scholarly journals AVALIAÇÃO DA TRANSMISSÃO DA FILARIOSE LINFÁTICA EM ÁREAS NÃO SUBMETIDAS AO TRATAMENTO EM MASSA NO MUNICÍPIO DO JABOATÃO DOS GUARARAPES/PE: PARTE 3

2021 ◽  
Author(s):  
Débora Nascimento Gomes da Silva
Keyword(s):  
Wuchereria Bancrofti

Introdução: A filariose linfática é uma doença parasitária endêmica, a qual no Brasil, o estado de Pernambuco, é o único endêmico com casos comprovados nos municípios do Recife, Olinda, Paulista e Jaboatão dos Guararapes. Sendo causada em grande parte das infecções pelos vermes Wuchereria bancrofti. Esses parasitas são transmitidos por mosquitos fêmeas dos gêneros Aedes, Anopheles, Culex , Mansonia e Ochlerotatus infectados após ingestão de sangue de pacientes microfilarêmicos. A Filariose Linfática continua a ser uma das principais causas de morbidade e incapacidade permanente em populações endêmicas. O município de Jaboatão dos Guararapes merece destaque, pois apresentou 14 áreas elencadas como prioritárias ao tratamento em massa. Entretanto, a intervenção ocorreu em quatro destas localidades. Nas outras 10 áreas que não receberam MDA foi implantado um plano de intervenção integrado. Um dos bairros o qual não foi passado o MDA, foi o bairro de Jardim Jordão, o qual apresentou uma das maiores taxas de microfilaremia e risco socioambiental. Objetivo: Sendo assim, o objetivo geral do trabalho foi investigar a infecção vetorial por Wuchereria bancrofti no bairro de Jardim Jordão, no município de Jaboatão dos Guararapes. Material e Métodos: Para a construção do indicador de risco socioambiental foram utilizadas as variáveis que refletissem as condições de vida da população. O estudo foi do tipo descritivo transversal, cuja medida de frequência foi definida para verificar a prevalência de infecção da filariose linfática. Os domicílios foram definidos usando o software de imagens de satélite e sistemas de informação geográfica (GIS). Resultados: A amostra foi composta por cerca de 5.000 fêmeas grávidas e/ou ingurgitadas de sangue, coletadas nos domicílios dentro dos limites geográficos do bairro. Foram capturados 10.742 mosquitos, sendo 10.112 (94,13%) do gênero Culex e 630 (5,86%) do gênero Aedes. Dentre os 10.112 mosquitos coletados de C. quinquefasciatus, 6.220 eram fêmeas e destas 5.068 apresentavam-se grávidas e/ou ingurgitadas no momento da separação, em seguida foram acondicionadas em pools de 10 fêmeas totalizando 506 pools para pesquisa de DNA de W. bancrofti. Conclusão: Assim, conclui-se a importância do acompanhamento de áreas elencadas como endêmicas no município de Jaboatão, em especial as que não passaram pelo MDA, para monitorar casos de filariose linfática.

FAKTOR-FAKTOR YANG MEMPENGARUHI KETIDAKPATUHAN MINUM OBAT SEBAGAI UPAYA PENCEGAHAN FILARIASIS DI KOTA PEKALONGAN

2019 ◽  
Vol 9 (1) ◽  
pp. 1-6
Author(s):  
Harfaina Harfaina ◽  
Suharyo Hadisaputro ◽  
Djoko Trihadi Lukmono ◽  
Mateus Sakundarno
Keyword(s):  
Self Efficacy ◽  
Random Sampling ◽  
Social Stigma ◽  
Brugia Malayi ◽  
Sampling Technique ◽  
Wuchereria Bancrofti ◽  
Drug Prevention ◽  
Permanent Disability ◽  
Social Environmental ◽  
Cluster Random Sampling

