scholarly journals The Effect of 6 Week Resistance Training Program on Foxo1 Expression in Liver Cells and Glucose and Insulin Levels in Type 2 Diabetic Rats

2020 ◽  
Vol 20 (3) ◽  
pp. 328-339
Author(s):  
Esmaeil Akbari ◽  
Saqqa Farajtabar Behrestaq ◽  
Babisan Askari ◽  
◽  
◽  
...  
Keyword(s):  
Resistance Training ◽  
Training Program ◽  
Liver Cells ◽  
Diabetic Rats ◽  
Resistance Training Program ◽  
Insulin Levels ◽  
Type 2 Diabetic

scholarly journals The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

2020 ◽  
Author(s):  
Ahmad Shokrolahi Ardakani ◽  
Hossein Abednatanzi ◽  
Mandana Gholami ◽  
Nader Shakeri
Keyword(s):  
Resistance Training ◽  
Training Group ◽  
Liver Cells ◽  
Diabetic Rats ◽  
Exercise Session ◽  
P Value ◽  
Insulin Levels ◽  
And Control ◽  
Type 2 Diabetic

Objective: The aim of this study was to determine the effect of 12 weeks resistance training on G6Pase expression in liver cells, as well as glucose and insulin levels in type 2 diabetic rats. Materials and Methods: In this experimental study, 16 wistar rats were selected as the research sample. After injection of nicotinamide and streptozocin to induce diabetes, the rats were randomly divided into two groups of resistance training and control. The resistance group participated in a course of resistance training for up to 12 week in five sessions per week, with intensity of 75% and a time of 30 to 45 minutes. Finally, 48 hours after the last exercise session, G6Pase expression in liver cells, as well as glucose and insulin levels were measured in both groups. Results: Comparison of resistance and control training groups showed a decrease in glucose levels (P-value= 0.001) and increased insulin levels (P-value= 0.001). Exercise also reduced the expression of G6Pase in liver cells in the resistance training group (P-value= 0.001). Conclusion: Based on the results of the study, it is recommended that diabetics use resistance training under the supervision of a specialist to reduce the negative effects of diabetes.  

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

scholarly journals The Effect of Three Months of Resistance Training on TCF7L2 Expression in Pancreas Tissues of Type 2 Diabetic Rats

2016 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mojtaba Eizadi ◽  
Ali Asghar Ravasi ◽  
Rahman Soory ◽  
Kazem Baesi ◽  
Sirous Choobineh
Keyword(s):  
Resistance Training ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Effect of an 8-week resistance training program on cutaneous perfusion in type 2 diabetes

2006 ◽  
Vol 71 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Sheri R. Colberg ◽  
Henri K. Parson ◽  
Tanja Nunnold ◽  
Matthew T. Herriott ◽  
Aaron I. Vinik
Keyword(s):  
Type 2 Diabetes ◽  
Resistance Training ◽  
Training Program ◽  
Resistance Training Program ◽  
Cutaneous Perfusion

scholarly journals The Effect of 12 Weeks Resistance Training on FOXO1 Expression in Hepatocytes, Glucose and Insulin in Diabetic Rats- A Brief-Report

2020 ◽  
Author(s):  
Masoomeh Yarmohammadi ◽  
Laleh Behboudi ◽  
Mojtaba Eizadi
Keyword(s):  
Resistance Training ◽  
Fasting Glucose ◽  
Serum Insulin ◽  
Liver Cells ◽  
Diabetic Rats ◽  
Exercise Session ◽  
P Value ◽  
Diabetic Patients ◽  
And Control

Objective: In diabetic patients, hyperglycemia is associated with impaired FOXO signaling pathways in liver cells. This study aimed to determine the effect of resistance training on FOXO1 expression in liver hepatocytes and fasting glucose levels in type 2 diabetic rats. Materials and Methods: In this experimental study, type 2 diabetes induced by intraperitoneal injection of nicotinamide-STZ in 16 male wistar rats (220±20 g) and were randomly divided into exercise (n=8) and control (n=8) groups. Exercise group were participated in resistance training program (12 weeks, 5 days/weekly). Fasting glucose and insulin as well as FOXO1 expressioninliver hepatocytes were measured lasted exercise session of 2 groups and compared by independent T-test. Results: Compared to control group, resistance training resulted in significant decrease in fasting glucose ( P -value< 0.0001) and decrease in serum insulin ( P -value< 0.0001). However, no significant difference was found in FOXO1 expression in liver cells between exercise and control groups ( P -value: 0.725). Conclusion: Based on this data, improvement of glycemic profile in response to resistance training in diabetic rats cannot be attributed to FOXO1 expression in liver cells. This improvement may be attributed to an increase in serum insulin or other hormonal or genetic changes in response to resistance exercise, which will require further studies in this area.

scholarly journals Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Giosuè Annibalini ◽  
Francesco Lucertini ◽  
Deborah Agostini ◽  
Luciana Vallorani ◽  
Annamaria Gioacchini ◽  
...  
Keyword(s):  
Resistance Training ◽  
Training Program ◽  
Mononuclear Cells ◽  
Intervention Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Resistance Training Program ◽  
Inflammatory Status ◽  
Age Related

Type 2 diabetes (T2D) is an age-related chronic disease associated with metabolic dysregulation, chronic inflammation, and activation of peripheral blood mononuclear cells (PBMC). The aim of this study was to assess the effects of a concurrent exercise training program on inflammatory status and metabolic parameters of T2D patients. Sixteen male patients (age range 55–70) were randomly assigned to an intervention group (n=8), which underwent a concurrent aerobic and resistance training program (3 times a week; 16 weeks), or to a control group, which followed physicians’ usual diabetes care advices. Training intervention significantly improved patients’ body composition, blood pressure, total cholesterol, and overall fitness level. After training, plasma levels of adipokines leptin (−33.9%) and RBP4 (−21.3%), and proinflammatory markers IL-6 (−25.3%), TNF-α (−19.8%) and MCP-1 (−15.3%) decreased, whereas anabolic hormone IGF-1 level increased (+16.4%). All improvements were significantly greater than those of control patients. Plasma proteomic profile of exercised patients showed a reduction of immunoglobulin K light chain and fibrinogen as well. Training also induced a modulation of IL-6, IGF-1, and IGFBP-3 mRNAs in the PBMCs. These findings confirm that concurrent aerobic and resistance training improves T2D-related metabolic abnormalities and has the potential to reduce the deleterious health effects of diabetes-related inflammation.

scholarly journals Thymus praecox subsp. skorpilii var. skorpilii extract attenuates degeneration of beta-cells and reduced insulin levels in type 2 diabetic rats

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO1-5-29
Author(s):  
Ayse Nur Hazar-Yavuz ◽  
Muhammet Emin Cam ◽  
Sila Yildiz ◽  
Turgut Taskin ◽  
Saadet Alan ◽  
...  
Keyword(s):  
Beta Cells ◽  
Diabetic Rats ◽  
Insulin Levels ◽  
Type 2 Diabetic
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