scholarly journals Hypoglycemic activity of Kaidarya Patra Choorna (Murraya koenigii linn.) in Diabetes mellitus type 2 with OHA’s

2020 ◽  
Vol 8 (06) ◽  
Author(s):  
Suraj Rawate
Keyword(s):  
Diabetes Mellitus ◽  
Modern Medicine ◽  
Hypoglycemic Agents ◽  
Placebo Control ◽  
Oral Hypoglycemic Agents ◽  
Plant Materials ◽  
Number Of Patients ◽  
Diet And Exercise ◽  
Treatment Of Diabetes ◽  
Oral Hypoglycemic Drugs

Abstract: Globally and nationally the Diabetes mellitus with its complications become the most important contemporary and challenging health problem. It should be treated with diet and exercise, typically in conjunction with oral hypoglycemic drugs (OHD) and the complications are so critical and hazardous, and oral hypoglycemic agents and insulin which is used for the treatment of diabetes mellitus by the allopathic system of medicine have numerous side effects. In spite of available treatment number of patients is on rise. It is convincing that the herbal or mineral remedies stated in ayurveda used singly or in combination have potency in the treatment of madhumeha. However, our country is indeed rich in its vast variety of flora, throught variegated physical feature of the land, extending from mountains to the oceans. The practitioners of Indian system of medicine have been using the plant materials and are claiming success in treatment of madhumeha even today. Therefore, taking a lead it will be worthwhile to reappraise the commonly used plant remedies in the treatment of madhumeha, with an unbiased scientific spirit. In Ayurveda kaidarya is mentioned as parvata nimba. Nimba is the best drug used in Prameha. Edible variety of Nimba i.e curry leaves can be useful. Kaidarya is having katu, tikta, and kashaya rasa and sheeta veerya. It pacifies vitiated kapha and pitta. Kaidarya has been used traditionally since few years for treatment of prameha. Placebo control may not be ethical in the disease hence single arm study along with modern medicine is preffered. Keywords: Diabetes mellitus, kaidarya, Oral Hypoglycemic agents

scholarly journals Diabetes Mellitus and Colon Carcinogenesis: Expectation for Inhibition of Colon Carcinogenesis by Oral Hypoglycemic Drugs

2019 ◽  
Vol 1 (2) ◽  
pp. 273-289 ◽  
Author(s):  
Junichi Kato ◽  
Yohei Shirakami ◽  
Masahito Shimizu
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Colon Carcinogenesis ◽  
Basic Research ◽  
Hypoglycemic Agents ◽  
Oral Hypoglycemic Agents ◽  
Antitumor Effects ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitors ◽  
Oral Hypoglycemic Drugs

The global deaths due to colorectal cancer and diabetes mellitus have increased by 57% and 90%, respectively. The relationship between various cancers and diabetes mellitus has been shown in multiple epidemiological studies. Hence, better management of diabetes mellitus is expected to reduce the risk of various cancers. This review focuses on colorectal cancer and aims to summarize recent findings on the antitumor effects of various oral hypoglycemic drugs on colorectal cancer and their estimated mechanisms. Of the seven classes of oral hypoglycemic agents, only metformin was found to have suppressive effects on colorectal cancer in both clinical and basic research. Clinical and basic researches on suppressing effects of glinides, dipeptidyl peptidase-4 inhibitors, thiazolidinedione, α-glucosidase inhibitors, and sodium glucose cotransporter-2 inhibitors against colon carcinogenesis have been insufficient and have not arrived at any conclusion. Therefore, further research regarding these agents is warranted. In addition, the suppressive effects of these agents in healthy subjects without diabetes should also be investigated.

An Overview on Anti Diabetic Drugs and Development

2016 ◽  
Vol 4 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Ved Prakash Singh ◽  
Keyword(s):  
Diabetes Mellitus ◽  
The United States ◽  
Insulin Analogues ◽  
Hypoglycemic Agents ◽  
Oral Hypoglycemic Agents ◽  
Related Complication ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Target Organs ◽  
Treatment Of Diabetes

Diabetes mellitus is one of the world’s major diseases and is the third leading cause of death in the United States after heart disease and cancer. In the India, about 2–6% population suffer from diabetes or related complication. Anti-diabetic drugs treat diabetes mellitus by lowering glucose levels in the blood. Mostly anti-diabetic drugs are administered orally except the insulin, exenatide, and pramlintide. There are different types of anti-diabetic drugs, and their selection depends on the nature of the diabetes, age and situation of the person, and many other factors. Treatments include the agents which increase the amount of insulin secreted by the pancreas, or increase the sensitivity of target organs to insulin, and agents which decrease the rate at which glucose is absorbed from the gastrointestinal tract. People are mainly focused on insulin, insulin analogues, oral hypoglycemic agents and various other complementary and alternate medicines to control the blood glucose levels in diabetes. The present review summarizes in brief about the drugs used for treatment of diabetes mellitus.

scholarly journals Investigations on anti-diabetic medicinal plants used by Sugali tribal inhabitants of Yerramalais of Kurnool district, Andhra Pradesh, India

2012 ◽  
Vol 4 (2) ◽  
pp. 19-24 ◽  
Author(s):  
S Khaleel Basha ◽  
G Sudarsanam ◽  
M Silar Mohammad ◽  
Niaz Parveen
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Rural Areas ◽  
Andhra Pradesh ◽  
Herbal Remedies ◽  
Eastern Ghats ◽  
Hypoglycemic Agents ◽  
Antidiabetic Activity ◽  
Oral Hypoglycemic Agents ◽  
Plant Materials

