scholarly journals Analysis of the effect of a one-time vibrotherapy treatment on selected skin characteristics, body composition and body circumferences of women with lipodystrophy

2021 ◽  
Vol 10 (2) ◽  
pp. 79-85
Author(s):  
Anna Piotrowska ◽  
◽  
Olga Czerwińska-Ledwig ◽  
Keyword(s):  
Single Treatment ◽  
Beneficial Effects ◽  
Intense Stimulus ◽  
In Series ◽  
The Many ◽  
Vibration Parameters ◽  
Body Circumferences ◽  
Observation Protocol ◽  
Body Parameters ◽  
Optimal Effect

Lipodystrophy is a common problem that is more common in women than in men. Among the many methods of therapy, local vibrotherapy can be distinguished. However, the literature does not indicate which parameters describing the vibration stimulus show the optimal effect. The aim of the study was to indicate the vibration parameters which, after a single treatment, will affect selected skin features, composition and body circumferences of women with lipodystrophy. A study was conducted among 33 women who were divided into two groups and underwent a one-time vibration treatment with the use of low and high vibration parameters. Changes in body parameters were noticed in all women. Vibration treatments used to eliminate cellulite must be performed in series. With a single treatment, the use of a less intense stimulus may bring more beneficial effects to the skin. Studies with an extended observation protocol will indicate in the future whether these beneficial effects are adaptable.

Effects of Respiration and Gravity on Infradiaphragmatic Venous Flow in Normal and Fontan Patients

Circulation ◽  
2000 ◽  
Vol 102 (suppl_3) ◽  
Author(s):  
Tain-Yen Hsia ◽  
Sachin Khambadkone ◽  
Andrew N. Redington ◽  
Francesco Migliavacca ◽  
John E. Deanfield ◽  
...  
Keyword(s):  
Flow Rate ◽  
Rate Ratio ◽  
Venous Return ◽  
Fontan Circulation ◽  
Flow Rate Ratio ◽  
Venous Flow ◽  
Beneficial Effects ◽  
In Series ◽  
Expiratory Flow ◽  
Fontan Patients

Background —In the Fontan circulation, pulmonary and systemic vascular resistances are in series. The implications of this unique arrangement on infradiaphragmatic venous physiology are poorly understood. Methods and Results —We studied the effects of respiration and gravity on infradiaphragmatic venous flows in 20 normal healthy volunteers (control) and 48 Fontan patients (atriopulmonary connection [APC] n=15, total cavopulmonary connection [TCPC] n=30). Hepatic venous (HV), subhepatic inferior vena caval (IVC), and portal venous (PV) flow rates were measured with Doppler ultrasonography during inspiration and expiration in both the supine and upright positions. The inspiratory-to-expiratory flow rate ratio was calculated to reflect the effect of respiration, and the supine-to-upright flow rate ratio was calculated to assess the effect of gravity. HV flow depended heavily on inspiration in TCPC compared with both control and APC subjects (inspiratory-to-expiratory flow rate ratio 3.4, 1.7, and 1.6, respectively; P <0.0001). Normal PV flow was higher in expiration, but this effect was lost in TCPC and APC patients (inspiratory-to-expiratory flow rate ratio 0.8, 1.0, and 1.1, respectively; P =0.01). The respiratory influence on IVC flow was the same in all groups. Gravity decreased HV flow more in APC than in TCPC patients (supine-to-upright flow rate ratio 3.2 versus 2.1, respectively; P <0.04) but reduced PV flow equally in all groups. Conclusions —Gravity and respiration have important influences on infradiaphragmatic venous return in Fontan patients. Although gravity exerts a significant detrimental effect on lower body venous return, which is more marked in APC than in TCPC patients, the beneficial effects of respiration in TCPC patients are mediated primarily by an increase in HV flow. These effects may have important short- and long-term implications for the hemodynamics of the Fontan circulation.

