A REVIEW ARTICLE ON DUSHTA VRANA AND ITS MANAGEMENT IN AYURVEDA

2020 ◽  
Vol 8 (04) ◽  
Author(s):  
Sharad Bajaj
Keyword(s):  
Wound Healing ◽  
Foreign Body ◽  
Review Article ◽  
Scar Formation ◽  
Normal Process ◽  
Factors Affecting ◽  
Surgical Practice ◽  
Contaminated Wound ◽  
Minimal Scar

Dushta Vrana is a common encountered problem faced in surgical practice. The presence of Dushta Vrana can damage the condition of the patient with different complications and may become fatal. Factors affecting on wound are slough, infection and foreign body, which can delay the normal process of healing. A healthy wound in a heals earlier as compared to a contaminated wound. Therefore it is important to keep the wound clean during the various stages of its healing. Good wound healing with minimal scar formation with least pain effectively is the prime motto of every surgeon. Acharya Sushruta has ornately explaind six types of Dushta Vrana and management of Dushta Vrana is included by number of drugs, broadly classified into Vranashaodhana and Vrana ropana.

scholarly journals A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFECT OF SAPTACCHADA (AL-STONIA SCHOLARIS) KSHARA PRATISARANA AND JATYADI GRITHA IN DUSHTAVRANA (NON-HEALING ULCERS)

2020 ◽  
Vol 08 (11) ◽  
pp. 5004-5012
Author(s):  
Divya Maheshbhai Bhalodi ◽  
Udaya D.K.
Keyword(s):  
Wound Healing ◽  
Clinical Study ◽  
Foreign Body ◽  
Surgical Practice ◽  
Local Factors ◽  
Normal Body ◽  
Comparative Clinical Study ◽  
Life Threatening ◽  
Contaminated Wound ◽  
Minimal Scar

Dushtavrana is a commonly and often encountered problem faced in surgical practice. The presence of Dushtavrana worsens the condition of the patient with different complications which may become fatal and life threatening. Local factors on wound like slough, infection and foreign body which affect the nor-mal process of healing. A healthy and fresh wound in a normal body heals earlier with minimal scar as compared with contaminated wound. Therefore, in the present study all efforts are made towards to keep the wound clean during various stages of healing. Good wound healing with Minimal Scar formation with minimal pain effectively is the prime motto of every surgeon. Acharya Sushrutha has explained 60 proce-dures for the management of Vrana at different stage. Kshara Karma is one among them which is men-tioned by Acharya Sushrutha and which is indicated in Dushtavrana due to its Chedana, Bhedana, Lek-hana & Tridosghna properties. Which does the Shodhna of Dushtavrana.

Comparative Clinical study of Jatyadi Taila and Jatyadi Ghrita in the management of Dushta Vrana

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Rajendra Joshi ◽  
N. B. Mashetti ◽  
Rakesh Kumar Gujar
Keyword(s):  
Clinical Study ◽  
Burning Sensation ◽  
Normal Process ◽  
Surgical Practice ◽  
Local Factors ◽  
Significant Difference ◽  
Comparative Clinical Study ◽  
Group A ◽  
Contaminated Wound ◽  
Group B

Dushta Vrana is a common and frequently encountered problem faced in surgical practice. The presence of Dushta Vrana worsens the condition of the patient with different complications and may become fatal. Local factors on wound like slough, infection and foreign body, affect the normal process of healing. A healthy wound in a normal body heals earlier with a minimum scar as compared to a contaminated wound. Therefore in this study all the efforts are made to make a Dushta Vrana into a Shuddha Vrana. Once the Vrana becomes Shuddha, Ropana of the Vrana will start. The objective of the study was to evaluate the clinical efficacy of Jatyadi Taila and Jatyadi Ghrita in Dushta Vrana. Clinically diagnosed 60 Patients of Dushta Vrana were randomly divided into two groups, each consisting of 30 Patients. Group A were treated with the Jatyadi Taila and Group B was treated by Jatyadi Ghrita. The results observed was based on the relief obtained on the subjective and objective parameters taken for consideration for this study viz, size of ulcer, discharge, smell, pain, burning sensation, itching and granulation were found significant (P Lass Than 0.05). On the basis of assessment criteria and overall result of treatment, the patients of Jatyadi Taila group showed better results when compared to Jatyadi Ghrita group. Even though statistically there is no much significant difference between the two groups, but by seeing the effect on individual parameters (subjective and objective) and over all response, Jatyadi Taila seems to be effective when compared to Jatyadi Ghrita. It is having more Ropana qualities when compared to Shodhana.

