Isolation and Evaluation of Tamarind Seed Coat Mucilage as Pharmaceutical Suspending Agent

Natural polymers, specifical mucilages, have been used as a suspending agent for a long period of time. Natural excipients can serve as an alternative to synthetic products since they are less expensive, less toxic, and devoid of environmental pollution. The present study was undertaken to evaluate the mucilage isolated from Tamarindusindica (Fabaceae) seed coat, commonly named tamarind, as an innovative suspending agent. Paracetamol suspensions (10% w/v) were prepared using the T. indica seed coat mucilage as a suspending agent, and it was evaluated for parameters like physical stability, sedimentation profile, dispersibility, and flow property. Furthermore, it was assessed for its stability. The effect of the tested mucilage on the suspension was compared with commonly used suspending agents, i.e. sodium carboxymethyl cellulose (CMC) at concentrations of 0.5, 1.0, and 1.5% w/v. The results obtained indicated that the T. indica seed coat mucilage could be used as a suspending agent.

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Evaluation of Aloe weloensis (Aloeacea) Mucilages as a Pharmaceutical Suspending Agent

Advances in Pharmacological and Pharmaceutical Sciences ◽

10.1155/2021/6634275 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Yohannes Mengesha ◽

Abdu Tuha ◽

Yimer Seid ◽

Admassu Assen Adem

Keyword(s):

Zinc Oxide ◽

Environmental Pollution ◽

Natural Polymers ◽

Flow Rates ◽

Lower Flow ◽

Long Period ◽

Sedimentation Volume ◽

Rate Of Sedimentation ◽

The Difference ◽

Suspending Agents

Natural polymers, specifically mucilages, have been used as a suspending agent for a long period of time. Natural excipients can serve as an alternative to synthetic products since they are less expensive, less toxic, and devoid of environmental pollution. There are many species of Aloe found in Ethiopia which can be used as a source of mucilage. In this study, mucilage from Aloe weloensis, which is found in Wollo floristic region, was extracted and tested as a suspending agent at different suspending agent concentrations and compared with standard suspending agents (acacia and sodium carboxy methylcellulose (NaCMC)) by formulating zinc oxide suspension. The mucilage obtained from Aloe weloensis leaves has shown comparable suspending agent ability with acacia. The rate of sedimentation and viscosity was higher at 1% and 4% mucilage concentrations than acacia though the difference was not significant ( p > 0.05 ). The suspension was slightly basic and easily dispersible than NaCMC. Suspensions formulated from NaCMC were superior in terms of viscosity and sedimentation volume which was significantly different ( p < 0.05 ) accompanied by lower flow rates than suspensions formulated from acacia and Aloe weloensis mucilages. The results suggested that Aloe weloensis mucilage could be used as an alternative suspending agent.

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Galactoglucomannan structure of Arabidopsis seed‐coat mucilage in GDP ‐mannose synthesis impaired mutants

Physiologia Plantarum ◽

10.1111/ppl.13519 ◽

2021 ◽

Author(s):

Naho Nishigaki ◽

Yoshihisa Yoshimi ◽

Hiroaki Kuki ◽

Tadashi Kunieda ◽

Ikuko Hara‐Nishimura ◽

...

Keyword(s):

Seed Coat ◽

Arabidopsis Seed ◽

Seed Coat Mucilage

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Polysaccharide components of the seed-coat mucilage from hyptis suaveolens

Phytochemistry ◽

10.1016/s0031-9422(00)80329-5 ◽

1984 ◽

Vol 23 (2) ◽

pp. 337-338 ◽

Cited By ~ 12

Author(s):

D.Channe Gowda

Keyword(s):

Seed Coat ◽

Hyptis Suaveolens ◽

Seed Coat Mucilage

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GALACTURONOSYLTRANSFERASE-LIKE5 Is Involved in the Production of Arabidopsis Seed Coat Mucilage

PLANT PHYSIOLOGY ◽

10.1104/pp.113.227041 ◽

2013 ◽

Vol 163 (3) ◽

pp. 1203-1217 ◽

Cited By ~ 26

Author(s):

Yingzhen Kong ◽

Gongke Zhou ◽

Ashraf A. Abdeen ◽

James Schafhauser ◽

Beth Richardson ◽

...

Keyword(s):

Seed Coat ◽

Arabidopsis Seed ◽

Seed Coat Mucilage

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Bora Rice: Natural Polymer for Drug Delivery

Materials Proceedings ◽

10.3390/iocps2021-11290 ◽

2021 ◽

Vol 7 (1) ◽

pp. 2

Author(s):

Kalyani Pathak ◽

Ratna Jyoti Das ◽

Riya Saikia ◽

Aparoop Das ◽

Mohammad Zaki Ahmad

Keyword(s):

Drug Delivery ◽

Cold Water ◽

Food Additives ◽

Physical Stability ◽

Colloidal Dispersion ◽

Delivery Systems ◽

Rice Starch ◽

Cancer Drug ◽

Natural Polymers ◽

Pharmaceutical Dosage Forms

Natural polymers play a vital part in the formulation of pharmaceutical dosage forms due to their use as excipients. Synthetic polymers have been introduced into drug delivery recently; the usage of natural polymers in drug delivery research continues to rise. It is not surprising that applications other than its caloric value have been found for starch. Various natural sources of the polymer have been investigated for delivery systems; among them, Assam Bora rice starch seems to be a promising candidate due to its interesting properties such as being non-toxic, biocompatible, biodegradable, mucoadhesive, and non-immunogenic. Assam Bora rice, locally known as Bora Chaul, was first introduced in Assam, India, from Thailand or Myanmar by Thai-Ahom, now widely cultivated throughout the Assam. The starch obtained from Assam Bora rice is characterized by its high amylopectin content (i.e., >95%) with a branched, waxy polymer which shows physical stability and resistance towards enzymatic action. Assam Bora rice starch hydrates and swells in cold water, forming viscous colloidal dispersion or sols responsible for its bioadhesive nature. Moreover, it is degraded by colonic bacteria but remains undigested in the upper GIT. Due to the excellent adhesion and gelling capability, it is often selected as a mucoadhesive matrix in a controlled release drug delivery system. Carboxymethyl Assam Bora rice starch has also been applied for SPIONs stabilization and, further, it can effectively bind and load cationic anti-cancer drug molecule, Doxorubicin hydrochloride (DOX), via electrostatic interaction. This article provides a critical assessment of Assam Bora rice literature and shows how the rice can be used in many ways, from food additives to drug delivery systems.

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