The Indispensable Value of Clinical Trials in the Modernization of Traditional Chinese Medicine: 12 Years' Experience at CUHK and Future Perspectives

2014 ◽  
Vol 42 (03) ◽  
pp. 587-604 ◽  
Author(s):  
Willmann Liang ◽  
David T. Yew ◽  
Kam Lun Hon ◽  
Chun Kwok Wong ◽  
Timothy C. Y. Kwok ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Chinese Medicine ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Artery Disease ◽  
The Many

The last decade has seen a wealth of information reporting the beneficial effects of Chinese herbal medicines. While a lot more studies were done using in vitro and in vivo research platforms, much fewer investigations were conducted according to evidence-based requirements in clinical settings. The Institute of Chinese Medicine at the Chinese University of Hong Kong (CUHK) has had the opportunity to collaborate with clinicians over the years to initiate and conduct dozens of clinical trials investigating and verifying the therapeutic values of Chinese herbs in selected disease conditions. Of the many disorders, we chose to focus on those that are known for their difficulties achieving perfect results with conventional treatment methods. Examples include non-healing ulcers, allergic conditions, degenerative diseases and cancer. Protective effects of the herbs in such chronic diseases as coronary artery disease and osteoporosis were also part of our focus. Even in healthy individuals and those recovering from chemotherapy, Chinese herbs could help with the immune system and were studied in our clinical trials as well. This paper aims to highlight the important findings from these clinical studies while at the same time, stressing the indispensable value of clinical trials in modernizing the use of Chinese herbs in present-day medicine.

The Evolving Basis for the Design of Light Gauge Steel Systems

2020 ◽  
Vol 20 (13) ◽  
pp. 2041008
Author(s):  
Pinelopi Kyvelou ◽  
David A. Nethercot ◽  
Nicolas Hadjipantelis ◽  
Constantinos Kyprianou ◽  
Leroy Gardner
Keyword(s):  
Numerical Models ◽  
Numerical Approach ◽  
Superior Performance ◽  
Exact Nature ◽  
Beneficial Effects ◽  
Plate Elements ◽  
Different Types ◽  
Test Behavior ◽  
General Basis ◽  
The Many

The importance of allowing for the many different types of structural interaction that have an effect on the performance of light gauge members when used in practical situations is emphasized. A distinction is drawn between internal interactions involving the various plate elements of the steel profiles and external interactions involving the other components in the system. Although full-scale testing of representative systems can capture this behavior, the costs involved make this an impractical general basis for design; codified methods generally consider only isolated plates within members and isolated members within systems, thereby neglecting the potentially beneficial effects of both forms of interaction. Properly used, modern methods of numerical analysis offer the potential to systematically allow for both forms of interaction — provided the numerical models used have been adequately validated against suitable tests. The use of such an approach is explained and illustrated for three commonly used structural systems: roof purlins, floor beams, and columns in stud walls. In each case, it is shown that, provided sufficient care is taken, the numerical approach can yield accurate predictions of the observed test behavior. The subsequently generated large portfolio of numerical results can then provide clear insights into the exact nature of the various interactions and, thus, form the basis for more realistic design approaches that are both more accurate in their predictions and which lead to more economic designs. Building on this, modifying existing arrangements so as to yield superior performance through specific modifications is now possible. Two such examples, one in which improved interconnection between the components in a system is investigated and a second in which prestressing is shown to provide substantial enhancement for relatively small and simple changes, are presented.

scholarly journals Insights into the Phytochemistry of the Cuban Endemic Medicinal Plant Phyllanthus orbicularis: Fideloside, a Novel Bioactive 8-C-glycosyl 2,3-Dihydroflavonol

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2855 ◽  
Author(s):  
Antonio Francioso ◽  
Katrin Franke ◽  
Claudio Villani ◽  
Luciana Mosca ◽  
Maria D’Erme ◽  
...  
Keyword(s):  
2D Nmr ◽  
Major Constituent ◽  
Beneficial Effects ◽  
Tropical Plant ◽  
Antiviral Effects ◽  
Bioactive Properties ◽  
Wide Range ◽  
Ft Ir ◽  
Endemic Medicinal Plant ◽  
The Many

