Biliary Dilation: An Unusual Presentation of Histoplasma capsulatum in a Dog

2020 ◽  
Vol 56 (5) ◽  
pp. 285
Author(s):  
Harry Cridge ◽  
Erin Brinkman ◽  
Patty Lathan
Keyword(s):  
Histoplasma Capsulatum ◽  
Abdominal Distension ◽  
Abdominal Ultrasound ◽  
Biliary Duct ◽  
Potential Complication ◽  
Intact Male ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Disseminated Histoplasmosis ◽  
History Of

ABSTRACT A 4 mo old intact male Labrador retriever was referred to the authors’ institution for a 3 wk history of weight loss and progressive abdominal distension. Thoracic radiographs revealed sternal lymphadenopathy and a diffuse unstructured interstitial and bronchial pulmonary pattern. An abdominal ultrasound revealed multifocal lymphadenopathy, hepatosplenomegaly, and biliary duct dilation. Fine-needle aspirates of the spleen and liver revealed Histoplasma capsulatum organisms. Antifungal therapy was initiated with itraconazole and terbinafine. Repeat ultrasound examinations revealed resolving hepatosplenomegaly and resolving cystic duct dilation. Ultrasonographic findings mirrored a decrease in urine H capsulatum antigen levels. Histoplasmosis should be considered as a differential for unexplained biliary duct dilation or obstruction in dogs. Dogs with disseminated histoplasmosis should be monitored for this potential complication.

scholarly journals Thyroid haemangiosarcoma in a seven-year-old female Shih Tzu

2020 ◽  
Vol 8 (2) ◽  
pp. e001012
Author(s):  
Luis Pedro Rocha Moreira ◽  
Emma Scurrell ◽  
Paul Mahoney ◽  
Stephen Baines
Keyword(s):  
Histopathological Examination ◽  
Abdominal Ultrasound ◽  
Neck Mass ◽  
Clinical Staging ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
History Of ◽  
The Right ◽  
Mixed Tumours

Canine thyroid tumours are uncommon and the majority of tumours are carcinomas or adenomas, with only very few mixed tumours or metastases from distant sites described to date. A primary thyroid haemangiosarcoma has never been reported in veterinary medicine. In this case report, we describe a dog with a history of a large, non-painful, mobile ventral neck mass in the right paralaryngeal region. CT and ultrasound-guided fine needle aspirates were used for clinical staging. The mass was surgically excised and histopathological examination indicated a haemangiosarcoma. Abdominal ultrasound revealed the presence of splenic nodules and splenectomy indicated the presence of haemangiosarcoma. Chemotherapy with doxorubicin was started, but the dog was euthanased after three rounds of therapy, 97 days after the mass was discovered.

Cytologic Diagnosis of Disseminated Histoplasmosis in the Wall of the Urinary Bladder of a Cat

2012 ◽  
Vol 48 (3) ◽  
pp. 203-208 ◽  
Author(s):  
Amanda R. Taylor ◽  
James W. Barr ◽  
Jessica A. Hokamp ◽  
Mark C. Johnson ◽  
Benjamin D. Young
Keyword(s):  
Urinary Bladder ◽  
Histoplasma Capsulatum ◽  
Bladder Wall ◽  
Abdominal Ultrasound ◽  
Cytologic Examination ◽  
Disseminated Histoplasmosis ◽  
Urinary Bladder Wall ◽  
History Of ◽  
Recurrent Hematuria ◽  
Abdominal Ultrasound Examination

A 10 yr old domestic longhair presented with a 2.5 mo history of recurrent hematuria. Abdominal ultrasound examination demonstrated a thickened urinary bladder, abdominal lymphadenopathy, and a thickened and rounded spleen. Cytologic examination of fine-needle aspirate samples revealed Histoplasma capsulatum organisms in the urinary bladder wall and spleen. The cat was treated with itraconazole (10 mg/kg per os q 24 hr for 2.5 wk). The cat was euthanized after 19 days of treatment because of lack of improvement. To the authors’ knowledge, this is the first documented case of feline disseminated histoplasmosis diagnosed in the urinary bladder wall.

