scholarly journals Quantitative analysis of astragaloside IV in traditional Chinese medicine 'Huang-Qi-Si-Wu' Capsules by HPLC/UV

2010 ◽  
Vol 19 (3) ◽  
Author(s):  
Yan-Li Zhang ◽  
Xiao-Ni Li
Keyword(s):  
Quantitative Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Astragaloside Iv

Astragaloside IV Inhibits Membrane Ca2+ Current but Enhances Sarcoplasmic Reticulum Ca2+ Release

2017 ◽  
Vol 45 (04) ◽  
pp. 863-877 ◽  
Author(s):  
Mei-Mi Zhao ◽  
Wen-Wen Lian ◽  
Zhuo Li ◽  
Dong-Xue Shao ◽  
Si-Chong Chen ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Sarcoplasmic Reticulum ◽  
Traditional Chinese Medicine ◽  
Cardiac Myocytes ◽  
Cardiac Disease ◽  
H9c2 Cells ◽  
Inhibitory Effects ◽  
Astragaloside Iv ◽  
Active Ingredients ◽  
Dependent Inactivation

Astragaloside IV (AS-IV) is one of the active ingredients in Astragalus membrananceus (Huangqi), a traditional Chinese medicine. The present study investigated the effects of AS-IV on Ca[Formula: see text] handling in cardiac myocytes to elucidate its possible mechanism in the treatment of cardiac disease. The results showed that AS-IV at 1 and 10[Formula: see text][Formula: see text]M reduced KCl-induced [Ca[Formula: see text]]i increase ([Formula: see text] from 1.33[Formula: see text][Formula: see text][Formula: see text]0.04 (control, [Formula: see text] 28) to 1.22[Formula: see text][Formula: see text][Formula: see text]0.02 ([Formula: see text], [Formula: see text] 29) and 1.22[Formula: see text][Formula: see text][Formula: see text]0.02 ([Formula: see text] 0.01, [Formula: see text]), but it enhanced Ca[Formula: see text] release from SR ([Formula: see text] from 1.04[Formula: see text][Formula: see text][Formula: see text]0.01 (control, [Formula: see text]) to 1.44[Formula: see text][Formula: see text][Formula: see text]0.03 ([Formula: see text], [Formula: see text]) and 1.60[Formula: see text][Formula: see text][Formula: see text]0.04 ([Formula: see text] 0.01, [Formula: see text]0), in H9c2 cells. Similar results were obtained in native cardiomyocytes. AS-IV at 1 and 10[Formula: see text][Formula: see text]M inhibited L-type Ca[Formula: see text] current ([Formula: see text] from [Formula: see text]4.42[Formula: see text][Formula: see text][Formula: see text]0.58 pA/pF of control to [Formula: see text]2.25[Formula: see text][Formula: see text][Formula: see text]0.12 pA/pF ([Formula: see text] 0.01, [Formula: see text] 5) and [Formula: see text]1.78[Formula: see text][Formula: see text][Formula: see text]0.28 pA/pF ([Formula: see text] 0.01, [Formula: see text] 5) respectively, when the interference of [Ca[Formula: see text]]i was eliminated due to the depletion of SR Ca[Formula: see text] store by thapsigargin, an inhibitor of Ca[Formula: see text] ATPase. Moreover, when BAPTA, a rapid Ca[Formula: see text] chelator, was used, CDI (Ca[Formula: see text]-dependent inactivation) of [Formula: see text] was eliminated, and the inhibitory effects of AS-IV on ICaL were significantly reduced at the same time. These results suggest that AS-IV affects Ca[Formula: see text] homeostasis through two opposite pathways: inhibition of Ca[Formula: see text] influx through L-type Ca[Formula: see text] channel, and promotion of Ca[Formula: see text] release from SR.

Quantitative analysis on tongue inspection in traditional Chinese medicine using optical coherence tomography

2008 ◽  
Vol 13 (1) ◽  
pp. 011004 ◽  
Author(s):  
Haixin Dong ◽  
Zhouyi Guo ◽  
Changchun Zeng ◽  
Huiqing Zhong ◽  
Yonghong He ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Optical Coherence ◽  
Tongue Inspection

scholarly journals An Approach to Rapid Determination of Tween-80 for the Quality Control of Traditional Chinese Medicine Injection by Partial Least Squares Regression in Near-Infrared Spectral Modeling

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Jin-Fang Ma ◽  
Tian-Ling Chen ◽  
Xiang-Dong Zhang ◽  
Xue Xiao ◽  
Fa-Huan Ge
Keyword(s):  
Quantitative Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Least Squares ◽  
Partial Least Squares ◽  
Near Infrared ◽  
Rapid Determination ◽  
Tween 80 ◽  
Least Squares Regression

This study established an approach to rapidly determine the Tween-80 in traditional Chinese medicine (TCM) injection by using near-infrared (NIR) spectroscopy. Totally 133 standard solutions of Tween-80 were prepared and randomly divided into calibration set and validation set, containing 109 and 24 samples, respectively. Spectral data were preprocessed and then subjected to establish a predictive model using partial least-squares (PLS). The standard error of cross validation (SECV), standard deviation of calibration (SEC), and the determination coefficient (R) of the established model were 0.0561, 0.0526, and 0.9986, respectively. The model was successfully applied to determine Tween-80 contents in 25 XBJ Injections and 40 FFSX Injections, and it produced satisfactory quantitative analysis results with average relative deviations 0.60% and 0.16%, respectively, for 25 XBJ Injections and 40 FFSX Injections, and the maximum relative deviations 8.57% and 7.60%, respectively. This work shows that NIR model displayed quite good predictive ability for Tween-80 quantitative analysis, which could potentially be applied to rapid determination of Tween-80 in the production process of TCM injections and other TCM products.

Establishment and validation of quantitative analysis of multi-components by a single marker for quality control of polygoni multiflori radix

2016 ◽  
Vol 8 (39) ◽  
pp. 7170-7176 ◽  
Author(s):  
Dan Gao ◽  
Yu-meng Li ◽  
Na Wang ◽  
Chun-yu Li ◽  
Cong-en Zhang ◽  
...  
Keyword(s):  
Quality Control ◽  
Clinical Practice ◽  
Quantitative Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Single Marker

Quality control of Traditional Chinese Medicine (TCM) is one of the biggest challenges facing its clinical practice.

An efficient, sensitive and accurate method for the detection of astragaloside IV in Chinese functional spirit by ultra-performance liquid chromatography–quadrupole-orbitrap mass spectrometry

2015 ◽  
Vol 7 (24) ◽  
pp. 10199-10206 ◽  
Author(s):  
Li Wang ◽  
Zhan Zhang ◽  
Xinyu Yu ◽  
Hongyan Zhao ◽  
Xinyue Wu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Accurate Method ◽  
Ultra Performance Liquid Chromatography ◽  
Health Food ◽  
Astragaloside Iv ◽  
Chinese White ◽  
Orbitrap Mass Spectrometry

Mainly consisting of Chinese white spirit and traditional Chinese medicine, Chinese functional spirit is a popular health food in China due to its healthy effects, such as resisting fatigue and enhancing immunity.

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