scholarly journals Histomorphological Hepato-teratogenic Effects of Ethanol on the Liver Lobule in Albino Rats (Rattus novegicus)

2021 ◽  
Vol 06 (05) ◽  
pp. 97-102
Author(s):  
Teresiah W. Musa ◽  
Kweri J. Kariuki ◽  
Caroline C. Sigei ◽  
Atanas N.Malik ◽  
Ann W. Mwangi ◽  
...  
Keyword(s):  
Albino Rats ◽  
Teratogenic Effects ◽  
Liver Lobule

scholarly journals Teratogenic Potential of Solenstemma Argel Extract in Wistar Albino Rats

2021 ◽  
Author(s):  
Nazik M.E. Mustafa ◽  
Shahenaz Satti ◽  
Nafisa A. Osman ◽  
Ahmed A.Gameel ◽  
Tarig M. El-hadiyah
Keyword(s):  
Fetal Development ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
P Value ◽  
Teratogenic Effects ◽  
Pregnant Rats ◽  
Liver Histopathology ◽  
Teratogenic Potential ◽  
Wistar Albino Rats

Abstract The majority of people in Africa receive their basic health care through herbal treatments. Herbal medicine may negatively impact fetal development irreparably. This study examined the teratogenic potential of Solenstemma argel extract in pregnant rats. Pregnant rats were treated with Solenstemma argel from 7th to 16th day of gestation. The dosage used was 250 mg/kg, intraperitoneal.Solenstemma argel extract treated group showed fetal abnormalities appeared as body hemorrhage, limbs abnormalities and resorption of fetuses. These appears in 25% of the fetuses (P-value = 0.01) which is significantly differed from control group. Furthermore, histopathological findings of liver sections from fetuses of Solenstemma argel - treated mothers showed loose liver texture and hepatocytes hemorrhage.In this study, we conclude that the use Solenstemma argel extract during the organogenesis period in pregnant rats has the potential to cause teratogenic effects, as well as abnormalities in liver histopathology.

scholarly journals Teratogenic Potential of Solenstemma argel Extract in Wistar Albino Rats

2022 ◽  
Author(s):  
Nazik M.E. Mustafa ◽  
Shahenaz Satti ◽  
Nafisa A. Osman ◽  
Ahmed A.Gameel ◽  
Tarig M. El-hadiyah
Keyword(s):  
Fetal Development ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
P Value ◽  
Teratogenic Effects ◽  
Pregnant Rats ◽  
Liver Histopathology ◽  
Teratogenic Potential ◽  
Wistar Albino Rats

Abstract The majority of people in Africa receive their basic health care through herbal treatments. Herbal medicine may negatively impact fetal development irreparably. This study examined the teratogenic potential of Solenstemma argel extract in pregnant rats. Pregnant rats were treated with Solenstemma argel from 7th to 16th day of gestation. The dosage used was 250 mg/kg, intraperitoneal.Solenstemma argel extract treated group showed fetal abnormalities appeared as body hemorrhage, limbs abnormalities and resorption of fetuses. These appears in 25% of the fetuses (P-value = 0.01) which is significantly differed from control group. Furthermore, histopathological findings of liver sections from fetuses of Solenstemma argel - treated mothers showed loose liver texture and hepatocytes hemorrhage.In this study, we conclude that the use Solenstemma argel extract during the organogenesis period in pregnant rats has the potential to cause teratogenic effects, as well as abnormalities in liver histopathology.

scholarly journals POSSIBLE TERATOGENIC EFFECTS OF ANTIEPILEPTICS IN ALBINO RATS: COMPARATIVE STUDY BETWEEN OLD AND NEW GENERATIONS: PART II

2017 ◽  
Vol 17 (1) ◽  
pp. 53-87
Author(s):  
Afaf M. Farghaly ◽  
Hala M. Fathy ◽  
Hoda A. Abd El Aziz ◽  
Saly Y. Abd El Hameed ◽  
Huda A. Omar
Keyword(s):  
Comparative Study ◽  
Albino Rats ◽  
Teratogenic Effects

scholarly journals Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed Aboubakr ◽  
Mohamed Elbadawy ◽  
Ahmed Soliman ◽  
Mohamed El-Hewaity
Keyword(s):  
Pregnant Female ◽  
Female Rats ◽  
Albino Rats ◽  
Distilled Water ◽  
Teratogenic Effects ◽  
Skeletal Defects ◽  
Group A ◽  
Group D ◽  
Fetal Defects

This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg·b·wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000 and 2000 mg/kg·b·wt/day orally for the same period, respectively; Group D behaved as control and received 0.5 mL distilled water orally for the same period. The dams were killed on 20th day of gestation and their fetuses were subjected to morphological, visceral, and skeletal examinations. Norfloxacin significantly decreased the number of viable fetuses, increased the number of resorbed fetuses, and induced retardation in growth of viable fetuses; some visceral and skeletal defects in these fetuses were seen and these effects were dose dependant. Conclusively, norfloxacin caused some fetal defects and abnormalities, so it is advisable to avoid using this drug during pregnancy.

