CLINICAL CASE: MICROSCOPIC POLYANGIITIS AS ONE OF THE MAIN VARIANTS OF PULMONARY-RENAL SYNDROME

Vestnik ◽  
2021 ◽  
pp. 345-349
Author(s):  
М.А. Жанузаков ◽  
М.К. Бапаева ◽  
А.Ж. Шурина ◽  
Э.М. Утежанов
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Research Methods ◽  
Clinical Case ◽  
Microscopic Polyangiitis ◽  
Clinical Manifestations ◽  
Additional Research ◽  
Treatment Goal ◽  
Adequate Treatment ◽  
Pulmonary Renal Syndrome

Клинические проявления микроскопического полиангиита многообразны, что затрудняет своевременную диагностику и соответственно адекватное лечение. Цель: привлечь внимание терапевтов, пульмонологов, нефрологов к своевременному выявлению легочно-почечного синдрома и установлению его нозологической основы, в частности микроскопического полиангиита на примере клинического случая. Материалы и методы: проведены обследование пациента с микроскопическим полиангиитом и дифференциальная диагностика в рамках легочно-почечного синдрома. Результаты: на основании анамнеза заболевания, результатов клинического и дополнительных методов исследования пациента, установлен диагноз микроскопического полиангиита. Выводы: для ранней диагностики микроскопического полиангиита необходима настороженность при возникновении легочно-почечного синдрома в виде сочетания гломерулонефрита и геморрагического альвеолита на фоне сосудистой пурпуры. Clinical manifestations of microscopic polyangiitis are diverse, which complicates timely diagnosis and, accordingly, adequate treatment. Goal: to draw the attention of therapists, pulmonologists, nephrologists to the timely detection of pulmonary-renal syndrome and the establishment of its nosological basis, in particular microscopic polyangiitis by the example of a clinical case. Materials and methods: an examination of a patient with microscopic polyangiitis and differential diagnosis within the framework of pulmonary-renal syndrome were carried out. Results: based on the anamnesis of the disease, the results of clinical and additional research methods of the patient, the diagnosis of microscopic polyangiitis was established. Conclusions: for early diagnosis of microscopic polyangiitis, alertness is necessary in the event of pulmonary-renal syndrome in the form of a combination of glomerulonephritis and hemorrhagic alveolitis against the background of vascular purpura.

CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME: DIAGNOSTICS AND TREATMENT

Vestnik ◽  
2021 ◽  
pp. 341-344
Author(s):  
М.А. Жанузаков ◽  
М.К. Бапаева ◽  
Г.К. Джалилова ◽  
А.Ж. Шурина ◽  
Э.М. Утежанов
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Multiple Organ Failure ◽  
Antiphospholipid Syndrome ◽  
Disseminated Intravascular Coagulation ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Multiple Organ ◽  
Catastrophic Antiphospholipid Syndrome ◽  
Adequate Treatment

Клинические проявления катастрофического антифосфолипидного синдрома многообразны, что затрудняет своевременную диагностику и соответственно адекватное лечение. Цель: устранить трудности, возникающие у практических врачей при постановке диагноза, дифференциальной диагностике и лечении катастрофического антифосфолипидного синдрома, основываясь на анализе данных литературы и на примере клинического случая. Материалы и методы: исследований по данной проблеме в отечественных источниках мы не встретили, что привело к необходимости остановиться на литературных данных и клиническом примере. Результаты: на основании анамнеза заболевания, результатов клинического и дополнительных методов исследования пациента, установлен диагноз катастрофического антифосфолипидного синдрома. Выводы: для ранней диагностики катастрофического антифосфолипидного синдрома необходима настороженность при возникновении признаков ДВС-синдрома и быстро развивающейся полиорганной недостаточности. Clinical manifestations of the catastrophic antiphospholipid syndrome are diverse, which complicates timely diagnosis and, accordingly, adequate treatment. Goal: eliminate the difficulties encountered by practitioners in the diagnosis, differential diagnosis and treatment of catastrophic antiphospholipid syndrome, based on the analysis of literature data and on the example of a clinical case. Materials and methods: we did not find any studies on this issue in domestic sources, which led to the need to focus on literature data and a clinical example. Results: on the basis of the anamnesis of the disease, the results of clinical and additional research methods of the patient, a diagnosis of catastrophic antiphospholipid syndrome was established. Conclusions: for early diagnosis of catastrophic antiphospholipid syndrome, alertness is required when signs of disseminated intravascular coagulation and rapidly developing multiple organ failure occur.

