96, P=0.03), length of stay before infection (OR 3.05, P=0.004), and previous use of first-generation cephalosporins (OR 2.38, P=0.02) or third-generation cephalosporins (OR 4.52, P=0.01). Appropriate antibiotics were more likely to be given to controls (27.0% versus 13.3%, P=0.05) and number of days to appropriate antibiotics was longer for cases (median 2.8 days versus 1.2 days, P=0.05).CONCLUSION: The importance of patient medical history, present admission and antibiotic use should be considered for allE coliorKlebsiellaspecies patients pending susceptibility testing results.

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Risk factors for periprocedural ischemic stroke following endovascular treatment of intracranial aneurysms

Chinese Neurosurgical Journal ◽

10.1186/s41016-021-00255-z ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Yisen Zhang ◽

Chao Wang ◽

Zhongbin Tian ◽

Wei Zhu ◽

Wenqiang Li ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Ischemic Stroke ◽

Treatment Modality ◽

Intracranial Aneurysms ◽

Univariate Analysis ◽

Multivariate Logistic Regression Analysis ◽

Flow Diverter ◽

Multivariate Logistic Regression

Abstract Background The aim of this study was to comprehensively evaluate the risk factors of periprocedural ischemic stroke associated with endovascular treatment of intracranial aneurysms using a real-world database. Methods From August 2016 to March 2017, 167 patients were enrolled. Univariate analysis and multivariate logistic regression analysis were used to examine the risk factors for periprocedural ischemic stroke. Results Among the 167 cases, periprocedural ischemic stroke occurred in 20 cases (11.98%). After univariate analysis, the ischemic group had a higher proportion of large (≥ 10 mm) aneurysms than the control group (45.0% vs. 23.1%, p = 0.036). The incidence of periprocedural ischemic stroke was higher in cases treated by flow diverter (21.6%) or stent-assisted coiling (11.8%) than in cases treated by coiling only (2.7%), and the differences were statistically significant (p = 0.043). After multivariate logistic regression analysis, treatment modality was the independent risk factor for periprocedural ischemic stroke. Compared with the coiling-only procedure, flow diverter therapy was associated with a significantly higher rate of periprocedural ischemic stroke (OR 9.931; 95% CI 1.174–84.038; p = 0.035). Conclusions Aneurysm size and treatment modality were associated with periprocedural ischemic stroke. Larger aneurysms were associated with increased risk of periprocedural ischemic stroke. Flow diverter therapy was associated with significantly more periprocedural ischemic stroke than the coiling procedure alone.

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Risk Factors of Thromboembolism in Lymphoma Patients Undergoing Chemotherapy and its Clinical Significance

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/10760296211037923 ◽

2021 ◽

Vol 27 ◽

pp. 107602962110379

Author(s):

Xiao Li ◽

Shu-Ling Hou ◽

Xi Li ◽

Li Li ◽

Ke Lian ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Clinical Significance ◽

Logistic Regression Analysis ◽

Univariate Analysis ◽

Multivariate Logistic Regression Analysis ◽

Stage Iii ◽

Multivariate Logistic Regression ◽

Ann Arbor

This study investigated the risk factors of thromboembolism (TE) in lymphoma patients undergoing chemotherapy and its clinical significance. A total of 304 lymphoma patients who received chemotherapy from January 2012 to July 2019 were retrospectively analyzed, including 111 patients with and 193 patients without TE. The clinical characteristics and related laboratory test results were compared between the 2 groups using univariate analysis, while the risk factors for TE in lymphoma patients undergoing chemotherapy were analyzed using multivariate logistic regression analysis. Univariate analysis revealed an increase in the risk of TE among lymphoma patients with chemotherapy in the following categories: female patients, patients with body mass index <18.5 or > 24, patients aged ≥60 years, those with platelet abnormality before chemotherapy, single hospital-stay patients, and Ann Arbor stage III/IV patients. Multivariate logistic regression analysis revealed that for platelet count abnormality before chemotherapy, Ann Arbor stage III/IV and female patients represented independent risk factors for TE among lymphoma patients after chemotherapy ( P < .05). For lymphoma patients treated with chemotherapy, the risk of TE occurring in women, patients with platelet abnormalities before chemotherapy, and patients at Ann Arbor stage III/IV was significantly higher compared with other patients. For these patients, we recommend prophylactic anticoagulant therapy.

