scholarly journals Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

2017 ◽  
Vol 30 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Patrícia MOLZ ◽  
Alana Nunes RAEL ◽  
Maiara de Queiroz FISCHER ◽  
Luana Beatriz LIMBERGER ◽  
Daniel PRÁ ◽  
...  
Keyword(s):  
Vitamin C ◽  
Glucose Tolerance ◽  
Body Mass ◽  
Wistar Rats ◽  
Area Under The Curve ◽  
Tolerance Test ◽  
Invert Sugar ◽  
Future Studies ◽  
Fasting Glycemia ◽  
Male Wistar Rats

ABSTRACT Objective: To evaluate whether vitamin C can help to prevent obesity and hyperglycemia in Wistar rats treated with excess invert sugar to induce prediabetes. Methods: One hundred-day-old Male Wistar rats with a mean weight of 336.58±23.43g were randomly assigned to the following groups: (1) control, receiving water (C); (2) invert sugar control, receiving a 32% watery solution of invert sugar; (3) vitamin C control, receiving a watery solution of vitamin C (60mg/L), and (4) vitamin C plus invert sugar, receiving a watery solution of vitamin C and invert sugar. All animals had access to chow and water ad libitum and were treated for 17 weeks. Prediabetes was assessed according to two criteria: obesity (based on body mass indexand peritoneal fat content) and impaired glucose tolerance (assessed by the intraperitoneal glucose tolerance test and expressed as area under the curve) . Results: Group invert sugar control gained significantly more weight (p=0.035) and visceral fat (p<0.001) than groups vitamin C control and vitamin C plus invert sugar. Consequently, groups vitamin C control and vitamin C plus invert sugar had gained as little body mass index as group C by the end of the experiment. Vitamin C decreased the fasting glycemia of both groups supplemented with vitamin C and normalized the glucose tolerance of group vitamin C plus invert sugar, whose area under the curve matched that of group C. Conclusion: Vitamin C has anti-obesogenic and glycemia-lowering effects in Wistar rats, which might be promising to prediabetics. Future studies are needed to understand the anti-obesogenic and anti-hyperglycemic mechanisms of vitamin C in prediabetes.

scholarly journals Glucose area under the curve during oral glucose tolerance test as an index of glucose intolerance

2015 ◽  
Vol 7 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Kazuhiko Sakaguchi ◽  
Kazuo Takeda ◽  
Mitsuo Maeda ◽  
Wataru Ogawa ◽  
Toshiyuki Sato ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Glucose Intolerance ◽  
Glucose Tolerance Test ◽  
Area Under The Curve ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

Effect of vitamin A and vitamin C on attenuation of ivermectin-induced toxicity in male Wistar rats

2018 ◽  
Vol 25 (29) ◽  
pp. 29408-29417 ◽  
Author(s):  
Fatemeh Sadat Hosseini Omshi ◽  
Roghayeh Abbasalipourkabir ◽  
Maliheh Abbasalipourkabir ◽  
Sedigheh Nabyan ◽  
Alireza Bashiri ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin C ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Effectiveness of Vitamin C and Vitamin E Antioxidant Combination on Caspase-3 Expression in Wistar White Rat Pulmonum Contusion

2020 ◽  
Vol 3 (1) ◽  
pp. 31-44
Author(s):  
Bermansyah ◽  
Gama Satria ◽  
Ahmad Umar
Keyword(s):  
Cell Death ◽  
Vitamin E ◽  
Vitamin C ◽  
Wistar Rats ◽  
Caspase 3 ◽  
Cell Function ◽  
Pulmonary Contusion ◽  
Tnf Α ◽  
Male Wistar Rats

Introduction.Pulmonary contusions can cause a progressive inflammatory response. Activation of TNF-α cytokines and reactive oxygen species (ROS) can cause pulmonary cell death. Antioxidants can have the potential to neutralize ROS. The purpose of this study is to determine the effectiveness of antioxidant administration in maintaining pulmonary cell function in wistar rats that have been induced to experience pulmonary contusions through caspase-3 levels. Methods.This study was an in vivo experimental study conducted on thirty male wistar rats and divided into five groups (n = 6): control, pulmonary contusion + asthaxanthine 5 mg/kgBW, pulmonary contusion + vitamin C and E 50 mg/kgBW, pulmonary contusion + vitamin C and E 100 mg/kgBW, pulmonary contusion + vitamin C and E 200 mg/kgBW. The value of Caspase-3 is evaluated by the IHC. All data analyzes used SPSS 18. Results. Low doses of antioxidants have the potential to reduce pulmonary cell death in wistar rats induced by pulmonary contusions.Conclussion. Vitamin C and E effective to reduce polmonary cell death in pulmonary contusion.Keywords: antioxidants, vitamin C, vitamin E, pulmonary contusions animal model, apoptosis, caspase-3

scholarly journals Influence of Cinnamon on Glycemic Control in Individuals With Prediabetes: A Randomized Controlled Trial

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Giulio R Romeo ◽  
Junhee Lee ◽  
Christopher M Mulla ◽  
Youngmin Noh ◽  
Casey Holden ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Controlled Trial ◽  
Area Under The Curve ◽  
Cost Effective ◽  
Tolerance Test ◽  
Controlled Clinical Trial ◽  
Oral Glucose ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Favorable Safety

