Thermodynamic Properties of Rifampicin Redox Current Peaks in Human Blood Samples Using Nano-Sensor (Carbon Nanotubes / Glassy Carbon Electrode)

2021 ◽  
Vol 43 (1) ◽  
pp. 41-41
Author(s):  
Sura Ali AL ASADI Sura Ali AL ASADI ◽  
Muhammed Mizher RADHI and Wisam Hindawi HOIDY Muhammed Mizher RADHI and Wisam Hindawi HOIDY
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Human Blood ◽  
Electrochemical Technique ◽  
Activation Entropy ◽  
Carbon Electrode ◽  
Different Temperatures ◽  
Human Blood Samples ◽  
The Impact

The cyclic voltammetric electrochemical technique was utilized to investigate the effect of different temperatures on the redox current peaks of rifampicin (RF), a drug commonly used to treat many diseases including tuberculosis (TB), in vitro for human blood medium. A modified working electrode of glassy carbon electrode (GCE) with carbon nanotube (CNT) (CNT / GCE) was used as a sensitive nano-sensor to evaluate the impact of temperature on the blood medium in the presence of RF ions. The results confirmed the presence of two oxidation and one reduction current peaks of RF in blood medium at 0.5, 1, and -0.5 V respectively. The redox current peaks of RF ions in blood medium were enhanced with increasing the temperature from 20 to 36oC. The activation energy (E*) values were determined by applying Arrhenius equation with oxidative and anti-oxidative peaks of Ea*(Ipa)= 9.252 and 11.026 kJ.mol-1.K-1,respectively. Other thermodynamic functions such as the change in each of activation Enthalpy (ΔH*), activation Gibbs energy (ΔG*) and activation Entropy (ΔS*) values were estimated using Eyring equation. The present results of the effects of different temperatures on the blood status in presence of RF lead to the explanation of the oxidative stress of the drug which used in an inflammatory of blood at different temperature.

Thermodynamic Properties of Rifampicin Redox Current Peaks in Human Blood Samples Using Nano-Sensor (Carbon Nanotubes / Glassy Carbon Electrode)

2021 ◽  
Vol 43 (1) ◽  
pp. 41-41
Author(s):  
Sura Ali AL ASADI Sura Ali AL ASADI ◽  
Muhammed Mizher RADHI and Wisam Hindawi HOIDY Muhammed Mizher RADHI and Wisam Hindawi HOIDY
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Human Blood ◽  
Electrochemical Technique ◽  
Activation Entropy ◽  
Carbon Electrode ◽  
Different Temperatures ◽  
Human Blood Samples ◽  
The Impact

The cyclic voltammetric electrochemical technique was utilized to investigate the effect of different temperatures on the redox current peaks of rifampicin (RF), a drug commonly used to treat many diseases including tuberculosis (TB), in vitro for human blood medium. A modified working electrode of glassy carbon electrode (GCE) with carbon nanotube (CNT) (CNT / GCE) was used as a sensitive nano-sensor to evaluate the impact of temperature on the blood medium in the presence of RF ions. The results confirmed the presence of two oxidation and one reduction current peaks of RF in blood medium at 0.5, 1, and -0.5 V respectively. The redox current peaks of RF ions in blood medium were enhanced with increasing the temperature from 20 to 36oC. The activation energy (E*) values were determined by applying Arrhenius equation with oxidative and anti-oxidative peaks of Ea*(Ipa)= 9.252 and 11.026 kJ.mol-1.K-1,respectively. Other thermodynamic functions such as the change in each of activation Enthalpy (ΔH*), activation Gibbs energy (ΔG*) and activation Entropy (ΔS*) values were estimated using Eyring equation. The present results of the effects of different temperatures on the blood status in presence of RF lead to the explanation of the oxidative stress of the drug which used in an inflammatory of blood at different temperature.

Impact Deposition of Radon Progeny (218Po ,214Po and 210Po) on the Surface of Human Blood: In Vitro Study

2011 ◽  
Vol 110-116 ◽  
pp. 2004-2009 ◽  
Author(s):  
Asaad Hamid Ismail ◽  
Mohamad S. Jaafar
Keyword(s):  
Human Blood ◽  
Radon Concentration ◽  
Absorbed Dose ◽  
Blood Component ◽  
Good Efficiency ◽  
Present Design ◽  
Human Blood Samples ◽  
The Impact ◽  
Exposure Technique

This work presented new irradiation technique to estimate the impact of radon's progeny deposition on the human blood surface on some blood diseases, using CR-39Nuclear Track Detectors (NTDs). The results show that the present design has good efficiency and the loss rate of radon concentration was a little. Amount of the loss of radon concentration during the process of mixing blood component did not affect on the efficiency of exposure technique. Therefore, method of mixing blood component process was successful. As well as, human blood exposure to radon gas (2210±5.1Bq/m3) make thrombocytopenia, and no effect on red blood cell. And rate of radon absorbed dose into the human blood samples is high at 20 minutes.

scholarly journals Electrografting of 4-Carboxybenzenediazonium on Glassy Carbon Electrode: The Effect of Concentration on the Formation of Mono and Multilayers

