scholarly journals Impact of Non-surgical Periodontal Therapy on Pulmonary functions, Periodontal Health and Salivary Matrix Metalloproteinase-8 of COPD Patients with Chronic Periodontitis: A Clinico-biochemical Study

2021 ◽  
Vol 22 (4) ◽  
pp. 324-332
Author(s):  
Sakshi Sharma ◽  
◽  
Abhaya Gupta ◽  
Ajay Kumar Verma ◽  
Anjani Pathak ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Chronic Periodontitis ◽  
Biochemical Study ◽  
Periodontal Therapy ◽  
Periodontal Health ◽  
Pulmonary Functions ◽  
Copd Patients

scholarly journals Gingival Crevicular Fluid and Serum Cystatin C Levels in Periodontal Health and Disease

2012 ◽  
Vol 32 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Anuj Sharma ◽  
A. R. Pradeep ◽  
N. M. Raghavendra ◽  
P. Arjun ◽  
Rahul Kathariya
Keyword(s):  
Cystatin C ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Therapy Group ◽  
Periodontal Diseases ◽  
Periodontal Therapy ◽  
Periodontal Health ◽  
Healthy Group ◽  
Health And Disease ◽  
Crevicular Fluid

Cystatin C (CSTC) is an inhibitor of cysteine proteinases and could play a protective and regulatory role under inflammatory conditions. The present study was designed to assess the concentration of CSTC in gingival crevicular fluid (GCF) and serum, to find out their association if any, in periodontal health and disease. 30 subjects were selected divided into 3 groups consisting of 10 subjects in each group based on clinical parameters: periodontally healthy group, gingivitis group and chronic periodontitis group, while, chronic periodontitis group after 8 weeks of the treatment (scaling and root planing) constituted after periodontal therapy group. GCF and serum samples were collected from all subjects to estimate the levels of CSTC by ELISA. The mean CSTC concentration in GCF and serum was observed to be the highest in periodontitis group and lowest in periodontally healthy group with intermediate concentration in gingivitis group and after periodontal therapy group. CSTC concentration in GCF and serum increased proportionally with the severity of periodontal disease (from health to periodontitis group) and decreased after treatment. This suggests that CSTC increases with disease progression to prevent further periodontal degeneration and decreases after treatment due to bone metabolic homeostasis. Further, longitudinal prospective studies involving larger population are needed to confirm the findings of present study and to better understand the role of CSTC in the pathogenesis of periodontal diseases.

Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis

2008 ◽  
Vol 53 (4) ◽  
pp. 337-345 ◽  
Author(s):  
Ali Gürkan ◽  
Gülnur Emingil ◽  
Buket Han Saygan ◽  
Gül Atilla ◽  
Serhat Çınarcık ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Chronic Periodontitis ◽  
Gene Polymorphisms ◽  
Matrix Metalloproteinase 2 ◽  
Periodontal Health

scholarly journals Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study

2013 ◽  
Vol 4 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Tabita Benjamin ◽  
Abdul S Aziz ◽  
Madhav G Kalekar ◽  
Adinath N Suryakar ◽  
Milsee M Prakashan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Chronic Periodontitis ◽  
Biochemical Study ◽  
Periodontal Therapy ◽  
Healthy Controls ◽  
Oxidative Stress Markers ◽  
Clinical Attachment Loss ◽  
Stress Markers ◽  
Nonsurgical Periodontal Therapy

ABSTRACT Introduction Chronic periodontitis is the inflammatory disease of the periodontium; the tissue that surround and support the teeth. The aim of the study was to estimate and compare some biochemical oxidative stress markers in patients with chronic periodontitis and healthy controls and to assess the effect of nonsurgical periodontal therapy on these parameters. Materials and methods Eighty-two chronic periodontitis patients and 120 healthy controls were recruited for the study. The periodontal status was evaluated using gingival index (GI), plaque index (PI), papillary bleeding index (PBI) and clinical attachment loss (CAL). The biochemical parameters estimated were total antioxidant capacity (TAOC), antioxidant enzymes RBC-superoxide dismutase (RBC-SOD) and glutathione peroxidase (GPx), vitamin C, malondialdehyde (MDA) and Creactive protein (CRP) were also evaluated. Nonsurgical periodontal therapy (scaling and root planing; SRP) was performed on chronic periodontitis patients and a follow-up was done after 3 months. Results The study suggests that oxidative stress is induced in chronic periodontitis, as the levels of CRP, MDA and RBC-SOD were significantly higher (p < 0.001) and those of TAOC, GPx and vitamin C were significantly lower (p < 0.001) compared to healthy controls at baseline. SRP therapy significantly improved the clinical and biochemical oxidative stress markers in periodontitis patients. Conclusion Chronic periodontitis patients show higher inflammatory manifestations and oxidative stress. SRP therapy helps in lowering inflammatory burden and improving systemic oxidant: Antioxidant imbalance. The SRP therapy may be a useful support in the control and prevention of various inflammatory diseases associated with periodontitis. How to cite this article Aziz AS, Kalekar MG, Benjamin T, Suryakar AN, Prakashan MM, Bijle MNA. Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study. World J Dent 2013;4(1):17-23.

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