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Prevalence and risk factors of depression and anxiety for inpatients with lung cancer in China: A hospital-based cross-sectional study

10.21203/rs.3.rs-1149458/v1 ◽

2022 ◽

Author(s):

Xueqian Wang ◽

Xuejiao Ma ◽

Mo Yang ◽

Yan Wang ◽

Yi Xie ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Logistic Regression ◽

Risk Factor ◽

Univariate Analysis ◽

Multivariate Logistic Regression Analysis ◽

Multivariate Logistic Regression Model ◽

Depression And Anxiety ◽

Multivariate Logistic Regression ◽

Cross Sectional

Abstract Background Lung cancer was often accompanied by depression and anxiety. Nowadays, most investigations for depression and anxiety were concentrated in western medical hospitals, while few related studies have been carried out in the tradition Chinese medicine (TCM) ward. It was necessary to understand the prevalence and risk factors of depression and anxiety in the inpatients with lung cancer in TCM hospital. Methods This study adopted cross-sectional research method, which enrolled a total of 222 inpatients with lung cancer in TCM hospital. PHQ-9 and GAD-7 scales were used to assess depression and anxiety for the inpatients, respectively. Demographic and clinical data were also collected. Statistical methods of the univariate analysis and the multivariate logistic regression model were used. Results The prevalence of depression and anxiety in the inpatients with lung cancer were 58.1% and 34.2%, respectively. Multivariate logistic regression analysis prompted that the common risk factor of depression and anxiety was the symptom of insomnia. Constipation and gender were the two anther risk factors of depression. Conclusion Depression and anxiety were common for the inpatients with lung cancer in TCM hospital. Gender, insomnia and constipation were risk factors for depression, and insomnia was risk factor for anxiety. Therefore, medical workers should pay close attention to the emotional changes of these high-risk patients and intervene the symptoms as early as possible.

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A Novel Prediction Model for Long-Term SARS-CoV-2 RNA Shedding in Non-death Hospitalized Patients with COVID-19: A Retrospective Cohort Study

10.21203/rs.3.rs-940304/v1 ◽

2021 ◽

Author(s):

Xiaoli Lei ◽

Junli Wang ◽

Lijie Kou ◽

Zhigang Yang

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Prediction Model ◽

Predictive Model ◽

Goodness Of Fit ◽

Multivariate Logistic Regression Analysis ◽

Hospitalized Patients ◽

Multivariate Logistic Regression ◽

Data Set

Abstract Background: Because of the lack of compelling evidence for predicting the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding, the purpose of this retrospective study was to establish a predictive model for long-term SARS-CoV-2 RNA shedding in non-death hospitalized patients with coronavirus disease-19 (COVID-19).Methods: 97 non-death hospitalized patients with COVID-19 admitted to two hospitals in Henan province of China from February 3, 2020 to March 31, 2020 were retrospectively enrolled. Multivariate logistic regression was performed to identify the high risk factors associated with long-term SARS-CoV-2 RNA shedding and a predictive model was established and represented by a nomogram. Its performance was assessed with discrimination and calibration.Results: 97 patients were divided into the long-term (>21 days) group (n = 27, 27.8%) and the short-term (≤ 21 days) group (n = 70, 72.2%) based on their viral shedding duration. Multivariate logistic regression analysis showed that time from illness onset to diagnosis (OR 1.224, 95% CI 1.070-1.400, P = 0.003) and interstitial opacity in chest computerized tomography(CT) scan (OR 6.516, 95% CI 2.041-20.798, P = 0.002) were independent risk factors for long-term SARS-CoV-2 RNA shedding. A prediction model, which is presented with a nomogram, was established by incorporating the two risk factors. The goodness-of-fit statistics for the nomogram was not statistically significant (χ2 = 8.292; P = 0.406), and its area under the receiver operator characteristic curve was 0.834 (95% CI 0.731- 0.936; P < 0.001).Conclusion: The established model has a good predictive performance on the long-term viral RNA shedding in non-death hospitalized patients with COVID-19, but it still needs further validation by independent data set of large samples in the future.

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Prevalence of and Risk Factors for Anxiety and Depression in Chinese Patients With Unruptured Intracranial Aneurysms Treated by Endovascular Intervention

10.21203/rs.2.23096/v2 ◽

2020 ◽

Author(s):

Xiao-Dong Zhai ◽

Jia-Xing Yu ◽

Yong-Jie Ma ◽

Si-Shi Xiang ◽

Gui-Lin Li ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Household Income ◽

