scholarly journals Hashimoto’s Disease - Involvement of Cytokine Network and Role of Oxidative Stress in the Severity of Hashimoto’s Thyroiditis

10.5772/30779 ◽  
2012 ◽  
Author(s):  
Julieta Gerenova ◽  
Irena Manolova ◽  
Veselina Gadjev
Keyword(s):  
Oxidative Stress ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Cytokine Network ◽  
Hashimoto’S Disease ◽  
Hashimoto's Disease

scholarly journals Hashimoto’s thyroiditis-a tertiary level hospital based study

2017 ◽  
Vol 5 (12) ◽  
pp. 5162
Author(s):  
Ganesh Manikantan ◽  
Meer M. Chisthi
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Indian Population ◽  
Tertiary Care ◽  
Hashimoto's Thyroiditis ◽  
Age Group ◽  
Tertiary Care Centre ◽  
Hashimoto’S Disease ◽  
Common Causes ◽  
Hashimoto's Disease ◽  
Level Hospital

Background: Hashimoto’s disease is a chronic, autoimmune form of thyroiditis and is one of the most common causes for hypothyroidism. Many studies have found an association between Hashimoto’s thyroiditis and various other thyroid pathologies, including cancers. The objectives of the study were to look for any association between Hashimoto’s thyroiditis and other forms of thyroid diseases and to analyse the pattern of patients treated with Hashimoto’s thyroiditis.Methods: This was a retrospective study conducted at a tertiary care centre from December 2008 to January 2014. Patients with Hashimoto’s thyroiditis confirmed by histology were selected as the cases. Their clinical and biochemical data and post-operative histopathological reports were collected and analysed.Results: 300 patients who underwent thyroidectomy were found to have a diagnosis of Hashimoto’s thyroiditis. 97.33% of the patients were females. Maximum patients belonged to the 31-40 age group. Of the 300 patients, 61.67% had other associated pathologies. The maximum association was with colloid goiters, followed by adenomas and malignancies. Among the malignancies, 80.65% were papillary cancers while the rest were follicular cancers. There were no cases of other malignancies associated with Hashimoto’s thyroiditis.Conclusions: Hashimoto’s thyroiditis is fairly common in the studied population, mostly among females. It is associated with other thyroid pathologies including differentiated cancers. Lymphoma is not found to be associated with Hashimoto’s disease in our population. Hashimoto’s thyroiditis thus forms a major share of goiters leading to thyroidectomy in Indian population. However, the decision to operate should be primarily governed by the associated cytology.

scholarly journals Integrative Analyses of Genes Associated with Hashimoto’s Thyroiditis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Kangli Qiu ◽  
Kai Li ◽  
Tianshu Zeng ◽  
Yunfei Liao ◽  
Jie Min ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Therapeutic Targets ◽  
Hashimoto's Thyroiditis ◽  
Chronic Lymphocytic Thyroiditis ◽  
Hub Genes ◽  
Hashimoto’S Disease ◽  
Ppi Networks ◽  
New Ideas ◽  
Hashimoto's Disease ◽  
Key Genes