An Ethno-botanical survey was carried out among the Sugali tribes in Yerramalais of Eastern Ghats, Kurnool District, Andhra Pradesh for the exploration of antidiabetic herbal remedies. Diabetes mellitus is one of the common metabolic disorders with micro-and macrovascular complications that results in significant morbidity and mortality. It is considered as one of the five leading causes of death in the world. In Allopathy medicine no satisfactory effective therapy is still available to cure diabetes mellitus. There is increasing demand by patients to use natural products with antidiabetic activity due to side effects associated with the use of insulin and oral hypoglycemic agents. The art of herbal treatment has very deep roots in Indian culture. Even today in most of the rural areas people are depending on herbal drug systems for primary health care. The indigenous knowledge of local traditional healers and native plants used for the treatment of diabetics related health disorders were collected through questionnaire and personal interviews. A total of 10 informants with in the age group of 50 to 68 were interviewed, among them two were tribal practitioners. A total of 21 genera and 18 families were identified which are being used for the treatment of diabetes. Results depict that fresh plant materials were invariably preferred for the treatment of long term complications associated with diabetics. Anti-diabetic medicinal plants used by Sugalis have been listed along with plant parts used. The collected information's are arranged in the alphabetic order of the plant botanical name, family with the local (or) common name, and mode of use is listed. DOI: http://dx.doi.org/10.3329/sjps.v4i2.10435 S. J. Pharm. Sci. 4(2) 2011: 19-24

The Diabetic Surgical Patient

2020 ◽  
Author(s):  
Cathline Layba ◽  
Lance Griffin
Keyword(s):  
Diabetes Mellitus ◽  
Perioperative Period ◽  
The United States ◽  
Postoperative Management ◽  
Hypoglycemic Agents ◽  
Surgical Patient ◽  
Diabetic Patients ◽  
Preoperative Management ◽  
Oral Hypoglycemic Agents ◽  
Intraoperative Management

Diabetes mellitus is the seventh leading cause of death in the United States; diabetic patients have a 50% chance of undergoing a surgical procedure during their lifetime, and operations in this patient population have been associated with a reported mortality of 4% to 13%. Careful planning of operative management and perioperative care must be taken into account when scheduling surgery for diabetic patients, especially patients taking insulin or oral hypoglycemic agents. Debate continues and inconsistencies remain regarding the management of both diabetes and hyperglycemia in the surgical setting. The review covers the evaluation of the diabetic patient, preoperative management, intraoperative management, postoperative management, total parenteral nutrition and blood glucose, cardiovascular and renal assessment, infection, and special populations.  This review contains 2 figures, 5 tables, and 21 references Keywords: Glucose, Hyperglycemia, perioperative period, surgery, diabetes mellitus, surgical site infection, preoperative management, postoperative management, wound healing

scholarly journals Cost analysis study of oral hypoglycemic agents available in Nepalese market

2015 ◽  
Vol 13 (2) ◽  
pp. 6-9
Author(s):  
Binaya Shrestha
Keyword(s):  
Economic Consequences ◽  
Hypoglycemic Agents ◽  
Pharmaceutical Companies ◽  
Manufacturing Companies ◽  
Oral Hypoglycemic Agents ◽  
Price Variation ◽  
Average Percentage ◽  
Wide Range ◽  
The Difference ◽  
Oral Hypoglycemic Drugs

Introduction: Diabetes Mellitus is one of the major causes of morbidity, mortality and needs lifelong treatment. There is a wide range of variation in the prices of antidiabetic drugs marketed in Nepal. Thus, a study was planned to find out price variations in the oral hypoglycemic drugs available singly and number of manufacturing companies for each, also to evaluate the difference in cost of different brands of same active drug by calculating percentage variation of cost.Methods: Cost of a particular drug being manufactured by different companies, in the same strength and dosage forms was obtained from the price list provided by the pharmaceutical companies in Nepal and Indian Drug Review September 2013. The difference in the maximum and minimum price of the same drug manufactured by different pharmaceutical companies and percentage variation in price was calculated.Results: Percentage price variation of the commonly used drugs found was metformin (500mg) 171.42%, metformin (850mg) 128.42%, metformin (1000mg) 80%, pioglitazone (15mg) 150% pioglitazone (30mg) 188.89%, sitagliptin (50mg) 33.33%, sitagliptin (100mg) 40% acarbose (25mg) 39.58%, acarbose (50mg) 32.60%, gliclazide (80mg) 108%, gliclazide (40mg) 83.33%, glibenclamide (2.5mg) 87%, glibenclamide (5mg), 80%, glimiperide (1mg) 91.67%, glimiperide (2mg) 300%, glimiperide (3mg) 100%, glimiperide (4mg) 36.84%.Conclusion: The average percentage price variation of different brands of the same oral hypoglycemic drugs manufactured in Nepal is very wide. The appraisal and management of marketing drugs should be directed toward maximizing the benefits of therapy and minimizing negative personal and economic consequences.

scholarly journals The importance and advantages of the timely prescription of insulin to the patients with type 2 diabetes mellitus

2012 ◽  
Vol 58 (3) ◽  
pp. 56-60
Author(s):  
I R Iarek-Martynova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Therapy ◽  
Clinical Situation ◽  
Hypoglycemic Agents ◽  
Negative Consequences ◽  
Oral Hypoglycemic Agents ◽  
Adequate Treatment

The onset of insulin therapy is an important stage in the treatment of type 2 diabetes mellitus. Its timely beginning ensures better control of glycemia and reduces the negative consequences of chronic glucose cytotoxicity and lipotoxicity. The achievement and maintenance of the stable compensation of the disease are the indispensable conditions for successful prophylaxis and adequate treatment of chronic complications of diabetes mellitus. The ADA guidelines recommend to initiate insulin therapy at the early stages of the disease provided it is dictated by the clinical situation or combine it with the use of oral hypoglycemic agents if the targeted HbA1c levels fail to be reached despite the intake of one or more tableted preparations.

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