scholarly journals The Comparison of Penile Doppler Ultrasonography Findings with Serum Lipid Parameters in Hyperlipidemic Patients with Erectile Dysfunction

2021 ◽  
Author(s):  
Mustafa Taşdemir ◽  
Ünal Öztekin ◽  
Mehmet Canikoğlu ◽  
Hafize Aktaş
Keyword(s):  
Erectile Dysfunction ◽  
Erectile Function ◽  
Doppler Ultrasonography ◽  
Oral Treatment ◽  
Post Treatment ◽  
Cholesterol Levels ◽  
Before And After ◽  
Function Domain ◽  
Lipid Parameters ◽  
High Triglyceride

Objective: The aim of this study is to investigate the effect of hyperlipidemia on the development of erectile dysfunction (ED) in hyperlipidemic patients with ED. Materials and Methods: Twenty-five patients who applied to the radiology clinic were included in the study. All patients have only hyperlipidemia as a risk factor of ED. The patients were evaluated in terms of ED by using International Index of Erectile Function (IIEF) form. Before and after oral treatment with daily doses of 10 mg atorvastatin, all parameters were measured. Paired t-test was used to compare vascular velocities between lipid profiles and Erectile Function Domain Scores (EFDS) and IIEFs, before and after treatment separately. Results: Cholesterol levels of 96% of patients were higher than 200 mg/dl and 52% of them had abnormal penile Doppler ultrasonography (PDU) findings. Patients with abnormal PDU findings had lower cholesterol levels than those with normal PDU findings. Significant differences existed between patients with normal and abnormal PDU in the high triglyceride group as for pre-, and post-treatment values . Pre-, and post-treatment EFD and IIEF scores were comparable. Conclusion: It can be said that a relationship exists between hyperlipidemia and erectile dysfunction. Therefore, lipid profile of a patient admitted with ED may be analyzed routinely

­Evaluation of Immediate and Short-Term Efficacy of DualStim Therapy with and without Intracavernosal Umbilical Cord-Derived Wharton’s Jelly in Patients with Erectile Dysfunction: Study Protocol for a Pilot Randomised Controlled Trial

2020 ◽  
Author(s):  
Ashim Gupta ◽  
Hugo C. Rodriguez ◽  
Kristin Delfino ◽  
Howard J. Levy ◽  
Saadiq F. El-Amin III ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Erectile Dysfunction ◽  
Umbilical Cord ◽  
Erectile Function ◽  
Wharton’S Jelly ◽  
Post Treatment ◽  
Controlled Clinical Trial ◽  
Short Term ◽  
Wharton's Jelly ◽  
Term Efficacy

Abstract Background Erectile Dysfunction (ED) affects a significant portion of the U.S. population and causes negative psychological burdens that affects men and their partner’s quality of life and satisfaction. Extracorporeal shock therapy (ESWT) utilizing focused ESWT (fESWT) and radial ESWT (rESWT) in Low-intensity shock wave therapy (LSIWT) has been used to treat ED with some success. Wharton’s Jelly (WJ) is a biologic substance with large amounts of stem cells, growth factors, cytokines and extracellular components. The use of simultaneous fESWT and rESWT (DualStim Therapy) combined with WJ have potential uses in ED that may have advantages over current treatments. Methods A randomized, single-blinded, controlled clinical trial will be conducted to evaluate the efficacy and safety of DualStim Therapy and ICIs of WJ in moderate to severe ED. A total of 60 patients with moderate to severe ED will be enrolled and treated with DualStim Therapy with intracavernosal injection (ICIs) of WJ or saline for a period of 7 weeks. The International Index of Erectile Function – Erectile Function (IIEF-EF) score will be used to gauge the treatment related changes in relation to the subject’s baseline. The scores will be recorded at baseline and compared to follow-ups 1,3 and 6 months post-treatment. Any Adverse events (AEs) or severe AEs will be recorded in the corresponding case report forms (CRFs). Sexual Encounter Profile (SEP), as well as the Global Assessment Questionnaire (GAQ) and the Erection Hardness Score (EHS) will be used to determine the sexual activity improvement from baseline leading to optimal penetration at follow-ups 1,3 and 6 months post-treatment.Discussion This clinical trial is a feasibility study to determine the immediate and short-term efficacy of DualStim Therapy, with and without ICIs of formulated umbilical cord-derived WJ to improve and/or restore erectile function in patients with moderate to severe ED. This study will also provide insight into the safety and efficacy of WJ. We anticipate clinically significant improvement in patients suffering from moderate and severe ED treated with DualStim therapy with WJ compared to their baseline and DualStim with saline.Trial registration Registered on ClinicalTrials.gov; the trial number is NCT04424394

Effect of correcting serum cholesterol levels on erectile function in patients with vasculogenic erectile dysfunction

