High Prevalence of Gastroesophageal Reflux Symptoms in Patients with both Acute and Nonacute Cough

2021 ◽  
Vol 15 (10) ◽  
pp. 3352-3355
Author(s):  
Kiran Maqbool ◽  
Laraib Zafar ◽  
Asim Maqsood ◽  
Shahid Waheed ◽  
Tahir Mukhtar Sayed ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Respiratory Symptoms ◽  
Previous History ◽  
Partial Gastrectomy ◽  
P Value ◽  
Esophageal Reflux ◽  
Acute Cough ◽  
Reflux Symptoms ◽  
High Prevalence ◽  
Gerd Symptoms

Background and Aim: Gastro esophageal reflux disease (GERD) affects more than 30% of the Asian population, and its symptoms are common. The high prevalence of atrophic gastritis in the Pakistani population is exacerbated by gastro esophageal reflux disease. The present study aims was to assess the high prevalence of gastro esophageal reflux symptoms in patients with both acute and no acute cough. Materials and Methods: This cross-sectional study was conducted on 426 consecutive patients who attended the General Medicine and Emergency department of Sheikh Khalifa bin Zayed Hospital Rawalakot and Avicenna Hospital, Lahore from February 2021 to July 2021. Informed consent in written form was taken from all the patients. Patients with partial gastrectomy previous history and user of antagonist H2-receptor, steroids, proton pump inhibitor (PPI), and other inflammatory drugs two months prior to the investigation were excluded. Helsinki Declaration was utilized for this study with ethical approval taken from the hospital ethics committee. SPSS version 24 was used for data analysis. Results: Of the total 426 patients, GERD diagnosed patients were 248 (58.2%) and 178 (41.8%) had respiratory symptoms. The prevalence of GERD symptoms was higher in respiratory symptoms patients compared to without respiratory symptoms patients (p-value=0.05). Out of 178respiratory symptoms patients, GERD symptoms were present in 71 (39.9%) of acute cough while 107 (60.1%) of non-acute cough while 86 (34.7%) of 248 had no respiratory symptoms. The GERD development has no significant association with respiratory symptoms duration, however, patients having respiratory symptoms are at substantially elevated risk for GERD development. Conclusion: Our study found that respiratory symptoms patients are considerably more likely to develop GERD. GERD prevalence was similar in both acute and non-acute cough patients, implying that the presence of respiratory diseases is associated with the development of GERD regardless of the duration of respiratory symptoms. Keywords: Gastro esophageal reflux; Acute cough; Respiratory symptoms

scholarly journals A cross-sectional study on prevalence of gastro esophageal reflux disease in regurgitant infant and children with evaluation of IGERQ score

2018 ◽  
Vol 5 (2) ◽  
pp. 395
Author(s):  
Elayaraja Kandasamy ◽  
Senthil Kumar Andy
Keyword(s):  
Negative Predictive Value ◽  
Reflux Disease ◽  
Predictive Value ◽  
High Specificity ◽  
Cross Sectional Study ◽  
P Value ◽  
Esophageal Reflux ◽  
Chi Square ◽  
Cross Sectional ◽  
Validated Questionnaire

Background: Gastro Esophageal Reflux Disease (GERD) is the most common esophageal disorder in children of all ages. GER becomes pathological when reflux increase in frequency and intensity, associated with esophageal and respiratory symptoms. Thus, the study was determined to assess the prevalence of GERD in regurgitant children of age 6 to 24 months with evaluation of IGERQ score (Infant Gastro Esophageal Reflux Questionnaire).Methods: A descriptive study was conducted in Gastroenterology Department, Institute of child Health and Hospital for Children, Egmore, Chennai from September 2007 to September 2009. 123 regurgitant children of age 6-24 months were enrolled. Clinical examination and validated questionnaire with total score of 25 was used. Data analysis was aided by EPI info programme. Chi square with P value <0.05 was considered statistically significant. IGERQ score was evaluated by calculating sensitivity, specificity, positive predictive valve and negative predictive valve.Results: The prevalence of GERD in regurgitant infant and children is 30.8%. Refusal of feeds and poor weight in regurgitant children significantly correlated with GERD. sensitivity was 84%, specificity was 96%, positive predictive value was 91%, negative predictive value was 93%Conclusions: Clinical diagnosis of GERD is sufficient in most instances and a questionnaire may aid in diagnosis the disease. IGERQ score is easily adaptable. IGERQ score >5 has high specificity positive and negative predictive value but reproducibility in our population need further evaluation. 

