scholarly journals Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis

2017 ◽  
Vol 33 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Xianhong Feng ◽  
Jingdong Wang ◽  
Xiuli Gu ◽  
Jingli Zhang ◽  
Xiaolin Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Smoking Status ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Control Study

Purpose: To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis. Methods: The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing. Results: The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding. However, data from a meta-analysis in the Asian population revealed a significant association between -283T>C and lung cancer risk in the allelic model (C vs. T: odds ratio [OR] = 1.28, 95% confidence interval [CI], 1.06-1.55, p = 0.01) and two genetic models (CC vs. TC: OR = 1.29, 95% CI, 1.04-1.59, p = 0.02; CC vs. TC + TT: OR = 1.30, 95% CI, 1.06-1.60, p = 0.01). Conclusions: These results provided evidence that the DNMT3B -283T>C polymorphism might significantly contribute to the lung cancer risk in the Asian population, but not the gastric cancer risk in the Chinese population.

scholarly journals The SNP rs931794 in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128201 ◽  
Author(s):  
Qi Wang ◽  
Juntao Ke ◽  
Qibin Song ◽  
Weiguo Hu ◽  
Xuzai Lu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

scholarly journals Neighbourhood deprivation and lung cancer risk: a nested case–control study in the USA

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e021059 ◽  
Author(s):  
Maureen Sanderson ◽  
Melinda C Aldrich ◽  
Robert S Levine ◽  
Barbara Kilbourne ◽  
Qiuyin Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Smoking Status ◽  
Case Control ◽  
Neighbourhood Deprivation ◽  
Former Smokers ◽  
Nested Case Control ◽  
Control Study

ObjectivesTo examine the association between neighbourhood deprivation and lung cancer risk.DesignNested case–control study.SettingSouthern Community Cohort Study of persons residing in 12 states in the southeastern USA.Participants1334 cases of lung cancer and 5315 controls.Primary outcome measureRisk of lung cancer.ResultsAfter adjustment for smoking status and other confounders, and additional adjustment for individual-level measures of socioeconomic status (SES), there was no monotonic increase in risk with worsening deprivation score overall or within sex and race groups. There was an increase among current and shorter term former smokers (p=0.04) but not among never and longer term former smokers. There was evidence of statistically significant interaction by sex among whites, but not blacks, in which the effect of worsening deprivation on lung cancer existed in males but not in females.ConclusionsArea-level measures of SES were associated with lung cancer risk in current and shorter term former smokers only in this population.

Flavonoid Intake in Relation to Lung Cancer Risk: Case-Control Study Among Women in Greece

2004 ◽  
Vol 49 (2) ◽  
pp. 139-143 ◽  
Author(s):  
Pagona Lagiou ◽  
Evi Samoli ◽  
Areti Lagiou ◽  
Klea Katsouyanni ◽  
Julia Peterson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
Flavonoid Intake ◽  
Control Study

Lung cancer risk in iron and steel foundry workers: A nested case control study in Asturias, Spain

2000 ◽  
Vol 38 (6) ◽  
pp. 644-650 ◽  
Author(s):  
Valent�n Rodr�guez ◽  
Adonina Tard�n ◽  
Manolis Kogevinas ◽  
Carlos S. Prieto ◽  
Antonio Cueto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
Iron And Steel ◽  
Nested Case Control ◽  
Foundry Workers ◽  
Control Study

CASE-CONTROL STUDY OF LUNG CANCER RISK FROM RESIDENTIAL RADON EXPOSURE IN WORCESTER COUNTY, MASSACHUSETTS

2008 ◽  
Vol 94 (3) ◽  
pp. 228-241 ◽  
Author(s):  
Richard E. Thompson ◽  
Donald F. Nelson ◽  
Joel H. Popkin ◽  
Zenaida Popkin
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
Radon Exposure ◽  
Control Study ◽  
Residential Radon

scholarly journals The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case–control study and meta-analysis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Bifeng Chen ◽  
Shang Wang ◽  
Guangxin Ma ◽  
Jin Han ◽  
Jingli Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lung Cancer ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
A Genome ◽  
Control Study

How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case–control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.

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