The value of functional research methods in the diagnosis of pre-asthma in children

1993 ◽  
Vol 74 (4) ◽  
pp. 251-255
Author(s):  
T. V. Klykova ◽  
A. M. Potemkina ◽  
A. G. Zagidullina
Keyword(s):  
Early Diagnosis ◽  
Research Methods ◽  
Bronchial Asthma ◽  
Diagnostic Value ◽  
External Respiration ◽  
Adequate Treatment ◽  
Respiratory Allergies ◽  
Asthma In Children

Respiratory allergies are one of the most common and severe allergic pathologies in children. Our observations showed that bronchial asthma is formed in more than 80% of children through the stage of pre-asthma. However, its early diagnosis and adequate treatment in 90% of cases can prevent the transition to bronchial asthma. In this regard, the problem of studying the methods of early diagnosis of pre-asthma and ways to prevent its transformation into bronchial asthma is urgent and practically significant. Since the formation of pre-asthma and bronchial asthma is based on a violation of the function of external respiration, the purpose of our work was, firstly, to study the function of external respiration in case of pre-asthma, and secondly, to determine the diagnostic value of various methods for studying FVD in this pathology in children.

CLINICAL CASE: MICROSCOPIC POLYANGIITIS AS ONE OF THE MAIN VARIANTS OF PULMONARY-RENAL SYNDROME

Vestnik ◽  
2021 ◽  
pp. 345-349
Author(s):  
М.А. Жанузаков ◽  
М.К. Бапаева ◽  
А.Ж. Шурина ◽  
Э.М. Утежанов
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Research Methods ◽  
Clinical Case ◽  
Microscopic Polyangiitis ◽  
Clinical Manifestations ◽  
Additional Research ◽  
Treatment Goal ◽  
Adequate Treatment ◽  
Pulmonary Renal Syndrome

Клинические проявления микроскопического полиангиита многообразны, что затрудняет своевременную диагностику и соответственно адекватное лечение. Цель: привлечь внимание терапевтов, пульмонологов, нефрологов к своевременному выявлению легочно-почечного синдрома и установлению его нозологической основы, в частности микроскопического полиангиита на примере клинического случая. Материалы и методы: проведены обследование пациента с микроскопическим полиангиитом и дифференциальная диагностика в рамках легочно-почечного синдрома. Результаты: на основании анамнеза заболевания, результатов клинического и дополнительных методов исследования пациента, установлен диагноз микроскопического полиангиита. Выводы: для ранней диагностики микроскопического полиангиита необходима настороженность при возникновении легочно-почечного синдрома в виде сочетания гломерулонефрита и геморрагического альвеолита на фоне сосудистой пурпуры. Clinical manifestations of microscopic polyangiitis are diverse, which complicates timely diagnosis and, accordingly, adequate treatment. Goal: to draw the attention of therapists, pulmonologists, nephrologists to the timely detection of pulmonary-renal syndrome and the establishment of its nosological basis, in particular microscopic polyangiitis by the example of a clinical case. Materials and methods: an examination of a patient with microscopic polyangiitis and differential diagnosis within the framework of pulmonary-renal syndrome were carried out. Results: based on the anamnesis of the disease, the results of clinical and additional research methods of the patient, the diagnosis of microscopic polyangiitis was established. Conclusions: for early diagnosis of microscopic polyangiitis, alertness is necessary in the event of pulmonary-renal syndrome in the form of a combination of glomerulonephritis and hemorrhagic alveolitis against the background of vascular purpura.

scholarly journals The relationship between the parameters of microcirculation and the lung function in bronchial asthma in children

2018 ◽  
pp. 30-35
Author(s):  
N. I. Lozko ◽  
N. G. Kolosova ◽  
N. A. Geppe ◽  
V. D. Denisova
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Process ◽  
Clinical Manifestations ◽  
External Respiration ◽  
Functional Diagnosis ◽  
Chronic Inflammatory Process ◽  
Asthma In Children ◽  
Severity Of The Disease ◽  
The University ◽  
Medical University

Among the chronic nonspecific lung diseases, bronchial asthma (BA) takes the leading place. BA in children is primarily diagnosed on the basis of clinical manifestations, methods of functional diagnosis, which allows you to verify the disease and assess the severity of the flow. An important role in the pathogenesis of asthma is played by the microcirculation system, affecting the course and progression of the disease. Dysfunction of microcirculation system supports chronic inflammatory process, affecting the level of perfusion, metabolism and gas exchange. The study was carried out on the basis of the University Children's Clinical Hospital (pulmonology department) of the First Moscow State Medical University named after I.M. Sechenov Ministry of Health of Russia (Sechenovsky University). 100 children aged 6-17 years with asthma were examined. Based on the study of the nature of microcirculatory disorders by the LDF method in bronchial asthma in children with different severity of the disease, correlation links between microcirculation indices, clinical manifestations and external respiration function (spirometry and computer bronchophonography) in children have been revealed. The observed decrease in microcirculation during the exacerbation of asthma is short-term and insignificant in mild severity and is longer and more significant with moderate BA, which supports a chronic inflammatory process in the bronchi. Correction of disorders of microcirculation is an important link in the therapeutic approach.