scholarly journals CYP2C19 genotype variability in patients with refractory gastroesophageal reflux after per-oral endoscopic myotomy (POEM)

2021 ◽  
Vol 09 (06) ◽  
pp. E843-E847
Author(s):  
Yaseen B. Perbtani ◽  
Donevan R. Westerveld ◽  
Dennis J. Yang ◽  
Peter V. Draganov
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Cyp2c19 Genotype ◽  
First Line Therapy ◽  
Reflux Symptoms ◽  
Refractory Gerd ◽  
Endoscopic Myotomy ◽  
Per Oral ◽  
Gerd Symptoms

Abstract Background and study aims Symptomatic gastroesophageal reflux is a recognized potential adverse event following peroral endoscopic myotomy (POEM). Proton pump inhibitors (PPIs) are an effective first-line therapy; although their efficacy can be affected by genotype cytochrome P450 2C19 (CYP2C19) variability leading to enhanced clearance of PPIs. The aim of our study was to evaluate the incidence of CYP2C19 genotype variability in POEM patients with refractory gastroesophageal reflux symptoms. Patients and methods This was a single-center, prospective, cohort study of consecutive POEM cases during a 7-year study period (2013–2020). Reflux symptoms were assessed with the validated gastroesophageal reflux disease questionnaire (GerdQ) and objective pH testing after POEM. CYP2C19 genotype testing was obtained in all patients with refractory gastroesophageal reflux disease (GERD) symptoms, defined as an abnormal pH study and GerdQ score ≥ 8 while on PPIs twice daily. Results POEM was performed in 325 consecutive patients (48.3 % female; mean age 57 years) during the study period. Twenty patients (6.8 %) had PPI-refractory, post-POEM gastroesophageal reflux based on their GerdQ score (median 9, range 8–11) and abnormal pH studies. CYP2C19 genotype testing identified 55 % (11/20) of these patients as being rapid metabolizers. Out of these, 9 (82 %) had improvement in clinical GERD symptoms after changing to a PPI less affected by CYP2C19 pharmacogenetics. Conclusions Post-POEM, PPI-refractory GERD is rare. As shown in this study, rapid metabolizers commonly respond by changing to a PPI less affected by CYP2C19 pharmacogenetics, thereby reducing the risk of long-term consequences from GERD and unnecessary anti-reflux surgery.

scholarly journals Frequency of Obesity among Gastroesophageal Reflux Disease Patients

2021 ◽  
Vol 15 (5) ◽  
pp. 1507-1510
Author(s):  
K. H. Samejo ◽  
S. K. Kumar ◽  
G. Lail ◽  
A. B. Langove ◽  
S. Ahsam ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Body Mass ◽  
Reflux Disease ◽  
Cross Sectional Study ◽  
P Value ◽  
Esophageal Reflux ◽  
Cross Sectional ◽  
Study Population

Objective: Gastroesophageal reflux disease (GERD) prevalence ranges from 24% to 35% in Pakistani population. Studies have demonstrated GERD frequency is directly proportional to increasing weight. Thus, the frequency of obesity among gastro esophageal reflux disease patients was determined. Methodology: This cross-sectional study was conducted on outpatients with GERD visiting Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi; from December 2017 to June 2018. Clinical and demographic parameters of study population were recorded. Body mass index (BMI) more than 27 was labeled as obese. Patients with history of ischemic heart disease, pregnancy, ascites and/or Patients on NSAIDS, bisphosphonates or steroids were excluded. Results: One hundred and fifty patients with mean age of 43.3±11.5 years were included in study. Eighty-seven patients (63.3%) had age more than 40 years. Majority of study population were males 95 (63.3%). Mean height and weight of study population were 163.09±9.56 cm and 72.92±15.13 kg, respectively. Mean BMI were 27.55±6.02 in which 71 (47.3%) were obese i.e., BMI >27. Majority were Urdu speaking i.e., 57 (38%) followed by Sindhi 31 (20%) Diabetes mellitus was documented in 22 (14.7%) and hypertension in 16 (10.7%) patients. Statistically significant association of GERD was seen in obese females (p-value: 0.018) Conclusion: Increase frequency of obesity is significantly associated with GERD. More proportion of obese females has GERD. Keywords: Gastro esophageal reflux disease; Body mass index; Weight; height

scholarly journals Effects of Life style factors on the symptoms of gastro esophageal reflux disease: A cross sectional study in a Pakistani population

