scholarly journals Tetracyclic Heteroaromatic Systems-Synthesis of Ethoxycarbonylphenylpyrido[3',2':5,6] Thiopyranoquinolines

2021 ◽  
Vol 64 (3) ◽  
pp. 191-194
Author(s):  
Muhammad Naeem Khan ◽  
Misbahul Ain Khan ◽  
Noreen Aslam ◽  
Pir Bakhsh Khan ◽  
Ehsan ul Haq
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Mass Spectra ◽  
Ethyl Pyruvate ◽  
Analysis Data ◽  
Elemental Analysis Data

7-benzylideneamino-5H-thiochromeno[2,3-b]pyridin-5-ones and 9-benzylideneamino-5H-thio- chromeno[2,3-b]pyridin-5-ones, on reaction with ethyl pyruvate to afford 1-ethoxycarbonyl-3-phenyl-12H- pyrido[3',2':5,6]thiopyrano[3,2-f]quinoline-12-ones and 4-ethoxycarbonyl-2-phenyl-7H- pyrido[3',2':5,6]thiopyrano[3,2-h]quinoline-7-ones respectively by the two different methods. These products were precipitated by addition of ethanol, water (1:1), were purified by recrystalizing from appropriate solvents and were characterized from their IR, 1H-NMR, mass spectra and elemental analysis data.  

scholarly journals The synthesis and characterization of some new diazoamino derivatives

2010 ◽  
Vol 16 (1) ◽  
pp. 89-95
Author(s):  
Mihaela Mocanu
Keyword(s):  
1H Nmr ◽  
Bioactive Compounds ◽  
Elemental Analysis ◽  
Analysis Data ◽  
Biological Properties ◽  
Synthesis And Characterization ◽  
Elemental Analysis Data ◽  
Spectral Measurements ◽  
Inflammatory Processes

The sulfonamidic moiety is much encountered in structures of bioactive compounds. In the present paper the studies on the sulfonamidated aryloxyalkylcarboxylic acids are extended by their attaching on certain substrata able to confer some special biological properties to the final products, such as anti-tumor and antioxidant actions useful in treating inflammatory processes, ulcer, convulsions and diabetes, as well as a herbicidal action. The stepwise syntheses of the sulfonamidated aryloxyalkylcarboxylic acid derivatives and their characterization by elemental analysis data and IR, 1H-NMR and UV-Vis spectral measurements are described. The newly obtained compounds could show potential pharmaceutical and herbicide properties.

scholarly journals Synthesis some 4-substituted 9,10-anthraquinones

2020 ◽  
Vol 8 (1) ◽  
pp. 58-65
Author(s):  
Vasyl Shupeniuk ◽  
Tetyana Taras ◽  
Oksana Sabadakh ◽  
Eugene Luchkevich ◽  
Yurii Kornii
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Coupling Reaction ◽  
13C Nmr Spectroscopy ◽  
Analysis Data ◽  
Elemental Analysis Data ◽  
Ullmann Coupling

New 4-substituted 9,10-anthraquinones (6 compouds) with amino derivations fragments were synthesized through the substitution of the bromaminic acid by amines using the Ullmann coupling reaction. The structures of the synthesized compounds were determined using LC-MS, 1H NMR, 13C NMR spectroscopy, and elemental analysis data.

scholarly journals Synthesis and study of the anticancer activity of some new 7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazines

2021 ◽  
Vol 14 (3) ◽  
pp. 320-327
Author(s):  
I. I. Myrko ◽  
T. I. Chaban ◽  
V. V. Ohurtsov ◽  
I. V. Drapak ◽  
V. S. Matiichuk
Keyword(s):  
Nmr Spectroscopy ◽  
Anticancer Activity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Anticancer Agents ◽  
1H Nmr Spectroscopy ◽  
Analysis Data ◽  
Elemental Analysis Data ◽  
Tumor Cell Death ◽  
Secondary Stage

The problem of finding effective low-toxic anticancer agents is one of the most important in modern medicine and pharmacy. Despite a large selection of anticancer drugs and a variety of mechanisms of their action, the effectiveness of existing drugs continues to be insufficient. Among the numerous natural and synthetic heterocyclic compounds that exhibit anticancer activity, 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives, which are able to initiate different pathways of tumor cell death. Based on this, the synthesis of new derivatives of this class of compounds and the study of their anticancer properties is relevant. The aim of the work is to synthesis of new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and study their anticancer activity. Materials and methods. It was used methods of organic synthesis, physical and chemical methods of analysis organic compounds (1H NMR spectroscopy, elemental analysis). Results. In order to obtain new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, the interaction implemented of 4-amino-4H-[1,2,4]triazole-3-thiols with the corresponding bromoacetophenones. The reaction proceeds by heating the above reagents in alcohol with the closure of the thiadiazine ring and the formation of 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine systems. The structure of all synthesized compounds was confirmed by 1H NMR spectroscopy and elemental analysis data. The study of the anticancer activity of the synthesized compounds was carried out in the framework of the international scientific program DTP (Developmental Therapeutics Program) of the National Cancer Institute (NCI, Bethesda, Maryland, USA). It was found that the synthesized compounds exhibited different levels of anticancer activity. The most active among the tested substances was compound 3j with an average GP value of 28.73. The most sensitive to it were the lines of melanoma MDA-MB-435 and SK-MEL-2, kidney cancer A498 and RXF 393, CNS cancer SNB-75, and non-small cell lung cancer NCI-H522. The secondary stage of studies of this compound confirmed its high anticancer activity against most cancer cell lines. Conclusions. As a result of the interaction of 4-amino-4H-[1,2,4]triazole-3-thiols with the relevant bromoacetophenones, a series of new triazolo[3,4-b][1,3,4]thiadiazines was not described in the literature was synthesized. Testing the synthesized compounds for the antitumor activity made it possible to isolate 1 highly active compound with a pronounced anticancer effect, which in terms of activity approaches or exceeds the known drugs 5-fluorouracil (5-FU) and cisplatin, as well as an anticancer agent, curcumin.  

