scholarly journals The Effect of Resistance Training on G6Pase Gene Expression in Liver Hepatocytes, Glucose and Insulin Resistance Levels in Type 2 Diabetic Rats

2020 ◽  
Author(s):  
Ahmad Shokrolahi Ardakani ◽  
Hossein Abednatanzi ◽  
Mandana Gholami ◽  
Nader Shakeri
Keyword(s):  
Resistance Training ◽  
Training Group ◽  
Liver Cells ◽  
Diabetic Rats ◽  
Exercise Session ◽  
P Value ◽  
Insulin Levels ◽  
And Control ◽  
Type 2 Diabetic

Objective: The aim of this study was to determine the effect of 12 weeks resistance training on G6Pase expression in liver cells, as well as glucose and insulin levels in type 2 diabetic rats. Materials and Methods: In this experimental study, 16 wistar rats were selected as the research sample. After injection of nicotinamide and streptozocin to induce diabetes, the rats were randomly divided into two groups of resistance training and control. The resistance group participated in a course of resistance training for up to 12 week in five sessions per week, with intensity of 75% and a time of 30 to 45 minutes. Finally, 48 hours after the last exercise session, G6Pase expression in liver cells, as well as glucose and insulin levels were measured in both groups. Results: Comparison of resistance and control training groups showed a decrease in glucose levels (P-value= 0.001) and increased insulin levels (P-value= 0.001). Exercise also reduced the expression of G6Pase in liver cells in the resistance training group (P-value= 0.001). Conclusion: Based on the results of the study, it is recommended that diabetics use resistance training under the supervision of a specialist to reduce the negative effects of diabetes.  

scholarly journals The Effect of 12 Weeks Resistance Training on FOXO1 Expression in Hepatocytes, Glucose and Insulin in Diabetic Rats- A Brief-Report

2020 ◽  
Author(s):  
Masoomeh Yarmohammadi ◽  
Laleh Behboudi ◽  
Mojtaba Eizadi
Keyword(s):  
Resistance Training ◽  
Fasting Glucose ◽  
Serum Insulin ◽  
Liver Cells ◽  
Diabetic Rats ◽  
Exercise Session ◽  
P Value ◽  
Diabetic Patients ◽  
And Control

Objective: In diabetic patients, hyperglycemia is associated with impaired FOXO signaling pathways in liver cells. This study aimed to determine the effect of resistance training on FOXO1 expression in liver hepatocytes and fasting glucose levels in type 2 diabetic rats. Materials and Methods: In this experimental study, type 2 diabetes induced by intraperitoneal injection of nicotinamide-STZ in 16 male wistar rats (220±20 g) and were randomly divided into exercise (n=8) and control (n=8) groups. Exercise group were participated in resistance training program (12 weeks, 5 days/weekly). Fasting glucose and insulin as well as FOXO1 expressioninliver hepatocytes were measured lasted exercise session of 2 groups and compared by independent T-test. Results: Compared to control group, resistance training resulted in significant decrease in fasting glucose ( P -value< 0.0001) and decrease in serum insulin ( P -value< 0.0001). However, no significant difference was found in FOXO1 expression in liver cells between exercise and control groups ( P -value: 0.725). Conclusion: Based on this data, improvement of glycemic profile in response to resistance training in diabetic rats cannot be attributed to FOXO1 expression in liver cells. This improvement may be attributed to an increase in serum insulin or other hormonal or genetic changes in response to resistance exercise, which will require further studies in this area.

scholarly journals Effect of Eight Weeks Resistance Training On Gene Expression of TNF-Α and IL10 in the Heart of Type II Diabetic Male Rats

2019 ◽  
Author(s):  
Zahra Soltanian ◽  
Behnaz Vanaky ◽  
Nasrin Ramezani ◽  
Nader Shakeri ◽  
Zahra Shams ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Resistance Training ◽  
Training Group ◽  
Heart Tissue ◽  
Diabetic Rats ◽  
Male Rats ◽  
Inflammatory Factors ◽  
Tnf Α ◽  
Type 2 Diabetic

Introduction: Type 2 diabetes has many complications, including cardiovascular disease, which is associated with an increase in inflammatory biomarkers. Research has shown that physical activity can reduce inflammatory factors and improve cardiovascular disease. The purpose of this study was to investigate the effect of resistance exercise on some of the inflammatory and anti-inflammatory factors in the heart tissue of type 2 diabetic rats. Methods: In this study, 18 male rats were selected. Rats were diabetic with nicotinamide and streptozotocin (stz) and then randomly divided into 2 groups of control (n=9) and training (n=9). The training group performed a resistance training program for 8 weeks, 5 days a week. Measurement of TNF-α and IL10 expression in the heart tissue was determined using the one step SYBR TAKARA single-step kit. To compare the difference between the mean of variables between exercise and control groups, independent t-test and t-test were used also to determine the effect of diabetes induction on variables. To determine the relationship between variables, Pearson correlation coefficient and separation correlation coefficient were used. Data were analyzed by SPSS software version 22. Results: The results showed that the insulin resistance index decreased significantly in the training group compared to the control group. On the other hand, the expression of TNF-α gene decreased and IL10 showed a significant increase (α≤0.05). Conclusion: The results indicate that resistance training may be effective in modulating the inflammatory factors of TNF-α and IL10 in the heart tissue of type 2 diabetic rats. Type 2 diabetes, Heart, Resistance training, Inflammatory factors.