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Shahid Ahmed ◽  
Sajjad Jamil ◽  
Hafeezullah Shaikh ◽  
Maryam Abbasi
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Reflux Disease ◽  
Cross Sectional Study ◽  
Lifestyle Factors ◽  
Sectional Study ◽  
Esophageal Reflux ◽  
Cross Sectional ◽  
Disease Symptoms ◽  
Pakistani Population ◽  
Gerd Symptoms

Background & Objective: Gastro esophageal reflux disease (GERD) broadly includes the whole spectrum of reflux disease symptoms like heartburn or acid regurgitation to endoscopic, reflux esophagitis or Barrett’s esophagus. Our aim therefore was to study the association between Gastroesophageal reflux disease symptoms and various lifestyle factors. Methods: A descriptive cross-sectional study was carried out in the outpatient department of Darul Sehat Hospital, Zubaida Medical Center and Liaquat National Hospital & Medical College, Karachi, Pakistan from January 2018 to October 2018. The selected candidates were asked to fill a validated GERD questionnaire and they were also asked about their lifestyle factors. Odds ratio and their 95% confidence interval were estimated using binary logistic regression with GERD symptoms as the study outcome. Results: A total of 2000 respondents completed the questionnaire. 69.3% gastroesophageal reflux disease cases were found in participants above 35 years of age while 56.9% subjects were male. The most common lifestyle factors associated with GERD were less exercise time (90.9%) (OR, 6.47; 95% CI, 4.91-8.53), 78.3% participants had habit of eating midnight snacks (OR, 5.08; 95% CI, 4.03-6.40), 87.3% participants reported less interval between dinner and sleep (OR, 6.98; 95% CI, 5.36-9.08). The most important factor relieving GERD symptoms was raising the head of bed during sleep (79.4%) while 43.3% subjects with the habit of post dinner walk reported fewer symptoms of GERD. Conclusion: Lifestyle factors particularly less physical activity, late evening meals, inadequate sleep, smoking and post dinner lying were found to be associated with GERD symptoms. doi: https://doi.org/10.12669/pjms.36.2.1371 How to cite this:Ahmed S, Jamil S, Shaikh H, Abbasi M. Effects of Life style factors on the symptoms of gastro esophageal reflux disease: A cross sectional study in a Pakistani population. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.1371 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals (Prevalence of Respiratory Symptoms Among Welders in Steel and Air Conditioning Plant (DAMMAM City

2015 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr. Fahad Ali Al-Faleh
Keyword(s):  
Air Conditioning ◽  
Respiratory Symptoms ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Steel Plant ◽  
P Value ◽  
Shortness Of Breath ◽  
Cross Sectional ◽  
Local Exhaust Ventilation ◽  
High Prevalence

Aims:  To determine the prevalence of welding related respiratory symptoms. Methods: Cross-sectional study with convenience sampling. The study was conducted among welding workers in air conditioning plant and steel plant in 2014, occupational history questionnaire and respiratory symptoms questionnaire were administered by person-to-person to 110 welders from two plants in DAMMAM city, Saudi Arabia. Results: this study involved 110 welders from two plants, 38 welders from AC plants and 72 welders from steel plants. All welders are male and welding type in AC plant are oxyacetylene welding (oxyacetylene welding (OAW)) and the welding type in steel plant are arc welding. 21 (19.1%) welders from AC plant reported shortness of breath compared to 26 (23.6%) welders from steel plant (Χ2 =2.62, P value =0.03). 16 (42.1%) of welders in AC plant reported cough compared to 24 (33.3%) of welders in steel plant (Χ2 =1.83, P value = 0.03). 20 (52.6%) of welders in AC plant reported phlegm compared to 27 (37.5%) of welders in steel plant (Χ2 =2.33, P value=0.02).  40 (36.4%) of welders reported cough (Χ2 =2.33, P value = 0.04). 47 (42.7%) of welders reported phlegm (Χ2 =3.07, P value = 0.02).  There is no significant associations was founded between (marital status and education level) and respiratory symptoms. Significant association was founded between duration of employment and respiratory symptoms (wheeze (p value=0.03), cough (p value= 0.04), phlegm (p value=0.01). Binary logistic regression was significantly associated between shortness of breath and type of plant (p value=0.01). Conclusion: high prevalence of respiratory symptoms related to type of plant, age of welders and duration of employment. Welders should understand the hazards of the materials they are working with. General ventilation, local exhaust ventilation systems, personal protective equipment are recommended.

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