scholarly journals The Diagnostic and Prognostic Role of Serum MicroRNAs in Ovarian Cancer

2018 ◽  
Vol 9 (2) ◽  
pp. 87
Author(s):  
Yin Min ◽  
Chen Aiping
Keyword(s):  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Research Progress ◽  
Clinical Value ◽  
Cancer Cell Growth ◽  
Diagnosis And Prognosis ◽  
Serum Mirnas ◽  
Tumor Specificity ◽  
Serum Micrornas

AimSummarize the research progress of serum miRNAs in clinical application for early diagnosis and prognosis of ovarian cancer. MethodsReview of the recently published literature these was conducted. We selected reviews and clinical researches from different scientific societies.ResultsThe abnormal expression of serum miRNAs has a certain clinical value in theearly diagnosis of ovarian cancer. Many miRNAs, which are involved in regulating ovarian cancer cell growth, migration, and drug resistance, are also closely related to the patients’ survival rate and affect the prognostic condition of the patients. So the serum miRNAs may be useful diagnostic and prognostic biomarkers.Conclusions Studies have shown that serum miRNAs has the tumor specificity and high stability, enabling it has the potential for early diagnosis, prognosis and sensitivity to chemotherapy. However, the researches on serum miRNAs is still at the primary stage, further researches is needed for application of serum miRNAs in early diagnosis and prognosis of ovarian cancer.

scholarly journals Biomechanical Properties of Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 887
Author(s):  
Gaël Runel ◽  
Noémie Lopez-Ramirez ◽  
Julien Chlasta ◽  
Ingrid Masse
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Crucial Role ◽  
Biomechanical Properties ◽  
Supplementary Information ◽  
Cancer Cell Growth ◽  
Diagnosis And Prognosis ◽  
Surrounding Environment ◽  
Surrounding Extracellular Matrix

Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for molecular biomarkers to try to classify and stratify cancers, much effort needs to be made to take account of morphological and nanomechanical parameters that could provide supplementary information concerning tissue complexity adaptation during cancer development. The biomechanical properties of cancer cells and their surrounding extracellular matrix have actually been proposed as promising biomarkers for cancer diagnosis and prognosis. The present review first describes the main methods used to study the mechanical properties of cancer cells. Then, we address the nanomechanical description of cultured cancer cells and the crucial role of the cytoskeleton for biomechanics linked with cell morphology. Finally, we depict how studying interaction of tumor cells with their surrounding microenvironment is crucial to integrating biomechanical properties in our understanding of tumor growth and local invasion.

Surgical Prevention in Ovarian Cancer

2021 ◽  
pp. 194-206
Author(s):  
Alexios Papanikolaou ◽  
Anastasios Liberis ◽  
Anastasia Vatopoulou
Keyword(s):  
Ovarian Cancer ◽  
Primary Prevention ◽  
Early Detection ◽  
Early Diagnosis ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Current Evidence ◽  
Advanced Stage ◽  
Stage Disease

Ovarian cancer is the second most common malignant disease of the female genital tract, but the first in mortality because it is usually diagnosed at an advanced stage. Options for early detection, diagnosis, and treatment are limited. Prevention of ovarian cancer relates to primary prevention by avoiding factors that are epidemiologically associated with an increased incidence of ovarian cancer and the adoption of protective habits. These include interventions to exclude the fallopian tubes and ovaries. Secondary prevention is related to early diagnosis. The chapter aims to summarize current evidence on prevention of ovarian cancer as well as role of surgery to prevent advanced-stage disease.

OC27.02: Early diagnosis in ovarian cancer: role of transvaginal color Doppler ultrasound, twelve years experience

2011 ◽  
Vol 38 (S1) ◽  
pp. 49-49
Author(s):  
M. Pascual ◽  
B. Graupera ◽  
L. Hereter ◽  
F. Tresserra ◽  
M. Cusidó ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Doppler Ultrasound ◽  
Color Doppler ◽  
Color Doppler Ultrasound

scholarly journals OP24.09: Role of transvaginal color Doppler ultrasound in early diagnosis of ovarian cancer: our experience since 1999

2012 ◽  
Vol 40 (S1) ◽  
pp. 128-128
Author(s):  
M. Pascual ◽  
B. Graupera ◽  
L. Hereter ◽  
F. Tresserra ◽  
M. Cusido ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Doppler Ultrasound ◽  
Color Doppler ◽  
Color Doppler Ultrasound

scholarly journals Early diagnosis in ovarian cancer: role of transvaginal ultrasound

2001 ◽  
Vol 18 ◽  
pp. P01-P01
Author(s):  
M. A. Pascual ◽  
F. Tresserra ◽  
P. J. Grases ◽  
S. Dexeus
Keyword(s):  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Transvaginal Ultrasound

scholarly journals OC191: Early diagnosis in ovarian cancer: Role of transvaginal color Doppler ultrasound. A nine years experience

2008 ◽  
Vol 32 (3) ◽  
pp. 305-305
Author(s):  
M. A. Pascual ◽  
L. Hereter ◽  
B. Graupera ◽  
F. Tresserra ◽  
I. Rodriguez ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Doppler Ultrasound ◽  
Color Doppler ◽  
Color Doppler Ultrasound

scholarly journals New Horizons in Early Dementia Diagnosis: Can Cerebellar Stimulation Untangle the Knot?

