scholarly journals Methotrexate in dermatology: from theory to practice

2021 ◽  
Author(s):  
А.А. Кубанов ◽  
Ю.А. Галлямова ◽  
А.В. Асоскова
Keyword(s):  
World Literature ◽  
Skin Diseases ◽  
Practical Experience ◽  
Cumulative Effects ◽  
Russian Society ◽  
Pharmacological Properties ◽  
Theory To Practice ◽  
The World ◽  
Leading Position ◽  
Anti Inflammatory

Метотрексат зарекомендовал себя как высокоэффективное средство для лечения псориаза с 1953 г. Эффективность метотрексата обусловлена его цитотоксическим и противовоспалительным действием. Согласно проекту клинических рекомендаций Российского общества дерматовенерологов и косметологов применение метотрексата обосновано при многих заболеваниях кожи. Длительная история и накопленный практический опыт применения не вызывают сомнения в эффективности метотрексата, обусловленной его уникальными фармакологическими свойствами, а именно противовоспалительным, иммуномодулирующим и кумулятивным эффектами, которые позволяют препарату занимать лидирующие позиции в терапии многих кожных заболеваний. В статье подробно раскрыты метаболизм метотрексата и его фармакодинамика. Согласно обзору современных данных мировой литературы авторы представили рекомендации по лечению метотрексатом, применению его у детей, мониторингу во время лечения, а также обратили внимание на показания при особых ситуациях (инфекции, прививки, контрацепция и т. д.). Methotrexate has established itself as a highly effective treatment for psoriasis since 1953. The effectiveness of methotrexate is due to its cytotoxic and anti-inflammatory effects. According to the draft clinical guidelines of the Russian Society of Dermatovenereologists and Cosmetologists, the use of methotrexate is justified in many skin diseases. A long history and accumulated practical experience of application do not raise doubts about the effectiveness of methotrexate due to its unique pharmacological properties, namely, anti-inflammatory, immunomodulatory and cumulative effects, which allow the drug to occupy a leading position in the treatment of many skin diseases. The article describes in detail the metabolism of methotrexate and its pharmacodynamics. According to a review of modern data from the world literature, the authors presented recommendations for treatment with methotrexate, its use in children, monitoring during treatment, and also drew attention to the indications in special situations (infections, vaccinations, contraception, etc.).

scholarly journals ТЕМА «ЗОЛОТОЇ ЛИХОМАНКИ» У ЗБІРЦІ ДЖЕКА ЛОНДОНА «ПІВНІЧНІ ОПОВІДАННЯ»

2019 ◽  
Vol 3 (93) ◽  
pp. 43-53
Author(s):  
М.А. Дерій
Keyword(s):  
World Literature ◽  
Practical Experience ◽  
Gold Rush ◽  
The Other ◽  
Jack London ◽  
Central Theme ◽  
The North ◽  
Physical Deterioration ◽  
The World ◽  
The One

Jack London's «Northern Stories» is the conventional name of the early writer's works, with which he entered the world literature. The collection is composed of a system of motifs related to the theme of «gold rush». The theme of «gold rush» raises serious problems for barbaric looting of nature to satisfy greed. Jack London reproduced beautiful pictures of nature and at the same time the terrible consequences of human activity in Alaska. The testing theme was the central theme in Jack London’s «Northern Stories». The writer consistently reproduced situations in which a person, remaining alone with danger, was given the opportunity to test their own forces in a difficult struggle against circumstances threatening its existence. Reproducing the realities of everyday life of goldsmiths, Jack London, of course, could not escape the naturalistic detail. But the writer’s proposed interpretation of man strongly opposed the leading concepts of naturalists. In particular, he freed characters from biological dependence: even under the worst circumstances, the heroes of the «Northern Stories» are not helpless – they overcome physical deterioration due to solid positions and moral stability. Characters that Jack London frankly sympathizes with embody the romantic ideal of the author: they are strong personalities who adhere to the laws of brotherhood and justice. One of the main features that permeates all Jack London’s writings about the North is the adventure motif, it unites people of different professions and nationalities, includes the danger, uncertainty and romanticism. Jack London wrote his «Northern Stories» based on his practical experience, in which the cruelty of «white silence», on the one hand, and the romance of the struggle for life, on the other hand, and, moreover, the preservation of the moral person’s face and kindness in situations where could stand only a person who has a strong spirit.