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

scholarly journals What is Important For You (WIFY) dan Life Map berbasis Goal Attaintment Model terhadap Self Care Behaviour pada Pasien Diabetes Melitus Tipe 2

2019 ◽  
Vol 12 (1) ◽  
pp. 1-11
Author(s):  
Kusnanto Kusnanto ◽  
Moh Zen Arifin ◽  
Ira Suarilah ◽  
Hidayat Arifin
Keyword(s):  
Goal Attainment ◽  
Self Care ◽  
Control Group ◽  
P Value ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
Type 2 Diabetic ◽  
Care Behavior

Introduction: Diabetes mellitus was an uncurable metabolic disease but it can be controlled. Diabetes can be controlled independently by diabetic with diabetes self-care behavior. Self-care behavior was challenge problem causing in adherence in majority diabetic clients especially in Persadia Darmo Hospital. Method: Research design was Quasy-Experiment study among type 2 diabetic client. This study involved 30 samples taken by purposive sampling. The independent variable were What is Important For You (WIFY) and Life Map. The dependent variable was self-care behavior. Data were taken by using SDSCA questionnaire then analyzed by using t-test with a= £0.05. Result and Analyze: WIFY and Life Map change self-care behavior in treatment group before and after treatment significantly with p value = 0,024. There was significant difference between treatment and control group of self-care behavior with p value = 0,029. Discussion: It could be concluded that application of WIFY and Life Map with goal attainment model increase self-care behavior in type 2 diabetic clients. The use of this approach could be optimizing diabetic counseling and education for clients. Further research to investigate WIFY and Life map effect on blood glucose level and HbA1c test in Type 2 Diabetic.

scholarly journals The Effect of Three Months of Resistance Training on TCF7L2 Expression in Pancreas Tissues of Type 2 Diabetic Rats

2016 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mojtaba Eizadi ◽  
Ali Asghar Ravasi ◽  
Rahman Soory ◽  
Kazem Baesi ◽  
Sirous Choobineh
Keyword(s):  
Resistance Training ◽  
Diabetic Rats ◽  
Type 2 Diabetic

scholarly journals Impact of Beta-Blocker Treatment and the Nutritional Status on Glycemic Response During Exercise in Type 2 Diabetic Patients

2007 ◽  
Vol 30 (3) ◽  
pp. 26
Author(s):  
A. Ferland ◽  
P. Brassard ◽  
S. Croteau ◽  
S. Lemieux ◽  
J. Bergeron ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Nutritional Status ◽  
Beta Blocker ◽  
Exercise Session ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Insulin Levels ◽  
Fasted State ◽  
Type 2 Diabetic

Background/Objective: More than 60% of type 2 diabetic individuals present with hypertension and have higher risk of cardiac complications. In addition to behavioural modifications, such as healthy food choices and regular physical activity, beta-blocker (BB) treatment may be considered in order to reduce morbidity and mortality especially following a cardiovascular event. However, this medication is generally associated with a deleterious impact on glucose metabolism. To assess the impact of a BB treatment on glucose response in type 2 diabetic patients exempt of cardiovascular complications. Methods: Six sedentary men, treated with diet and/or a hypoglycemic agent performed four exercise sessions at 60% of their VO2 peak, in the fasted state or 2 hours after a standardized breakfast, with and without BB (Atenolol 100 mg id for five consecutive days). Blood samples were assayed during the resting period, at 15-minutes intervals during the exercise session and the recovery period. Results: A reduction of blood glucose levels was observed following the exercise session performed in the postabsorptive state (41% and 37% reduction with and without BB treatment respectively; P < 0.01). One hour of exercise performed in the fasted state had minimal impact on glucose and insulin levels, with or without BB. BB treatment was not associated with increased baseline blood glucose or insulin levels in the fasted or the postabsorptive situation. Conclusion: These results suggest that the nutritional status has a more important impact on plasma glucose and insulin modulation than short-term use of BB per se.

scholarly journals Thymus praecox subsp. skorpilii var. skorpilii extract attenuates degeneration of beta-cells and reduced insulin levels in type 2 diabetic rats

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO1-5-29
Author(s):  
Ayse Nur Hazar-Yavuz ◽  
Muhammet Emin Cam ◽  
Sila Yildiz ◽  
Turgut Taskin ◽  
Saadet Alan ◽  
...  
Keyword(s):  
Beta Cells ◽  
Diabetic Rats ◽  
Insulin Levels ◽  
Type 2 Diabetic
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