Risk factors and oncological impact of positive resection margins in gastrectomy for cancer: are they salvaged by an additional resection?

2021 ◽  
Author(s):  
Yusuke Muneoka ◽  
Manabu Ohashi ◽  
Naoki Ishizuka ◽  
Masaru Hayami ◽  
Rie Makuuchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Resection Margins ◽  
Positive Resection Margins ◽  
Additional Resection

Risk factors associated with positive resection margins in patients with adrenocortical carcinoma

2020 ◽  
Vol 220 (4) ◽  
pp. 932-937
Author(s):  
Nicholas J. Skertich ◽  
John F. Tierney ◽  
Sitaram V. Chivukula ◽  
Nasim T. Babazadeh ◽  
Martin Hertl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adrenocortical Carcinoma ◽  
Resection Margins ◽  
Factors Associated ◽  
Positive Resection Margins

scholarly journals The Occurrence of Postoperative Complications in Patients Undergoing Surgery due to Complications from Crohn's Disease: A Case Report

2018 ◽  
Vol 35 (1) ◽  
pp. 73-80
Author(s):  
Vladimir Joksimović ◽  
Nikola Jankulovski ◽  
Svetozar Antović ◽  
Marija Joksimović ◽  
Ljubinka Mančeva
Keyword(s):  
Risk Factors ◽  
Crohn’S Disease ◽  
Surgical Treatment ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Resection Margins ◽  
Chronic Inflammatory Condition ◽  
Positive Resection Margins ◽  
Low Levels ◽  
Emergent Case

Summary Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract that can give rise to strictures, inflammatory masses, fistulas, abscesses, hemorrhage, and cancer. This disease commonly affects the small bowel, colon, rectum or anus. Less commonly, it affects the stomach, esophagus and mouth. Often, the disease affects multiple areas of the gastrointestinal tract. The cause of CD is not known and there is no curative treatment. The current medical and surgical treatment is effective in controlling the disease, but even with optimal treatment, recurrences and relapses are frequent. Various risk factors specific for the patients with conditions related to the CD can influence the outcome of the surgical treatment in the postoperative period. Those risk factors can be preoperative laboratory inflammatory markers such as WBC and CRP values, phlegmona of the anterior abdominal wall and preoperative interintestinal abscess, positive resection margins. Here we present a case of a patient who was surgically treated as an emergent case because of the complication due to Crohn's disease. At presentation, the patient had leukocytosis, elevated CRP, anemia, low levels of total proteins, and albumin.

scholarly journals Population-Based Study on Risk Factors for Tumor-Positive Resection Margins in Patients with Gastric Cancer

2019 ◽  
Vol 26 (7) ◽  
pp. 2222-2233 ◽  
Author(s):  
Leonie R. van der Werf ◽  
Charlotte Cords ◽  
Ivo Arntz ◽  
Eric J. T. Belt ◽  
Ivan M. Cherepanin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Population Based ◽  
Resection Margins ◽  
Population Based Study ◽  
Positive Resection Margins

Risk Factors for Tumor Positive Resection Margins After Neoadjuvant Chemoradiotherapy for Esophageal Cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ingmar L. Defize ◽  
Lucas Goense ◽  
Alicia S. Borggreve ◽  
Stella Mook ◽  
Gert J. Meijer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Neoadjuvant Chemoradiotherapy ◽  
Resection Margins ◽  
Positive Resection Margins

Risk Factors Associated with Positive Resection Margins in Patients with Adrenocortical Carcinoma

2019 ◽  
Vol 229 (4) ◽  
pp. S82-S83
Author(s):  
John F. Tierney ◽  
Sitaram Chivukula ◽  
Nasim T. Babazadeh ◽  
Jennifer Poirier ◽  
Xavier M. Keutgen
Keyword(s):  
Risk Factors ◽  
Adrenocortical Carcinoma ◽  
Resection Margins ◽  
Factors Associated ◽  
Positive Resection Margins

scholarly journals Radiation-Associated Angiosarcoma of the Breast and Chest Wall Treated with Thermography-Controlled, Contactless wIRA-Hyperthermia and Hypofractionated Re-Irradiation