Phyllanthus orbicularis (Phyllanthaceae) is an endemic evergreen tropical plant of Cuba that grows in the western part of the island and is used in traditional medicine as an infusion. The aqueous extract of this plant presents a wide range of pharmacological activitiessuch as antimutagenic, antioxidant and antiviral effects. Given the many beneficial effects and the great interest in the development of new pharmacological products from natural sources, the aim of this work was to investigate the phytochemistry of this species and to elucidate the structure of the main bioactive principles. Besides the presence of several known polyphenols, the major constituent was hitherto not described. The chemical structure of this compound, here named Fideloside, was elucidated by means of HR-ESIMS/MSn, 1D/2D NMR, FT-IR, and ECD as (2R,3R)-(−)-3’,4′,5,7-tetrahydroxydihydroflavonol-8-C-β-D-glucopyranoside. The compound, as well as the plant aqueous preparations, showed promising bioactive properties, i.e., anti-inflammatory capacity in human explanted monocytes, corroborating future pharmacological use for this new natural C-glycosyl flavanonol.

scholarly journals Focal Muscle Vibration for Stroke Rehabilitation: A Review of Vibration Parameters and Protocols

2020 ◽  
Vol 10 (22) ◽  
pp. 8270
Author(s):  
Hongwu Wang ◽  
Raghuveer Chandrashekhar ◽  
Josiah Rippetoe ◽  
Mustafa Ghazi
Keyword(s):  
Stroke Rehabilitation ◽  
Web Of Science ◽  
Narrative Synthesis ◽  
Muscle Vibration ◽  
Single Treatment ◽  
Exclusion Criteria ◽  
Treatment Frequency ◽  
Session Duration ◽  
Vibration Parameters ◽  
Selection Of

In this review, we present a narrative synthesis of studies on the use of focal muscle vibration (FMV) in stroke rehabilitation with a focus on vibration device, parameters, and protocols. A search was conducted via PubMed, SCOPUS, PEDro, REHABDATA, and Web of Science using the keywords “stroke and focal vibration” or “focal muscle vibration”. Inclusion and exclusion criteria to select the articles were determined. Twenty-two articles involving FMV and stroke were included in this review. Eight different vibration devices were used in the 19 articles that reported the vibration apparatuses. The vibration frequencies ranged from 30 Hz to 300 Hz with amplitudes ranging from 0.01 mm to 2 mm. The vibration treatment frequency ranged from a single treatment to 5 days/week. The session duration ranged from 14 s to 60 min/session with a duration of a single treatment to eight weeks. Twenty different muscles were targeted with 37 different outcome measures used to assess the effects of FMV. The clinical applications of FMV were not confirmed based on available evidence. More research is needed to improve the FMV technology, guide the selection of vibration parameters, optimize the vibration dosage, and develop standardized protocols for FMV therapy in patients with stroke.

scholarly journals Translation Attenuation by Minocycline Increases Lifespan and Improves Proteostasis in Old Post-Stress-Responsive Organisms

2018 ◽  
Author(s):  
Gregory M. Solis ◽  
Rozina Kardakaris ◽  
Elizabeth R. Valentine ◽  
Liron Bar-Peled ◽  
Alice L. Chen ◽  
...  
Keyword(s):  
Protein Folding ◽  
Protein Aggregation ◽  
Relative Increase ◽  
C Elegans ◽  
Beneficial Effects ◽  
Folding Pathways ◽  
Protein Folding Pathways ◽  
The Many ◽  
Cytoplasmic Ribosomes ◽  
Post Stress

SummaryAging impairs the activation of Stress Signaling Pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficient C. elegans by targeting cytoplasmic ribosomes, preferentially attenuating translation of highly translated mRNAs. In contrast to most other longevity paradigms, minocycline inhibits rather than activates all major SSPs and extends lifespan in mutants deficient in the activation of SSPs, lysosomal or autophagic pathways. We propose that minocycline lowers the concentration of newly synthesized aggregation-prone proteins, resulting in a relative increase in protein-folding capacity without the necessity to induce protein-folding pathways. Our study suggests that in old individuals with incapacitated SSPs or autophagic pathways, pharmacological attenuation of cytoplasmic translation is a promising strategy to reduce protein aggregation. Altogether, it provides a geroprotecive mechanism for the many beneficial effects of tetracyclines in models of neurodegenerative disease.

