scholarly journals Prognostic impact of human papillomavirus infection on cervical dysplasia, cancer, and patient survival in Saudi Arabia: A 10-year retrospective analysis

2021 ◽  
Vol 41 (6) ◽  
pp. 350-360
Author(s):  
Fatimah Alhamlan ◽  
Dalia Obeid ◽  
Hadeel Khayat ◽  
Tulbah Asma ◽  
Ismail A. Al-Badawi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Saudi Arabia ◽  
Human Papillomavirus ◽  
Sample Size ◽  
Survival Rates ◽  
Small Sample ◽  
Prognostic Impact ◽  
Cervical Biopsy ◽  
Biopsy Specimens ◽  
Hpv Status

BACKGROUND: Data on human papillomavirus (HPV) prevalence and survival rates among HPV-infected women are scarce in Saudi Arabia. OBJECTIVE: Assess the prevalence of HPV genotypes in cervical biopsy specimens and its effect on survival over a 10-year timeframe. DESIGN: Retrospective, cross-sectional. SETTINGS: Saudi referral hospital. PATIENTS AND METHODS: Cervical biopsy specimens were collected from women aged 23-95 years old who underwent HPV detection, HPV genotyping, p16 INK4a expression measurement using immunohistochemistry. Kaplan-Meier plots were constructed to analyze overall survival rates. MAIN OUTCOME MEASURES: Survival rate of HPV-positive cervical cancer patients. SAMPLE SIZE: 315 cervical biopsy specimens. RESULTS: HPV was detected in 96 patients (30.4%): 37.3% had cervical cancer; 14.2% cervical intraepithelial neoplasia (CIN) III, 4.1% CIN II, and 17.0% CIN I. A significant association was found between HPV presence and cervical cancer (χ 2 =56.78; P <.001). The expression of p16 INK4a was a significant predictor of survival: women who had p16 INK4a overexpression had poorer survival rates (multivariate Cox regression, hazard ratio, 3.2; 95% CI, 1.1–8.8). In addition, multivariate models with HPV status and cervical cancer diagnosis showed that HPV status was a significant predictor of survival: HPV-positive women had better survival rates than HPV-negative women. CONCLUSION: These findings suggest that implementing cervical and HPV screening programs may decrease cervical cancer rates and improve survival rates of women in Saudi Arabia. LIMITATION: Single center and small sample size. CONFLICT OF INTEREST: None.

scholarly journals Prognostic Impact of Human Papillomavirus Infection on Cervical Dysplasia, Cancer, and Patient Survival in Saudi Arabia: A 10-Year Retrospective Analysis

2020 ◽  
Author(s):  
F.S. Alhamlan ◽  
D.A. Obeid ◽  
H.H. Khayat ◽  
A.M. Tulbah ◽  
I.A. Al-Badawi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Saudi Arabia ◽  
Human Papillomavirus ◽  
Viral Load ◽  
Cox Regression ◽  
Survival Rates ◽  
Hpv Infection ◽  
Prognostic Impact ◽  
Screening Programs ◽  
Hpv Status

AbstractCervical cancer is caused by persistent human papillomavirus (HPV) infection. However, HPV prevalence data and survival rates among HPV-infected women are scare in Saudi Arabia. This study assessed the prevalence of HPV genotypes in a 10 year time-frame. Cervical biopsy specimens underwent HPV detection, HPV viral load using qPCR, HPV genotyping, p16INK4a expression measurement using immunohistochemistry. Kaplan-Meier plots were constructed to analyze overall survival rates. Of the 316 cervical specimens examined, HPV was detected in 96 (30.4%); 37.3% had cervical cancer; 14.2% cervical intraepithelial neoplasia (CIN) III, 4.1% CIN II, and 17.0% CIN I. A significant association was found between HPV-16 viral load and disease progression (P < .001, Mann-Whitney U) and between HPV presence and cervical cancer (χ2, 56.78; P < .001). The expression of p16INK4a was a significant predictor of survival: women who had p16INK4a overexpression had poorer survival rates (multivariate Cox regression, hazard ratio, 3.2; 95% CI, 1.1-8.8). In addition, multivariate models with HPV status and cervical cancer diagnosis showed that HPV status was a significant predictor of survival: HPV-positive women had better survival rates than HPV-negative women (haza. These findings suggest that implementing cervical cancer and HPV screening programs may decrease cervical cancer rates and improve survival rates of women in Saudi Arabia.