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4575
Author(s):  
Sereilakhena Phal ◽  
Kenichi Shimizu ◽  
Daniel Mwanza ◽  
Philani Mashazi ◽  
Andrey Shchukarev ◽  
...  
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Photoelectron Spectroscopy ◽  
Diazonium Salt ◽  
Oxidation Potential ◽  
Carbon Surface ◽  
Carbon Electrode ◽  
Number Of Layers ◽  
The Impact

Grafting of electrodes with diazonium salts using cyclic voltammetry (CV) is a well-established procedure for surface modification. However, little is known about the effect of the concentration of the diazonium salt on the number of layers grafted on the electrode surface. In this work, the impact of concentration on the grafting of 4-carboxybenzenediazonium (4-CBD) onto a glassy carbon electrode (GCE) is elucidated. The number of layers grafted on the GCE was linearly dependent on the concentration of 4-CBD and varied between 0.9 and 4.3 when the concentration was varied between 0.050 and 0.30 mmol/L at 0.10 V.s−1. Characterization of modified glassy carbon surface with X-ray photoelectron spectroscopy (XPS) confirmed the grafting of carboxyphenyl layer on the surface. Grafting with 0.15 mmol/L 4-CBD (1 CV cycle) did not form a detectable amount of carboxyphenyl (CP) moieties at the surface, while a single scan with higher concentration (2.5 mmol/L) or multiple scans (22 cycles) gave detectable signals, indicating formation of multilayers. We also demonstrate the possibility of removing the thin layer grafted on a glassy carbon electrode by applying high oxidation potential +1.40 V.

FLOWER-LIKE NANOPARTICLES OF Pt–BiIII ASSEMBLED ON AGMATINE SULFATE MODIFIED GLASSY CARBON ELECTRODE AND THEIR ELECTROCATALYSIS OF H2O2

2015 ◽  
Vol 22 (03) ◽  
pp. 1550043 ◽  
Author(s):  
MINGSHU XIAO ◽  
YUHUA YAN ◽  
KAI FENG ◽  
YANPING TIAN ◽  
YUQING MIAO
Keyword(s):  
Electron Microscopy ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Pt Nanoparticles ◽  
Standard Addition ◽  
Electrochemical Technique ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Addition Method ◽  
Scanning Electron

A new electrochemical technique to detect hydrogen peroxide ( H 2 O 2) was developed. The Pt nanoparticles and Bi III were subsequently assembled on agmatine sulfate (AS) modified glassy carbon electrode (GCE) and the prepared GCE–AS- Pt – Bi III was characterized by scanning electron microscopy (SEM) with result showing that the flower-like nanostructure of Pt – Bi III was yielded. Compared with Pt nanoparticles, the flower-like nanostructure of Pt – Bi III greatly enhanced the electrocatalysis of GCE–AS- Pt – Bi III towards H 2 O 2, which is ascribed to more Pt – OH obtained on GCE–AS- Pt – Bi III surface for the presence of Bi III . Based on its high electrocatalysis, GCE–AS- Pt – Bi III was used to determine the content of H 2 O 2 in the sample of sheet bean curd with standard addition method. Meantime, its electrocatalytic activity also was studied.

scholarly journals ELECTROCHEMICAL SENSORS BASED ON POLY (L-PHENYL ALANINE) FILM ON MWCNT FOR DETERMINATION OF TPS

2020 ◽  
Vol 17 (35) ◽  
pp. 579-590
Author(s):  
A. M. Al-Jawadi EMAN ◽  
I. Majeed MOHAMMED
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Sensors ◽  
Deposition Potential ◽  
Electrochemical Technique ◽  
Equilibration Time ◽  
Carbon Electrode ◽  
Scan Rate ◽  
The Stability ◽  
Phenyl Alanine

In this study, cyclic voltammetry (CV) is presented with a sensitive electrochemical technique for the assessment of the anti-cancer medicine Toposar (TPS). The electrode was formed on the surface of a modified glassy carbon electrode with MWCNT using a coating of L-phenyl alanine to become the new electrode in a formula (PPA-MWCNT/GCE). PPA was polymerized at pH 8.0, which showed advanced advantages for the study and estimation of TPS electroanalysis treatment. A group of factors on the bare glassy carbon electrode were studied to enhance the electrode 's work to study TPS, including these factors(Influence of pH, calibration curve, the stability of the electrode, scan rate, deposition potential, voltage step, equilibration time, deposition time). As a result of the electrode development, the stability of the prepared electrode was observed with the PPA layer with the Morphology of the layer by the SEM analysis showing the morphology of PPA/GCE and MWCNTs/PPA/GCE by SEM, respectively. The PPA film width on TPS response has higher sensitivity on the surface of MWCNTs/PPA/GCE compared to GCE and increased redox reversibility with 8 cycles number. The CV of 5.0 nM TPS on GCE with scanning rates of between 50 and 400 mV.s?1 This reaction was predicted for an irrevocable electrode mechanism. A comparison was made between the TPS CVs on the MWCNPs, and the PPA modified electrode with the bare GCE at pH 7.0 with a scan rate of 100 mV.s?1, the oxidation current is 11.18 times higher than the comparable one on the bare GCE.

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