scholarly journals A COMPARATIVE STUDY OF THE TERATOGENIC EFFECTS OF ANTIEPILEPTIC DRUGS: LAMOTRIGINE AND LEVETIRACETAM ON ADULT ALBINO RATS

2019 ◽  
Vol 16 (Supplement) ◽  
pp. 87-111
Author(s):  
Ibrahim S. Elgndy ◽  
Ola G. Hagag ◽  
Shereen M.S. EL Kholy ◽  
Naglaa A. S. Sarg ◽  
Amina A. M. Farag
Keyword(s):  
Comparative Study ◽  
Antiepileptic Drugs ◽  
Albino Rats ◽  
Teratogenic Effects

Effects of renovascular hypertension on rat adrenal zona glomerulosa

1978 ◽  
Vol 36 (2) ◽  
pp. 582-583
Author(s):  
G. Mazzocchi ◽  
P. Rebuffat ◽  
C. Robba ◽  
P. Vassanelli ◽  
G. G. Nussdorfer
Keyword(s):  
Renovascular Hypertension ◽  
Left Kidney ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Zona Glomerulosa ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Left Renal Artery ◽  
Angiotensin System ◽  
And Control

It is well known that the rat adrenal zona glomerulosa steroidogenic activity is controlled by the renin-angiotensin system. The ultrastructural changes in the rat zona glomerulosa cells induced by renovascular hypertension were described previously, but as far as we are aware no correlated biochemical and morphometric investigations were performed.Twenty adult male albino rats were divided into 2 experimental groups. One group was subjected to restriction of blood flow to the left kidney by the application of a silver clip about the left renal artery. The other group was sham-operated and served as a control. Renovascular hypertension developed in about 10 days: sistolic blood pressure averaged 165 ± 6. 4 mmHg, whereas it was about 110 ± 3. 8 mmHg in the control animals. The hypertensive and control rats were sacrificed 20 days after the operation. The blood was collected and plasma renin activity was determined by radioimmunological methods. The aldosterone concentration was radioimmunologically assayed both in the plasma and in the homogenate of the left capsular adrenal gland.

Further Studies on the Ultrastructure of Harderian Gland in Adult Rats

1974 ◽  
Vol 32 ◽  
pp. 288-289
Author(s):  
Alfredo Feria-Velasco ◽  
Guadalupe Tapia-Arizmendi
Keyword(s):  
Fine Structure ◽  
Domestic Fowl ◽  
Animal Species ◽  
Acinar Cells ◽  
Harderian Gland ◽  
Myoepithelial Cells ◽  
The Other ◽  
Albino Rats ◽  
Adult Rats ◽  
Cell Components

The fine structure of the Harderian gland has been described in some animal species (hamster, rabbit, mouse, domestic fowl and albino rats). There are only two reports in the literature dealing on the ultrastructure of rat Harderian gland in adult animals. In one of them the author describes the myoepithelial cells in methacrylate-embbeded tissue, and the other deals with the maturation of the acinar cells and the formation of the secretory droplets. The aim of the present work is to analize the relationships among the acinar cell components and to describe the two types of cells located at the perifery of the acini.

Cell Fine Structure as Revealed in Dessicator-Dried Resinless Sections

1981 ◽  
Vol 39 ◽  
pp. 622-623
Author(s):  
R. P. Becker ◽  
J. J. Wolosewick ◽  
J. Ross-Stanton
Keyword(s):  
Fine Structure ◽  
Tannic Acid ◽  
Three Dimensional ◽  
Albino Rats ◽  
Cell Organelles ◽  
Vascular Perfusion ◽  
Thin Sections ◽  
Carbon Coated ◽  
Embedding Medium ◽  
Polyethylene Glycol 6000

Methodology has been introduced recently which allows transmission and scanning electron microscopy of cell fine structure in semi-thin sections unencumbered by an embedding medium. Images obtained from these “resinless” sections show a three-dimensional lattice of microtrabeculfee contiguous with cytoskeletal structures and membrane-bounded cell organelles. Visualization of these structures, especially of the matiiDra-nous components, can be facilitated by employing tannic acid in the fixation step and dessicator drying, as reported here.Albino rats were fixed by vascular perfusion with 2% glutaraldehyde or 1.5% depolymerized paraformaldehyde plus 2.5% glutaraldehyde in 0.1M sodium cacodylate (pH 7.4). Tissues were removed and minced in the fixative and stored overnight in fixative containing 4% tannic acid. The tissues were rinsed in buffer (0.2M cacodylate), exposed to 1% buffered osmium tetroxide, dehydrated in ethyl alcohol, and embedded in pure polyethylene glycol-6000 (PEG). Sections were cut on glass knives with a Sorvall MT-1 microtome and mounted onto poly-L-lysine, formvar-carbon coated grids while submerged in a solution of 95% ethanol containing 5% PEG.

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