scholarly journals Therapeutic possibilities of coriaria myrtifolia L. in high dilutions

2021 ◽  
Vol 10 (36) ◽  
pp. 211-214
Author(s):  
Marcia Amoedo Cheng ◽  
Francisco José de Freitas
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Status Epilepticus ◽  
Respiratory Arrhythmia ◽  
Materia Medica ◽  
Clinical Indications ◽  
Epileptic Syndromes ◽  
High Dilutions ◽  
Clonic Seizures ◽  
Therapeutic Possibilities

Background: Homeopathy literature shows references about Coriaria myrtifolia L. at some important Homeopathic Materia Medica: Allen,TF [1], Voisin H [2] and Vijnovsky B [3]. Those reports are unsatisfactory to fulfill a contemporary standardized study basis on: origin and description, preparation, medicine general action, sensations and modalities; demanding a broader investigation. Aims: Identify therapeutic possibilities on Coriaria myrtifolia L. from ratifying and broadening the homeopathic materia medica knowledge. Methodology: Literature review on botanical, biochemical and pharmacological data [4-12]. The use of plant in various fields since XVIII century and analyzes of clinical-toxicological reports described in medical reviews published. Results: Coriaria myrtifolia L. is a toxic shrub, growing wild in western Mediterranean region. The entire plant contains a sesquiterpene-lactone called coriamyrtin, a potent convulsivant neurotoxin. Clinical manifestations of acute intoxication includes: Central Nervous System – generalized tonic-clonic seizures, recurrent, which may evolve to status epilepticus, coma, apnea and death. Respiratory Tract – respiratory depression due to anoxia, respiratory arrhythmia alternating with apnea, respiratory muscles tetanization evolving to respiratory arrest. Cardiovascular System – central excitatory action which may initially promote increased blood pressure followed by heart failure, as a result of the seizures, due to anoxia and acidosis, leading to cardiac arrest. Gastrointestinal Tract – nausea, vomiting and stomach pains that precede seizures; since there is no evidence of toxin direct action on mucosa, those symptoms may relate to Central Nervous System action (attributed to impairment of cranial nerve VIII). Knowledge of these aspects gave us possibility to build a Coriaria myrtifolia L. materia medica with broader clinical indications. Conclusion: Coriaria myrtifolia L. is a valuable source to be used in high dilutions as medicine indicated for epileptic syndromes treatment, characterized by tonic-clonic seizures, mainly presenting a malignant tendency, with recurrent seizures, which may evolve to status epilepticus and potential mortality risk. Among the clinical indications proposed stand out etiologies of great incidence at emergency rooms such as metabolic or vascular primary disorders, or resulting from systemic diseases (diabetes, hepatopathy, nephropathy), encephalitis and meningitis with or without Acquired Immunodeficiency Syndrome, withdrawal syndrome from alcohol or drugs, exogenous poisoning, poisoning or overdose of alcohol or drugs, traumatic brain injury and intracranial expanding lesions.

Ifosfamide-Induced Nonconvulsive Status Epilepticus

1995 ◽  
Vol 29 (12) ◽  
pp. 1237-1239 ◽  
Author(s):  
Ashwani Bhardwaj ◽  
Pritam S Badesha
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Status Epilepticus ◽  
Temporal Relationship ◽  
Pediatric Population ◽  
Laboratory Data ◽  
Nonconvulsive Status Epilepticus ◽  
Case Summary ◽  
History Of ◽  
Clonic Seizures

Objective: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus. Case Summary: A 71-year-old woman with a history of malignant mixed mesodermal tumor involving the uterus, cervix, and vagina was admitted because of local recurrence. After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive. Physical examination and laboratory data revealed no significant changes. An electroencephalogram was consistent with the diagnosis of nonconvulsive status epilepticus. The patient's mental status returned to baseline after treatment with intravenous phenytoin and discontinuation of ifosfamide therapy. Discussion: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population. Among CNS toxicities, generalized tonic-clonic seizures have been reported in both children and adults. This represents the first report of nonconvulsive status epilepticus induced by ifosfamide. Conclusions: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion. No other identifiable factor contributed to the unresponsiveness.

scholarly journals Central nervous system paracoccidioidomycosis. Report of a case successfully treated with Itraconazol

2000 ◽  
Vol 42 (4) ◽  
pp. 231-234 ◽  
Author(s):  
Luis A. VILLA ◽  
Angela TOBÓN ◽  
Antonio RESTREPO ◽  
Daniel CALLE ◽  
David S. ROSERO ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Improvement ◽  
Brain Biopsy ◽  
Yeast Cells ◽  
Control Drug ◽  
Antibody Titers ◽  
The Central Nervous System ◽  
Clonic Seizures ◽  
The Brain

Paracoccidioidomycosis (PCM) is a primary pulmonary infection that often disseminates to other organs and systems. Involvement of the central nervous system (CNS) is rare and due to the fact that both clinical alertness and establishment of the diagnosis are delayed, the disease progresses causing serious problems. We report here a case of neuroparacoccidioidomycosis (NPCM), observed in a 55 year-old male, who consulted due to neurological symptoms (left hemiparesis, paresthesias, right palpebral ptosis, headache, vomiting and tonic clonic seizures) of a month duration. Upon physical examination, an ulcerated granulomatous lesion was observed in the abdomen. To confirm the diagnosis a stereotactic biopsy was taken; additionally, mycological tests from the ulcerated lesion and a bronchoalveolar lavage were performed. In the latter specimens, P. brasiliensis yeast cells were visualized and later on, the brain biopsy revealed the presence of the fungus. Treatment with itraconazole (ITZ) was initiated but clinical improvement was unremarkable; due to the fact that the patient was taking sodium valproate for seizure control, drug interactions were suspected and confirmed by absence of ITZ plasma levels. The latter medication was changed to clonazepam and after several weeks, clinical improvement began to be noticed and was accompanied by diminishing P. brasiliensis antigen and antibody titers. In the PCM endemic areas, CNS involvement should be considered more often and the efficacy of itraconazole therapy should also be taken into consideration.