Abstract Context The identification of adjunct safe, durable, and cost-effective approaches to reduce the progression from prediabetes to type 2 diabetes (T2D) is a clinically relevant, unmet goal. It is unknown whether cinnamon’s glucose-lowering properties can be leveraged in individuals with prediabetes. Objective The objective of this work is to investigate the effects of cinnamon on measures of glucose homeostasis in prediabetes. Design, Setting, Participants, and Intervention This double-blind, placebo-controlled, clinical trial randomly assigned adult individuals meeting any criteria for prediabetes to receive cinnamon 500 mg or placebo thrice daily (n = 27/group). Participants were enrolled and followed at 2 academic centers for 12 weeks. Main Outcome Measures Primary outcome was the between-group difference in fasting plasma glucose (FPG) at 12 weeks from baseline. Secondary end points included the change in 2-hour PG of the oral glucose tolerance test (OGTT), and the change in the PG area under the curve (AUC) derived from the OGTT. Results From a similar baseline, FPG rose after 12 weeks with placebo but remained stable with cinnamon, leading to a mean between-group difference of 5 mg/dL (P &lt; .05). When compared to the respective baseline, cinnamon, but not placebo, resulted in a significant decrease of the AUC PG (P &lt; .001) and of the 2-hour PG of the OGTT (P &lt; .05). There were no serious adverse events in either study group. Conclusions In individuals with prediabetes, 12 weeks of cinnamon supplementation improved FPG and glucose tolerance, with a favorable safety profile. Longer and larger studies should address cinnamon’s effects on the rate of progression from prediabetes to T2D.

Substitution of starch for palm oil during gestation: impact on offspring survival and hepatic gene expression in the pig

2015 ◽  
Vol 27 (7) ◽  
pp. 1057 ◽  
Author(s):  
K. L. Almond ◽  
H. P. Fainberg ◽  
M. A. Lomax ◽  
P. Bikker ◽  
M. E. Symonds ◽  
...  
Keyword(s):  
Gene Expression ◽  
Glucose Tolerance ◽  
Palm Oil ◽  
Low Birthweight ◽  
Area Under The Curve ◽  
Later Life ◽  
Tolerance Test ◽  
Energy Status ◽  
Fatty Acid Binding ◽  
Piglet Mortality

Piglet neonatal mortality rates are high (~20%), so nutritional strategies to reduce this are highly desirable. Maternal fat substitution (FS) may promote the preweaning survival of piglets by improving their energy status. Therefore, the aim of the present study was to investigate the effects of FS throughout pregnancy on offspring viability, together with the gene expression of stress-related markers in the liver. Sixteen pregnant sows were randomly allocated to one of two isocaloric diets, control (C) or FS in the form of palm oil, fed from 0 to 110 days gestation. Glucose tolerance was examined on Day 108. Median and low birthweight offspring were allocated to tissue sampling at either 7 days or 6 months postnatal age. In response to a glucose tolerance test, FS sows exhibited a raised glucose area under the curve with no change in basal glucose. Average piglet mortality (up to Day 28) was increased fourfold in the FS group, with surviving median-sized piglets exhibiting significantly lower fatty acid binding protein 1 (FABP1) expression at 7 days. There were no effects on the abundance of any other stress- or metabolic-related genes examined. Thus, this study demonstrates that maternal FS throughout gestation causes maternal glucose intolerance that may be linked to the observed increase in piglet mortality. However, the surviving offspring do not exhibit any detectable differences in postnatal growth or hepatic gene profile in later life.

scholarly journals Severity of carbohydrate metabolism disturbances, arterial hypertension stage, and lipid profile in patients with metabolic syndrome

2012 ◽  
Vol 11 (2) ◽  
pp. 13-18 ◽  
Author(s):  
Yu. V. Zhernakova ◽  
I. E. Chazova ◽  
S. P. Olimpieva ◽  
V. V. Kilikovskyi
Keyword(s):  
Metabolic Syndrome ◽  
Glucose Tolerance ◽  
Arterial Hypertension ◽  
Lipid Profile ◽  
Carbohydrate Metabolism ◽  
Blood Pressure Monitoring ◽  
Tolerance Test ◽  
Fasting Glycemia ◽  
Blood Biochemical ◽  
Increased Risk

Aim. To investigate the associations between the severity of carbohydrate metabolism disturbances, arterial hypertension (AH) severity (based on AH stage and 24-hour blood pressure monitoring (BPM) parameters), and lipid profile. Material and methods. In 403 patients with AH and metabolic syndrome (MS), blood biochemical assay, glucose tolerance test, and 24-hour BMP were performed. Results. Patients with impaired glucose tolerance (IGT), compared to participants with impaired fasting glycemia (IFG) or particularly to individuals with normal carbohydrate metabolism, demonstrated more severe lipid profile disturbances, more advanced AH stage, and increased mean BP levels, BP load, and BP variability at 24-hour BPM. Conclusion. IGT, as a more severe variant of carbohydrate metabolism disturbances, could be associated with increased risk of cardiovascular disease and Type 2 diabetes mellitus.

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