2008 ◽  
Vol 42 (5) ◽  
pp. 437-440 ◽  
Author(s):  
Serkan Cevdet Gokkaya ◽  
Cuneyt Ozden ◽  
Ozdem Levent Ozdal ◽  
Hasbey Hakan Koyuncu ◽  
Ozer Guzel ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Serum Cholesterol ◽  
Erectile Function ◽  
Cholesterol Levels ◽  
Vasculogenic Erectile Dysfunction

Abstract 18240: Poor Sexual Outcome Among Male ICD Patients Who Have Received Shock and Antitachycardia Pacing Therapy

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Pernille Palm Johansen ◽  
Ann-Dorthe Zwisler ◽  
Jesper Hastrup Svendsen ◽  
Selina K Berg
Keyword(s):  
Erectile Dysfunction ◽  
Primary Prevention ◽  
Secondary Prevention ◽  
Erectile Function ◽  
Test Reliability ◽  
Antitachycardia Pacing ◽  
Cross Sectional ◽  
Scale Range ◽  
Male Patients ◽  
Function Domain

Purpose: To investigate (i) the prevalence of erectile dysfunction (ED) in male patients with implantable cardioverter defibrillator (ICD), and (ii) the association between ICD, indication, therapy and poor sexual outcome. Methods: This cross-sectional study included male patients with ICD. Inclusion criteria were NYHA I-II. Exclusion criteria were no partner and no known urinary tract diseases. Participants completed the International Index of Erectile Function questionnaire that concerns sexual function and meet psychometric criteria for test reliability and validity. The study was conducted as a postal survey and questionnaires were mailed out to 818 patients from two university hospitals. Data on indication (primary prevention vs secondary prevention) and therapy (shock and antitachycardia pacing ) was collected from local databases. Results: Data from the 370 responders (response rate 45.2 %) were analyzed. Mean age of patients was 63.9 ± 12.1. International Index of Erectile Function total mean score was 39.6 ± 24.2 (scale range 5 to 75, with higher score indicating better function). The Erectile Function domain mean score was 14.5 ± SD 11.5 (Scale range 1 to 30). The Erectile Function domain was distributed between 48.9 % having severe ED, 7.6 % moderate ED, 7.0 % moderate to mild ED, 7.0 % mild ED and 29.5 % having no ED. Age was highly associated with ED (OR 0.91, 95% CI: 0.88-0.93). Adjusted for age, ED was associated with therapy from the ICD (OR 1.84, 95% CI: 1.07-3.2) and primary prevention indication (OR 1.90, 95% CI: 1.19 - 3.06) compared to patients having an ICD on secondary prevention indication. Conclusions: Erectile dysfunction was present in more than 70 % of male patients with ICD and more than 48 % had severe erectile dysfunction, resulting in inability to perform a sexual intercourse. Age, primary prevention indication and therapy from the ICD were all associated with a poor sexual outcome.

Is Erectile Dysfunction a Reliable Proxy of General Male Health Status? The Case for the International Index of Erectile Function—Erectile Function Domain

2012 ◽  
Vol 9 (10) ◽  
pp. 2708-2715 ◽  
Author(s):  
Andrea Salonia ◽  
Giulia Castagna ◽  
Antonino Saccà ◽  
Matteo Ferrari ◽  
Umberto Capitanio ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Health Status ◽  
Erectile Function ◽  
Male Health ◽  
Function Domain

scholarly journals Can Eosinophil Count, Platelet Count, and Mean Platelet Volume Be a Positive Predictive Factor in Penile Arteriogenic Erectile Dysfunction Etiopathogenesis?

2016 ◽  
Vol 11 (3) ◽  
pp. 678-683 ◽  
Author(s):  
Mehmet Giray Sönmez ◽  
Yunus Emre Göğer ◽  
Leyla Öztürk Sönmez ◽  
Arif Aydın ◽  
Mehmet Balasar ◽  
...  
Keyword(s):  
Platelet Count ◽  
Erectile Dysfunction ◽  
Predictive Factor ◽  
Blood Cells ◽  
Mean Platelet Volume ◽  
Eosinophil Count ◽  
Erectile Function ◽  
Doppler Ultrasonography ◽  
Platelet Volume ◽  
Significant Difference