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3911
Author(s):  
Markus Notter ◽  
Emanuel Stutz ◽  
Andreas R. Thomsen ◽  
Peter Vaupel
Keyword(s):  
Local Recurrence ◽  
Background Radiation ◽  
Definitive Treatment ◽  
Resection Margins ◽  
Recurrence Rates ◽  
Rate Dependent ◽  
Angiosarcoma Of The Breast ◽  
Positive Resection Margins ◽  
Locally Recurrent ◽  
Tumor Extent

Background: Radiation-associated angiosarcoma of the breast (RAASB) is a rare, challenging disease, with surgery being the accepted basic therapeutic approach. In contrast, the role of adjuvant and systemic therapies is a subject of some controversy. Local recurrence rates reported in the literature are mostly heterogeneous and are highly dependent on the extent of surgery. In cases of locally recurrent or unresectable RAASB, prognosis is very poor. Methods: We retrospectively report on 10 consecutive RAASB patients, most of them presenting with locally recurrent or unresectable RAASB, which were treated with thermography-controlled water-filtered infrared-A (wIRA) superficial hyperthermia (HT) immediately followed by re-irradiation (re-RT). Patients with RAASB were graded based on their tumor extent before onset of radiotherapy (RT). Results: We recorded a local control (LC) rate dependent on tumor extent ranging from a high LC rate of 100% (two of two patients) in the adjuvant setting with an R0 or R2 resection to a limited LC rate of 33% (one of three patients) in patients with inoperable, macroscopic tumor lesions. Conclusion: Combined HT and re-RT should be considered as an option (a) for adjuvant treatment of RAASB, especially in cases with positive resection margins and after surgery of local recurrence (LR), and (b) for definitive treatment of unresectable RAASB.

Predicting Surgical Margins in Patients With Borderline Resectable and Locally Advanced Pancreatic Cancer Undergoing Resection

2021 ◽  
pp. 000313482110111
Author(s):  
Weizheng Ren ◽  
Dimitrios Xourafas ◽  
Stanley W. Ashley ◽  
Thomas E. Clancy
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Univariate Analysis ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Ductal Adenocarcinoma ◽  
Resection Margins ◽  
Borderline Resectable ◽  
Stepwise Selection ◽  
R1 Resection ◽  
Positive Resection Margins

Background Many patients with borderline resectable/locally advanced pancreatic ductal adenocarcinoma (borderline resectable [BR]/locally advanced [LA] pancreatic ductal adenocarcinoma [PDAC]) undergoing resection will have positive resection margins (R1), which is associated with poor prognosis. It might be useful to preoperatively predict the margin (R) status. Methods Data from patients with BR/LA PDAC who underwent a pancreatectomy between 2008 and 2018 at Brigham and Women’s Hospital were retrospectively reviewed. Logistic regression analysis was used to evaluate the association between R status and relevant preoperative factors. Significant predictors of R1 resection on univariate analysis ( P < .1) were entered into a stepwise selection using the Akaike information criterion to define the final model. Results A total of 142 patients with BR/LA PDAC were included in the analysis, 60(42.3%) had R1 resections. In stepwise selection, the following factors were identified as positive predictors of an R1 resection: evidence of lymphadenopathy at diagnosis (OR = 2.06, 95% CI: 0.99-4.36, P = .056), the need for pancreaticoduodenectomy (OR = 3.81, 96% CI: 1.15-15.70, P = .040), extent of portal vein/superior mesenteric vein involvement at restaging (<180°, OR = 3.57, 95% CI: 1.00-17.00, P = .069, ≥180°, OR = 7,32, 95% CI: 1.75-39.87, P = .010), stable CA 19-9 serum levels (less than 50% decrease from diagnosis to restaging, OR = 2.27, 95% CI: 0.84-6.36 P = .107), and no preoperative FOLFIRINOX (OR = 2.17, 95% CI: 0.86-5.64, P = .103). The prognostic nomogram based on this model yielded a probability of achieving an R1 resection ranging from <5% (0 factors) to >70% (all 5 factors). Conclusions Relevant preoperative clinicopathological characteristics accurately predict positive resection margins in patients with BR/LA PDAC before resection. With further development, this model might be used to preoperatively guide surgical decision-making in patients with BR/LA PDAC.

Sign in / Sign up

Export Citation Format

Share Document