scholarly journals The role of Charakokta Varnya Mahakashaya for maintenance of skin complexion (Varnya Vriddhi ) – a literature review

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Pallavi R. Parde
Keyword(s):  
Skin Diseases ◽  
Cynodon Dactylon ◽  
Pharmacological Properties ◽  
Vetiveria Zizanioides ◽  
White Variety ◽  
Hemidesmus Indicus ◽  
Wide Range ◽  
The World ◽  
Medical Importance

Beauty is a subject of socio-medical importance. Cosmetics are used in a wide range throughout the world which leads to many hazardous effects due to chemicals contain. The aim of this study is to evaluate the use and the mode of action of herbs mentioned in Varnya Mahakashaya of Acharya Charak for maintenance of skin complexion i.e. for Varna Vriddhi of Twaka or Rupaprasadan.  According to Ayurveda Skin is divided in 7 different layers – Avabhasini, Lohita, Shweta, Tamra, Vedini, Rohini, Mamsadhara. These layers are responsible for various characters of skin like complexion, and also the Bhrajak Pitta which is closely associated with skin is responsible for skin complexion. The Charak Samhita is great text in Ayurveda stated a group of 10 medicinal plants known as Varnya Mahakashaya that can be used to obtain glowing skin. It includes- Shweta Chandan ( Sntalum albam ), Nagakeshar (Mesuva ferra), Padmak (Prnus cerasoides) , Ushira (Vetiveria zizanioides), Madhuka (Glycerrhiza glabra), Manjishtha (Rubia cordifolia), Sariva (Hemidesmus indicus), Payasya (Ipomoea digitata), Sita (white variety of Cynodon dactylon) and Lata (green veriety of Cynodon dactylon). These drugs can be used individually or in combination also internally and externally. All of them work under varnya, raktashodhak, pittashamak, kushthaghna guna. Most of them are prescribed for skin diseases, the pharmacological properties of these herbs indicate complexion promotion action.

scholarly journals Socio-Psychological Resources of the Development of Society in Digital Technology

2020 ◽  
Vol 8 (2) ◽  
pp. 24-40
Author(s):  
Anatoly L. Zhuravlev ◽  
Dzhuletta A. Kitova
Keyword(s):  
Quality Of Life ◽  
Large Scale ◽  
Russian Society ◽  
Psychological Resources ◽  
Political Processes ◽  
The World ◽  
Close Study ◽  
Leading Position ◽  
Psychological Knowledge

Russia occupies a leading position in the world ranking of countries with the richest natural resources, but lags behind many countries of the world in terms of living standards. Studies of Russian sociologists also suggest that, according to Russians, negative dynamics are manifested in many indicators characterizing the main areas of life of Russian society. To overcome this situation, a close study of the laws of functioning and the cyclical stages of social processes is necessary, which is impossible without reliance on socio-psychological knowledge, which is increasingly being integrated into international models for assessing the quality of life at the macro, meso- and micro- levels. Recent studies convincingly demonstrate the relationship of psychological factors with the quality of life of society, there is a realization that these factors can serve as important levers in optimizing socio-economic processes, can increase their productivity and are effective in implementing public administration programs. In modern conditions, no scientific field can give a complete answer to the question about the nature of the factors (legal, economic, social, psychological, etc.) that determine an increase in the standard of living of the population and ensure the stability of its social development. Accordingly, the optimization of the social sphere is a complex interdisciplinary problem, which, in one of its manifestations, is associated with the need to identify various historical and everyday cycles that affect the effectiveness of economic and political processes, as well as the mindset of the population. In this direction, the development of information technology creates serious opportunities for combining the efforts of representatives of the humanities, social and technical sciences, and the organization of large-scale integrated research.

scholarly journals THE OCCURRENCE OF CAFESTOL AND KAHWEOL DITERPENES IN DIFFERENT COFFEE BREWS

