Serum Paraoxonase with HDL-C as a predictor of atherosclerosis in patients of Chronic Kidney Disease
Introduction and Aim: CKD (Chronic Kidney Disease) is a problem in health care spread all over the world with adverse consequences. CKD is associated with premature atherosclerosis and increased morbidity and mortality due to cardiovascular complications. Hypertriglyceridemia is a commonly seen lipid abnormality in CKD patients. PON-1 (Paraoxanase-1) is a glycoprotein synthesized in the liver and is released into the blood, where it links with HDL. This study was undertaken to find out the relation between PON-1 and HDL-C and its effect on atherosclerosis. Materials and Methods: A total number of 123 subjects participated in the study. Serum was used for estimating the parameters such as serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) by calculation, creatinine, urea in a fully automated analyzer BS300. Serum paraoxonase-1(PON) was estimated by spectrophotometric method. Results: The metabolic derangement was very evident in the CKD group with significantly higher creatinine, urea, and dyslipidemia, and abnormal paraoxonase activity being observed in the cases compared to controls. Conclusion: This study suggests the need for assessing PON-1 activity, a measure of the antioxidant capacity of HDL-C which improves the predictive accuracy of atherosclerosis in CKD.