scholarly journals Differential diagnosis of hypokinetic disorders in hereditary neuromuscular diseases

1997 ◽  
Vol XXIX (1-2) ◽  
pp. 81-83
Author(s):  
L. A. Saikova ◽  
V. D. Kosachev ◽  
V. G. Pustozerov ◽  
Т. M. Alekseeva ◽  
Т. N. Vasilyeva ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Research Methods ◽  
Clinical Manifestations ◽  
Neuromuscular Diseases ◽  
Additional Research ◽  
Congenital Myopathies

For determination criteria of differential diagnosis analysis of clinical manifestations and indices of additional research methods (EMG, ENMY, biochemical, histomorphological) of paroxysmal hypokinetic conditions in myoplegia, myopathic syndromes, glycogenosis and Mc Ardl syndrome in polymyositis, Eulenburg-Lewandowsky paramyotoxia, remittent form of neural amyotrophy, some forms of congenital myopathies was carried out.

scholarly journals Penile angioedema in a child: A nightmare to parents!

2022 ◽  
Vol 1 ◽  
pp. 21-23
Author(s):  
K. S. Lakshmi Srividya ◽  
Vidyasagar P
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Clinical Manifestations ◽  
Diagnosis And Management ◽  
Fatal Complications

Angioedema is a transient, non-pitting oedema that involves subcutaneous or submucosal tissue. Angioedema in children can have varied aetiology and clinical manifestations, unlike that in adults. We report a case of angioedema of penis in a child resulting from insect bite and treated successfully with anti-histamine and leukotriene inhibitor. Penile angioedema should be kept in mind as a differential diagnosis of penile swelling, as early diagnosis and management may prevent fatal complications.

scholarly journals Poorly Differentiated Chordoma: Case Review

2020 ◽  
Vol 3 (4) ◽  
pp. 86-93
Author(s):  
N. V. Kochergina ◽  
I. V. Boulytcheva ◽  
S. N. Prokhorov ◽  
A. B. Bludov ◽  
A. V. Fеdorova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Research Methods ◽  
Female Patient ◽  
Clinical Case ◽  
Immunohistochemical Study ◽  
Case Review ◽  
Immunohistochemical Examination ◽  
Imaging Methods ◽  
Wide Range ◽  
Poorly Differentiated

Purpose: Demonstrate a clinical case of poorly differentiated chordoma, confirmed using a wide range of research methods.Material and methods: A 63-year-old female patient with poorly differentiated chordoma who underwent immunohistochemical examination, MRI, CT and scintigraphy.Results: An immunohistochemical study confirmed the morphological affiliation of the tumor, supplemented by the data of imaging methods.Conclusion: The poorly differentiated type of chordoma has a specific immunohistochemical picture, however, differential diagnosis based on imaging methods is currently a difficult task.

scholarly journals PATHOGENETIC APPROACH TO EARLY DIAGNOSIS OF MILD NEURO-ORTHOPEDIC PATHOLOGY IN CHILDREN

2020 ◽  
Vol 76 (4) ◽  
pp. 106-109
Author(s):  
M.E. Winderlich ◽  
◽  
N.B. Schekolova ◽  
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Children And Adolescents ◽  
Research Methods ◽  
Musculoskeletal System ◽  
Spinal Deformity ◽  
Foot Placement ◽  
Pelvic Bones ◽  
Timely Diagnosis ◽  
Treatment And Prevention