Blood count parameters of patients referring with erectile dysfunction (ED) were examined in this study and it was investigated whether eosinophil count (EC), platelet count (PC), and mean platelet volume values among the suspected predictive parameters which may play a role in especially penile arteriogenic ED etiopathogenesis had a contribution on pathogenesis. Patients referring with ED complaint were evaluated. Depending on the medical story, ED degree was determined by measuring International Index of Erectile Function. Penile Doppler ultrasonography was taken in patients suspected to have vasculogenic ED. According to penile Doppler ultrasonography result, patients with arterial deficiency were included in the penile arteriogenic ED group and the patients with normal results were included in the nonvasculogenic ED group. A total of 36 patients participated in the study from the penile arteriogenic ED group and 32 patients from the nonvasculogenic ED group. Compared with the nonvasculogenic ED group, the penile arteriogenic ED group’s low International Index of Erectile Function score, high EC, mean platelet volume and PC values were detected to be statistically significant ( p < .001, p = .021, p = .018, p = .034, respectively). No statistically significant difference was observed among the two groups when age, white blood cells, red blood cells, and hemoglobin values were considered. Pansystolic volume velocities were detected as statistically significantly low compared with the nonvasculogenic ED group in the measurements made in 5th, 10th, 15th, and 20th minutes on the right and left sides in the penile arteriogenic ED group. High MPV value and PC is a significant predictive factor for penile arteriogenic ED and vasculogenic ED and high EC is specifically predictive of arteriogenic ED.

scholarly journals CHANGES IN ERECTILE FUNCTION BEFORE AND AFTER PROSTATE BIOPSY

2013 ◽  
Vol 20 (2) ◽  
Author(s):  
Wibisono Wibisono ◽  
Doddy Musbadianto Soebadi ◽  
Sabilal Alif ◽  
Widodo Pudjirahardjo
Keyword(s):  
Erectile Dysfunction ◽  
Rectal Bleeding ◽  
Prostate Biopsy ◽  
Erectile Function ◽  
Transrectal Ultrasound ◽  
Minimal Invasive ◽  
Pathological Examination ◽  
Before And After ◽  
Function Assessment

Objective: To evaluate erectile function before and after transrectal ultrasound (TRUS) guided prostate biopsy using International Index of Erectile Function-5 (IIEF-5) and Erection Hardness Score (EHS) instrument. Material & Method: We conducted a study on 17 BPH LUTS patients who underwent TRUS guided prostate biopsy from January to April 2011 in Urological Minimal Invasive Installation (IIU) Dr. Soetomo Hospital. Out of 17 patients, three patients had mild ED, while 14 other patients had normal erectile function before the procedure. After TRUS guided prostate biopsy, we performed erectile function assessment using the IIEF-5 and EHS at weeks I, II, and IV. Results: Pathological examination of all specimens from prostate biopsy results revealed BPH. There were 2 patients with hematuria and 1 patient with rectal bleeding shortly after the biopsy, which resolved spontaneously less than 24 hours. Based on the IIEF-5 there were 4 patients (23,5%) with decreased erectile function in the evaluation of first week after prostate biopsy, and it reduced to 2 patients (11,7%) whose erectile function was still decreasing in the evaluation week II, while in fourth week evaluation there was 1 patient (5,9%) with decreased erectile function. Based on EHS data obtained, there were 5 patients (29,4%) with decreased scores in evaluations week II, and in the evaluation of week IV there were no patients having erectile function problems compared with EHS data before prostate biopsy. Conclusion: TRUS guided prostate biopsy can have temporary effect on erectile function.Keywords: Erectile dysfunction, prostate biopsy, international index of erectile function-5, erection hardness score.

When should the evaluation of erectile function be done before radical prostatectomy?

2019 ◽  
Vol 86 (3) ◽  
pp. 148-151
Author(s):  
Ali Yıldız ◽  
Kaan Karamık ◽  
Yasin Aktaş ◽  
Hakan Anıl ◽  
Ekrem İslamoğlu ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Surgical Treatment ◽  
Radical Prostatectomy ◽  
Prostate Biopsy ◽  
Erectile Function ◽  
Transrectal Ultrasound ◽  
Before And After

The aim of this study is to assess the erectile function of patients before and after transrectal ultrasound prostate biopsy comparatively in order to determine the appropriate time to evaluate erectile function before radical prostatectomy. A total of 44 patients underwent transrectal ultrasound biopsy. We used the International Index of Erectile Function-5 questionnaire to assess all the patients. In total, 44 volunteered patients were included in this study. All patients were evaluated with the International Index of Erectile Function-5 questionnaire before the biopsy and at 4 weeks after the transrectal ultrasound biopsy. A total of 50% of patients were potent before the biopsy was done. A month after the biopsies, erectile dysfunction was reported by 29 of 44 patients (66%) as mild in 10 (22.7%), as mild-moderate in 14 (31.8%), as moderate in 4 (9.1%), and severe in 1 (2.3%). The differences were statistically significant in the first month of the biopsy ( p < 0.05). The effect of prostate biopsy upon the erectile function is non-negligible. However, this situation is temporary and transient. Therefore, it is recommended that the International Index of Erectile Function-5 questionnaire is to be administered prior to prostate biopsy rather than before surgical treatment.

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