Filariasis adalah penyakit infeksi yang disebabkan oleh cacing Wuchereria Bancrofti, Brugia Malayi, dan Brugia Timori yang menyebabkan cairan limfe tidak dapat tersalurkan dengan baik sehingga menyebabkan pembengkakan pada tungkai dan lengan. Meskipun tidak ada penyebab kematian tetapi menyebabakan cacat permanen dan stigma sosial. Eliminasi Filariasis dilakukan dengan Program Pengobatan Massal ke seluruh penduduk di daerah endemis setahun sekali selama 5 tahun. Keberhasilan program ini memerlukan kepatuhan minum obat pencegahan filariasis. Tujuan penelitian ini untuk mengetahui faktor-faktor yang mempengaruhi ketidakpatuhan minum obat sebagai upaya pencegahan filariasis. Penelitian ini Populasi dalam penelitian ini adalah penduduk berusia 15-65 tahun di dua kelurahan endemis yaitu kelurahan kuripan kertoharjo dan kelurahan jenggot selama mei-juli 2018. Sampel dalam penelitian ini 80 kasus dan 80 kontrol dengan teknik cluster random sampling. Variabel yang terbukti berpengaruh yaitu persepsi kerentanan negatif (OR=4,093) 95%CI=1,356-12,350 dan self efficacy negatif (OR=30,298) 95%CI=8,986-102,156. Persepsi kerentanan negatif dan self efficacy negatif merupakan faktor perilaku yang mempengaruhi ketidakpatuhan minum obat pencegahan filariasis. Diharapkan ada penelitian lanjutan tentang ketidakpatuhan minum obat pencegahan filariasis bukan berwujud persepsi tetapi dengan pengukuran faktor lingkungan sosial secara objektif dengan melakukan intervensi berupa perubahan perilaku.   Kata kunci : Filariasis, Ketidakpatuhan, Minum Obat, Mix Method   FACTORS THAT INFLUENCE DRINKING DRUG PREVENTION NON COMPLIANCE OF FILARIASIS IN PEKALONGAN CITY   ABSTRACT Filariasis is an infectious disease caused by worms Wuchereria Bancrofti, Brugia Malayi, and Brugia Timori, adult worm lives and damage reulting in blockage of lymph channels, causing swelling of the legs and arms. Although no cause of death but causes permanent disability and social stigma. Filariasis elimination done with the Mass Treatment Program to the entire population in endemic areas a year for 5 year. Succesfully this program required a medication adherence. The purpose of this study was to determine the factors that influence drug disobedience as an effort to prevent filariasis. This study uses a mix method. The population in this study were residents aged 15-65 years in two endemic villages, namely kuripan kertoharjo and jenggot villages during May-July 2018. Samples in this study were 80 cases and 80 controls with cluster random sampling technique. Variables that proved influential were perceptions of negative vulnerability (OR = 4,093) 95% CI = 1,356-12,350 and negative self efficacy (OR = 30,298) 95% CI = 8,986-102,156. Negative vulnerability perceptions and negative self efficacy are behavioral factors that influence non-compliance with filariasis prevention drugs. It is expected that further research on non-compliance with taking drugs to prevent filariasis is not a form of perception but objective measurement of social environmental factors by intervening in the form of behavior change.   Keywords: Filariasis, Noncompliance, Medication, Mix Method

scholarly journals Progress towards elimination of lymphatic filariasis in the Americas region

2020 ◽  
Vol 13 (Supplement_1) ◽  
pp. S33-S38
Author(s):  
Gilberto Fontes ◽  
Eliana Maria Mauricio da Rocha ◽  
Ronaldo Guilherme Carvalho Scholte ◽  
Rubén Santiago Nicholls
Keyword(s):  
Dominican Republic ◽  
Lymphatic Filariasis ◽  
Wuchereria Bancrofti ◽  
World Health ◽  
Vector Species ◽  
Effective Coverage ◽  
The Third ◽  
Assessment Survey ◽  
Health Organization ◽  
Important Progress

Abstract In South and Central America, lymphatic filariasis (LF) is caused by Wuchereria bancrofti, which is transmitted by Culex quinquefasciatus, the only vector species in this region. Of the seven countries considered endemic for LF in the Americas in the last decade, Costa Rica, Suriname and Trinidad and Tobago were removed from the World Health Organization list in 2011. The remaining countries, Brazil, Dominican Republic, Guyana and Haiti, have achieved important progress in recent years. Brazil was the first country in the Americas to stop mass drug administration (MDA) and to establish post-MDA surveillance. Dominican Republic stopped MDA in all LF-endemic foci: La Ciénaga and Southwest passed the third Transmission Assessment Survey (TAS) and the Eastern focus passed TAS-1 in 2018. Haiti passed the TAS and interrupted transmission in >80% of endemic communes, achieving effective drug coverage. Guyana implemented effective coverage in MDAs in 2017 and 2018 and in 2019 scaled up the treatment for 100% of the geographical region, introducing ivermectin in the MDA in order to achieve LF elimination by the year 2026. The Americas region is on its way to eliminating LF transmission. However, efforts should be made to improve morbidity management to prevent disability of the already affected populations.