216 children and adolescents from 3 months to 17 years with mild neuroorthopedic pathology – torticollis, abnormal foot placement, flat-valgus feet, posture disorders, scoliosis, shortening of the limb were examined. The etiological factors of Natal trauma and the pathogenesis of torticollis formation were determined with confirmation by instrumental research methods. During the growth of the child, there is a progression of neuroorthopedic pathology in the form of scoliotic spinal deformity with a misalignment of the pelvic bones due to an asymmetric flat-valgus installation of the feet. The program for differential diagnosis and prevention of mild neuroorthopedic disorders was developed depending on the age of children. It is shown, that the leading link in the pathogenesis of neuroorthopedic pathology is natal trauma. Timely diagnosis, treatment and prevention of disorders of the musculoskeletal system will prevent the formation of pathology in various age periods.

scholarly journals Clinical case of differential diagnosis of retrocervical endometriosis

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Sergey A. Levakov ◽  
Ainur E. Mamedova ◽  
Gyullar Y. Azadova ◽  
Sergey V. Paukov
Keyword(s):  
Differential Diagnosis ◽  
Histological Examination ◽  
Clinical Case ◽  
Progressive Disease ◽  
Abdominal Cavity ◽  
Clinical Manifestations ◽  
Fallopian Tubes

Endometriosis is a chronic hormone-dependent progressive disease characterized by the presence of ectopic endometrioid tissue. Most often, endometriosis affects the ovaries, fallopian tubes and the abdominal cavity, but endometrioid foci are also found in the intestines, heart, lungs, skin and other atypical localizations. This article presents a clinical case of retrocervical endometriosis diagnosed based on the results of pathological and histological examination. It is important to note the complexity of the differential diagnosis of this form of endometriosis due to secondary changes in the area of the colon and the absence of characteristic clinical manifestations.

scholarly journals MESENCHYMAL TUMORS OF THE COLON AND RECTUM: DIAGNOSIS, TREATMENT, PROGNOSIS (case report and review)

2020 ◽  
Vol 19 (3) ◽  
pp. 97-112
Author(s):  
O. A. Mainovskaya ◽  
M. A. Tarasov ◽  
E. M. Romanova ◽  
S. V. Chernyshov
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Mesenchymal Tumor ◽  
Mesenchymal Tumors ◽  
Different Types ◽  
Colon And Rectum ◽  
Treatment Prognosis ◽  
Derivatives Of

Mesenchymal tumors of the colon and rectum are extremely rare and do not have specific clinical manifestations, their diagnosis and staging cause certain difficulties.Different types of mesenchymal tumors differ in prognosis and choice of the treatment. It explains the importance of differential diagnosis of these neoplasms among themselves and tumors-derivatives of other embryonic structures.The article describes the clinical case of a rare mesenchymal tumor and management of the patient.

scholarly journals Challenges of the differential diagnosis between the subtypes of the junctional epidermolysis bullosa: presentation of two clinical cases

2019 ◽  
Vol 47 (1) ◽  
pp. 83-93
Author(s):  
Yu. Yu. Kotalevskaya ◽  
N. M. Marycheva
Keyword(s):  
Differential Diagnosis ◽  
Epidermolysis Bullosa ◽  
Skin Disease ◽  
Clinical Case ◽  
Molecular Genetic ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Junctional Epidermolysis Bullosa ◽  
Reliable Determination ◽  
Clinical Cases

