The impact of Hashimoto’s disease on skin, hair, and nails

The thyroid is an odd endocrine gland located in the neck. Hashimoto’s thyroiditis is a diseases of the gland which often leads to changes in skin and its appendages. The aim of this study was to investigate the relationship between hormonal disorders due to chronic autoimmune thyroiditis and skin, hair and nails conditions. This article presents the results and conclusions of a survey conducted in a group women suffering from Hashimoto’s thyroiditis, diagnosed for at least a year. The conclusions from the questionnaire showed that Hashimoto’s disease adversely affects skin, hair and nails.

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The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s disease

BMC Cancer ◽

10.1186/1471-2407-12-610 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 52

Author(s):

Ling Zhang ◽

Hui Li ◽

Qing-hai Ji ◽

Yong-xue Zhu ◽

Zhuo-ying Wang ◽

...

Keyword(s):

Thyroid Cancer ◽

Papillary Thyroid Cancer ◽

Clinical Features ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Papillary Thyroid ◽

Hashimoto’S Disease ◽

High Prevalence ◽

Hashimoto's Disease

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Long-Term Follow-Up of Antithyroid Peroxidase Antibodies in Patients with Chronic Autoimmune Thyroiditis (Hashimoto's Thyroiditis) Treated with Levothyroxine

Thyroid ◽

10.1089/thy.2008.0008 ◽

2008 ◽

Vol 18 (7) ◽

pp. 755-760 ◽

Cited By ~ 32

Author(s):

Matthias Schmidt ◽

Michael Voell ◽

Ilka Rahlff ◽

Markus Dietlein ◽

Carsten Kobe ◽

...

Keyword(s):

Autoimmune Thyroiditis ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Chronic Autoimmune Thyroiditis ◽

Long Term Follow Up

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Hashimoto’s thyroiditis-a tertiary level hospital based study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20175077 ◽

2017 ◽

Vol 5 (12) ◽

pp. 5162

Author(s):

Ganesh Manikantan ◽

Meer M. Chisthi

Keyword(s):

Hashimoto’S Thyroiditis ◽

Indian Population ◽

Tertiary Care ◽

Hashimoto's Thyroiditis ◽

Age Group ◽

Tertiary Care Centre ◽

Hashimoto’S Disease ◽

Common Causes ◽

Hashimoto's Disease ◽

Level Hospital

Background: Hashimoto’s disease is a chronic, autoimmune form of thyroiditis and is one of the most common causes for hypothyroidism. Many studies have found an association between Hashimoto’s thyroiditis and various other thyroid pathologies, including cancers. The objectives of the study were to look for any association between Hashimoto’s thyroiditis and other forms of thyroid diseases and to analyse the pattern of patients treated with Hashimoto’s thyroiditis.Methods: This was a retrospective study conducted at a tertiary care centre from December 2008 to January 2014. Patients with Hashimoto’s thyroiditis confirmed by histology were selected as the cases. Their clinical and biochemical data and post-operative histopathological reports were collected and analysed.Results: 300 patients who underwent thyroidectomy were found to have a diagnosis of Hashimoto’s thyroiditis. 97.33% of the patients were females. Maximum patients belonged to the 31-40 age group. Of the 300 patients, 61.67% had other associated pathologies. The maximum association was with colloid goiters, followed by adenomas and malignancies. Among the malignancies, 80.65% were papillary cancers while the rest were follicular cancers. There were no cases of other malignancies associated with Hashimoto’s thyroiditis.Conclusions: Hashimoto’s thyroiditis is fairly common in the studied population, mostly among females. It is associated with other thyroid pathologies including differentiated cancers. Lymphoma is not found to be associated with Hashimoto’s disease in our population. Hashimoto’s thyroiditis thus forms a major share of goiters leading to thyroidectomy in Indian population. However, the decision to operate should be primarily governed by the associated cytology.

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Integrative Analyses of Genes Associated with Hashimoto’s Thyroiditis

Journal of Immunology Research ◽

10.1155/2021/8263829 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Kangli Qiu ◽

Kai Li ◽

Tianshu Zeng ◽

Yunfei Liao ◽

Jie Min ◽

...

Keyword(s):

