scholarly journals Identification and Molecular Analysis of Respiratory Syncytial Virus In Children With Lower Respiratory Tract Infections

2021 ◽  
Author(s):  
İmran Sağlık ◽  
Dilek Çolak ◽  
Derya Mutlu ◽  
Rabia Can Sarıoğlu ◽  
Dilara İnan ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Nosocomial Infections ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
University Hospital ◽  
Nasopharyngeal Swab ◽  
Microbiological Analysis ◽  
Lower Respiratory Tract Infections ◽  
Increased Risk ◽  
Tract Infections

Objective: This study was performed with the aim to define the genotypes of RSV strains in pediatric patients with lower respiratory tract infections (LRTIs), and to evaluate their molecular correlations. Method: Nasopharyngeal swab samples were obtained from 72 patients with LRTI, between December 2012 and May 2013, in the Pediatrics Department of Akdeniz University Hospital. Twenty- eight RSV-A isolates and one RSV-B isolate were determined by real-time PCR (RealStar RSV RT-PCR, Altona Diagnostics). The part of the G gene was sequenced for genotyping 20 RSV-A strains. Nucleotide sequences were analyzed with ClustalX program (version 2.1). The phylogenetic tree was constructed with “neighbor-joining” by the using the MEGA (version 6.06) software. Results: The median age of the patients were 35 days (range: 8-6061). All RSV-A isolates were identified as genotype GA2. Eleven isolates were identical; six of them caused hospital-acquired and five communityacquired RSV infections. Six patients were considered to have nosocomial infections including 4 cases in the Neonatal Intensive Care Unit (premature), one in the Neonatal Clinics and one in the Pediatric HematologyOncology Clinics. Five of eleven identical isolates were identified in patients with community-acquired infections. Conclusion: Nosocomial and community-acquired RSV infections in our hospital were caused by RSV A GA2 subtype. Identical strains were detected in community- acquired infections in the same region, and; these strains also caused nosocomial infections. Monitoring of RSV infections, detecting of genotype with molecular microbiological analysis and applied standard isolation precautions are important in clinics at increased risk for nosocomial infections.

scholarly journals Lower Respiratory Tract Infections Associated with Rhinovirus during Infancy and Increased Risk of Wheezing during Childhood. A Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69370 ◽  
Author(s):  
Cristina O’Callaghan-Gordo ◽  
Quique Bassat ◽  
Núria Díez-Padrisa ◽  
Luis Morais ◽  
Sónia Machevo ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Lower Respiratory Tract Infections ◽  
Increased Risk ◽  
Tract Infections

scholarly journals Prevalence of Bacterial Lower Respiratory Tract Infections at a Tertiary Hospital in Jordan

10.3823/837 ◽  
2019 ◽  
Vol 9 (3) ◽  
Author(s):  
Nathir Obeidat ◽  
Isam Bsisu ◽  
Faruque Parvez ◽  
Zafrin Islam ◽  
Zaina Obeidat ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Bacterial Infections ◽  
Respiratory Tract Infections ◽  
Morbidity And Mortality ◽  
University Hospital ◽  
World Health ◽  
Lower Respiratory Tract Infections ◽  
Tract Infections

Background: Lower respiratory tract infections (LRTI) are a major cause of morbidity and mortality globally. The World Health Organization (WHO) estimates that LRTI are the most common global cause of death from infectious diseases.  However, the specific etiologic agent associated with LRTI is often unknown. Aims: We determined the bacterial infections and seasonal patterns associated with LRTI among hospitalized cases at Jordan University Hospital (JUH) for a period of five years. Methods: We conducted a multi-year study among hospitalized patients in Jordan on LRTI-associated bacterial etiology. Results: We found bacterial infections among 105 (21.1%) out of 495 LRTI patients. The most frequently identified bacteria in the LRTI patients were Staphylococcus aureus (7.7%) followed by Pseudomonas aeruginosa (5.1%). Most of the LRTI patients (95.2%) had at least one chronic disease and many were admitted to the Intensive Care Unit (16.8%). Of the 18 (3.64%) patients with LRTI who died at the hospital, 2 had a bacterial infection. We noticed a seasonal pattern of bacterial infections, with the highest prevalence during the winter months. Conclusions: Our findings suggest that early identification of bacterial agents and control of chronic disease may improve clinical management and reduce morbidity and mortality from LRTI.

STUDY OF VITAMIN D LEVELS IN CHILDREN WITH LOWER RESPIRATORY TRACT INFECTION AT CRGH AND ASSOCIATED HOSPITALS OF R.D. GARDI MEDICAL COLLEGE

2021 ◽  
pp. 57-59
Author(s):  
Nency Sahu ◽  
Mamta Dhaneria
Keyword(s):  
Vitamin D ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Vitamin D Supplementation ◽  
Study Data ◽  
Lower Respiratory Tract Infections ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Tract Infections