Multivariate Logistic Regression Analysis ◽

Endovascular Intervention ◽

Chinese Patients ◽

Anxiety And Depression ◽

Multivariate Logistic Regression ◽

Annual Household Income

Abstract Background: Studies on anxiety and depression in unruptured intracranial aneurysm (UIA) patients after treatment via endovascular intervention are rare and controversial. We aimed to explore the prevalence of anxiety and depression among Chinese patients with UIAs treated by endovascular intervention and to identify which factors contribute to the development of these symptoms.Methods: We performed a cross-sectional study on anxiety and depression in patients who underwent endovascular treatment for UIAs using the Hospital Anxiety and Depression Scale (HADS). The demographic, clinical and radiological data for all patients were retrospectively collected from the aneurysm database and medical records. Moreover, we utilized data from a large sample of 200 UIA patients and multivariate logistic regression analysis to investigate the risk factors for anxiety and depression in these patients. Candidate variables with P values less than 0.20 in univariate analysis were included in the multivariate logistic regression analysis.Results: Two hundred patients returned completed questionnaires in this study. Of these 200 patients, 34 (17.0%) suffered from anxiety and 31 (15.5%) suffered from depression 30.67±8.6 months after being discharged. The multivariate analysis results indicated that treatment costs exceeding the annual household income was significantly associated with anxiety (AOR = 2.42, 95% CI: 1.08~5.41, P= 0.03). Shorter sleep times were significantly associated with anxiety (AOR= 1.51, 95% CI: 1.06~2.14, P= 0.02) and depression (AOR = 1.62, 95% CI: 1.14~2.29, P= 0.007).Conclusion: The prevalences of anxiety and depression in UIA patients treated by endovascular intervention were 17.0% and 15.5%, respectively. Treatment costs exceeding the annual household income was significantly associated with anxiety. Shorter sleep times were significantly associated with anxiety and depression. Our findings provide valuable evidence for the clinical and psychological management of these patients.

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Risk Factors for Periprocedural Ischemic Stroke following Endovascular Treatment of Intracranial Aneurysms

10.21203/rs.3.rs-146234/v1 ◽

2021 ◽

Author(s):

Yisen Zhang ◽

Chao Wang ◽

Zhongbin Tian ◽

Wei Zhu ◽

Wenqiang Li ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Ischemic Stroke ◽

Intracranial Aneurysms ◽

Endovascular Procedures ◽

Univariate Analysis ◽

Multivariate Logistic Regression Analysis ◽

Flow Diverter ◽

Multivariate Logistic Regression

Abstract BackgroundThe aim of this study was to comprehensively evaluate the risk factors of periprocedural ischemic stroke associated with endovascular treatment of intracranial aneurysms using a real-world prospective database.MethodsFrom August 2016 to March 2017, 200 patients with 217 aneurysms who underwent 206 endovascular procedures were enrolled. Univariate analysis and multivariate logistic regression analysis were used to examine the risk factors for periprocedural ischemic stroke.ResultsAmong the 206 endovascular procedures, periprocedural ischemic stroke occurred in 23 procedures (11.17%). After univariate analysis, the ischemic group had a higher proportion of large (≥ 10 mm) aneurysms than the control group (39.1% vs. 20.2%, p = 0.040). The incidence of periprocedural ischemic stroke was higher in cases treated by flow diverter (18.60%) or stent-assisted coiling (12.28%) than in cases treated by coiling only (2.04%), and the differences were statistically significant (p = 0.036). After multivariate logistic regression analysis, treatment modality was the independent risk factor for periprocedural ischemic stroke. Compared with the coiling-only procedure, flow diverter therapy was associated with a significantly higher rate of periprocedural ischemic stroke (OR 13.839; 95% CI 1.617–118.416; p = 0.016). Stent-assisted coiling also tended to present more often with periprocedural ischemic stroke than coiling alone (OR 7.559; 95% CI 0.958–59.618; p = 0.055).ConclusionsAneurysm size and treatment modality were associated with periprocedural ischemic stroke. Larger aneurysms were associated with increased risk of periprocedural ischemic stroke. Flow diverter therapy was associated with significantly more periprocedural ischemic stroke than the coiling procedure alone.

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Prevalence and Risk Factors of Hypertension, Diabetes, and Dyslipidemia among Adults in Northwest China

International Journal of Hypertension ◽

10.1155/2021/5528007 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Lin Qiu ◽