Prevalence and genotypes' distribution of human papillomavirus in invasive cervical cancer in Saudi Arabia

2011 ◽  
Vol 121 (3) ◽  
pp. 522-526 ◽  
Author(s):  
Ghazi Alsbeih ◽  
Raef Ahmed ◽  
Najla Al-Harbi ◽  
L. Aubrey Venturina ◽  
Asma Tulbah ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Saudi Arabia ◽  
Human Papillomavirus ◽  
Invasive Cervical Cancer

scholarly journals Perception of the Saudi Community towards Human Papilloma Virus Vaccination in Jeddah, Saudi Arabia

2017 ◽  
Vol 9 (9) ◽  
pp. 158
Author(s):  
Ahlam A. Alzahrani ◽  
Nebras AlGhanaim ◽  
Samia Abdulmageed
Keyword(s):  
Cervical Cancer ◽  
Saudi Arabia ◽  
Human Papillomavirus ◽  
Pap Smear ◽  
Hpv Vaccination ◽  
Cross Sectional Study ◽  
Community Perception ◽  
Human Papillomavirus Vaccination ◽  
Cross Sectional ◽  
Males And Females

To examine the awareness and perception of Saudi community towards Human Papillomavirus Vaccination. A cross-sectional study has examined the perception and awareness of Saudi individuals towards Human Papillomavirus HPV vaccination. A sample of 278 Saudi individuals were included. A close-ended survey questionnaire was employed to collect the data of Papillomavirus HPV vaccination. Around, 78.30% female and male participants were unaware of the availability of HPV vaccination against cervical cancer. 90.06% of females supported cervical cancer screening Pap smear by gynecologist after enduring vaccination. Only, 40.66% visited the gynecologist for screening. Results demonstrated 85.77% female agreed on receiving expensive vaccination. Conversely, 97.48% supported on HPV vaccination free of charge. A lack of knowledge about HPV, Pap smear, and cervical cancer. The data obtained can be used as a standard to devise effective awareness programs. Data was collected particularly from Saudi Arabia for evaluating Saudi community perception. Both males and females were observed to be interested in taking vaccination and prevention initiatives against the cervical cancer, whereas, there is a lack of awareness observed among the males and females included in the study.

scholarly journals Current studies on human papillomavirus in Saudi Arabia

2015 ◽  
Vol 9 (06) ◽  
pp. 571-576 ◽  
Author(s):  
Fatimah Saeed Alhamlan ◽  
Ahmed A Al-Qahtani ◽  
Mohammed N Al-Ahdal
Keyword(s):  
Cervical Cancer ◽  
Saudi Arabia ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hpv Infection ◽  
World Health ◽  
Cervical Lesions ◽  
Hpv Types ◽  
Health Organization ◽  
Low Prevalence

Human papillomavirus (HPV) infection is a significant etiological factor and an important prognosticator in cervical cancer. Indeed, researchers worldwide have confirmed these roles for high-risk HVPs in over 70% of cervical cancer cases. According to the World Health Organization, approximately 561,200 new cancer cases (5.2% of all new cancers) are attributed to HPV infection. Over 120 types of HPV are classified further as either low-risk HPV (LR-HPV) or high-risk HPV (HR-HPV) based on their oncological potential of transforming cells. The LR-HPV types cause benign hyperproliferative lesions (i.e. genital warts) while the HR-HPV types are strongly associated with premalignant and malignant cervical lesions. Data on the prevalence of HPV, survival of infected patients, and mortality rate are scarce in Saudi Arabia. The unsubstantiated assumption of a low prevalence of HPV in Saudi Arabia has contributed to limiting HPV research in this conservative country. Therefore, the goal of this review is to shed light on the current HPV research being conducted and the prevalence of HPV in Saudi Arabia.

scholarly journals Differential effect of GLUT1 overexpression on survival and tumor immune microenvironment of human papilloma virus type 16-positive and -negative cervical cancer