Synthesis and Anticonvulsant Activity of 3-(alkylamino, alkoxy)-1,3,4,5- Tetrahydro-2H-benzo [b] azepine-2-one Derivatives

2018 ◽  
Vol 17 (6) ◽  
pp. 448-457 ◽  
Author(s):  
Xia Huang ◽  
Tie Chen ◽  
Rong-Bi Han ◽  
Feng-Yu Piao
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Anticonvulsant Activity ◽  
Mass Spectra ◽  
Maximal Electroshock ◽  
Test Compound ◽  
Maximal Electroshock Test ◽  
Mes Test ◽  
Structure Activity

Background & Objective: A series of novel 3-Substituted-1,3,4,5-Tetrahydro-2H-benzo [b] azepine-2-one Derivatives (4, 5, 7, 10, 12, 5a-j, 8a-e) were synthesized from 1,2,3,4-Tetrahydro-1- naphthalenone. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR, MASS spectra and elemental analysis. Their anticonvulsant activity was evaluated by the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scPTZ) test, and their neurotoxicity was evaluated by the rotarod neurotoxicity test. Compound 4 showed the maximum anticonvulsant activity against the maximal electroshock test (ED50=26.4, PI =3.2) and against the subcutaneous pentylenetetrazol test (ED50=40.2, PI =2.1). Conclusion: Possible structure-activity relationship was discussed.

Electrical Conductivity of Chloro(phenyl)glyoxime and Its Co(II), Ni(II) and Cu(II) Complexes

2003 ◽  
Vol 68 (7) ◽  
pp. 1233-1242 ◽  
Author(s):  
Orhan Turkoglu ◽  
Mustafa Soylak ◽  
Ibrahim Belenli
Keyword(s):  
Electrical Conductivity ◽  
Temperature Dependence ◽  
Electric Conductivity ◽  
Crystal Structures ◽  
Elemental Analysis ◽  
Analysis Data ◽  
Elemental Analysis Data ◽  
The Stability ◽  
Xrd Patterns ◽  
Metal Ligand

Chloro(phenyl)glyoxime, a vicinal dioxime, and its Ni(II), Cu(II) and Co(II) complexes were prepared. XRD patterns of the complexes point to similar crystal structures. IR and elemental analysis data revealed the 1:2 metal-ligand ratio in the complexes. The Co(II) complex is a dihydrate. Temperature dependence of electrical conductivity of the solid ligand and its complexes was measured in the temperature range 25-250 °C; it ranged between 10-14-10-6 Ω-1 cm-1 and increased with rising temperature. The activation energies were between 0.61-0.80 eV. The Co(II) complex has lower electric conductivity than the Ni(II) and Cu(II) complexes. This difference in the conductivity has been attributed to differences in the stability of the complexes.

Synthesis and anticancer evaluation of some coumarin and azacoumarin derivatives

2021 ◽  
Vol 23 (2) ◽  
pp. 27-34
Author(s):  
Safyah B. Bakare
Keyword(s):  
Carboxylic Acid ◽  
Elemental Analysis ◽  
Biological System ◽  
Analysis Data ◽  
Elemental Analysis Data ◽  
Coumarin Derivatives ◽  
Anti Cancer ◽  
Analgesic Agents ◽  
Mcf 7

Abstract Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones and lactams, respectively, which are indispensable heterocyclic units to both chemists and biochemists. 1-Aza coumarin derivatives, which ultimately metabolize as the corresponding 8-hydroxy coumarins in the biological system are therefore found to be very good anti-inflammatory, anti-cancer, and analgesic agents. A series of hybrid substituted coumarin and azacoumarin-3-carboxylic acid derivatives (8-methoxycoumarin-3-carboxylic acid (4a), 8-methoxyazacoumarin-3-carboxylic acid (4b), 5-bromo-8-methoxycoumarin-3-carboxylic acid (5a), 5-bromo-8-methoxyazacoumarin-3-carboxylic acid (5b), 2-acetoxy-5-bromo-8-methoxyquinoline-3-carboxylic acid (6), and 5,7-di(phenylazo)-8-methoxycoumarin-3-carboxylic acid (7) were synthesized and structurally proved using spectral and elemental analysis data. Substituted coumarin-3-carboxylic acid (4a and 5a) and Substituted azacoumarin-3-carboxylic acid (4b, 5b and 6) were tested for their in vitro cytotoxic activity against MCF-7 and HepG-2 cell lines.

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