Background: Lower Respiratory tract infections (LRTIs) remain among the most important causes of morbidity and mortality among children. Several studies have associated vitamin D deciency with an increased risk of LRTIs. The main objective of this study is to assess the prevalence of vitamin D deciency in children from 6 months to 5 years of age with LRTI, and to evaluate the correlation between vitamin D levels and the incidence and severity of LRTI. A hospital based Material and Methods: observational study was carried out in the patients admitted for LRTI in pediatric ward of CR Gardi hospital of RDGMC from October 2018 to July 2020. A total of 70 children were included between the age group 6 months to 5 years were selected for the study. Data were entered in MS excel and analyzed by software Stata 10. Vitamin D levels were divided Results: into three categories, decient, insufcient, and sufcient. Average Vitamin D levels were 25.98ng/dl. Out of 70 children with lower respiratory tract infections 28.57% (n=20) children, had decient levels (<20ng/ml) of vitamin D, 38.57% (n=27) had insufcient levels (21-29ng/ml), while 32.86% (n=23) patients had sufcient (>30ng/ml) vitamin D levels. Vitamin D levels are found to be decient in 39% cases of LRTI, However Conclusion: 26% children had Vitamin D levels in a decient range. Since 65% of children with LRTI had either decient or insufcient levels of Vitamin D. Vitamin D should be estimated in all children with LRTI. In places where Vitamin D levels cannot be estimated Vitamin D supplementation should be given. There is a need of more studies to be done on a larger sample size to reach to a certain conclusion.

scholarly journals A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma

Thorax ◽  
2017 ◽  
Vol 73 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Evelien R van Meel ◽  
Herman T den Dekker ◽  
Niels J Elbert ◽  
Pauline W Jansen ◽  
Henriëtte A Moll ◽  
...  
Keyword(s):  
Lung Function ◽  
Respiratory Tract ◽  
Early Life ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Population Based ◽  
Lower Respiratory Tract Infections ◽  
School Aged Children ◽  
Increased Risk ◽  
Tract Infections

BackgroundEarly-life respiratory tract infections could affect airway obstruction and increase asthma risk in later life. However, results from previous studies are inconsistent.ObjectiveWe examined the associations of early-life respiratory tract infections with lung function and asthma in school-aged children.MethodsThis study among 5197 children born between April 2002 and January 2006 was embedded in a population-based prospective cohort study. Information on physician-attended upper and lower respiratory tract infections until age 6 years (categorised into ≤ 3 and >3–6 years) was obtained by annual questionnaires. Spirometry measures and physician-diagnosed asthma were assessed at age 10 years.ResultsUpper respiratory tract infections were not associated with adverse respiratory outcomes. Compared with children without lower respiratory tract infections ≤3 years, children with lower respiratory tract infections ≤3 years had a lower FEV1, FVC, FEV1:FVC and forced expiratory flow at 75% of FVC (FEF75) (Z-score (95% CI): ranging from −0.22 (−0.31 to –0.12) to −0.12 (−0.21 to −0.03)) and an increased risk of asthma (OR (95% CI): 1.79 (1.19 to 2.59)). Children with lower respiratory tract infections >3–6 years had an increased risk of asthma (3.53 (2.37 to 5.17)) only. Results were not mediated by antibiotic or paracetamol use and not modified by inhalant allergic sensitisation. Cross-lagged modelling showed that results were not bidirectional and independent of preschool wheezing patterns.ConclusionEarly-life lower respiratory tract infections ≤3 years are most consistently associated with lower lung function and increased risk of asthma in school-aged children.

scholarly journals Occupation And Occurrence of Respiratory Infections Among Adults With Newly Diagnosed Asthma

2021 ◽  
Author(s):  
Maritta S. Jaakkola ◽  
Taina K. Lajunen ◽  
Aino K. Rantala ◽  
Rachel Nadif ◽  
Jouni J.K. Jaakkola
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
Upper Respiratory Tract ◽  
Newly Diagnosed ◽  
Lower Respiratory Tract Infections ◽  
Increased Risk ◽  
Study Population ◽  
Tract Infections

Abstract Background: Work environments are potential areas for spreading respiratory infections. We hypothesized that certain occupations increase susceptibility to respiratory infections among adults with asthma. Our objective was to compare the occurrence of respiratory infections among different occupations in adults with newly diagnosed asthma.Methods: We analysed a study population of 492 working-age adults with newly diagnosed asthma who were living in the geographically defined Pirkanmaa Area in Southern Finland during a population-based Finnish Environment and Asthma Study (FEAS). The determinant of interest was occupation at the time of diagnosis of asthma. We assessed potential relations between occupation and occurrence of both upper respiratory tract infections and lower respiratory tract infections during the past 12 months. The measures of effect were incidence rate ratio (IRR) and risk ratio (RR) adjusted for age, gender, and smoking habits. Professionals, clerks, and administrative personnel formed the reference group. Results: The mean number of common colds in the study population was 1.85 (95% CI 1.70, 2.00) infections in the last 12 months. The following occupational groups showed increased risk of common colds: forestry and related workers (aIRR 2.20, 95% CI 1.15-4.23) and construction and mining (aIRR 1.67, 95% CI 1.14-2.44). The risk of lower respiratory tract infections was increased in the following groups: glass, ceramic, and mineral workers (aRR 3.82, 95% CI 2.54-5.74), fur and leather workers (aRR 2.06, 95% CI 1.01-4.20) and metal workers (aRR 1.80, 95% CI 1.04-3.10).Conclusions: We provide evidence that the occurrence of respiratory infections is related to certain occupations.

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