Anopheles (Cellia) balabacensis baisas is a vector of Wuchereria bancrofti in Sabah, Malaysia

1984 ◽  
Vol 78 (2) ◽  
pp. 281-282 ◽  
Author(s):  
J.L.K. Hii ◽  
Spencer Kan ◽  
Chin Kui Foh ◽  
Mechiel K.C. Chan
Keyword(s):  
Wuchereria Bancrofti

scholarly journals Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis

2000 ◽  
Vol 68 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Ramya Gopinath ◽  
L. E. Hanna ◽  
V. Kumaraswami ◽  
V. Perumal ◽  
V. Kavitha ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Wuchereria Bancrofti ◽  
Activation Markers ◽  
Interleukin 5 ◽  
Hla Dr ◽  
Before And After ◽  
Early Peak ◽  
Eosinophil Activation ◽  
Later Phase ◽  
Second Peak

ABSTRACT Treatment of patients with patent Wuchereria bancroftiinfection results in an acute clinical reaction and peripheral eosinophilia. To investigate the dynamics of the eosinophil response, changes in eosinophil activation and degranulation and plasma levels of eosinophil-active chemokines and cytokines were studied in 15 microfilaremic individuals in south India by sequential blood sampling before and after administration of 300 mg of diethylcarbamazine (DEC). Clinical symptoms occurred within 24 h. Plasma interleukin-5 (IL-5) and RANTES levels peaked 1 to 2 days posttreatment, preceding a peak peripheral eosinophil count at day 4. Major basic protein secretion from eosinophils paralleled IL-5 secretion, while levels of eosinophil-derived neurotoxin peaked at day 13 after treatment. Expression of the activation markers HLA-DR and CD25 on eosinophils rose markedly immediately after treatment, while expression of VLA-4 and α4β7 showed an early peak within 24 h and a second peak at day 13. Thus, the posttreatment reactions seen in filarial infections can be divided into an early phase with killing of microfilariae, clinical symptomatology, increases in plasma IL-5 and RANTES levels, and eosinophil activation and degranulation and a later phase with expression of surface integrins on eosinophils, recruitment of eosinophils from the bone marrow to tissues, and clearance of parasite antigen.

Semiannual Treatment of Albendazole Alone is Efficacious for Treatment of Lymphatic Filariasis: A Randomized Open-label Trial in Cote d'Ivoire

2021 ◽  
Author(s):  
Allassane F Ouattara ◽  
Catherine M Bjerum ◽  
Méité Aboulaye ◽  
Olivier Kouadio ◽  
Vanga K Marius ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Primary Outcome ◽  
Central Africa ◽  
Wuchereria Bancrofti ◽  
Bancroftian Filariasis ◽  
Loa Loa ◽  
Open Label ◽  
Treatment Groups ◽  
Open Label Trial ◽  
To Receive

Abstract Background Ivermectin (IVM) plus albendazole (ALB), or IA, is widely used in mass drug administration (MDA) programs that aim to eliminate lymphatic filariasis (LF) in Africa. However, IVM can cause severe adverse events in persons with heavy Loa loa infections that are common in Central Africa. ALB is safe in loiasis, but more information is needed on its efficacy for LF. This study compared the efficacy and safety of three years of semiannual treatment with ALB to annual IA in persons with bancroftian filariasis. Methods Adults with Wuchereria bancrofti microfilaremia (Mf) were randomized to receive either three annual doses of IA (N=52), six semiannual doses of ALB 400mg (N=45), or six semiannual doses of ALB 800mg (N=47). The primary outcome amicrofilaremia at 36 months. Findings IA was more effective for completely clearing Mf than ALB 400mg or ALB 800mg (79%, CI 67-91; vs. 48%, CI 32-66 and 57%, CI 41-73, respectively). Mean % reductions in Mf counts at 36 months relative to baseline tended to be greater after IA (98%, CI 88-100) than after ALB 400mg (88%, CI 78-98) and ALB 800mg (89%, CI 79-99) (P=0.07 and P=0.06, respectively). Adult worm nest numbers (assessed by ultrasound) were reduced in all treatment groups. Treatments were well tolerated. Interpretation Repeated semiannual treatment with ALB is macrofilaricidal for W. bancrofti and leads to sustained reductions in Mf counts. This is a safe and effective regimen that could be used as MDA to eliminate LF in areas ivermectin cannot be used.