Background: Epidermolysis bullosa (EB) is a rare hereditary skin disease. It is subdivided into EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB) and Kindler syndrome. JEB is diagnosed in 2 per 1,000,000 of the population. There are few descriptions of clinical JEB cases in the literature. Clinical diagnosis of JEB and its subtypes is a challenge, especially in the early age. The paper presents 2 clinical cases of JEB in patients of the West Slavonic origin. Clinical case No. 1 was a girl of Ukrainian ethnicity, with confirmed definitive diagnosis of severe generalized JEB. Molecular genetic tests identified mutations of the LAMA3 gene that had not been described previously. The patient died at the age of 24 months from acute respiratory failure. When the patient was alive, her EB type and subtype was not possible to identify, because she had a combination of clinical manifestations typical for various JEB subtypes. Despite such symptoms as hoarse voice, stenoses, granulation tissue of typical location, laryngeal granulations, the girl was steadily gaining weight, with some periods of relative stabilization of the skin disease; she also had longer life longevity than was common for patients with severe generalized JEB. All this made a precise diagnosis difficult. Clinical case No. 2: an ethnic Russian boy with non-classified JEB. Molecular genetic testing helped to identify a homozygote mutation in the LAMA3 gene that had not been previously described; reliable determination of the subtype was not possible. The patient had mixed clinical manifestation similar both to generalized severe JEB and to laryngo-onycho-cutaneous (LOC) syndrome. During his lifetime, the patient was clinically diagnosed with Hallopeau acrodermatitis and LOC syndrome. The differential diagnostic problems were associated with the presence of signs not typical for each of the subtypes. Significant life longevity of the proband is not characteristic for severe generalized JEB (at the time of the publication the patient is 13 years old), whereas for LOC syndrome the absence of eye involvement is not typical, as well as severe laryngeal involvement at adolescence.Conclusion: Detailed descriptions of phenotype of JEB subtypes including rare and minimal clinical signs can be useful to study the clinical manifestations and natural course of the disease, including its differential diagnosis.

A CASE REPORT: KAZABACH-MERRITT SYNDROME (KMS)

Vestnik ◽  
2021 ◽  
pp. 73-77
Author(s):  
Г.Ж. Бодыков ◽  
Г.Н. Балмагамбетова ◽  
С.А. Лисогор ◽  
В.М. Шмонин
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Early Diagnosis ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Vascular Anomalies ◽  
Diagnosis And Treatment ◽  
Pediatric Practice

Синдром Казабаха - Мерритта в детской практике встречается крайне редко. Клинические проявления многообразны, что затрудняет своевременную диагностику и лечение данного заболевания. Цель: привлечь внимание неонатологов и педиатров к своевременной диагностике редких гематологических синдромов. Материалы и методы. Проведено расширенное обследование ребенка и тщательная дифференциальная диагностика с другими сосудистыми аномалиями. Результаты. На основании оценки анамнеза, клинико - лабораторных и инструментальных методов обследования установлен диагноз СКМ. Выводы. Постановка диагноза СКМ требует проведения расширенного обследования ребенка и тщательной дифференцировки с другими сосудистыми аномалиями. Kazabach-Merritt syndrome is extremely rare in pediatric practice. Clinical manifestations are diverse- and this fact complicates the early diagnosis and treatment of the disease.Purpose: to draw the attention of neonatologists and pediatricians to the early diagnosis of rare hematological syndromes.Materials and methods. An extended examination of the child and a thorough differential diagnosis with other vascular anomalies were carried out. Results. The KMS was diagnosed on the base of: the assessment of the anamnesis, clinical - laboratory and instrumental examination methods.Conclusion. The diagnosis of KMS requires an extended examination of the child and careful differentiation of other vascular anomalies.

The value of functional research methods in the diagnosis of pre-asthma in children

1993 ◽  
Vol 74 (4) ◽  
pp. 251-255
Author(s):  
T. V. Klykova ◽  
A. M. Potemkina ◽  
A. G. Zagidullina
Keyword(s):  
Early Diagnosis ◽  
Research Methods ◽  
Bronchial Asthma ◽  
Diagnostic Value ◽  
External Respiration ◽  
Adequate Treatment ◽  
Respiratory Allergies ◽  
Asthma In Children

Respiratory allergies are one of the most common and severe allergic pathologies in children. Our observations showed that bronchial asthma is formed in more than 80% of children through the stage of pre-asthma. However, its early diagnosis and adequate treatment in 90% of cases can prevent the transition to bronchial asthma. In this regard, the problem of studying the methods of early diagnosis of pre-asthma and ways to prevent its transformation into bronchial asthma is urgent and practically significant. Since the formation of pre-asthma and bronchial asthma is based on a violation of the function of external respiration, the purpose of our work was, firstly, to study the function of external respiration in case of pre-asthma, and secondly, to determine the diagnostic value of various methods for studying FVD in this pathology in children.

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