2019 ◽  
Vol 14 (2) ◽  
pp. 265 ◽  
Author(s):  
Fábio Junior Moreira Novaes ◽  
Fernanda Calvente Bayan ◽  
Francisco Radler Aquino Neto ◽  
Claudia Moraes Resende
Keyword(s):  
Serum Cholesterol ◽  
Pharmacological Properties ◽  
Preparation Methods ◽  
Coffee Tree ◽  
Coffee Brew ◽  
Coffee Beans ◽  
The World ◽  
Anti Inflammatory ◽  
Coffee Brews

Coffee is the second most consumed brew in the world, after water. Cafestol and kahweol are two diterpenes that have been identified, until now, exclusively in the coffee tree. They are co-extracted from the coffee beans that are roasted and ground for the beverage preparation. Their pharmacological properties are related to anticancer and anti-inflammatory activities, although they also increase the serum cholesterol. Several researches reported that coffee brew preparation methods influence directly the levels of the diterpenes. This paper describes a compilation of the main results published for different coffee brews and all variables related to their preparation. Major differences in the reported concentrations have been noted.

Modern approaches to organ-conserving surgical hemostasis in obstetric bleeding

2021 ◽  
Vol 70 (3) ◽  
pp. 115-120
Author(s):  
Irina B. Fatkullina ◽  
Alfia G. Yashchuk ◽  
Yulia N. Fatkullina ◽  
Anna Yu. Lazareva
Keyword(s):  
Maternal Mortality ◽  
World Literature ◽  
Female Reproductive System ◽  
Obstetric Hemorrhage ◽  
Anatomical Features ◽  
Domestic Literature ◽  
The World ◽  
Leading Position ◽  
Global Health Care ◽  
Analyze Data

BACKGROUND: Obstetric hemorrhage is an urgent problem of global health care, since it occupies a leading position in the structure of maternal mortality. AIM: The aim of this study was to analyze data on hemostasis in obstetric bleeding. MATERIALS AND METHODS: The article presents a review of the world literature on modern approaches to hemostasis, which take into account new data on the anatomical structure of the female reproductive system. RESULTS AND CONCLUSIONS: Based on the foreign and domestic literature data, a strict step-by-step implementation of all prescribed measures along with a differentiated approach to treatment that takes into account anatomical features is the key to success in the fight against obstetric bleeding as the main cause of maternal mortality in the world.

Indonesian Literature’s Position in World Literature

TEKNOSASTIK ◽  
2018 ◽  
Vol 14 (2) ◽  
pp. 1
Author(s):  
Dina Amelia
Keyword(s):  
World Literature ◽  
The Other ◽  
National Literature ◽  
Western World ◽  
The World ◽  
The One ◽  
The Voice

There are two most inevitable issues on national literature, in this case Indonesian literature. First is the translation and the second is the standard of world literature. Can one speak for the other as a representative? Why is this representation matter? Does translation embody the voice of the represented? Without translation Indonesian literature cannot gain its recognition in world literature, yet, translation conveys the voice of other. In the case of production, publication, or distribution of Indonesian Literature to the world, translation works can be very beneficial. The position of Indonesian literature is as a part of world literature. The concept that the Western world should be the one who represent the subaltern can be overcome as long as the subaltern performs as the active speaker. If the subaltern remains silent then it means it allows the “representation” by the Western.

Comparing Comparisons: Political Implications of Different Notions of Difference

2016 ◽  
Vol 13 (1) ◽  
pp. 7-26
Author(s):  
Glenn Odom
Keyword(s):  
Cultural Studies ◽  
World Literature ◽  
The West ◽  
Political Debates ◽  
Political Implications ◽  
The World ◽  
Critical Attention ◽  
David Damrosch ◽  
Location Point

With the rise of the American world literature movement, questions surrounding the politics of comparative practice have become an object of critical attention. Taking China, Japan and the West as examples, the substantially different ideas of what comparison ought to do – as exhibited in comparative literary and cultural studies in each location – point to three distinct notions of the possible interactions between a given nation and the rest of the world. These contrasting ideas can be used to reread political debates over concrete juridical matters, thereby highlighting possible resolutions. This work follows the calls of Ming Xie and David Damrosch for a contextualization of different comparative practices around the globe.