Field trial of a rapid card test for Wuchereria bancrofti

The Lancet ◽  
1997 ◽  
Vol 350 (9092) ◽  
pp. 1681 ◽  
Author(s):  
David O Freedman ◽  
Adriana de Almeida ◽  
Janaina Miranda ◽  
D Adam Plier ◽  
Cynthia Braga
Keyword(s):  
Field Trial ◽  
Wuchereria Bancrofti ◽  
Card Test

Frequency distribution of Wuchereria bancrofti microfilariae in human populations and its relationships with age and sex

Parasitology ◽  
1990 ◽  
Vol 101 (3) ◽  
pp. 429-434 ◽  
Author(s):  
P. K. Das ◽  
A. Manoharan ◽  
A. Srividya ◽  
B. T. Grenfell ◽  
D. A. P. Bundy ◽  
...  
Keyword(s):  
Frequency Distribution ◽  
Negative Binomial ◽  
Age Distribution ◽  
Indirect Evidence ◽  
Wuchereria Bancrofti ◽  
Parameter Estimates ◽  
Human Populations ◽  
Sampling Errors ◽  
Frequency Distributions ◽  
Age And Sex

SUMMARYThis paper examines the effects of host age and sex on the frequency distribution of Wuchereria bancrofti infections in the human host. Microfilarial counts from a large data base on the epidemiology of bancroftian filariasis in Pondicherry, South India are analysed. Frequency distributions of microfilarial counts divided by age are successfully described by zero-truncated negative binomial distributions, fitted by maximum likelihood. Parameter estimates from the fits indicate a significant trend of decreasing overdispersion with age in the distributions above age 10; this pattern provides indirect evidence for the operation of density-dependent constraints on microfilarial intensity. The analysis also provides estimates of the proportion of mf-positive individuals who are identified as negative due to sampling errors (around 5% of the total negatives). This allows the construction of corrected mf age–prevalence curves, which indicate that the observed prevalence may underestimate the true figures by between 25% and 100%. The age distribution of mf-negative individuals in the population is discussed in terms of current hypotheses about the interaction between disease and infection.

scholarly journals Lymphatic filariasis, infection status in Culex quinquefasciatus and Anopheles species after six rounds of mass drug administration in Masasi District, Tanzania

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Eliza Lupenza ◽  
Dinah B. Gasarasi ◽  
Omary M. Minzi
Keyword(s):  
Vector Control ◽  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Wuchereria Bancrofti ◽  
Elimination Phase ◽  
Anopheles Species ◽  
The Status ◽  
Household Environment ◽  
Indoor And Outdoor

Abstract Background Lymphatic filariasis (LF) elimination program in Tanzania started in 2000 in response to the Global program for the elimination of LF by 2020. Evidence shows a persistent LF transmission despite more than a decade of mass drug administration (MDA). It is advocated that, regular monitoring should be conducted in endemic areas to evaluate the progress towards elimination and detect resurgence of the disease timely. This study was therefore designed to assess the status of Wuchereria bancrofti infection in Culex quinqefasciatus and Anopheles species after six rounds of MDA in Masasi District, South Eastern Tanzania. Methods Mosquitoes were collected between June and July 2019 using Center for Diseases Control (CDC) light traps and gravid traps for indoor and outdoor respectively. The collected mosquitoes were morphologically identified into respective species. Dissections and PCR were carried out to detect W. bancrofti infection. Questionnaire survey and checklist were used to assess vector control interventions and household environment respectively. A Poisson regression model was run to determine the effects of household environment on filarial vector density. Results Overall, 12 452 mosquitoes were collected of which 10 545 (84.7%) were filarial vectors. Of these, Anopheles gambiae complex, An. funestus group and Cx. quinquefasciatus accounted for 0.1%, 0.7% and 99.2% respectively. A total of 365 pools of Cx. quinquefasciatus (each with 20 mosquitoes) and 46 individual samples of Anopheles species were analyzed by PCR. For Cx. quinquefasciatus pools, 33 were positive for W. bancrofti, giving an infection rate of 0.5%, while the 46 samples of Anopheles species were all negative. All 1859 dissected mosquitoes analyzed by microscopy were also negative. Households with modern latrines had less mosquitoes than those with pit latrines [odds ratio (OR) = 0.407, P < 0.05]. Houses with unscreened windows had more mosquitoes as compared to those with screened windows (OR = 2.125, P < 0.05). More than 80% of the participants own bednets while 16.5% had no protection. Conclusions LF low transmission is still ongoing in Masasi District after six rounds of MDA and vector control interventions. The findings also suggest that molecular tools may be essential for xenomonitoring LF transmission during elimination phase.

Microfilaria of Wuchereria bancrofti in Cytologic Smears

2008 ◽  
Vol 52 (6) ◽  
pp. 710-712 ◽  
Author(s):  
Bimal Kishore ◽  
Pratima Khare ◽  
Rashmi Jain Gupta ◽  
Sonali Pande Bisht
Keyword(s):  
Wuchereria Bancrofti
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