The Role of Pathya - Apathya in Psoriasis w. s. r to Kushtha – A literary review.

Background: Psoriasis is a non-infectious chronic inflammatory disease of skin characterized by well-defined erythematous plaques with silvery scales having chronic fluctuatory course affecting both sex and different age groups. In India, its prevalence varies from 0.84% - 6%. Psoriasis can be correlated to different varieties of (Skin diseases) like or due to the resemblances of signs and symptoms. The etiological factors explained for can be classified as and. Each plays an important role in the manifestation of the disease. As Ayurveda emphasizes as the first line of treatment to treat a disease, so it is essential to prevent the manifestation of the disease and further to check the progression of the disease through and which the unique contributions of Ayurvedic science are. Aim & Obective: The objective of this review is to assess dietary factors which play a role in psoriasis. Discussion: The risk of dietary factors & their interactions in psoriasis is discussed. Conclusion: In this review, dietary factors which play a role in psoriasis are assessed and their potential benefit is evaluated. Keyword: Psoriasis, Kushtha, Pathya, Apathya, Ahara Vihara, Sadvritta.

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ROLE OF PATHYAPATHYA IN THE MANAGEMENT OF EKA KUSHTHA (PSORIASIS)

AYUSHDHARA ◽

10.47070/ayushdhara.v7i6.621 ◽

2021 ◽

pp. 3009-3013

Author(s):

Chandrakar Srishti ◽

Diwan Rashmi ◽

Sahu Jeevan Lal

Keyword(s):

Skin Diseases ◽

Medical Science ◽

Signs And Symptoms ◽

Lifestyle Changes ◽

First Line ◽

Basic Principles ◽

Complete Treatment ◽

Exact Etiology ◽

Busy Schedule

Ayurveda is not merely a medical science. It is a complete life science. In Ayurveda all skin diseases are described under the Kushtha, which are further divided into Maha Kushtha and Kshudra Kushtha. Eka Kushtha is one of the Kshudra Kushtha described in different Ayurvedic classics. It is Vata-Kaphaj disorder. Ekakushtha has signs and symptoms i.e., Aswedanam (absence of sweating), Mahavastu (big size lesions) and Matsyasha kalopamam (scaling) which can be compared with Psoriasis. The exact etiology of Psoriasis is not known but many precipitating factors like genetic, dietary, immunological and psychological has been found. It is spreading fast because of unsuitable lifestyle changes such as dietary pattern, busy schedule and stress. The aim is to find out safe and effective treatment for psoriasis. Ayurveda plays an important role. There are three basic principles to treat any disease in Ayurveda i.e., Shodhana, Shamana and Nidana Parivarjana. Nidana Parivarjana is considered as the first line of treatment in most of the diseases. In Ayurveda diet plays a major role in the prevention and management of the disease. Sometimes Pathya and Apathya are the complete treatment of any diseases. So the main aim of this article is to focus on etiological factors of Ekakushtha and its management by various dietary regimens described in different Ayurvedic texts.

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SHP2 promotes NETosis through ERK5 pathway and mediates the development of psoriasis

10.1101/2021.11.10.21266198 ◽

2021 ◽

Author(s):

Yang Sun ◽

Yan Ding ◽

Jiao Qu ◽

Chenyang Zhang ◽

Yuyu Zhu ◽

...

Keyword(s):

Immune Cells ◽

Experimental Verification ◽

Inflammatory Disease ◽

Therapeutic Target ◽

Tyrosine Phosphatase ◽

Skin Lesions ◽

Chronic Inflammatory Disease ◽

Potential Therapeutic Target ◽

Single Cell Rna Sequencing

Psoriasis is a chronic inflammatory disease which infiltrated a large number of neutrophils among skin lesions. Here, we investigated the contribution of tyrosine phosphatase SHP2 in neutrophils, as well as its pathogenesis in psoriasis. We combined single-cell RNA sequencing with experimental verification to declare that SHP2 in neutrophils could promote the NETs formation through the ERK5 pathway, and resulted in the infiltration of inflammatory immune cells, which leads to psoriasis. Our study provides evidence for the role of SHP2 in NETosis in the progression of psoriasis, and SHP2 may be a potential therapeutic target for the treatment of psoriasis.