De evolutie van het communautair gebeuren op economisch vlak : evaluatie en alternatief

Res Publica ◽  
1984 ◽  
Vol 26 (3) ◽  
pp. 323-330
Author(s):  
Jozef Maton
Keyword(s):  
National Level ◽  
Policy Instruments ◽  
Role Playing ◽  
Public Works ◽  
Federal State ◽  
High Tech ◽  
Protective Measures ◽  
Financial Responsibility ◽  
Beneficial Effects ◽  
The Many

The Belgian conflict can be compared with a game theoretical model with two groups (Flemish and Walloons) and a negative sum-game. Within each of the groups there is hierarchisation, role playing and formation ofcoalitions. On the Flemish side the main actor is the CVP, on the Walloon side it is the PS.The main objectives of the communities in the economie field are:  temporary boarding employment in depressed industries and, simultaneously, the creation of high tech industries. Policy instruments to attain those goals are : general economie measures (such as wage level, interest-rate and exchange rate); selective-protective measures ( with respect to depressed industries); selective-innovative measures (with respect to high techindustries).Why is the sum-game negative or at least suboptimal?1. Mentioned policy instruments are spread over an incoherent set of institutions on the national and regional level, with rules that are partly centralist, partly federalist, partly confederalist. This leads to a complicated, unstable set of game rules in which the financial implications of decisions are shifted from the regional to the national level and vice versa.2. Selective-protective measures are of such large size that they offset and erode the beneficial effects of general policy measures regarding wages, taxes and exchange rate.Federalism or confederalism would and should establish a new set of rules between the two regions and between regional and (con) federal state. Since a return to the ancien régime is politically unfeasible, this is the only logical way out of the present chaotic decision making process. Federalism would, inter alia, shift the financial responsibility of decisions in the field of industrial policy, education, health and public works towards the regions.This political reform requires a new constitution and therefore an agreement between the two communities. The chances for a new «talk» are presently not very high. Among the many reasons, one in particular strikes the eye : the major partner on the Flemish side, namely the Christian Democrats, have a multi-dimensional utility function, which not only is «concealed» for the others, but also undefined and unclear for the party itself.

PASSIVE COUNTERPULSATION: BIOMECHANICAL RATIONALE AND CLINICAL VALIDATION

2013 ◽  
Vol 13 (05) ◽  
pp. 1340004 ◽  
Author(s):  
IVAN CORAZZA ◽  
GIOVANNI MELANDRI ◽  
SAMUELE NANNI ◽  
EMANUELA MARCELLI ◽  
LAURA CERCENELLI ◽  
...  
Keyword(s):  
Aortic Pressure ◽  
Critical Conditions ◽  
Clinical Validation ◽  
Reservoir Pressure ◽  
Beneficial Effects ◽  
Diastolic Phase ◽  
The Mean ◽  
Intra Aortic Balloon Counterpulsation ◽  
Mean Aortic Pressure ◽  
Optimal Effect