Central nervous system

2011 ◽  
pp. 372-383
Author(s):  
Dr Mark Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Status Epilepticus ◽  
Tricyclic Antidepressants ◽  
Opioid Analgesics ◽  
Nausea And Vomiting ◽  
Sleeping Disorders ◽  
System P

4.1 Hypnotics and anxiolytics, 373 4.2 Antipsychotics, 374 4.3 Antimania drugs, 376 4.4 Tricyclic antidepressants, 377 4.5 Nausea and vomiting (N&V), 377 4.6 Analgesics, 379 4.7 Non-opioid analgesics, 379 4.8 Opioid analgesics, 380 4.9 Antiepileptics, 382 4.10 Status epilepticus, 383 • Hypnotics - Used to treat sleeping disorders (sleeping tablets)...

scholarly journals Partial Status Epilepticus with Paradoxical Protein-Cytologic Dissociation in Cerebrospinal Fluid

2020 ◽  
Author(s):  
Neeraj Singh ◽  
John J. Lansing ◽  
Aparna Polavarapu
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Status Epilepticus ◽  
Central Nervous System Infection ◽  
Case Series ◽  
Refractory Status Epilepticus ◽  
Multiple Drug ◽  
High Morbidity ◽  
Drug Interventions

AbstractStatus epilepticus is associated with high morbidity and mortality, often requiring multiple drug interventions and intensive care monitoring. Etiology of status epilepticus plays a crucial role in the treatment, natural course and outcome of the patient, prompting extensive testing and imaging. For example, an important risk for status epilepticus in adults and children is the presence of an underlying viral or bacterial central nervous system infection, appropriate treatment of which can improve the outcome of the patient. We present three cases of new-onset refractory status epilepticus in women who did not have evidence of a central nervous system infection and had significantly elevated leukocytes compared to protein in the cerebrospinal fluid. This finding suggests an autoimmune etiology; however, standard autoimmune testing was unremarkable in all cases. This case series highlights the variability in presentation and clinical course in patients presenting with status epilepticus of unknown cause, and we discuss the importance of further research into appropriate and reliable diagnostic evaluations.

Chlorambucil-Induced Myoclonus in a Cat With Lymphoma

2003 ◽  
Vol 39 (3) ◽  
pp. 283-287 ◽  
Author(s):  
Noémi Benitah ◽  
Louis-Philippe de Lorimier ◽  
Michele Gaspar ◽  
Barbara E. Kitchell
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Side Effect ◽  
Alkylating Agent ◽  
Laboratory Animals ◽  
Intestinal Lymphoma ◽  
Potential Side Effect ◽  
Patient Reported ◽  
Clonic Seizures

Chlorambucil is an alkylating agent commonly used in veterinary oncology for conditions including lymphoma. Chlorambucil neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil. This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity. Neurotoxicity should be considered a potential side effect of chlorambucil therapy in veterinary patients.

scholarly journals A Case Of Primary Central Nervous System Vasculitis Who Presented With Status Epilepticus

2014 ◽  
Vol 20 (3) ◽  
pp. 106-111
Author(s):  
Sırma Geyik ◽  
Erman Altunışık ◽  
Mehmet Ali Elçi ◽  
Münife Neyal ◽  
Akif Şirikçi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Status Epilepticus ◽  
Central Nervous System Vasculitis

Presence of Chlamydophila psittaci DNA in the Central Nervous System of a Patient with Status Epilepticus

2003 ◽  
Vol 35 (1) ◽  
pp. 71-73 ◽  
Author(s):  
GERNOT WALDER ◽  
HANS SCHÖNHERR ◽  
HELMUT HOTZEL ◽  
CORNELIA SPETH ◽  
ALBRECHT OEHME ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Status Epilepticus ◽  
Chlamydophila Psittaci ◽  
The Central Nervous System

scholarly journals Fahr’s Syndrome and Secondary Hypoparathyroidism

2016 ◽  
Vol 54 (1) ◽  
pp. 63-65 ◽  
Author(s):  
Vitorino Modesto dos Santos ◽  
Ana Medeiros De Farias Da Mata ◽  
Kelle Regina Alves Ribeiro ◽  
Isadora Cartaxo De Sousa Calvo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Management ◽  
Typical Case ◽  
Imaging Studies ◽  
Characteristic Distribution ◽  
Mood Changes ◽  
Fahr’S Syndrome ◽  
The Central Nervous System ◽  
Clonic Seizures

A typical case of Fahr’s syndrome is described in a 76-year-old Brazilian female who underwent a total thyroidectomy three decades ago. Six years before the current admission, she started with generalized tonic-clonic seizures. Associated disorders involved extra-pyramidal, cognitive, nocturnal terror and mood changes. With suspicion of hypocalcemia due to secondary hypoparathyroidism, laboratory determinations confirmed the diagnoses. Furthermore, imaging studies of the central nervous system detected multiple calcifications, with characteristic distribution of Fahr’s syndrome. Clinical management was successful.

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