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Osteoporosis in chronic inflammatory disease: the role of malnutrition

Endocrine ◽

10.1007/s12020-012-9813-x ◽

2012 ◽

Vol 43 (1) ◽

pp. 59-64 ◽

Cited By ~ 36

Author(s):

Tiziana Montalcini ◽

Stefano Romeo ◽

Yvelise Ferro ◽

Valeria Migliaccio ◽

Carmine Gazzaruso ◽

...

Keyword(s):

Inflammatory Disease ◽

Chronic Inflammatory Disease

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Role of Dysregulation of the Human Oral and Gastrointestinal Microbiome in Chronic Inflammatory Disease

Microbiome-Host Interactions ◽

10.1201/9781003037521-12 ◽

2021 ◽

pp. 157-178

Author(s):

Diana R. Cundell ◽

Manuela Tripepi

Keyword(s):

Inflammatory Disease ◽

Chronic Inflammatory Disease ◽

Gastrointestinal Microbiome

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Adjusting the role of hydroxychloroquine with or without azithromycin in patients with COVID-19

Kachestvennaya klinicheskaya praktika ◽

10.37489/2588-0519-2020-s4-53-59 ◽

2020 ◽

pp. 53-59

Author(s):

V. A. Otdelenov ◽

Yu. Yu. Kiselev ◽

K. B. Mirzaev ◽

A. V. Matveev ◽

D. A. Sychev

Keyword(s):

Potential Benefit ◽

Safety Monitoring ◽

Qt Prolongation ◽

Laboratory Monitoring ◽

Line Treatment ◽

First Line ◽

Increased Risk ◽

Outpatient Settings ◽

First Line Treatment

Taking recent publications into account, one should consider avoiding routine use of hydroxychloroquine, especially if combined with azithromycin, for COVID-19. Such treatment may be associated with the increased risk for hospital mortality and QT prolongation, while there is no documented effectiveness regarding SARS-CoV-2 clearance and outcomes. This treatment may be considered in individual cases, provided potential benefit and risks are carefully weighted, and safety monitoring is enhanced. Hydroxychloroquine safety in outpatients with COVID-19 is poorly studied and risks are increased by challenges in monitoring QT and electrolytes, hence hydroxychloroquine cannot be considered as first line treatment in outpatient settings. Such use of hydroxychloroquine is not recommended if clinical, instrumental, and laboratory monitoring are not in place.

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Skin Microbiota in Atopic Dermatitis

International Journal of PharmTech Research ◽

10.20902/ijptr.2019.130409 ◽

2020 ◽

Vol 13 (4) ◽

pp. 374-382

Author(s):

Jessica Herlianez Saiful ◽

Satya Wydya Yenny

Keyword(s):

Immune Response ◽

Atopic Dermatitis ◽

Microbial Community ◽

Immune Responses ◽

Skin Diseases ◽

Major Influence ◽

First Line ◽

Skin Microbiota ◽

Immune Mediators

In human body, the skin is the largest organ that has the function of mediating contact with the outside world and providing our body first line of defense against all kinds of pathogens, poisons and dangerous environments. The role of skin which are physical and immunological, supported by the microbial community that inhabits the skin. Skin microbiota contributes to barrier function by competing with pathogens and dealing with immune cells in the skin, to modulate local and systemic immune responses. Skin microbiota and immune mediators, for example complement system, have two-way interactions, and this shows that commensal microbes must be considered an important part of healthy skin. Many evidence shows that the composition of microbiota, especially in the intestines and also on the skin, can have a major influence on an individual's health. The influence of gut microbiota and its influence on the immune response has been widely studied, but the link of skin microbiota, immune response and certain skin diseases has not been widely discussed in the literature. Skin microbiota is expected to be affected in certain dermatological conditions, such as in psoriasis and in atopic dermatitis, which further shows the importance of the skin microbial community for human health. Understanding of skin microbiota role in pathogenesis of atopic dermatitis is still needed.