scholarly journals Metastatic thymoma in the liver of a dog

2018 ◽  
Vol 30 (5) ◽  
pp. 774-778
Author(s):  
Valerie Wiles ◽  
Jamie Haddad ◽  
Nicole Leibman ◽  
Anne C. Avery ◽  
Kelly L. Hughes
Keyword(s):  
Flow Cytometry ◽  
T Cell Receptor ◽  
Mediastinal Mass ◽  
Abdominal Ultrasound ◽  
Cell Receptor ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
T Cell Receptor Genes ◽  
History Of ◽  
Portuguese Water

A 12-y-old neutered male Portuguese Water dog was presented because of a 1-y history of persistent hyporexia, diarrhea, and recurrent pyelonephritis. Abdominal ultrasound revealed hepatic nodules and diffuse splenomegaly, and radiographs revealed a mediastinal mass. Fine-needle aspirates of the liver, spleen, and mediastinal mass were suspicious for lymphoma. Flow cytometry identified small T cells that co-expressed CD4 and CD8 at all sites, most suspicious for thymoma, but lymphoma could not be ruled out. PCR for antigen receptor rearrangements analysis identified polyclonal amplification of the T-cell receptor genes, more consistent with thymoma than lymphoma. Histopathology of the liver and thymic mass confirmed thymoma with hepatic metastasis.

scholarly journals A Case Report on Bilateral Adrenal Histoplasmosis

2020 ◽  
Vol 23 (2) ◽  
pp. 210-212
Author(s):  
Md Sazzad Hossain ◽  
Mohammad Zahid Hasan ◽  
Mir Ehteshamul Haque ◽  
Mostakim Maoya
Keyword(s):  
Adrenal Mass ◽  
Adrenal Glands ◽  
Histoplasma Capsulatum ◽  
Needle Aspiration ◽  
Immunosuppressed Patient ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Disseminated Histoplasmosis ◽  
Adrenal Masses ◽  
Needle Aspiration Cytology

Disseminated histoplasmosis affecting the adrenal glands is a very rare infection and an uncommon cause of adrenal insufficiency. We present a case of bilateral adrenal histoplasmosis in a 77 years old immunosuppressed patient who presented with bilateral adrenal masses. The fine needle aspiration cytology of the adrenal mass was positive for Histoplasma capsulatum. Bangladesh Journal of Urology, Vol. 23, No. 2, July 2020 p.210-212

scholarly journals A 8- year Bangladeshi girl with disseminated histoplasmosis, presented as chronic liver disease with portal hypertension: a rare case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Luthfun Nahar ◽  
Md Benzamin ◽  
Naznin Sarkar ◽  
Urmi Roy ◽  
Kamrun Nahar ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Abdominal Distension ◽  
Pulmonary Involvement ◽  
Tuberculosis Patient ◽  
Blood Product Transfusion ◽  
Disseminated Histoplasmosis ◽  
Rare Case Report ◽  
History Of ◽  
Generalized Lymphadenopathy ◽  
Medical University

Abstract Background Histoplasmosis is a rare infectious condition with mainly pulmonary involvement. Disseminated histoplasmosis may occur in immunocompromised condition. It can present in different ways but jaundice and ascites is very uncommon. Case presentation A 8- year old girl visited to department of pediatric gastroenterology & nutrition, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Child presented with fever, jaundice and abdominal distension for 2 ½ months. There was no history of contact with tuberculosis patient and travelling to kala-azar, malaria endemic zone and no history of previous jaundice, blood or blood product transfusion, history of sib death, family history of jaundice or neuropsychiatric disorder, significant weight loss. On general examination she was fretful, febrile, moderately icteric, mildly pale, vitally stable, severely wasted and moderately stunted, skin survey revealed infected scabies, BCG vaccine mark was absent, generalized lymphadenopathy, hepato-splenomegaly and ascites present. After evaluating the physical findings, several investigations was done including lymphnode biopsy, then the case was finally diagnosed as Disseminated histoplasmosis with portal hypertension. Child was treated with injectable Deoxycholate Amphotericin B for 28 days and improved on follow up. Conclusion We suggest that children presenting with fever, jaundice, lymphadenopathy and hepatosplenomegaly and portal hypertension, disseminated histoplasmosis can be one differential.