Increased Oral Fibroblast Lifespan Is Telomerase-independent

2009 ◽  
Vol 88 (10) ◽  
pp. 916-921 ◽  
Author(s):  
S. Enoch ◽  
I. Wall ◽  
M. Peake ◽  
L. Davies ◽  
J. Farrier ◽  
...  
Keyword(s):  
Wound Healing ◽  
Telomeric Repeat ◽  
Scar Formation ◽  
Skin Fibroblasts ◽  
Telomeric Repeat Amplification Protocol ◽  
Phenotypic Characteristics ◽  
Amplification Protocol ◽  
Population Doublings ◽  
Minimal Scar ◽  
Mucosal Wound

Oral mucosal wound-healing is characterized by rapid re-epithelialization and remodeling, with minimal scar formation. This may be attributed to the distinct phenotypic characteristics of the resident fibroblasts. To test this hypothesis, we investigated patient-matched oral mucosal and skin fibroblasts. Compared with skin fibroblasts, oral mucosal fibroblasts had longer proliferative lifespans, underwent more population doublings, and experienced senescence later, which was directly related to longer telomere lengths within oral mucosal fibroblasts. The presence of these longer telomeres was independent of telomerase expression, since both oral oral mucosal fibroblasts and skin fibroblasts were negative for active telomerase, as assessed according to the Telomeric Repeat Amplification Protocol. This study has demonstrated that, compared with skin fibroblasts, oral mucosal fibroblasts are ‘younger’, with a more embryonic/fetal-like phenotype that may provide a notable advantage for their ability to repair wounds in a scarless fashion.

Factors Affecting Wound Healing in Individuals With Pressure Ulcers: A Retrospective Study

2018 ◽  
Vol 64 (2) ◽  
pp. 32-39 ◽  
Author(s):  
Azize Karahan ◽  
Aysel Abbasoglu ◽  
Sevcan Isik ◽  
Banu Cevik ◽  
Cigdem Saltan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Retrospective Study ◽  
Pressure Ulcers ◽  
Factors Affecting

scholarly journals Activation of NF-κB signaling via cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA common deletion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xin Zhou ◽  
Ludvig J. Backman ◽  
Patrik Danielson
Keyword(s):  
Wound Healing ◽  
Mitochondrial Dna ◽  
Scar Formation ◽  
Mitochondrial Rna ◽  
Peripheral Part ◽  
Double Stranded Rna ◽  
Corneal Wound ◽  
Biochemical Approach ◽  
Common Deletion ◽  
Underlying Mechanisms

AbstractScar formation as a result of corneal wound healing is a leading cause of blindness. It is a challenge to understand why scar formation is more likely to occur in the central part of the cornea as compared to the peripheral part. The purpose of this study was to unravel the underlying mechanisms. We applied RNA-seq to uncover the differences of expression profile in keratocytes in the central/peripheral part of the cornea. The relative quantity of mitochondrial RNA was measured by multiplex qPCR. The characterization of mitochondrial RNA in the cytoplasm was confirmed by immunofluoresence microscope and biochemical approach. Gene expression was analyzed by western blot and RT qPCR. We demonstrate that the occurrence of mitochondrial DNA common deletion is greater in keratocytes from the central cornea as compared to those of the peripheral part. The keratocytes with CD have elevated oxidative stress levels, which leads to the leakage of mitochondrial double-stranded RNA into the cytoplasm. The cytoplasmic mitochondrial double-stranded RNA is sensed by MDA5, which induces NF-κB activation. The NF-κB activation thereafter induces fibrosis-like extracellular matrix expressions and IL-8 mRNA transcription. These results provide a novel explanation of the different clinical outcome in different regions of the cornea during wound healing.