2019 ◽  
Vol 8 (9) ◽  
pp. 1470
Author(s):  
Antonino Naro ◽  
Angela Marra ◽  
Luana Billeri ◽  
Simona Portaro ◽  
Rosaria De Luca ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
New Horizons ◽  
Diagnosis And Prognosis ◽  
Challenging Tasks ◽  
Early Dementia ◽  
Diagnosis Of Dementia ◽  
Theta Burst ◽  
Cerebellar Stimulation

Differentiating Mild Cognitive Impairment (MCI) from dementia and estimating the risk of MCI-to-dementia conversion (MDC) are challenging tasks. Thus, objective tools are mandatory to get early diagnosis and prognosis. About that, there is a growing interest on the role of cerebellum-cerebrum connectivity (CCC). The aim of this study was to differentiate patients with an early diagnosis of dementia and MCI depending on the effects of a transcranial magnetic stimulation protocol (intermittent theta-burst stimulation -iTBS) delivered on the cerebellum able to modify cortico-cortical connectivity. Indeed, the risk of MDC is related to the response to iTBS, being higher in non-responder individuals. All patients with MCI, but eight (labelled as MCI-), showed preserved iTBS aftereffect. Contrariwise, none of the patients with dementia showed iTBS aftereffects. None of the patients showed EEG aftereffects following a sham TBS protocol. Five among the MCI- patients converted to dementia at 6-month follow-up. Our data suggest that cerebellar stimulation by means of iTBS may support the differential diagnosis between MCI and dementia and potentially identify the individuals with MCI who may be at risk of MDC. These findings may help clinicians to adopt a better prevention/follow-up strategy in such patients.

scholarly journals Microvesicles as Potential Ovarian Cancer Biomarkers

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Ilaria Giusti ◽  
Sandra D’Ascenzo ◽  
Vincenza Dolo
Keyword(s):  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Advanced Disease ◽  
Gynecologic Malignancy ◽  
Cancer Markers ◽  
Diagnosis And Prognosis ◽  
Pathological Conditions ◽  
Low Sensitivity ◽  
Disease Stages ◽  
Specific Symptoms

Although the incidence of ovarian cancer is low (i.e., less than 5% in European countries), it is the most lethal gynecologic malignancy and typically has a poor prognosis. To ensure optimal survival, it is important to diagnose this condition when the pathology is confined to the ovary. However, this is difficult to achieve because the first specific symptoms appear only during advanced disease stages. To date, the biomarker mainly used for the diagnosis and prognosis of ovarian cancer is CA125; however, this marker has a low sensitivity and specificity and is associated with several other physiological and pathological conditions. No other serum ovarian cancer markers appear to be able to replace or complement CA125, and the current challenge is therefore to identify novel markers for the early diagnosis of this disease. For this purpose, studies have focused on the microvesicles (MVs) released from tumor cells. MVs may represent an ideal biomarker because they can be easily isolated from blood, and they have particular features (mainly regarding microRNA profiles) that strongly correlate with ovarian cancer stage and may be effective for early diagnosis.

Autocrine Role of Gonadotropin-Releasing Hormone and Its Receptor in Ovarian Cancer Cell Growth

Endocrine ◽  
2000 ◽  
Vol 13 (3) ◽  
pp. 297-304 ◽  
Author(s):  
Sung K. Kang ◽  
Kwai W. Cheng ◽  
Parimal S. Nathwani ◽  
Kyung-Chul Choi ◽  
Peter C. K. Leung
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Gonadotropin Releasing Hormone ◽  
Cancer Cell Growth ◽  
Releasing Hormone

scholarly journals A Novel Prognostic Biomarker ARRDC2 has Potential to Define Tumor Microenvironment in Ovarian Cancer

2021 ◽  
Author(s):  
Mengjun Zhang ◽  
Yunduo Liu ◽  
Yuan Liu ◽  
Siyu Hou ◽  
Hao Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Immune Microenvironment ◽  
Poor Overall Survival ◽  
Protein Levels ◽  
Diagnosis And Prognosis ◽  
Tumor Immune Microenvironment ◽  
Cell Signaling Pathways

Abstract Purpose: The abnormal expression of α-arrestin protein family plays a key regulatory role in the occurrence and development of many cancers, including colorectal cancer and cervical cancer, and is inseparable from changes in the tumor immune microenvironment. However, the role of ARRDC2, an important member of this family, in the malignant biological process of ovarian cancer (OC) has not been reported, and its role in the change of the immune microenvironment is also unknown.Methods: In this study, HPA, TCGA, GEO and other databases were used to explore the role of ARRDC2 in the diagnosis and prognosis assessment of ovarian cancer. Then, GO, KEGG analysis and GSEA analysis of the biological processes and cell signaling pathways that ARRDC2 may be involved in activated or inhibited. In addition, the TIMER and TISIDB database were used to conduct in-depth research on the role of ARRDC2 in the change of the immune microenvironment of ovarian cancer. Finally, the CMAP database explored and screened drugs that may be used for treatment.Results: There were significant differences between OC and ARRDC2 mRNA and protein levels. High ARRDC2 expression level is associated with poor overall survival and can be used as an independent prognostic factor. Interestingly, ARRDC2 expression is positively correlated with B cells, Neutrophils, Dendritic cells and CD8+ T cells, signifying that ARRDC2 may be related to infiltration of immune cells. ARRDC2 and its co-expressed genes are enriched in cell signaling pathways related to the immune system. Finally, we explored two possible drugs for the treatment of ovarian cancer.Conclusion: The differentially expressed ARRDC2 may be a potential prognostic and diagnostic indicator and can be used as a novel biomarker for exploring the immune microenvironment of ovarian cancer.

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