The beneficial effects of allopurinol in cardiology practice: decrease in uric acid and vascular oxidative stress/ The effects of lowering uric acid levels using allopurinol on markers of metabolic syndrome in end-stage renal disease patients: a pilot study

2010 ◽  
Vol 10 (3) ◽  
pp. 294-295
Author(s):  
Omer Yiginer ◽  
Fatih Ozcelik ◽  
Mustafa Aparci ◽  
Zafer Isilak ◽  
Omer Uz
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Pilot Study ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Beneficial Effects ◽  
Stage Renal Disease ◽  
End Stage ◽  
Vascular Oxidative Stress

scholarly journals Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis

2017 ◽  
Vol 95 (11) ◽  
pp. 1383-1388 ◽  
Author(s):  
Diana Uțu ◽  
Stelian Pantea ◽  
Oana M. Duicu ◽  
Danina M. Muntean ◽  
Adrian Sturza
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Renal Disease ◽  
Vascular Access ◽  
End Stage Renal Disease ◽  
Mao Inhibitors ◽  
Monoamine Oxidases ◽  
Stage Renal Disease ◽  
End Stage ◽  
Vascular Oxidative Stress

Arteriovenous fistula (AVF) is the “lifeline” for patients with end-stage renal disease (ESRD) undergoing hemodialysis. AVF maturation failure is a poorly understood process, one of the contributors being endothelial dysfunction due to oxidative stress. Monoamine oxidases (MAOs) A and B were recently identified as novel sources of vascular oxidative stress. The aim of the present study was to assess the contribution of MAOs to the endothelial dysfunction in patients with ESDR with indication of hemodialysis. Fragments of brachial artery collaterals were harvested from ESRD patients during the surgical procedure aimed at creating the vascular access in the cubital fossa. The effect of increasing concentrations (10, 30, 100 μmol/L) of the irreversible MAO-A inhibitor, clorgyline, and MAO-B inhibitor, selegiline, on endothelial-dependent relaxation (EDR) in response to cumulative doses of acetylcholine was studied in isolated phenylephrine-preconstricted vascular rings. Hydrogen peroxide (H2O2) production was assessed using ferrous oxidation xylenol orange assay. We showed that incubation of brachial rings with MAO inhibitors significantly improved EDR and attenuated H2O2 generation in patients with ESRD. MAO-related oxidative stress might contribute to the primary dysfunction/non-maturation of the AVF and MAO inhibitors could improve maturation and long-term patency of the vascular access in dialysis patients.

Could Antioxidant Supplementation Delay Progression of Cardiovascular Disease in End-Stage Renal Disease Patients?

2020 ◽  
Vol 19 (1) ◽  
pp. 41-54 ◽  
Author(s):  
Stefanos Roumeliotis ◽  
Athanasios Roumeliotis ◽  
Xenia Gorny ◽  
Peter R. Mertens
Keyword(s):  
Oxidative Stress ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Close Association ◽  
Omega 3 ◽  
Endstage Renal Disease ◽  
Increased Risk ◽  
Underlying Mechanisms ◽  
Stage Renal Disease ◽  
End Stage

In end-stage renal disease patients, the leading causes of mortality are of cardiovascular (CV) origin. The underlying mechanisms are complex, given that sudden heart failure is more common than acute myocardial infarction. A contributing role of oxidative stress is postulated, which is increased even at early stages of chronic kidney disease, is gradually augmented in parallel to progression to endstage renal disease and is further accelerated by renal replacement therapy. Oxidative stress ensues when there is an imbalance between reactive pro-oxidants and physiologically occurring electron donating antioxidant defence systems. During the last decade, a close association of oxidative stress with accelerated atherosclerosis and increased risk for CV and all-cause mortality has been established. Lipid peroxidation has been identified as a trigger for endothelial dysfunction, the first step towards atherogenesis. In order to counteract the deleterious effects of free radicals and thereby ameliorate, or delay, CV disease, exogenous administration of antioxidants has been proposed. Here, we attempt to summarize existing data from studies that test antioxidants for CV protection, such as vitamins E and C, statins, omega-3 fatty acids and N-acetylcysteine.