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Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting

PLoS ONE ◽

10.1371/journal.pone.0245534 ◽

2021 ◽

Vol 16 (1) ◽

pp. e0245534

Author(s):

Aasia Khaliq ◽

Resmi Ravindran ◽

Samia Afzal ◽

Prasant Kumar Jena ◽

Muhammad Waheed Akhtar ◽

...

Keyword(s):

Immune Responses ◽

Inflammatory Disease ◽

Gut Microbiome ◽

Gene Copy Number ◽

Chronic Inflammatory Disease ◽

Gene Copy ◽

Gut Health ◽

Plasma Antibody ◽

Immune Impairment

Tuberculosis (TB) is the largest infectious disease with 10 million new active-TB patients and1.7 million deaths per year. Active-TB is an inflammatory disease and is increasingly viewed as an imbalance of immune responses to M. tb. infection. The mechanisms of a switch from latent infection to active disease is not well worked out but a shift in the immune responses is thought to be responsible. Increasingly, the role of gut microbiota has been described as a major influencer of the immune system. And because the gut is the largest immune organ, we aimed to analyze the gut microbiome in active-TB patients in a TB-endemic country, Pakistan. The study revealed that Ruminococcacea, Enetrobactericeae, Erysipelotrichaceae, Bifidobacterium, etc. were the major genera associated with active-TB, also associated with chronic inflammatory disease. Plasma antibody profiles against several M. tb. antigens, as specific biomarkers for active-TB, correlated closely with the patient gut microbial profiles. Besides, bcoA gene copy number, indicative of the level of butyrate production by the gut microbiome was five-fold lower in TB patients compared to healthy individuals. These findings suggest that gut health in TB patients is compromised, with implications for disease morbidity (e.g., severe weight loss) as well as immune impairment.

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CLINICAL STUDY OF KANTKARI AVLEHA AND VASA AVLEHA IN THE MANAGEMENT OF TAMAK SHWASA W.S.R TO BRONCHIAL ASTHMA

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj08p5022020 ◽

2021 ◽

Vol p5 (02) ◽

pp. 2705-2713

Author(s):

Nishu Raina

Keyword(s):

Clinical Study ◽

Bronchial Asthma ◽

Inflammatory Disease ◽

Signs And Symptoms ◽

Chronic Inflammatory Disease ◽

Ayurvedic Medicine ◽

Dietary Control ◽

Allergic Disorder ◽

Effect Of Therapy

Asthma is a chronic inflammatory disease which causes the lining of the airways to become swollen and inflamed, which further leads to production of thick, sticky mucous. These changes further cause the airways to become narrow, making it difficult for the patient to breathe properly. In this study, efficacy of formulations like Vasavaleha and Kantakari Avaleha are studied in the patients of Tamaka Shwasa w.s.r to bronchial asthma. Tamaka Shwasa is a Yapya Vyadhi. The etiopathogenesis, signs, and symptoms of Tamaka Shwasa may be correlated with Bronchial Asthma. Each patient reacts differently to the factors that trigger asthma and are treated symptomatically. Asthma is the most common chronic allergic disorder in childhood and third leading cause of hospitalization under the age of 15 years. As it is a Kapha-Vata predominant disorder, Ayurvedic medicine may help to decrease the recurrence, improve immunity, and check symptoms naturally. With this aim, a clinical study was undertaken on two groups for a duration of 6 weeks. The Kantakari Avaleha and Vasa Avaleha were given orally, separately in both the groups. All the patients were kept under strict dietary control during the treatment. The observation on the effect of therapy was encouraging and showed less recurrence.

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