scholarly journals Relevant risk factors and the prognostic impact of positive resection margins after endoscopic resection of gastrointestinal neuroendocrine tumors

2020 ◽  
Vol 15 (2) ◽  
pp. 276-282
Author(s):  
Jing Wen ◽  
Bin Yan ◽  
Jing Yang ◽  
Zhongsheng Lu ◽  
Xuqiang Bian ◽  
...  
2020 ◽  
Vol 220 (4) ◽  
pp. 932-937
Author(s):  
Nicholas J. Skertich ◽  
John F. Tierney ◽  
Sitaram V. Chivukula ◽  
Nasim T. Babazadeh ◽  
Martin Hertl ◽  
...  

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 688-688
Author(s):  
Jin-Oh Kim

688 Background: The management of patients with a positive resection margin after endoscopic resection of early colorectal cancer (ECC) depends on various clinical factors, including the pathology. There is little information on the clinical outcomes according to the subsequent management of a positive resection margin in patients with ECC treated by endoscopic resection. We assessed the management according to the pathology of the positive margin and evaluated the clinical outcomes. Methods: Consecutive patients with ECC who underwent endoscopic resection from January 2004 to December 2014 were reviewed. This study retrospectively analyzed 363 lesions from 338 patients (mean age, 60.1 years; 68% [230/338] male). Results: The resection margin was positive in 29.2% of patients, including cancer cells in 9.9%, adenoma in 16.5%, and high-grade dysplasia (HGD) in 2.8%. Subsequent surgery was performed on 11.8% of patients, 72.2% (26/43) of whom were cancer cell–positive, while 23.3% (10/43) were resection margin–negative but had deep submucosal (SM) or lymphatic invasion. Remnant cancer cells were identified in 25.6% (11/43) of the operated group and 81.8% (9/11) of the cancer cell–positive group. On early follow-up surveillance colonoscopy (mean interval, 3.57 months) in 88.2% of patients (320/363), including 95.7% (67/70) of the adenoma and HGD-positive group, only one (0.3%, 1/320) case of remnant adenoma was found. In the multivariate analysis, deep SM invasion ( p=0.026), number of pieces of piecemeal resection (p=0.03) and cancer cell positivity ( p=0.001) predicted subsequent surgery. In the multivariate analysis, an endoscopic appearance of incomplete resection ( p=0.002) and cancer cell positivity (p=0.041) were related to the identification of remnant cancer cells after subsequent surgery. Conclusions: Patients with an adenoma-positive resection margin had favorable clinical outcomes during subsequent surveillance. The choice of subsequent surgery was related to deep SM invasion and cancer cell–positive resection margins, and subsequent surgery group showed a high rate of remnant cancer cells.


2016 ◽  
Vol 83 (5) ◽  
pp. AB234-AB235
Author(s):  
Hyun Gun Kim ◽  
Seong-Ran Jeon ◽  
Jun-Hyung Cho ◽  
Bong Min Ko ◽  
Jin Oh Kim ◽  
...  

2018 ◽  
Vol 35 (1) ◽  
pp. 73-80
Author(s):  
Vladimir Joksimović ◽  
Nikola Jankulovski ◽  
Svetozar Antović ◽  
Marija Joksimović ◽  
Ljubinka Mančeva

Summary Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract that can give rise to strictures, inflammatory masses, fistulas, abscesses, hemorrhage, and cancer. This disease commonly affects the small bowel, colon, rectum or anus. Less commonly, it affects the stomach, esophagus and mouth. Often, the disease affects multiple areas of the gastrointestinal tract. The cause of CD is not known and there is no curative treatment. The current medical and surgical treatment is effective in controlling the disease, but even with optimal treatment, recurrences and relapses are frequent. Various risk factors specific for the patients with conditions related to the CD can influence the outcome of the surgical treatment in the postoperative period. Those risk factors can be preoperative laboratory inflammatory markers such as WBC and CRP values, phlegmona of the anterior abdominal wall and preoperative interintestinal abscess, positive resection margins. Here we present a case of a patient who was surgically treated as an emergent case because of the complication due to Crohn's disease. At presentation, the patient had leukocytosis, elevated CRP, anemia, low levels of total proteins, and albumin.


2019 ◽  
Vol 26 (7) ◽  
pp. 2222-2233 ◽  
Author(s):  
Leonie R. van der Werf ◽  
Charlotte Cords ◽  
Ivo Arntz ◽  
Eric J. T. Belt ◽  
Ivan M. Cherepanin ◽  
...  

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ingmar L. Defize ◽  
Lucas Goense ◽  
Alicia S. Borggreve ◽  
Stella Mook ◽  
Gert J. Meijer ◽  
...  

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