scholarly journals The effect of extrusion conditions on the acidic polysaccharide, ginsenoside contents and antioxidant properties of extruded Korean red ginseng

2013 ◽  
Vol 37 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Ying Gui ◽  
Gi Hyung Ryu
Keyword(s):  
Antioxidant Properties ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Acidic Polysaccharide

scholarly journals Anti-hyperlipidemic Effects of Red Ginseng Acidic Polysaccharide from Korean Red Ginseng

2010 ◽  
Vol 33 (3) ◽  
pp. 468-472 ◽  
Author(s):  
Yi-Seong Kwak ◽  
Jong-Soo Kyung ◽  
Jong Soo Kim ◽  
Jae Youl Cho ◽  
Man-Hee Rhee
Keyword(s):  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Acidic Polysaccharide

scholarly journals Immune Activity of Polysaccharide Fractions Isolated from Korean Red Ginseng

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3569 ◽  
Author(s):  
Soo Hyun Youn ◽  
Sang Min Lee ◽  
Chang-Kyun Han ◽  
Gyo In ◽  
Chae-Kyu Park ◽  
...  
Keyword(s):  
Optimal Dose ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Immune Activity ◽  
Acidic Polysaccharide ◽  
Water Fraction ◽  
Macrophage Activity ◽  
Macrophage Phagocytosis ◽  
Activity Comparison ◽  
Phagocytosis Activity

Korean red ginseng (KRG)’s pharmacological efficacy and popular immunomodulatory effects have already been proven in many studies; however, the component of KRG that is effective in immune activity has not been studied before. Therefore, this study extracted and separated KRG for an immune activity comparison. In the water fraction obtained by extracting KRG powder with water, a red ginseng neutral polysaccharide (RGNP) fraction and a red ginseng acidic polysaccharide (RGAP) fraction were obtained. Each fraction was orally administered for 10 days to mice with reduced immunity, and the number of IgM antibody-forming cells (AFCs) in splenocytes was measured to compare the immune activity of the water fractions. The results showed that the RGAP fraction has the greatest number of AFCs. To set the optimal dose of the RGAP fraction, which had the highest immune activity, the AFCs, macrophage activity, and splenocyte subtype in the mice were analyzed. As a result, the number of AFCs was significantly increased in the RGAP fraction compared to RGNP. The intraperitoneal macrophage phagocytosis activity and the number of T cells, B cells, and macrophages in the spleen increased significantly. It can, therefore, be confirmed that immune activity increases by a fraction containing higher RGAP content, and we hypothesize that RGAP activates immune activity.

scholarly journals Molecular Mechanism of Macrophage Activation by Red Ginseng Acidic Polysaccharide from Korean Red Ginseng

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Se Eun Byeon ◽  
Jaehwi Lee ◽  
Ji Hye Kim ◽  
Woo Seok Yang ◽  
Yi-Seong Kwak ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Intracellular Signaling ◽  
Morphological Changes ◽  
Target Surface ◽  
Raw264.7 Cells ◽  
No Production ◽  
Mrna Levels ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Acidic Polysaccharide

Red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng, displays immunostimulatory and antitumor activities. Even though numerous studies have been reported, the mechanism as to how RGAP is able to stimulate the immune response is not clear. In this study, we aimed to explore the mechanism of molecular activation of RGAP in macrophages. RGAP treatment strongly induced NO production in RAW264.7 cells without altering morphological changes, although the activity was not strong compared to LPS-induced dendritic-like morphology in RAW264.7 cells. RGAP-induced NO production was accompanied with enhanced mRNA levels of iNOS and increases in nuclear transcription factors such as NF-κB, AP-1, STAT-1, ATF-2, and CREB. According to pharmacological evaluation with specific enzyme inhibitors, Western blot analysis of intracellular signaling proteins and inhibitory pattern using blocking antibodies, ERK, and JNK were found to be the most important signaling enzymes compared to LPS signaling cascade. Further, TLR2 seems to be a target surface receptor of RGAP. Lastly, macrophages isolated from RGS2 knockout mice or wortmannin exposure strongly upregulated RGAP-treated NO production. Therefore, our results suggest that RGAP can activate macrophage function through activation of transcription factors such as NF-κB and AP-1 and their upstream signaling enzymes such as ERK and JNK.

scholarly journals Inhibitory effect of red ginseng acidic polysaccharide from Korean red ginseng on phagocytic activity and intracellular replication ofBrucella abortusin RAW 264.7 cells

2016 ◽  
Vol 17 (3) ◽  
pp. 315 ◽  
Author(s):  
Alisha Wehdnesday Bernardo Reyes ◽  
Hannah Leah Tadeja Simborio ◽  
Huynh Tan Hop ◽  
Lauren Togonon Arayan ◽  
Won Gi Min ◽  
...  
Keyword(s):  
Phagocytic Activity ◽  
Inhibitory Effect ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Red Ginseng ◽  
Intracellular Replication ◽  
Korean Red Ginseng ◽  
Acidic Polysaccharide

The effects of Korean red ginseng on diabetic complications and glucose modulation in type 2 diabetic patients

2018 ◽  
Author(s):  
Ahn Chul Woo ◽  
Kim Jung Hye ◽  
Kahui Park ◽  
Lee Sang Bae ◽  
Nam Ji Sun ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Diabetic Patients ◽  
Red Ginseng ◽  
Type 2 Diabetic Patients ◽  
Korean Red Ginseng ◽  
Type 2 Diabetic

Effect of Monascus purpureus-Fermented Korean Red Ginseng Powder on the Serum Lipid Levels and Antioxidative Activity in Rats

2009 ◽  
Vol 38 (9) ◽  
pp. 1153-1160 ◽  
Author(s):  
Jae-Young Cha ◽  
Jin-Chul Park ◽  
Hee-Young Ahn ◽  
Kyung-Eun Eom ◽  
Bo-Kyung Park ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Antioxidative Activity ◽  
Monascus Purpureus ◽  
Red Ginseng ◽  
Lipid Levels ◽  
Korean Red Ginseng ◽  
Serum Lipid Levels
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