scholarly journals Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Prasan K. Panda ◽  
Siddharth Jain ◽  
Rita Sood ◽  
Rajni Yadav ◽  
Naval K. Vikram
Keyword(s):  
Histoplasma Capsulatum ◽  
Bone Marrow Aspiration ◽  
Febrile Illness ◽  
Immunocompetent Patient ◽  
Dimorphic Fungus ◽  
Recent Onset ◽  
Disseminated Histoplasmosis ◽  
The Face ◽  
History Of ◽  
Progressive Disseminated Histoplasmosis

Histoplasmosis is caused by a dimorphic fungusHistoplasma capsulatumin endemic areas, mainly America, Africa, and Asia. In India, it is being reported from most states; however, it is endemic along the Ganges belt. We report a case of an apparently immunocompetent male who presented with 3-month history of fever, cough, and weight loss with recent onset odynophagia and had hepatosplenomegaly and mucocutaneous lesions over the face. The differential diagnosis of leishmaniasis, tuberculosis, leprosy, fungal infection, lymphoproliferative malignancy, and other granulomatous disorders was considered, but he succumbed to his illness. Antemortem skin biopsy and bone marrow aspiration along with postmortem liver, lung, and spleen biopsy showed disseminated histoplasmosis. This case highlights the need for an early suspicion of progressive disseminated histoplasmosis in the presence of classical mucocutaneous lesions even in an immunocompetent patient suffering from a febrile illness. Cure rate approaches almost 100% with early treatment, whereas it is universally fatal if left untreated.

scholarly journals The initial intravenous treatment of a human immunodeficiency virus-infected child with complicated abdominal tuberculosis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Anthony K. Enimil ◽  
Brian Eley ◽  
James Nuttall
Keyword(s):  
Human Immunodeficiency Virus ◽  
Abdominal Distension ◽  
Abdominal Tuberculosis ◽  
Abdominal Ultrasound ◽  
Infected Child ◽  
Antibody Testing ◽  
Hiv Viral Load ◽  
Immunodeficiency Virus ◽  
History Of ◽  
Cluster Of Differentiation

Introduction: There is very limited published experience with intravenous (IV) antituberculosis (anti-TB) and antiretroviral therapy (ART) especially in children. We have described a human immunodeficiency virus (HIV)-infected child with complicated abdominal tuberculosis who was initially treated with IV anti-TB and a partially IV ART regimen before transitioning to oral therapy.Patient presentation: A 3-year-old boy presented with hypovolaemic shock with a 3-day history of inability to pass stools, abdominal distension and bile-stained vomiting. Abdominal ultrasound and X-ray showed small-bowel obstruction. Human immunodeficiency virus antibody testing was positive, and Cluster of Differentiation (CD)4+ lymphocyte count was 56 cells/mL (15%). Xpert Mycobacterium tuberculosis (MTB)/Rifampicin (RIF) Ultra and TB culture on induced sputum detected MTB complex sensitive to rifampicin and isoniazid.Management and outcome: Following laparotomy and closure of bowel perforations, the child was commenced on IV rifampicin, moxifloxacin and amikacin. Amikacin was stopped after 3 days because of nephrotoxicity, and meropenem and IV linezolid were added. After 20 days, ART comprising IV zidovudine, oral lamivudine solution, oral lopinavir/ritonavir solution and additional oral ritonavir solution for super boosting was commenced. By day 40, the patient was well established on oral feeds and was switched to standard oral anti-TB medications. Sputum examined 1 month after starting the treatment was found culture-negative for MTB. After 4 months of treatment, the HIV viral load was 100 copies/mL. He completed a total of 12 months of anti-TB treatment.Conclusion: Despite limited experience and few available IV formulations of standard anti-TB and ARV medications, initial IV therapy may be beneficial for patients in whom oral medication is not an option.

scholarly journals SEPTIC SHOCK IN PATIENT WITH DISSEMINATED HISTOPLASMOSIS ASSOCIATED WITH AIDS: A CASE REPORT

2013 ◽  
Vol 55 (4) ◽  
pp. 283-286
Author(s):  
Fabiano de Oliveira Poswar ◽  
Jair Almeida Carneiro ◽  
Janice Mendes Stuart ◽  
Jorge Patrick Oliveira Feliciano ◽  
Daniella Cristina Nassau
Keyword(s):  
Septic Shock ◽  
Histoplasma Capsulatum ◽  
Peripheral Blood Smear ◽  
The Body ◽  
Rapid Progression ◽  
Newly Diagnosed ◽  
Systemic Mycosis ◽  
Disseminated Histoplasmosis ◽  
Serious Infection ◽  
History Of