Weihua Wang ◽

Rina Sa ◽

Feng Liu

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Chronic Diseases ◽

Central Obesity ◽

Personal Information ◽

Univariate Analysis ◽

Multivariate Logistic Regression Analysis ◽

Northwest China ◽

Overweight And Obesity ◽

Multivariate Logistic Regression

Objective. To understand the prevalence and its risk factors of hypertension, diabetes mellitus, and dyslipidemia among adults aged over 18 years in Northwest China and provide data for the prevention and control of chronic diseases in Northwest China. Methods. Three waves of survey on chronic diseases and nutrition monitoring with multistage stratified cluster random sampling were conducted in 10 counties of Northwest China in 2013, 2015, and 2018, respectively. Personal information, socioeconomic status (SES), and behavioral risk factors (cigarettes smoking, alcohol consumption, diets, and physical activity) were collected by face-to-face interview. Height, weight, and blood pressure were measured, and blood glucose and serum lipid were tested. Prevalence of hypertension, diabetes, and dyslipidemia of the three waves was estimated, and multivariate logistic regression was used to analyze their risk factors. Results. The prevalence of hypertension, diabetes, and dyslipidemia was 41.59%, 11.16%, and 32.48%, respectively. Their standardized prevalence was 29.31%, 7.94%, and 31.54%. Univariate analysis showed that the prevalence of hypertension, diabetes, and dyslipidemia was significantly different among educational levels, marital status, occupation, smoking, drinking, central obesity, and BMI classification ( P < 0.05 ). Multivariate logistic regression analysis showed that factors like male gender, central obesity, overweight, and obesity were associated with hypertension, diabetes, and dyslipidemia ( P < 0.05 ). High BMI index is one of the risk factors of the three diseases. The odds ratio (OR) of general overweight associated with hypertension, diabetes, and dyslipidemia was 1.663, 1.206, and 1.579 compared to normal body weight, respectively. And that was 3.094, 1.565, and 2.285 for obesity. Age was one of the risk factors for hypertension and diabetes ( P < 0.05 ). Age groups of 45–59 years and 60 years and above were more associated with hypertension than of 18–44 age group (OR45-59 group = 2.777, OR60 years and above = 6.948), similar to their association with diabetes (OR45-59 group = 2.357, OR60 years and above = 3.521). Daily smoking is associated with diabetes and dyslipidemia (OR for diabetes = 1.217, OR for dyslipidemia = 1.287) and alcohol drinking associated with hypertension and dyslipidemia (OR for hypertension = 1.014, OR fordyslipidemia = 1.034). Hypertension, diabetes, and dyslipidemia were also associated with each other ( P < 0.05 ). The number of participants with hypertension, diabetes, and dyslipidemia accounted for 2.33% of all the participants, 15.60% for participants with hypertension and dyslipidemia, 4.58% for hypertension and diabetes, and 3.57% for diabetes and dyslipidemia, respectively. Conclusion. Factors like male, smoking, drinking, central obesity, overweight, and obesity were associated with hypertension, diabetes, and dyslipidemia in northwest China. Interventions on these risk factors and coexistence of the three diseases may help improve public health in this area.

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Risk factors for tissue expander infection in scar reconstruction: a retrospective cohort study of 2374 consecutive cases

Burns & Trauma ◽

10.1093/burnst/tkaa037 ◽

2020 ◽

Vol 8 ◽

Author(s):

Chen Dong ◽

Minhui Zhu ◽

Luguang Huang ◽

Wei Liu ◽

Hengxin Liu ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Treatment Failure ◽

Logistic Regression Analysis ◽

Disease Duration ◽

Multivariate Logistic Regression Analysis ◽

Tissue Expansion ◽

Multivariate Logistic Regression ◽

Hematoma Evacuation

Abstract Background Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes; however, the complications that emerge from tissue expansion hinder repair. Infection is considered a major complication of tissue expansion. This study aimed to analyze the perioperative risk factors for expander infection. Methods A large, retrospective, single-institution observational study was carried out over a 10-year period. The study enrolled consecutive patients who had undergone tissue expansion for scar reconstruction. Demographics, etiological data, expander-related characteristics and postoperative infection were assessed. Univariate and multivariate logistic regression analysis were performed to identify risk factors for expander infection. In addition, we conducted a sensitivity analysis for treatment failure caused by infection as an outcome. Results A total of 2374 expanders and 148 cases of expander infection were assessed. Treatment failure caused by infection occurred in 14 expanders. Multivariate logistic regression analysis identified that disease duration of ≤1 year (odds ratio (OR), 2.07; p < 0.001), larger volume of expander (200–400 ml vs <200 ml; OR, 1.74; p = 0.032; >400 ml vs <200 ml; OR, 1.76; p = 0.049), limb location (OR, 2.22; p = 0.023) and hematoma evacuation (OR, 2.17; p = 0.049) were associated with a high likelihood of expander infection. Disease duration of ≤1 year (OR, 3.88; p = 0.015) and hematoma evacuation (OR, 10.35; p = 0.001) were so related to high risk of treatment failure. Conclusions The rate of expander infection in patients undergoing scar reconstruction was 6.2%. Disease duration of <1 year, expander volume of >200 ml, limb location and postoperative hematoma evacuation were independent risk factors for expander infection.

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