scholarly journals Clinical analysis of tracheobronchial foreign body aspiration in children: a focus on external and intrinsic factors

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Weigang Gan ◽  
Ning Xiao ◽  
Yiyuan Feng ◽  
Danmei Zhou ◽  
Juanjuan Hu ◽  
...  
Keyword(s):  
Foreign Body ◽  
Pediatric Patients ◽  
Treatment Delay ◽  
Rigid Bronchoscopy ◽  
Foreign Body Aspiration ◽  
External Factors ◽  
Factors Affecting ◽  
Intrinsic Factors ◽  
Common Location ◽  
Tracheobronchial Foreign Body

Abstract Background Tracheobronchial foreign body aspiration (TFBA) is a critical disease in children and is extremely dangerous, even life-threatening. The factors affecting the occurrence and prognosis of TFBA are complex. The purpose of this study is to examine the external and intrinsic factors affecting clinical features of TFBA in West China and propose potential effective intervention measures. Methods We retrospectively analyzed the clinical data of pediatric patients diagnosed with TFBA with foreign bodies (FBs) removed by rigid bronchoscopy under general anesthesia at the otolaryngology department from December 2017 to November 2018. The data included age, sex, clinical symptoms, type and location of FB, guardians, prehospital duration and residence of these pediatric patients. Results The ratio of males (72) to females (53) was 1.4:1. Children aged from 1 to 3 years accounted for 76% (95/125) of patients. Cough, continuous fever and dyspnea were the primary symptoms. The right primary bronchus was the most common location of FB detection by rigid bronchoscopy (67 cases, 53.6%). Organic FBs were most common in our study. Guardians of patients significantly differed in the rural (parents 16, grandparents 31) and urban (parents 52, grandparents 26) groups (χ2 = 12.583, p = 0.000). More children in the rural group than in the urban group had a treatment delay longer than 72 h. More children in the group with no history of FB aspiration (12, 25%) than in the group with prior FB aspiration had a treatment delay longer than 72 h. Conclusion Pediatric TFBA is a common emergency in otolaryngology. Age, sex, tracheobronchial anatomy and other physiological elements were defined as intrinsic factors, while guardians, residence, FB species and prehospital time were defined as external factors of TFBA. External and intrinsic factors both influence the occurrence and progression of TFBA. It is extremely important to take effective measures to control external factors, which can decrease morbidity and mortality.

SUTURE MATERIALS AND SUTURE TECHNIQUES IN AYURVEDA – A REVIEW ARTICLE

2021 ◽  
Vol 9 (4) ◽  
pp. 843-847
Author(s):  
Singh Balendra ◽  
Singh Shweta ◽  
Prasad Deveshwar ◽  
Kumar Gopesh
Keyword(s):  
Wound Healing ◽  
Surgical Training ◽  
Operative Procedure ◽  
Review Article ◽  
Experimental Surgery ◽  
Suture Materials ◽  
Living Things ◽  
Operative Surgery ◽  
Traumatic Wound ◽  
Preoperative Procedure

Seevan Karma (suturing) is the closing method of surgical or traumatic wound and also last step of every operative procedure. Among these Seevan Karma of prime importance as appropriate suturing with specified thread and nee- dle leads to fast wound healing and minimized scar formation after surgery. Acharya Sushruta described the basic tents of experimental operative surgery for surgical training. The great need of such a training and describes the methods of experimental surgery using artificial objects (Non-living things) for learning the operative procedure like suturing2. In suturing or Seevan Karma using appropriate principals and instrument also describing the indica- tion, contraindication and method (Poorva Karma – preoperative procedure, Pradhan Karma- main procedure, Paschat Karma- post suturing procedure). Keywords: Seevan Karma, Sutra, Needle, Kartari

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