SUMMARY Histoplasmosis is a systemic mycosis caused by Histoplasma capsulatum, which may present itself as a serious infection in immunocompromised individuals. We present a case of 31-year-old female with newly diagnosed HIV infection and history of fever, general and respiratory symptoms and diffuse hyperchromic papules through the body. She was admitted, with rapid progression to septic shock, and the presence of neutrophils filled with yeast-like organisms was detected on peripheral blood smear hematoscopia on the third day of hospitalization. The following is a brief review on the clinical picture and management of histoplasmosis.

scholarly journals Solitary Fibrous tumor arising from the Omentum

2016 ◽  
Vol 9 (4) ◽  
Author(s):  
Salem A ◽  
Madden M ◽  
Bateson P
Keyword(s):  
Ct Scan ◽  
Solitary Fibrous Tumor ◽  
Abdominal Mass ◽  
Abdominal Distension ◽  
Abdominal Ultrasound ◽  
Greater Omentum ◽  
Midline Laparotomy ◽  
Tender Mass ◽  
History Of ◽  
Fibrous Tumor

A 60-year old man presented with a one week history of intermittent periumbilical pain. He had weight loss of half a stone over 6 weeks and abdominal distension for 2 weeks, there was no other systemic complaint. General examination revealed bilateral Dupuytren`s contracture and grade 4 finger clubbing. Abdominal palpation revealed a very large non tender mass. The Liver and spleen were difficult to assess because of the size of the mass. Rectal examination was normal. An abdominal Ultrasound showed a central abdominal mass of mixed echogenicity. CT scan showed a large lobulated mass with overlying serpinginous vessels with a clear plane posteriorly separating it from the retro-peritoneum. Liver, spleen and pancreas showed no abnormality. CT scan of the chest showed no abnormality. Core biopsy under ultrasound guidance revealed features consistent with a solitary fibrous tumor, haemangiopericytoma or angiosarcoma. The patient underwent a midline laparotomy. The huge mass was attached to the greater omentum by a pedicle with minimal adhesions to the lateral peritoneum. It was excised compeletly. The post-operative course was uneventful. Gross pathological findings macroscopically revealed the mass measuring 24x19x10 cm, weighing 3870 grams and on section it was a fleshy lobulated tumour with a few cystic areas. There was some attenuated fat on part of the surface. Histologically, the architecture was pattern-less with prominent stromal hyalinization, varying cellularity (mainly spindle and ovoid cells) and branching (haemangiopericytoma-like) vessels.

Urine antigen-negative disseminated histoplasmosis mimicking post-transplant lymphoproliferative disorder

2020 ◽  
Vol 13 (6) ◽  
pp. e233976 ◽  
Author(s):  
Surbhi Gupta ◽  
Colin Andrew Hinkamp ◽  
Matthew Lo
Keyword(s):  
Liposomal Amphotericin ◽  
Histoplasma Capsulatum ◽  
Complement Fixation ◽  
Streptococcal Pharyngitis ◽  
Disseminated Histoplasmosis ◽  
Urine Antigen ◽  
History Of ◽  
Multiple Challenges ◽  
Elevated Transaminases ◽  
Antigen Testing

A 50-year-old woman with a history of kidney transplant presented with 2 days of abdominal pain after 6 months of recurrent streptococcal pharyngitis, fevers, weight loss and a new rash on her chest and back. Her examination was notable for a unilateral tonsillar exudate and 2–3 mm pink papules with a fine scale over her chest and back. CT of the abdomen and chest demonstrated several large lymph nodes, and laboratory investigation revealed new cytopenias and elevated transaminases. Urine antigen testing for Histoplasma capsulatum was negative, but a fungal complement fixation panel was reactive for Histoplasma antibodies. Skin biopsy revealed intracellular organisms consistent with H. capsulatum. She underwent treatment with liposomal amphotericin B but due to nephrotoxicity, drug interactions and worsening transaminitis, therapy was changed to itraconazole. The diagnosis and management of disseminated histoplasmosis presents multiple challenges, which are of particular importance in patients with a history of renal transplantation.

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