scholarly journals Serum albumin fragmentation in end-stage renal disease patients – a pilot study

2009 ◽  
Vol 47 (11) ◽  
Author(s):  
Elena Donadio ◽  
Francesco Piccolomini ◽  
Veronica Dimuccio ◽  
Antonio Felicioli ◽  
Ettore Balestreri ◽  
...  
Keyword(s):  
Pilot Study ◽  
Renal Disease ◽  
Serum Albumin ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

Impact of hemodialysis on exhaled volatile organic compounds in end-stage renal disease: a pilot study

Nanomedicine ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. 1035-1045 ◽  
Author(s):  
Suheir Assady ◽  
Ophir Marom ◽  
Matan Hemli ◽  
Radu Ionescu ◽  
Raneen Jeries ◽  
...  
Keyword(s):  
Pilot Study ◽  
Volatile Organic Compounds ◽  
Renal Disease ◽  
Organic Compounds ◽  
End Stage Renal Disease ◽  
Volatile Organic ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study

Aging ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 16357-16367
Author(s):  
Keiichi Sumida ◽  
Zhongji Han ◽  
Ankur A. Dashputre ◽  
Praveen K. Potukuchi ◽  
Csaba P. Kovesdy
Keyword(s):  
Pilot Study ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

Role of vitamin D in oxidative stress modulation in end‐stage renal disease patients: A double‐blind randomized clinical trial

2020 ◽  
Vol 24 (3) ◽  
pp. 367-373
Author(s):  
Leila Malekmakan ◽  
Zeinab Karimi ◽  
Afshin Mansourian ◽  
Maryam Pakfetrat ◽  
Jamshid Roozbeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Vitamin D ◽  
Renal Disease ◽  
Randomized Clinical Trial ◽  
End Stage Renal Disease ◽  
Double Blind ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Serum Prolidase Activity and Oxidative Stress in Diabetic Nephropathy and End Stage Renal Disease: A Correlative Study with Glucose and Creatinine

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Akhilesh Kumar Verma ◽  
Subhash Chandra ◽  
Rana Gopal Singh ◽  
Tej Bali Singh ◽  
Shalabh Srivastava ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
Renal Disease ◽  
Serum Creatinine ◽  
End Stage Renal Disease ◽  
Prolidase Activity ◽  
Stage Renal Disease ◽  
End Stage ◽  
And Oxidative Stress

Association of oxidative stress and serum prolidase activity (SPA) has been reported in many chronic diseases. The study was aimed at evaluating the correlation of glucose and creatinine to SPA and oxidative stress in patients with diabetic nephropathy (DN) and end stage renal disease (ESRD) concerned with T2DM. 50 healthy volunteers, 50 patients with T2DM, 86 patients with DN, and 43 patients with ESRD were considered as control-1, control-2, case-1, and case-2, respectively. Blood glucose, creatinine, SPA, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were measured by colorimetric tests. SPA, TOS, and OSI were significantly increased in case-1 and case-2 than control-1 and control-2, while TAS was significantly decreased(P<0.001). Blood glucose was linearly correlated to SPA, TOS, TAS, and OSI in control-2, case-1 and case-2(P<0.001). Serum creatinine was linearly correlated with SPA, TOS, TAS and OSI in control-2 and case-1(P<0.001). In case-2, serum creatinine was significantly correlated with SPA only(P<0.001). Thus, the study concluded that SPA and oxidative stress significantly correlated with blood glucose and creatinine. SPA, TOS, TAS, and OSI can be used as biomarkers for diagnosis of kidney damage.

scholarly journals Oxidative stress in end-stage renal disease: an emerging threat to patient outcome

2003 ◽  
Vol 18 (7) ◽  
pp. 1272-1280 ◽  
Author(s):  
F. Locatelli ◽  
B. Canaud ◽  
K.-U. Eckardt ◽  
P. Stenvinkel ◽  
C. Wanner ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Patient Outcome ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage
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