Boatmen, Wastrels, and Demons: Figures of Literature

CounterText ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 30-56 ◽  
Author(s):  
Simona Sawhney
Keyword(s):  
Social Studies ◽  
World Literature ◽  
Literary Texts ◽  
Sanskrit Text ◽  
Modern Democracy ◽  
Political Debates ◽  
The World ◽  
National Literatures

Engaging some of the questions opened by Ranjan Ghosh's and J. Hillis Miller's book Thinking Literature Across Continents (2016), this essay begins by returning to Aijaz Ahmad's earlier invocation of World Literature as a project that, like the proletariat itself, must stand in an antithetical relation to the capitalism that produced it. It asks: is there an essential link between a certain idea of literature and a figure of the world? If we try to broach this link through Derrida's enigmatic and repeated reflections on the secret – a secret ‘shared’ by both literature and democracy – how would we grasp Derrida's insistence on the ‘Latinity’ of literature? The groundlessness of reading that we confront most vividly in our encounter with fictional texts is both intensified, and in a way, clarified, by new readings and questions posed by the emergence of new reading publics. The essay contends that rather than being taught as representatives of national literatures, literary texts in ‘World Literature’ courses should be read as sites where serious historical and political debates are staged – debates which, while being local, are the bearers of universal significance. Such readings can only take place if World Literature strengthens its connections with the disciplines Miller calls, in the book, Social Studies. Paying particular attention to the Hindi writer Premchand's last story ‘Kafan’, and a brief section from the Sanskrit text the Natyashastra, it argues that struggles over representation, over the staging of minoritised figures, are integral to fiction and precede the thinking of modern democracy.

Development of Dermatological Skin Disease Detection and Classification based on Wavelet and ANN

2018 ◽  
Vol 8 (5) ◽  
pp. 10
Author(s):  
Revati Kadu ◽  
U. A. Belorkar
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Skin Disease ◽  
Skin Diseases ◽  
Screening Method ◽  
Phase Detection ◽  
Statistical Measures ◽  
The World ◽  
Artificial Neural ◽  
Wavelet Techniques

One of the most common and augmenting health problems in the world are related to skin. The most  unpredictable and one of the most difficult entities to automatically detect and evaluate is the human skin disease because of complexities of texture, tone, presence of hair and other distinctive features. Many cases of skin diseases in the world have triggered a need to develop an effective automated screening method for detection and diagnosis of the area of disease. Therefore the objective of this work is to develop a new technique for automated detection and analysis of the skin disease images based on color and texture information for skin disease screening. In this paper, system is proposed which detects the skin diseases using Wavelet Techniques and Artificial Neural Network. This paper presents a wavelet-based texture analysis method for classification of five types of skin diseases. The method applies tree-structured wavelet transform on different color channels of red, green and blue dermoscopy images, and employs various statistical measures and ratios on wavelet coefficients. In all 99 unique features are extracted from the image. By using Artificial Neural Network, the system successfully detects different types of dermatological skin diseases. It consists of mainly three phases image processing, training phase, detection  and classification phase.

Pelvic schwannoma

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 84-86
Author(s):  
Sergei P. Sinchikhin ◽  
Sarkis G. Magakyan ◽  
Oganes G. Magakyan
Keyword(s):  
Auditory Nerve ◽  
World Literature ◽  
Morphological Study ◽  
Clinical Observation ◽  
Nerve Trunk ◽  
Practical Case ◽  
Surgical Volume ◽  
The World ◽  
Brain And Spinal Cord ◽  
The Brain

Relevance.A neoplasm originated from the myelonic sheath of the nerve trunk is called neurinoma or neurilemmoma, neurinoma, schwannoglioma, schwannoma. This tumor can cause compression and dysfunction of adjacent tissues and organs. The most common are the auditory nerve neurinomas (1 case per 100 000 population per year), the brain and spinal cord neurinomas are rare. In the world literature, there is no information on the occurrences of this tumor in the pelvic region. Description.Presented below is a clinical observation of a 30-year-old patient who was scheduled for myomectomy. During laparoscopy, an unusual tumor of the small pelvis was found and radically removed. A morphological study allowed to identify the remote neoplasm as a neuroma. Conclusion.The presented practical case shows that any tumor can hide under a clinical mask of another disease. The qualification of the doctor performing laparoscopic myomectomy should be sufficient to carry out, if necessary, another surgical volume.

Sign in / Sign up

Export Citation Format

Share Document