Lung Function Tests in Children with and without Sickle Cell Anaemia at South Western Nigerian Tertiary Hospitals

Sickle cell anaemia (SCA) is a common cause of morbidity and mortality in Nigerian children. Sickle cell haemoglobin disorder and carrier state have incidence at birth in Nigeria of about 2% and 25% respectively. The Chronic anaemia and recurrent vaso-occlusion in this disease condition can lead to impairment of function of body organs or systems. The knowledge on how SCA affects the lung and pulmonary tissue function in Nigerian children is inadequate. Aims: To compare lung function tests results of apparently healthy sickle cell anaemia patients recruited from tertiary hospitals in South West Nigeria with those of apparently healthy controls. Method: A comparative cross sectional study of children attending the Sickle Cell anaemia clinics of Wesley Guild Hospital, Obafemi Awolowo University Teaching Hospital Complex and Ladoke Akintola University of Technology Teaching Hospital was done. Ethical approval was obtained from the Ethical review boards of the different hospitals where the studies were conducted. Randomly selected consenting matched apparently well children and children with Sickle cell anaemia had their weights, height and Packed cell volume on the days of their clinics. In addition the Forced Expiratory Volume at one second, Forced Vital capacity and Peak expiratory flow rates were measured and recorded. The data obtained was analyzed using SPSS 12 version. Results: The total of 74 HBSS patients studied comprised of 35(43.7%) boys and 39 (52.7%) girls, giving a male to female ratio of 1: 1.1, while the 73 apparently healthy controls were made up of 39(53.4%) boys and 34(46.6%) girls, giving a male to female ratio of 1.2 : 1.0. The mean weight and BMI of the children with SCA were 24.9 ± 8.0kg and 14.4 ± 1.8m2 compared with 29.4 ± 2.9kg and 15.4 ± 1.8m2 in the apparently healthy controls. Higher values of weight and BMI in healthy controls than in the SCA subjects and statistically significant p< 0.05. The mean values of the FEV1 , FVC, PEFR and FEV percent were 1.54 ±0.51, 1.76 ± 0.45, 271.37 ± 72.20 and 87.5 ± 4.43 respectively in children with SCA as against 1.83 ± 0.61, 2.03 ± 0.65, 296.44±75.0 and 90.2 ± 5.76 respectively in the healthy controls. Higher lung function tests are statistically significant (p < 0.05). Conclusion: Children with Sickle Cell anaemia have significantly lower anthropometric measurement and lung function test values (FEV1, FVC, & PEFR) than controls. The lower lung function test values in the sickle cell anaemia patients may be as a result of the lower anthropometric measurements. Further studies need to be conducted find out why the lung function tests are lower in children with sickle cell anaemia preferably after eliminating cofounders such as anthropometry. Key words: Lung Function Tests, Sickle Cell Anaemia, Children.

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Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests

Pediatric Pulmonology ◽

10.1002/ppul.24257 ◽

2019 ◽

Vol 54 (5) ◽

pp. 610-619 ◽

Cited By ~ 1

Author(s):

Azza A. Tantawy ◽

Amira A. Adly ◽

Fatma S. E. Ebeid ◽

Eman A. Ismail ◽

Mahitab M. Hussein ◽

...

Keyword(s):

Sickle Cell Disease ◽

Lung Function ◽

Sickle Cell ◽

Pediatric Patients ◽

Surfactant Protein ◽

Pulmonary Complications ◽

Surfactant Protein D ◽

Lung Function Tests ◽

Cell Disease ◽

Function Tests

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Lung function tests in sickle cell patients

American Journal of Hematology ◽

10.1002/ajh.21378 ◽

2009 ◽

Vol 84 (5) ◽

pp. 310-310 ◽

Cited By ~ 1

Author(s):

Chloe I. Bloom ◽

Kevin Murphy ◽

Andrew R. Cummin

Keyword(s):

Lung Function ◽

Sickle Cell ◽

Lung Function Tests ◽

Function Tests

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Lung function tests in patients with sickle cell disease: A reply

American Journal of Hematology ◽

10.1002/ajh.21414 ◽

2009 ◽

Vol 84 (5) ◽

pp. 310-311

Author(s):

Eduard van Beers ◽

John-John Schnog ◽

Bart Biemond

Keyword(s):

Sickle Cell Disease ◽

Lung Function ◽

Sickle Cell ◽

Lung Function Tests ◽

Cell Disease ◽

Function Tests

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Interpretation of lung function tests in the sickle-cell haemoglobinopathies.

