scholarly journals Protective Effect of White-Skinned Sweet Potato (Ipomoea batatas L.) against Renal Damage in Streptozotocin-Induced Diabetic Rats

2010 ◽  
Vol 20 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Hye-Won Jang ◽  
Moch. Saiful Bachri ◽  
Kyung-Ok Moon ◽  
Jong-Ok Park
2010 ◽  
Vol 20 (11) ◽  
pp. 1569-1576 ◽  
Author(s):  
Moch. Saiful Bachri ◽  
Hye-Won Jang ◽  
Jong-Won Choi ◽  
Jong-Ok Park

2009 ◽  
Vol 47 (10) ◽  
pp. 2516-2521 ◽  
Author(s):  
Kunga Mohan Ramkumar ◽  
Ponnirul Ponmanickam ◽  
Shanmugam Velayuthaprabhu ◽  
Govindaraju Archunan ◽  
Palanisamy Rajaguru

Molekul ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 48
Author(s):  
Dody Novrial ◽  
Soebowo Soebowo ◽  
Parno Widjojo

Sweet potato (Ipomoea batatas L) leaf is one of well known vegetables among Indonesian people.  It is also often used as traditional medicine for diabetes mellitus.  This research aimed to investigate the protective effect of I. batatas L leaves extract on the pancreas of IDDM animal model.  Twenty five male Sprague-Dawley rats were divided into 3 treatment groups, and 2 control groups.  Streptozotocin (STZ) was injected at multiple low doses (40 mg/kg BW) intraperitoneally for 5 consecutive days,  I. batatas L leaves extract (doses 0.25, 0.8, and 2.5 g/ kg BW) were administered for 14 days after the first STZ injection.  Fasting blood glucose was analyzed after complete STZ induction (day 6), and after 14 days treatment.  At the end of the study, rats were terminated, and pancreas were removed for histological examination and immunohistochemical procedure using anti-insulin antibody.  Diabetic rats treated with 2.5 g/kg BW I. batatas L leaves extract showed lowest fasting blood glucose among treatment groups, and had approximately 50% normal Langerhans islets with functional beta cells.  These results suggest that I. batatas L leaves extract has anti diabetic activity through its protection effect on the pancreas.


Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
D Rosas-Ramírez ◽  
R Pereda-Miranda
Keyword(s):  

2018 ◽  
Vol 15 (2) ◽  
pp. 146
Author(s):  
BRILIAN DINANTI ◽  
FITRI HANDAJANI

<p>Liver is an organ with complex metabolism. When the liver is inflamed, cellular immunity will defend against inflammatory agents by stimulating immune cells to produce reactive oxygen species (ROS). Excessive ROS accumulation cause oxydative stress with increased  liver malondialdehyde (MDA) level. Some researches showed that purple sweet potato contain flavonoids (anthocyanins) that functioned as antioxydants. This study aimed to show the prophylactic effect of purple sweet potato extract to the liver MDA level of male Wistar rats induced by carrageenan.</p><p>This study used post-only control group method using 18 male Wistar rats divided into 3 groups: group of rats without treatment, group of rats induced by 0,1 ml of 1% carrageenan by intraplantar injection on day-8, and group of rats given with 872 mg/kgBW of purple sweet potato extract for 7 days and induced by 0,1 ml of 1% carrageenan. In the end of the study, the liver MDA levels were measured by Thio-Barbituric Acid method on each groups.</p><p>The results of One-Way ANOVA test showed there was no significant difference (p = 0,290) between group of rats without treatment (<em>x̅</em>= 207,50) and group of rats induced by carrageenan (<em>x̅</em>=233,17). Then, there is no significant difference (p = 0.978) between group of rats induced by carrageenan and group of rats given with prophylactic purple sweet potato extract and induced by carrageenan (<em>x̅</em>= 232,50).</p><p>The conclusion of this study is giving intraplantar injection of carrageenan can increase liver MDA level insignificantly and giving prophylactic purple sweet potato extract has an effect to decrease the liver MDA level of rats induced by carragenan insignificantly because it contains anthocyanins as antioxidants.</p><p> </p><strong>Keywords: </strong>Liver, <em>Ipomoea batatas</em> L., Malondialdehyde, Anthocyanins


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