Objective. Hashimoto’s thyroiditis, also known as chronic lymphocytic thyroiditis, is a common autoimmune thyroiditis, which mostly occurs in young and middle-aged women. It can be manifested as hyperthyroidism in the early stage; hypothyroidism may appear with the progression of the disease. Studies have shown that multiple factors such as heredity, environment, and autoimmunity are involved in the pathogenesis, but the specific mechanism is not clear. In our study, we tried to find key genes and potential molecular mechanisms of Hashimoto’s thyroiditis to provide new ideas for the therapeutic targets of Hashimoto’s thyroiditis. Method. GSE138198 and GSE54958 were downloaded from the GEO database, and two datasets were combined for analysis. The combined data were normalized to identify the differentially expressed genes (DEGs), and GO and KEGG enrichment analyses were performed. Protein-protein interaction (PPI) networks and hub genes between DEGs were identified. We also used the miRWalk database to identify regulatory miRNAs associated with expressions of DEGs. Result. We identified 182 DEGs (160 upregulated and 22 downregulated) between Hashimoto’s disease patients and the healthy control group. GO analysis showed that DEGs were mostly concentrated in detection of chemical stimulus involved in sensory perception, intermediate filament cytoskeleton, and olfactory receptor activity. KEGG pathway analysis showed that DEGs were mainly related to olfactory transduction. Some members of the KRTAP family and HTR5A, KNG1, DRD3, HTR1D, TAS2R16, INSL5, TAS2R42, and GRM7 are the most important hub genes in the PPI network. In addition, we recognized that OTUD4, LLPH, and ECHDC1 were the most important hub genes in the miRNA-target gene network. Conclusion. In this study, a series of bioinformatics analyses of DEGs were performed to identify the key genes and pathways associated with Hashimoto’s thyroiditis. These genes and pathways provide a more detailed understanding of the pathogenesis of Hashimoto’s disease and provide new ideas for the therapeutic targets of Hashimoto’s thyroiditis.

scholarly journals The impact of Hashimoto’s disease on skin, hair, and nails

2021 ◽  
Vol 10 (6) ◽  
pp. 277-285
Author(s):  
Olga Koczorowska-Talarczyk ◽  
◽  
Katarzyna Kordus ◽  
Keyword(s):  
Autoimmune Thyroiditis ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Endocrine Gland ◽  
Chronic Autoimmune Thyroiditis ◽  
Hashimoto’S Disease ◽  
Hashimoto's Disease ◽  
The Impact ◽  
The Relationship

The thyroid is an odd endocrine gland located in the neck. Hashimoto’s thyroiditis is a diseases of the gland which often leads to changes in skin and its appendages. The aim of this study was to investigate the relationship between hormonal disorders due to chronic autoimmune thyroiditis and skin, hair and nails conditions. This article presents the results and conclusions of a survey conducted in a group women suffering from Hashimoto’s thyroiditis, diagnosed for at least a year. The conclusions from the questionnaire showed that Hashimoto’s disease adversely affects skin, hair and nails.

Role of Pro-inflammatory biomarkers in Hashimoto's thyroiditis: A prospective study

2018 ◽  
Author(s):  
B Ramesh ◽  
B Rajesh ◽  
Reddy B Rajkiran ◽  
G Gayathri ◽  
Reddy M Venkateshwara ◽  
...  
Keyword(s):  
Prospective Study ◽  
Hashimoto’S Thyroiditis ◽  
Inflammatory Biomarkers ◽  
Hashimoto's Thyroiditis ◽  
A Prospective Study

scholarly journals Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Aleksandra Pyzik ◽  
Ewelina Grywalska ◽  
Beata Matyjaszek-Matuszek ◽  
Jacek Roliński
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
T Regulatory Cells ◽  
Hashimoto Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Regulatory Cells ◽  
Review Of Literature ◽  
Immune Disorders ◽  
Cd4 Cells ◽  
Immune Defect

This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors. The frequency of Hashimoto’s disease is a growing trend and among Caucasians it is estimated at approximately 5%. The dysfunction of the gland may be clinically evident (0.1–2% of the population) or subclinical (10–15%). The pathology is diagnosed five to ten times more often in women than men and its incidence increases with the age (the peak of the number of cases is between 45 and 65); however, it can also be diagnosed in children. The pathogenesis of Hashimoto’s thyroiditis is still not fully comprehended. In the etiology of Hashimoto thyroiditis excessively stimulated T CD4+ cells are known to play the most important role. Recent research has demonstrated an increasing role of newly discovered cells such as Th17 (CD4+IL-17+) or T regulatory cells (CD4+CD25+highFoxP3+) in the induction of autoimmune disorders. The process of programmed cell death also plays an equally important role in the pathogenesis and the development of hypothyroidism.

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