Thorax ◽

10.1136/thx.33.1.85 ◽

1978 ◽

Vol 33 (1) ◽

pp. 85-88 ◽

Cited By ~ 12

Author(s):

G J Miller ◽

G R Serjeant ◽

M J Saunders ◽

C Richardson ◽

R J Gilson

Keyword(s):

Lung Function ◽

Sickle Cell ◽

Lung Function Tests ◽

Function Tests

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Lung Involvement in Langerhans' Cell Histiocytosis: Prevalence, Clinical Features, and Outcome

PEDIATRICS ◽

10.1542/peds.89.3.466 ◽

1992 ◽

Vol 89 (3) ◽

pp. 466-469

Author(s):

S. Y. Ha ◽

P. Helms ◽

M. Fletcher ◽

V. Broadbent ◽

J. Pritchard

Keyword(s):

Lung Function ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Similar Proportion ◽

Lung Pathology ◽

Lung Involvement ◽

Lung Function Tests ◽

Multisystem Disease ◽

Female Ratio ◽

Function Tests

In Langerhans' cell histiocytosis, the prognostic significance of pulmonary disease is controversial. The clinical and radiological features and lung function tests of Langerhans' cell histiocytosis patients presenting to a single tertiary referral center between 1981 and 1987 were reviewed. Age at diagnosis ranged from 2 weeks to 16 years (median 1.7 years) and the male-female ratio was 2.4:1. No child presented with lung involvement alone. In 18 (40%) of 45 patients with multisystem disease there was clinical and/or radiological evidence of lung pathology. Another 6 children (13%) with normal chest roentgenograms had abnormal lung function tests, suggesting subclinical ("occult") involvement. Those with overt lung disease tended to present at a younger than average age (median 0.6 years). The most common functional disturbance was reduced lung or respiratory compliance with reduced lung volumes. Patients with and without lung involvement showed a similar pattern of involvement of other organs, with skin and bone most commonly affected. Of the 45 children with multisystem disease, 38 (84%) survived 2 to 7 years after diagnosis; there was a similar proportion of deaths in children with and without lung involvement. It is concluded that lung involvement occurs in nearly half of young children with multisystem Langerhans' cell histiocytosis but does not adversely affect outcome.

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Short-term effects of exposure to PM2.5, PM10, NO2, CO, SO2, O3 on lung function test indices among students of Tehran city, Iran

Journal of Air Pollution and Health ◽

10.18502/japh.v6i1.7606 ◽

2021 ◽

Author(s):

Siavash Kooranifar ◽

Gholamreza Alizadeh Attar ◽

Atefeh Talebi ◽

Maryam Pourashraf ◽

Razieh Rostami

Keyword(s):

Air Pollution ◽

Lung Function ◽

Lung Function Test ◽

Estimating Equation ◽

Epidemiological Studies ◽

Study Data ◽

Air Pollutant ◽

Lung Function Tests ◽

Function Tests ◽

Function Test

Introduction: The adverse health effects of air pollution have been observed in many epidemiological studies. The aim of this research was to study the effects of air pollution on pulmonary functions in schoolchildren in Tehran city. Materials and methods: Total number of 167 schoolchildren were selected to participate in this study. Data were analyzed using analysis of variance (ANOVA) and generalized estimating equation (GEE) to determine the relationship of air pollution and lung function tests. Results: The result of this study showed that there are statistically significant differences in value of air pollution between areas. The results present that concentration of O3, PM10, NO2 has a negative association with lung function tests but concentration of CO, PM2.5, and SO2 had no association with decreased lung function tests. Time variable of air pollution was not statistically significant effect on lung function test. Conclusion: In this study, we conclude that air pollution in Tehran city can be decreased lung function test indexes that may be affected by short-time exposure to air pollutant.

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A Review on Functions of Rakt Dhatu and Prana Vayu to Establish Lung Function Capacity

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol03-i01/13 ◽

2018 ◽

Vol 3 (01) ◽

Author(s):

Dr. Vishal Shamrao Patil ◽

Dr. (Mrs.) Manisha V. Bhalsing

Keyword(s):

Lung Function ◽

Functional Status ◽

Respiratory System ◽

Lung Function Tests ◽

Lung Volumes ◽

Happy Life ◽

Pathological Conditions ◽

Function Tests ◽

Forced Breathing

Lung function tests are useful in assessing the functional status of Respiratory system in both in physiological as well as pathological conditions. These are based on the measurement of volume of air breathed in and out in quite breathing & forced breathing. Air in lungs is classified in to two divisions’ lung volumes & lung capacities. Lung Capacities are the combination of two or more lung volumes. The concept of Rakt Dhatu & Vayu is important in case of respiration because Charaka says that pure blood provides the person with strength, luster & happy life because vital breath follows blood. It represents mechanism of oxygenated & deoxygenated blood & its relation with functioning capacity of Lungs. So In this article attempt has been made to review concepts regarding functions of Rakt Dhatu & Vayu to Establish Lung Function Capacity.

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