Neighbourhood deprivation and lung cancer risk: a nested case–control study in the USA

ObjectivesTo examine the association between neighbourhood deprivation and lung cancer risk.DesignNested case–control study.SettingSouthern Community Cohort Study of persons residing in 12 states in the southeastern USA.Participants1334 cases of lung cancer and 5315 controls.Primary outcome measureRisk of lung cancer.ResultsAfter adjustment for smoking status and other confounders, and additional adjustment for individual-level measures of socioeconomic status (SES), there was no monotonic increase in risk with worsening deprivation score overall or within sex and race groups. There was an increase among current and shorter term former smokers (p=0.04) but not among never and longer term former smokers. There was evidence of statistically significant interaction by sex among whites, but not blacks, in which the effect of worsening deprivation on lung cancer existed in males but not in females.ConclusionsArea-level measures of SES were associated with lung cancer risk in current and shorter term former smokers only in this population.

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Lung cancer risk in iron and steel foundry workers: A nested case control study in Asturias, Spain

American Journal of Industrial Medicine ◽

10.1002/1097-0274(200012)38:6<644::aid-ajim5>3.0.co;2-m ◽

2000 ◽

Vol 38 (6) ◽

pp. 644-650 ◽

Cited By ~ 32

Author(s):

Valent�n Rodr�guez ◽

Adonina Tard�n ◽

Manolis Kogevinas ◽

Carlos S. Prieto ◽

Antonio Cueto ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Lung Cancer Risk ◽

Case Control ◽

Iron And Steel ◽

Nested Case Control ◽

Foundry Workers ◽

Control Study

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The association between proton pump inhibitors (PPI) use for gastro-esophageal reflux disease (GERD) and lung cancer (LC): A nested case-control study.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.1562 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 1562-1562

Author(s):

Hadas Dresler ◽

Daniel Keizman ◽

Ronac Mamtani ◽

Maya Gottfried ◽

Natalie Maimon ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Cancer Diagnosis ◽

Case Control Study ◽

Lung Cancer Risk ◽

Case Control ◽

Sensitivity Analyses ◽

Diagnostic Code ◽

Nested Case Control ◽

Control Study

1562 Background: Data suggests that GERD with recurrent reflux and microaspiration of stomach contents, may be associated with lung injury, inflammation, activation of proliferative signals, and eventually DNA damage and malignant transformation. Recently, a large population based cohort study found that GERD may increase the risk of lung cancer in Asians. In the present nested case control study, we aimed to evaluate the association between PPI use as a surrogate for GERD and lung cancer in a large western population. Methods: We conducted a matched case-control study within a population-representative database from the United Kingdom. Study cases were defined as individuals with any diagnostic code of lung cancer. For every case, four eligible controls were matched on age, gender, practice site, time and duration of follow-up. Exposure of interest was PPI use prior to cancer diagnosis. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer were estimated using conditional logistic regression. Adjustment was performed for smoking. Results: The study population included 19143 lung cancer cases and 74473 matched controls. PPI use was associated with a significantly increased lung cancer risk (adjusted OR 1.70, 95%CI 1.64-1.77, p < 0.001). In a sensitivity analyses we observed similar associations when PPI use was initiated more than one year prior to cancer diagnosis (adjusted OR 1.18, 95%CI 1.13-1.23, p < 0.001) and more than two years prior to cancer diagnosis (adjusted OR 1.15, 95%CI 1.10-1.20, p < 0.001) Conclusions: ChronicPPI use, as a surrogate for symptomatic GERD, may be associated with a higher lung cancer risk.

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Cruciferous Vegetable Intake and Lung Cancer Risk: A Nested Case-Control Study Matched on Cigarette Smoking

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-10-0475 ◽

2010 ◽

Vol 19 (10) ◽

pp. 2534-2540 ◽

Cited By ~ 35

Author(s):

Tram Kim Lam ◽

Ingo Ruczinski ◽

Kathy J. Helzlsouer ◽

Yin Yao Shugart ◽

Laura E. Caulfield ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Cigarette Smoking ◽

Case Control Study ◽

Lung Cancer Risk ◽

Vegetable Intake ◽

Case Control ◽

Cruciferous Vegetable ◽

Nested Case Control ◽

Control Study

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Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial

British Journal of Cancer ◽

10.1038/s41416-018-0075-0 ◽

2018 ◽

Vol 118 (11) ◽

pp. 1513-1517 ◽

Cited By ~ 1

Author(s):

Jennifer Anne Doherty ◽

Laurie Grieshober ◽

John R. Houck ◽

Matt J. Barnett ◽

Jean De Dieu Tapsoba ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Lung Cancer Risk ◽

Case Control ◽

Efficacy Trial ◽

Nested Case Control ◽

Β Carotene ◽

Control Study ◽

Heavy Smokers

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Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis

The International Journal of Biological Markers ◽

10.5301/ijbm.5000306 ◽

2017 ◽

Vol 33 (2) ◽

pp. 195-200 ◽

Cited By ~ 2

Author(s):

Xianhong Feng ◽

Jingdong Wang ◽

Xiuli Gu ◽

Jingli Zhang ◽

Xiaolin Li ◽

...

Keyword(s):

Gastric Cancer ◽

Lung Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Lung Cancer Risk ◽

Smoking Status ◽

Meta Analysis ◽

Asian Population ◽

Case Control ◽

Control Study

Purpose: To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis. Methods: The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing. Results: The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding. However, data from a meta-analysis in the Asian population revealed a significant association between -283T>C and lung cancer risk in the allelic model (C vs. T: odds ratio [OR] = 1.28, 95% confidence interval [CI], 1.06-1.55, p = 0.01) and two genetic models (CC vs. TC: OR = 1.29, 95% CI, 1.04-1.59, p = 0.02; CC vs. TC + TT: OR = 1.30, 95% CI, 1.06-1.60, p = 0.01). Conclusions: These results provided evidence that the DNMT3B -283T>C polymorphism might significantly contribute to the lung cancer risk in the Asian population, but not the gastric cancer risk in the Chinese population.

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