Hashimoto’S Thyroiditis ◽

Therapeutic Targets ◽

Hashimoto's Thyroiditis ◽

Chronic Lymphocytic Thyroiditis ◽

Hub Genes ◽

Hashimoto’S Disease ◽

Ppi Networks ◽

New Ideas ◽

Hashimoto's Disease ◽

Key Genes

Objective. Hashimoto’s thyroiditis, also known as chronic lymphocytic thyroiditis, is a common autoimmune thyroiditis, which mostly occurs in young and middle-aged women. It can be manifested as hyperthyroidism in the early stage; hypothyroidism may appear with the progression of the disease. Studies have shown that multiple factors such as heredity, environment, and autoimmunity are involved in the pathogenesis, but the specific mechanism is not clear. In our study, we tried to find key genes and potential molecular mechanisms of Hashimoto’s thyroiditis to provide new ideas for the therapeutic targets of Hashimoto’s thyroiditis. Method. GSE138198 and GSE54958 were downloaded from the GEO database, and two datasets were combined for analysis. The combined data were normalized to identify the differentially expressed genes (DEGs), and GO and KEGG enrichment analyses were performed. Protein-protein interaction (PPI) networks and hub genes between DEGs were identified. We also used the miRWalk database to identify regulatory miRNAs associated with expressions of DEGs. Result. We identified 182 DEGs (160 upregulated and 22 downregulated) between Hashimoto’s disease patients and the healthy control group. GO analysis showed that DEGs were mostly concentrated in detection of chemical stimulus involved in sensory perception, intermediate filament cytoskeleton, and olfactory receptor activity. KEGG pathway analysis showed that DEGs were mainly related to olfactory transduction. Some members of the KRTAP family and HTR5A, KNG1, DRD3, HTR1D, TAS2R16, INSL5, TAS2R42, and GRM7 are the most important hub genes in the PPI network. In addition, we recognized that OTUD4, LLPH, and ECHDC1 were the most important hub genes in the miRNA-target gene network. Conclusion. In this study, a series of bioinformatics analyses of DEGs were performed to identify the key genes and pathways associated with Hashimoto’s thyroiditis. These genes and pathways provide a more detailed understanding of the pathogenesis of Hashimoto’s disease and provide new ideas for the therapeutic targets of Hashimoto’s thyroiditis.

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Long-Term Follow-Up of Antithyroid Peroxidase Antibodies in Patients with Chronic Autoimmune Thyroiditis (Hashimoto's Thyroiditis) Treated with Levothyroxine

Yearbook of Endocrinology ◽

10.1016/s0084-3741(09)79286-8 ◽

2009 ◽

Vol 2009 ◽

pp. 89-91

Author(s):

M. Schott

Keyword(s):

Autoimmune Thyroiditis ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Chronic Autoimmune Thyroiditis ◽

Long Term Follow Up

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Hashimoto’s Disease - Involvement of Cytokine Network and Role of Oxidative Stress in the Severity of Hashimoto’s Thyroiditis

A New Look at Hypothyroidism ◽

10.5772/30779 ◽

2012 ◽

Cited By ~ 2

Author(s):

Julieta Gerenova ◽

Irena Manolova ◽

Veselina Gadjev

Keyword(s):

Oxidative Stress ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Cytokine Network ◽

Hashimoto’S Disease ◽

Hashimoto's Disease

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Cause of Hypothyroidism in Post Iniversal Salt Iodization era in Nepal

Journal of Diabetes and Endocrine Association of Nepal ◽

10.3126/jdean.v3i1.24059 ◽

2019 ◽

Vol 3 (1) ◽

pp. 10-15

Author(s):

Sunil Pokharel

Keyword(s):

Iodine Deficiency ◽

Autoimmune Thyroiditis ◽

Subclinical Hypothyroidism ◽

Hashimoto’S Thyroiditis ◽

Statistical Significance ◽

Hashimoto's Thyroiditis ◽

Female Ratio ◽

Chronic Autoimmune Thyroiditis ◽

Salt Iodization ◽

Iodine Sufficiency

Introduction: Iodine deficiency remains the most common cause of hypothyroidism worldwide, but in areas of iodine sufficiency autoimmune disease (Hashimoto’s thyroiditis) is most common. After implementation of Universal Salt Iodization (USI) to control Iodine Deficiency Disorder(IDD), Nepal is heading towards iodine sufficiency but the prevalence of clinical and subclinical hypothyroidism is still high. So this study was done to find out either chronic autoimmune thyroiditis is the cause of clinical hypothyroidism in post universal salt iodization era of Nepal by measuring Anti-TPO antibody. Method: Newly diagnosed patients with Clinical or Sub clinical hypothyroidism by thyroid function test were included in this study. Anti-TPO antibody was measured by Elisa method, Anti-TPO >34 was considered positive. All the data’s were analyzed using SPSS software. Result: In this study 1000 patients were included, male to female ratio was 5:1. 270 patients had clinical hypothyroidism among which 230(85.1%) patients had Anti-TPO antibody positive. Among 730 patients with subclinical hypothyroidism only 220(30.1%) patients had antibody positive. Our result showed that TPO antibody was positive in clinical hypothyroidism compared to subclinical hypothyroidism with statistical significance (p<0.001). Our result also showed that clinical hypothyroidism had higher TPO value (mean 225.14) compared to subclinical hypothyroidism (74.34) with statistical significance p<0.001. Conclusion: The cause of hypothyroidism in present day Nepal is chronic autoimmune thyroiditis (Hashimoto’s thyroiditis). As we are moving from iodine deficiency status to iodine adequate or iodine excess status there might be an increased burden of thyroid disorders in Nepal due to the increased prevalence of autoimmune thyroiditis.

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