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Byoung Hyuck Kim ◽  
Ji Hyun Chang
Keyword(s):  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Immune Cell ◽  
Human Papilloma Virus Type ◽  
Prognostic Impact ◽  
Glucose Transporter 1 ◽  
Papilloma Virus ◽  
Positive Group ◽  
Hpv Status ◽  
Glut1 Expression

Abstract Glucose transporter-1 (GLUT1) has been proposed as a prognosticator in various cancers associated with therapeutic resistance and immune evasion; however little data is available on the role of GLUT1 in cervical cancer. Most cervical cancers are caused by human papilloma virus (HPV), but studies on the treatment response and prognosis depending on the HPV subtype, are conflicting. This hypothesis-generating study aims to investigate the prognostic impact of GLUT1 in cervical cancer, in conjunction with HPV subtype. Clinicopathologic factors, along with mRNA expression data were obtained using The Cancer Genome Atlas database. Tumor HPV status and immune cell scores were extracted from previous publications. In total, 298 patients were analyzed. High GLUT1 expression was associated with old age, squamous cell carcinoma, high tumor stage, pelvic lymph node metastases, and low hysterectomy rate. Multivariate survival analysis revealed that high GLUT1 expression (Hazard ratio (HR) 2.57, p = 0.002) and HPV16 subtype (HR 0.56, p = 0.033) were independent prognostic factors for overall survival. In the subgroup analysis, poor prognostic impact of high GLUT1 expression was maintained in HPV16-positive group (p < 0.001), but not in HPV16-negative group (p = 0.495). Decreased immune cell scores of CD8+ T cells, B cells, and Th1 cells by high GLUT1 expression were observed only in HPV16-positive group. In conclusion, these results suggested that GLUT1 expression and HPV16 subtype might have an independent prognostic value in cervical cancer. GLUT1-mediated immunomodulation might be an important cause of treatment failure, especially in HPV16-positive group.

Detection of Human Papillomavirus in Cervical Swab Samples by ViraPap and in Cervical Biopsy Specimens byIn SituHybridization

1993 ◽  
Vol 100 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Michael P. Meyer ◽  
Rafael I. Carbonell ◽  
Nancy A. Mauser ◽  
Anisa I. Kanbour ◽  
Antonio J. Amortegui
Keyword(s):  
Human Papillomavirus ◽  
Cervical Biopsy ◽  
Biopsy Specimens ◽  
Cervical Swab

scholarly journals Cervical Cancer and Human Papillomavirus Awareness among Women in Saudi Arabia

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1373
Author(s):  
Khalid Akkour ◽  
Lolowah Alghuson ◽  
Hicham Benabdelkamel ◽  
Hani Alhalal ◽  
Nada Alayed ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Saudi Arabia ◽  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Public Awareness ◽  
Cervical Screening ◽  
The Internet ◽  
Cross Sectional ◽  
Saudi Women ◽  
Source Of Information

Background and Objectives: Cervical cancer (CC) is the eighth most common cancer among Saudi women of all ages. With limited national data, we aimed to evaluate the public awareness of cervical cancer, CC risk factors, HPV infection, and HPV vaccines in different regions of Saudi Arabia. Materials and Methods: This was a survey-based cross-sectional study that encompassed 564 Saudi women over a period of a month. A self-administrated questionnaire was distributed through different social media platforms. Results: The collected data included sociodemographic variables and questions assessing awareness of CC, and the attitudes toward CC screening and human papillomavirus (HPV) vaccination. Most respondents were aware of CC (84.0%), although their primary source of information was the internet. However, only 45 females (8.0%) had a history of cervical screening. Furthermore, most females did not know that HPV was transmitted sexually (78.9%), or that it caused genital warts (81.7%) and CC (81.9%). Regarding the HPV vaccine, 100 females (17.7%) had heard about it, but only 11 (2.0%) took the vaccine, although more than half of the respondents (54.1%) were willing to take the vaccine after being informed about it. Conclusions: We noticed a remarkable lack of awareness among the respondents regarding HPV’s clinical implications; and the HPV vaccine, and its importance and availability. The main source of information for most of the Saudi women in this study was the internet, which may be an unreliable source, or provide misleading information that may delay screening or discourage vaccination. Thus, organized campaigns by the Ministry of Health or other health-advocating agencies, in addition to screening and vaccination programs, are strongly encouraged.

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