scholarly journals The diagnosis of the autoimmune process in bronchial asthma in children using antigens of the bronchopulmonary system

2018 ◽  
Keyword(s):  
Bronchial Asthma ◽  
Comparison Group ◽  
Morphological Changes ◽  
Diagnostic Value ◽  
Healthy Children ◽  
Autoimmune Process ◽  
Protein Antigens ◽  
Cell Tissue ◽  
Protein Nature ◽  
Asthma In Children

The paper presents data on the detection of an autoimmune process in the bronchopulmonary system in children with BA aged from 5 to 14 years in the period of exacerbation. The comparison group consisted of 25 healthy children aged from 7 to 14 years. It has been shown that lipopolysaccharide antigens from the interstitial connective tissue of bronchopulmonary structures obtained from accidentally killed children have a higher specificity than protein antigens and allow identifying morphological changes in the bronchopulmonary system, the severity of the course and monitoring the effectiveness of the therapy. Antigens obtained from the sectional material of the bronchopulmonary system of protein nature cannot be obtained industrially, since they are not standardized for protein, do not possess sterility, which greatly limits their use and reduces the diagnostic value. The multicomponent antigenic composition of protein homogenates obtained from the cell-tissue structures of the bronchopulmonary system does not clearly identify the nature of the morphological changes in bronchial asthma in children. Lipopolysaccharide antigens from bronchopulmonary structures do not contain protein in their composition; they can be obtained industrially under sterile conditions and stored in a lyophilized state for more than two years, which allows them to be widely used in immunodiagnostics of clinical forms and severity of asthma in children.

Structural and functional condition of the left departments of heart in the patients with bronchial asthma

10.12737/4784 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Ищенко ◽  
O. Ishchenko ◽  
Демко ◽  
I. Demko ◽  
Рязанова ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Diastolic Dysfunction ◽  
Bronchial Asthma ◽  
Color Doppler ◽  
Significant Risk ◽  
Functional Condition ◽  
Diagnostic Value ◽  
Bronchial Obstruction ◽  
External Respiration ◽  
Design Assessment

The purpose of the research was studying of clinical and diagnostic value of bronchial obstruction, hypoxemia, as well structural and functional condition of the left departments of heart in the patients with middle and severe degree of bronchial asthma. This research had prospective open design. Assessment of cardiac remodeling was carried out by means of the echocardiography with color Doppler mapping in period of exacerbation and after 12 months. Indicators of function of external respiration were estimated by means of the spirography and the bodyplethismography at the same periods. According to research data, it was revealed that with the severity of asthma is increasing the size of the left atrium and a decrease in the ratio of the AO/LA. The importance of early identification of a hypertrophy of a left ventricle in the patients with severe bronchial asthma is bound to the fre-quency of accompanying cardiac pathology and the correlation between hypertrophy of a left ventricle and the subsequent adverse clinical course of cardiovascular diseases. In patients with bronchial asthma parallel to the severity of the disease are formed changes of structural and functional state of myocardium of the left ventricle, causing diastolic dysfunction. The most significant risk factors in the formation of diastolic dysfunction of the left ventricle in patients with bronchial asthma are bronchial obstruction and hypoxemia.

scholarly journals Diagnostic and informative values of clinical and phenotypical signs for early detection of bronchial asthma

2005 ◽  
pp. 48-52
Author(s):  
Z. Sh. Golevtsova ◽  
N. V. Bagisheva ◽  
N. V. Ovsyannikov
Keyword(s):  
Early Detection ◽  
Early Diagnosis ◽  
Physical Exercise ◽  
Bronchial Asthma ◽  
Correct Diagnosis ◽  
Diagnostic Value ◽  
Medical Documentation ◽  
Chest Tightness ◽  
Cold Air ◽  
Diagnostic Values

Regarding poor detection of bronchial asthma (BA) in outpatient facilities diagnostic values of main clinical and phenotypical BA signs were investigated to improve early diagnosis of the disease. To verify the diagnosis we elaborated a clinic variant of BA, assessed medical documents and questioned 96 patients. The correct diagnosis was found to be reached usually in some years after the appearance of the first BA symptoms (in average 12.49 ± 7.32 yrs) in spite of typical onset of the disease in all the cases: dry cough attacks in 82.2 %, asthma attacks in 6.3 %, dyspnoea in 46.9 %, and chest tightness while contacting with an allergen or an unspecific irritant (dynamic physical exercise, stress, cold air) in 7.3 % of the patients. Detailing of symptoms was performed and diagnostic value of every sign was determined. Discriminative coefficients were calculated for reliably high influencing signs; their informative values and probability of BA detection were defined. Subjective and objective causes of late BA diagnosis were retrospectively analyzed based on medical documentation and questioning 92 doctors of outpatient facilities.

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