Intra-aortic balloon counterpulsation (IABP) is the leading technique for cardiovascular support in most critical conditions. The beneficial effects of the procedure are widely known, but some drawbacks remain unsolved: high cost and controversial effect in presence of cardiac arrhythmia, both related to the control of intra-aortic balloon inflation and deflation. This paper describes the clinical validation of a completely passive solution (PIABP), which substitutes the time-controlled pumping system by a simple pressure-controlled reservoir. The test was performed on 10 patients, switching from IABP to PIABP and changing the reservoir pressure to obtain an optimal effect in terms of mean aortic pressure increase as an estimate of cardiac output. For each patient the reservoir pressure was increased in 10 mmHg steps and the aortic pressure was recorded together with electrocardiogram. The PIABP showed a positive effect in all the patients, with a significant increase of the mean aortic pressure (+6.5%, p < 0.05) and of the mean pressure of the aortic pulse diastolic phase (+7%, p < 0.05). The change of heart rate between basal and optimal effect condition was not significant. Also an unexpected, significant increase of aortic maximal pressure (8%, p < 0.05) was found. The proposed passive solution cannot be a substitute of the active one in all the situation, but may be useful in border line conditions, where the IABP is no more necessary but a ventricular support is still desirable.

Influence of myofascial therapy on painful erection – case study

Ból ◽  
2020 ◽  
Vol 21 (3) ◽  
pp. 1-6
Author(s):  
Adrian Rogala ◽  
Grażyna Brzuszkiewicz-Kuźmicka
Keyword(s):  
Pain Relief ◽  
Connective Tissue ◽  
Muscle Tone ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Trigger Points ◽  
Pelvic Pain Syndrome ◽  
Beneficial Effects ◽  
The Many

Pain during sexual intercourse in men is a well-recognized symptom that is considered in the context of sexual dysfunction. Because there is no clear definition, it can be a joint feature of chronic prostatitis, chronic pelvic pain syndrome (CPPS), or come from connective tissue. Because of the many possible causes of genitourinary pain, a multimodal approach is necessary. The aim of this study is to present the effect of myofascial therapy on chronic, unpleasant, dull pain at the level of VAS = 9, occurring during erection and ejaculation, as well as during touch of the testicle in a 35-year-old man. The patient did not have erection problems, which was confirmed by an accurate and reliable tool in the form of the International Index of Erectile Function (IIEF-5). The man received two myofascial therapies, 45 min. each, 7 days apart followed by significant improvement in pain relief (VAS = 0). The manual techniques were used to find and remove changes manifested by increased muscle tone and fascia, lack of displacement of structures relative to each other, maximum painful points, and trigger points. In the follow-up examination performed after 1, 3 and 6 months, the patient confirmed that the effects of therapy were maintained. Connective tissue may play an important role in the occurrence of genitourinary pain. Physiotherapeutic examination and usage of myofascial techniques can bring beneficial effects in the form of pain relief in the relevant region.

The Use of Trained Observers as an Evaluation Tool for a Multi-Hospital Bioterrorism Exercise

2005 ◽  
Vol 20 (3) ◽  
pp. 159-163 ◽  
Author(s):  
Kelly R. Klein ◽  
Dale C. Brandenburg ◽  
Jenny G. Atas ◽  
Ann Maher
Keyword(s):  
Value Added ◽  
Evaluation Tool ◽  
Healthcare Organizations ◽  
Independent Observer ◽  
Beneficial Effects ◽  
Evaluation Protocol ◽  
A Value ◽  
The Many ◽  
Trained Observers ◽  
Exercise Design

AbstractIntroduction:Evidence suggests that regular disaster exercises have beneficial effects on subsequent mock and actual disaster responses. The purpose of this report is to describe a multiple hospital, bioterrorism exercise, evaluated by independent observers who used an evaluation template.Methods:The overall tabletop exercise design included participation from 23 Joint Commission Accreditation of Healthcare Organizations hospitals, four health departments, and a representative from one federal agency. The exercise was evaluated by trained exercise observers utilizing an independently prepared, evaluation protocol.Results:All exercise sites successfully identified the bio-agent involved and answered after-exercise debriefing questions without much difficulty. Evaluations, in the form of an after-action report by the independent observers, commented upon the many limitations to the construct of the exercise.Conclusion:Having an independent observer group at the exercise appeared to provide a value-added benefitfor capturing subjective information and data. However, these data were not in a form conducive to statisticalanalysis. Further work is needed to create an evaluation tool that would allow for statistical analysis so that exercises can be compared and improvements can be objective.

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